利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

21 条记录 (耗时 0.026 秒)

    Methods for treatment of sexual dysfunction
    1.
    发明授权
    Methods for treatment of sexual dysfunction 有权
    治疗性功能障碍的方法

    公开(公告)号：US08552060B2

    公开(公告)日：2013-10-08

    申请号：US11922128

    申请日：2006-06-13

    申请人： Joseph Palumbo ,  Jonathan Sporn ,  Thomas Steckler ,  Yong Choi ,  James S. Lee

    发明人： Joseph Palumbo ,  Jonathan Sporn ,  Thomas Steckler ,  Yong Choi ,  James S. Lee

    IPC分类号： A61K31/24

    CPC分类号： A61K31/165

    摘要： This invention is directed to a method of treating sexual dysfunction in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, CI, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and O to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.

    摘要翻译： 本发明涉及治疗受试者的性功能障碍的方法，其包括施用治疗有效量的式（I）化合物或其药学上可接受的盐或酯的步骤，其中Rx是选自下组的成员 由氢，1至8个碳原子的低级烷基，选自F，Cl，Br和I的卤素，含有1至3个碳原子的烷氧基，硝基，羟基，三氟甲基和含有1至3个碳原子的硫代烷氧基组成; x为1〜3的整数，条件是当x为2或3时R可以相同或不同; R 1和R 2可以相同或不同，并且独立地选自氢，1至8个碳原子的低级烷基，芳基，芳基烷基，3至7个碳原子的环烷基; R1和R2可以连接形成被选自氢，烷基和芳基的成员所取代的5至7元杂环，其中环状化合物可包含1至2个氮原子和0至1个氧原子 其中氮原子彼此不直接连接或与氧原子直接连接。

    Methods for Treatment of Sexual Dysfunction
    2.
    发明申请
    Methods for Treatment of Sexual Dysfunction 有权
    治疗性功能障碍的方法

    公开(公告)号：US20090221553A1

    公开(公告)日：2009-09-03

    申请号：US11922128

    申请日：2006-06-13

    申请人： Joseph Palumbo ,  Jonathan Sporn ,  Thomas Steckler ,  Yong Moon Choi ,  James S. Lee

    发明人： Joseph Palumbo ,  Jonathan Sporn ,  Thomas Steckler ,  Yong Moon Choi ,  James S. Lee

    IPC分类号： A61K31/553 ,  A61K31/27 ,  A61K31/55 ,  A61P15/00

    CPC分类号： A61K31/165

    摘要： This invention is directed to a method of treating sexual dysfunction in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, CI, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and O to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.

    摘要翻译： 本发明涉及治疗受试者的性功能障碍的方法，其包括施用治疗有效量的式（I）化合物或其药学上可接受的盐或酯的步骤，其中Rx是选自下组的成员 由氢，1至8个碳原子的低级烷基，选自F，Cl，Br和I的卤素，含有1至3个碳原子的烷氧基，硝基，羟基，三氟甲基和含有1至3个碳原子的硫代烷氧基组成; x为1〜3的整数，条件是当x为2或3时R可以相同或不同; R 1和R 2可以相同或不同，并且独立地选自氢，1至8个碳原子的低级烷基，芳基，芳基烷基，3至7个碳原子的环烷基; R1和R2可以连接形成被选自氢，烷基和芳基的成员所取代的5至7元杂环，其中环状化合物可包含1至2个氮原子和0至1个氧原子 其中氮原子彼此不直接连接或与氧原子直接连接。

    Magnetically mounted door hardware template
    5.
    发明授权
    Magnetically mounted door hardware template 有权
    磁性门硬件模板

    公开(公告)号：US09376835B2

    公开(公告)日：2016-06-28

    申请号：US14449450

    申请日：2014-08-01

    申请人： William Schildwachter ,  James S. Lee ,  Ferdinand E. Orbeta

    发明人： William Schildwachter ,  James S. Lee ,  Ferdinand E. Orbeta

    IPC分类号： G01B5/24 ,  E05B17/06

    CPC分类号： E05B17/06 ,  E05B47/0038

    摘要： A magnetically mounted template for identifying the optimum installation location for a door hardware device. The template has a working element that engages a cooperating door hardware device, for example, a working latch that engages a bolt. The template is particularly suitable for installing electrically operable door hardware devices, such as electric strikes, which require wiring as well as mechanical attachment to a door frame or door.

    摘要翻译： 用于识别门硬件设备的最佳安装位置的磁性安装模板。 模板具有与协作的门硬件装置（例如，与螺栓接合的工作闩锁）接合的工作元件。 该模板特别适用于安装电动可操作的门硬件设备，例如电击，其需要布线以及机械附接到门框或门。

    Eagle wing tips tamper-proof fastener and driver tool
    8.
    发明授权
    Eagle wing tips tamper-proof fastener and driver tool 失效
    鹰翼尖防篡改紧固件和驱动工具

    公开(公告)号：US5598753A

    公开(公告)日：1997-02-04

    申请号：US384922

    申请日：1995-02-07

    申请人： James S. Lee

    发明人： James S. Lee

    IPC分类号： B25B13/48 ,  F16B23/00 ,  B25B23/00

    CPC分类号： F16B23/0007 ,  B25B13/485 ,  F16B23/0076 ,  Y10S411/911

    摘要： An eagle wing tips tamper-proof fastener and driver tool with complementary driver head contact for operating the same. A conventional threaded shank is perpendicularly connected to a substantially flat head. The head comprises a plurality of recessed channels numbering three and the channels radially curve outwards from a common center point. In one embodiment, the substantially vertical right and left walls of each channel allow application of torque with the driver tool in both directions. In an alternate embodiment, the substantially vertical right wall and the surface of the substantially inclined left wall allow application of torque with the driver tool to the right only.

    摘要翻译： 鹰翼提示防篡改紧固件和驱动器工具，具有互补的驱动头接触，用于操作。 常规的螺纹杆垂直地连接到基本平坦的头部。 头部包括多个凹槽，编号为三个，并且通道从公共中心点向外径向弯曲。 在一个实施例中，每个通道的大致垂直的左右壁允许在两个方向上与驱动器工具施加扭矩。 在替代实施例中，基本上垂直的右壁和基本上倾斜的左壁的表面允许仅将驾驶工具施加扭矩。

    Magnetically Mounted Door Hardware Template
    9.
    发明申请
    Magnetically Mounted Door Hardware Template 有权
    磁性门硬件模板

    公开(公告)号：US20150113817A1

    公开(公告)日：2015-04-30

    申请号：US14449450

    申请日：2014-08-01

    申请人： William Schildwachter ,  James S. Lee ,  Ferdinand E. Orbeta

    发明人： William Schildwachter ,  James S. Lee ,  Ferdinand E. Orbeta

    IPC分类号： E05B17/06

    CPC分类号： E05B17/06 ,  E05B47/0038

    摘要： A magnetically mounted template for identifying the optimum installation location for a door hardware device. The template has a working element that engages a cooperating door hardware device, for example, a working latch that engages a bolt. The template is particularly suitable for installing electrically operable door hardware devices, such as electric strikes, which require wiring as well as mechanical attachment to a door frame or door.

    摘要翻译： 用于识别门硬件设备的最佳安装位置的磁性安装模板。 模板具有与协作的门硬件装置（例如，与螺栓接合的工作闩锁）接合的工作元件。 该模板特别适用于安装电动可操作的门硬件设备，例如电击，其需要布线以及机械附接到门框或门。