摘要:
This invention is directed to a method of treating sexual dysfunction in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, CI, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and O to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.
摘要翻译:本发明涉及治疗受试者的性功能障碍的方法,其包括施用治疗有效量的式(I)化合物或其药学上可接受的盐或酯的步骤,其中Rx是选自下组的成员 由氢,1至8个碳原子的低级烷基,选自F,Cl,Br和I的卤素,含有1至3个碳原子的烷氧基,硝基,羟基,三氟甲基和含有1至3个碳原子的硫代烷氧基组成; x为1〜3的整数,条件是当x为2或3时R可以相同或不同; R 1和R 2可以相同或不同,并且独立地选自氢,1至8个碳原子的低级烷基,芳基,芳基烷基,3至7个碳原子的环烷基; R1和R2可以连接形成被选自氢,烷基和芳基的成员所取代的5至7元杂环,其中环状化合物可包含1至2个氮原子和0至1个氧原子 其中氮原子彼此不直接连接或与氧原子直接连接。
摘要:
The present disclosure relates to a multi-channel detector having a reduced number of output channels and including: a linear amplifier linearly amplifying an input signal; an offset correcting unit configured by a circuit that is independent from the linear amplifier, including an operational amplifier inside, and correcting an offset level that changes in accordance with an amplification rate of the operational amplifier; a uniformity correcting unit reducing a non-uniform characteristic of the input signal by finely adjusting a gain of an output signal of the linear amplifier; a signal delay unit delaying an output signal of the uniformity correcting unit until a time point when output signals are generated from a comparison unit and a signal determining unit, and a switch circuit receives a trigger from the signal determining unit; a comparison unit comparing the output signal of the uniformity correcting unit with a signal of a predetermined level with each other; a signal determining unit receiving a trigger signal from the comparison unit, determining channel position information of a channel in which an event occurs, transmitting a trigger signal to a switch circuit located at the determined channel position, and outputting the determined position information; and a channel information processing unit receiving energy information, time information, or the channel position information of a channel in which an event occurs as input when a trigger signal is input from the signal determining unit to the switch circuit located at the determined channel position.
摘要:
Provided is a method for removing noise of a positron emission tomography (PET) signal in a PET-magnetic resonance imaging (MRI) fusion device without using an MRI radio frequency (RF) shield that degrades image quality. The method includes: (a1) converting a PET analog signal into a digital signal having a predetermined sampling frequency; (b1) determining whether the resulting PET digital signal is to be included in image reconstruction based on modeling using sampling points of the PET digital signal or an integration value of the PET digital signal; and (c1) extracting only the PET digital signal that will be included in image reconstruction. The method allows acquisition of molecular-level images without declined performance of a PET detector.
摘要:
There is provided a dishwasher. The dishwasher includes a tub for receiving dishes, a steam generation unit provided at an outside of the tub and generating steam that will be supplied to the tub, a steam passage along which the steam generated from the steam generation unit is supplied to the tub, and a chamber for storing water used for generating the steam.
摘要:
Azole compounds containing carbamoyl group and pharmaceutically useful salts thereof are described. The compounds are effective anticonvulsants which are used in the treatment of disorders of the central nervous system, especially as anxiety, depression, convulsion, epilepsy, migraine, bipolar disorder, drug abuse, smoking, ADHD, obesity, sleep disorder, neuropathic pain, stroke, cognitive impairment, neurodegeneration, stroke and muscle spasm.
摘要:
A semiconductor device having a high voltage MOS transistor. The device includes a gate oxide layer disposed between a gate electrode and a substrate on an active area and having relatively thick portions at edges thereof. A fabrication method includes forming on the substrate is a nitride layer having an opening in a high voltage region. An oxide layer is deposited over the substrate and anisotropically etched to remain only on sidewalls of the opening. A first gate oxide layer is formed on the substrate in the opening, and the nitride layer is removed. Then a second gate oxide layer is formed over the substrate such that the second gate oxide layer has a relatively thinner thickness than the first gate oxide layer. Gate electrodes are then formed in the high voltage region and the low voltage region.
摘要:
A process for preparing O-carbamoyl aminoalcohols represented by Formula I wherein: n is an integer from 0 and 5; R1, R2, R3 and R4 are individually selected from the group consisting of hydrogen, alkyl, cycloalkyl, substituted or unsubstituted aryl and arylalkyl the aryl portion of which may be unsubstituted or substituted: R5 and R6 are individually selected from the group consisting of hydrogen, alkyl or arylalkyl the aryl portion of which may be unsubstituted or substituted; or R1 and R5 together with the carbon and nitrogen to which they are attached may form an unfused or fused heterocyclic ring having from 4 to 10 members. comprising reacting an aminoalcohol represented by Formula II wherein n, R1, R2, R3, R4, R5 and R6 are as defined; with a cyanate and an excess of an acid in an organic solvent medium.
摘要:
A method for manufacturing a semiconductor device which, on performing a via first Dual Damascene process, inhibits or prevents the formation of a void in a bottom anti-reflective coating filling a via hole. The method typically includes the steps of forming a bottom anti-reflective coating (BARC) in a via hole in an interlayer dielectric on a semiconductor substrate sufficiently to fill the via hole; disposing an acid diffusion material on the BARC; forming a cross-link layer between the BARC and the acid diffusion material; removing the remaining acid diffusion material; and etching the cross-link layer, the BARC and the interlayer dielectric to form a trench extending from an upper portion of the via hole.
摘要:
According to method of managing and reproducing additional audio files of an interactive optical disc, additional audio data associated with main video data of an optical disc such as an interactive DVD are recorded as a file of a prescribed format. File information about the additional audio data and buffering information thereabout recorded in the file of a prescribed format. An optical disc apparatus interprets the file information and buffering information and then carries out a series of operations storing and reading out and playing the additional audio data in a way suitable to the buffering area allocated within a buffer. Consequently, additional audio data of various contents are read out from the optical disc or provided by a content providing server connected through the Internet.
摘要:
There is disclosed a connection structure and method of a plasma display panel that is adaptive for preventing a short circuit caused by conductive ball mass and improving connection cohesiveness. A connection structure of a plasma display panel according to an embodiment of the present invention includes a first substrate having a plurality of panel-electrodes; a second substrate having a plurality of connecting-electrodes arranged to correspond to the panel-electrodes; and a connection member located between the first substrate and the second substrate to directly connect the connecting-electrodes with the panel-electrodes upon compression. Accordingly, there is no conductive ball, so the occurrence of short circuit caused by the conductive ball mass of prior art is prevented and, at the same time, the copper electrode penetrates the panel-electrode, thereby improving connection cohesiveness.