-
公开(公告)号：US20050096705A1
公开(公告)日：2005-05-05
申请号：US10700368
申请日：2003-11-03
CPC分类号： A61N1/36114 , A61N1/3622 , A61N1/3627 , A61N1/368
摘要： A method and device for delivering multi-site ventricular pacing therapy in conjunction with parasympathetic stimulation for reducing ventricular wall stress. Such reduction in ventricular wall stress is useful in reversing or preventing the ventricular remodeling which can occur in heart failure patients.
摘要翻译： 结合副交感神经刺激减少心室壁应力的方法和装置，用于多局部心室起搏治疗。 心室壁应激的这种减少可用于逆转或预防心力衰竭患者发生的心室重塑。
-
2.发明申请Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure 有权在缺血后或心力衰竭期间调节细胞代谢的方法和装置公开(公告)号：US20080091138A1
公开(公告)日：2008-04-17
申请号：US11998969
申请日：2007-12-03
申请人： Joseph Pastore , Julio Spinelli , Helen Reeve , Jeffrey Ross , Rodney Salo , Allan Shuros
发明人： Joseph Pastore , Julio Spinelli , Helen Reeve , Jeffrey Ross , Rodney Salo , Allan Shuros
IPC分类号： A61M31/00
CPC分类号： A61M5/1723 , A61B5/0031 , A61B5/1107 , A61B5/14532 , A61B5/14546 , A61B5/4839 , A61M5/14244 , A61M5/14276 , A61M2205/3523 , A61N1/3627
摘要： A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.
摘要翻译： 药物递送系统检测指示需要增加心脏代谢水平的心脏状况，并且作为响应将药物释放到组织或血液中以将促进心脏收缩的代谢合成能量的来源从脂肪酸转移到葡萄糖。 这种系统的一个实例包括检测缺血的可植入装置和当检测到缺血状况时递送药物的透皮药物递送装置。 这种系统的另一个例子包括一个或多个可植入装置，用于检测心脏代谢水平的预定变化并在检测到变化时递送药物。 这种系统被应用于治疗例如患有缺血和/或心力衰竭的患者和患有心肌梗塞的患者。
-
公开(公告)号：US20070260284A1
公开(公告)日：2007-11-08
申请号：US11381211
申请日：2006-05-02
申请人： Joseph Pastore , Tamara Baynham , Andrew Kramer , Julio Spinelli , Jeffrey Ross , Rodney Salo
发明人： Joseph Pastore , Tamara Baynham , Andrew Kramer , Julio Spinelli , Jeffrey Ross , Rodney Salo
IPC分类号： A61N1/362
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/37211 , A61N1/3956
摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
摘要翻译： 各种系统实施例包括神经刺激器，脉冲发生器和控制器。 神经刺激器适于产生神经刺激信号。 脉冲发生器适用于产生起搏信号以提供心肌起搏。 控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。 调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。 本文提供了其它方面和实施例。
-
公开(公告)号：US20060259088A1
公开(公告)日：2006-11-16
申请号：US11129058
申请日：2005-05-13
申请人： Joseph Pastore , Andrew Kramer , Julio Spinelli , Rodney Salo , Tamara Baynham , Jeffrey Ross , Frits Prinzen , Ward Vanagt , Richard Cornelussen
发明人： Joseph Pastore , Andrew Kramer , Julio Spinelli , Rodney Salo , Tamara Baynham , Jeffrey Ross , Frits Prinzen , Ward Vanagt , Richard Cornelussen
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/3627 , A61N1/36557 , A61N1/37205 , A61N1/3787 , A61N2001/0585
摘要： An implantable cardiac protection pacing system delivers pacing pulses to protect the heart from injuries associated with ischemia and myocardial infarction. The system includes an implantable pulse generator (PG) that delivers the pacing pulses and a coronary stent electrically connected to the implantable PG to function as a pacing electrode through which the pacing pulses are delivered. In one embodiment, an intravascular lead provides the electrical connection between the coronary stent and the implantable PG to allow the implantable PG to be implanted in the femoral region. In another embodiment, the coronary stent and the implantable PG are integrated into an intravascular pulse generator-stent.
-
5.发明申请Method and apparatus for device controlled gene expression for cardiac protection 有权心脏保护装置控制基因表达的方法和装置公开(公告)号：US20070054871A1
公开(公告)日：2007-03-08
申请号：US11220397
申请日：2005-09-06
申请人： Joseph Pastore , Jeffrey Ross , Tamara Baynham , Rodney Salo , Andrew Kramer , Julio Spinelli
发明人： Joseph Pastore , Jeffrey Ross , Tamara Baynham , Rodney Salo , Andrew Kramer , Julio Spinelli
CPC分类号： A61N1/3627 , A61K48/0083 , A61N1/36514
摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.
摘要翻译： 基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。 生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。 在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。 基因调控信号直接或间接调控基因产物的基因表达。
-
公开(公告)号：US20060149326A1
公开(公告)日：2006-07-06
申请号：US11030575
申请日：2005-01-06
IPC分类号： A61N1/36
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
-
7.发明申请公开(公告)号：US20060253156A1
公开(公告)日：2006-11-09
申请号：US11151015
申请日：2005-06-13
申请人： Joseph Pastore , Julio Spinelli
发明人： Joseph Pastore , Julio Spinelli
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61N1/36557 , A61N1/3684 , A61N1/3688 , A61N1/3702
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
-
公开(公告)号：US20070021789A1
公开(公告)日：2007-01-25
申请号：US11458286
申请日：2006-07-18
IPC分类号： A61N1/00
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了以提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
-
公开(公告)号：US20080027495A1
公开(公告)日：2008-01-31
申请号：US11868767
申请日：2007-10-08
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
-
10.发明申请Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure 失效在缺血后或心力衰竭期间调节细胞代谢的方法和装置公开(公告)号：US20050043675A1
公开(公告)日：2005-02-24
申请号：US10645823
申请日：2003-08-21
申请人： Joseph Pastore , Julio Spinelli , Helen Reeve , Jeffrey Ross , Rodney Salo , Allan Shuros
发明人： Joseph Pastore , Julio Spinelli , Helen Reeve , Jeffrey Ross , Rodney Salo , Allan Shuros
CPC分类号： A61M5/1723 , A61B5/0031 , A61B5/1107 , A61B5/14532 , A61B5/14546 , A61B5/4839 , A61M5/14244 , A61M5/14276 , A61M2205/3523 , A61N1/3627
摘要： A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.
摘要翻译： 药物递送系统检测指示需要增加心脏代谢水平的心脏状况，并且作为响应将药物释放到组织或血液中以将促进心脏收缩的代谢合成能量的来源从脂肪酸转移到葡萄糖。 这种系统的一个实例包括检测缺血的可植入装置和当检测到缺血状况时递送药物的透皮药物递送装置。 这种系统的另一个例子包括一个或多个可植入装置，用于检测心脏代谢水平的预定变化并在检测到变化时递送药物。 这种系统被应用于治疗例如患有缺血和/或心力衰竭的患者和患有心肌梗塞的患者。
-
-
-
-
-
-
-
-
-
搜索结果
57 条记录 (耗时 0.019 秒)
