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公开(公告)号：US20150211025A1
公开(公告)日：2015-07-30
申请号：US14682354
申请日：2015-04-09
发明人： Frank Anthony Skraly , Ning Li
CPC分类号： C12P5/02 , C07C9/15 , C10L1/08 , C10L2200/04 , C10L2270/026 , C10L2270/04 , C12N9/0008 , C12N9/1288 , C12N9/16 , C12N9/88 , C12N15/63 , C12N15/74 , C12Y102/99006 , C12Y207/08007 , C12Y301/02014 , C12Y401/99005 , Y02P20/52
摘要： The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently produce alkanes, and in particular the use of such organisms for the commercial production of alkanes and related molecules. Other materials, methods, and compositions are also described.
摘要翻译： 本公开内容确定用于将光自养生物修饰为宿主的方法和组合物，使得生物体有效地产生烷烃，特别是使用这种生物来商业生产烷烃和相关分子。 还描述了其它材料，方法和组合物。
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公开(公告)号：US20140213826A1
公开(公告)日：2014-07-31
申请号：US14165214
申请日：2014-01-27
发明人： Frank Anthony Skraly , Ning Li
CPC分类号： C12P5/02 , C07C9/15 , C10L1/08 , C10L2200/04 , C10L2270/026 , C10L2270/04 , C12N9/0008 , C12N9/1288 , C12N9/16 , C12N9/88 , C12N15/63 , C12N15/74 , C12Y102/99006 , C12Y207/08007 , C12Y301/02014 , C12Y401/99005 , Y02P20/52
摘要： The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently produce alkanes, and in particular the use of such organisms for the commercial production of alkanes and related molecules. Other materials, methods, and compositions are also described.
摘要翻译： 本公开内容确定用于将光自养生物修饰为宿主的方法和组合物，使得生物体有效地产生烷烃，特别是使用这种生物来商业生产烷烃和相关分子。 还描述了其它材料，方法和组合物。
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3.发明申请ENGINEERED CO2 FIXING MICROORGANISMS PRODUCING CARBON-BASED PRODUCTS OF INTEREST 审中-公开工程化二氧化碳固定微生物生产基于碳的产品公开(公告)号：US20160040191A1
公开(公告)日：2016-02-11
申请号：US14834115
申请日：2015-08-24
发明人： David Arthur Berry , Dan Eric Robertson , Frank Anthony Skraly , Brian D. Green , Christian Perry Ridley , Sriram Kosuri , Nikos Basil Reppas , Martha Sholl , Noubar Boghos Afeyan
CPC分类号： C12Y101/01002 , C12N9/0006 , C12P5/026 , C12P7/065 , C12P7/18 , Y02E50/17
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译： 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些有机物用于商业生产乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体。
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公开(公告)号：US20150152438A1
公开(公告)日：2015-06-04
申请号：US14562294
申请日：2014-12-05
发明人： Frank Anthony Skraly , Ning Li
CPC分类号： C12P5/02 , C12N9/0004 , C12N9/1288 , C12N9/16 , C12N9/88 , C12N15/8247 , Y02E50/343
摘要： The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently produce alkanes, and in particular the use of such organisms for the commercial production of alkanes and related molecules. Other materials, methods, and compositions are also described.
摘要翻译： 本公开内容确定用于将光自养生物修饰为宿主的方法和组合物，使得生物体有效地产生烷烃，特别是使用这种生物来商业生产烷烃和相关分子。 还描述了其它材料，方法和组合物。
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公开(公告)号：US09034629B2
公开(公告)日：2015-05-19
申请号：US14165214
申请日：2014-01-27
发明人： Frank Anthony Skraly , Ning Li
IPC分类号： C12N1/20 , C12N15/00 , C12N9/06 , C12N9/88 , C12P5/00 , C07H21/04 , C12P5/02 , C12N15/63 , C12N15/74 , C12N9/02 , C12N9/16
CPC分类号： C12P5/02 , C07C9/15 , C10L1/08 , C10L2200/04 , C10L2270/026 , C10L2270/04 , C12N9/0008 , C12N9/1288 , C12N9/16 , C12N9/88 , C12N15/63 , C12N15/74 , C12Y102/99006 , C12Y207/08007 , C12Y301/02014 , C12Y401/99005 , Y02P20/52
摘要： The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently produce alkanes, and in particular the use of such organisms for the commercial production of alkanes and related molecules. Other materials, methods, and compositions are also described.
摘要翻译： 本公开内容确定用于将光自养生物修饰为宿主的方法和组合物，使得生物体有效地产生烷烃，特别是使用这种生物来商业生产烷烃和相关分子。 还描述了其它材料，方法和组合物。
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公开(公告)号：US20130273613A1
公开(公告)日：2013-10-17
申请号：US13797559
申请日：2013-03-12
发明人： Eric James Devroe , Sriram Kosuri , David Arthur Berry , Noubar Boghos Afeyan , Frank Anthony Skraly , Dan Eric Robertson , Brian Green , Christian Perry Ridley
IPC分类号： C12N15/74
CPC分类号： C12N15/74 , C12N9/1007 , C12N15/52 , C12P7/6409 , C12P7/6436 , C12P7/6463 , C12P7/649 , C12Y111/01006 , Y02E50/13 , Y02P60/247
摘要： The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed that provide for light capture, carbon dioxide fixation, NADH production, NADPH production, thermotolerance, pH tolerance, flue gas tolerance, salt tolerance, nutrient independence and near infrared absorbance. The disclosed engineered organisms can include one or more of these modules. Also provided are methods of using the engineered organism to produce carbon-based products of interest, biomass or pharmaceutical agents.
摘要翻译： 本公开确定了赋予工程生物体的改善的工业适应性的途径和机制。 它还公开了具有改善的工业适应性的工程生物。 公开了合成生物工程模块，其提供轻捕获，二氧化碳固定，NADH生产，NADPH生产，耐热性，pH耐受性，烟气耐受性，耐盐性，营养独立性和近红外吸光度。 所公开的工程生物体可以包括这些模块中的一个或多个。 还提供了使用工程生物体产生感兴趣的碳基产物，生物质或药剂的方法。
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公开(公告)号：US09528127B2
公开(公告)日：2016-12-27
申请号：US14682354
申请日：2015-04-09
发明人： Frank Anthony Skraly , Ning Li
IPC分类号： C12N1/20 , C12N15/00 , C12N9/12 , C12N9/88 , C12N9/16 , C12N9/06 , C12P5/00 , C07H21/04 , C12P5/02 , C12N15/63 , C12N15/74 , C12N9/02 , C07C9/15 , C10L1/08
CPC分类号： C12P5/02 , C07C9/15 , C10L1/08 , C10L2200/04 , C10L2270/026 , C10L2270/04 , C12N9/0008 , C12N9/1288 , C12N9/16 , C12N9/88 , C12N15/63 , C12N15/74 , C12Y102/99006 , C12Y207/08007 , C12Y301/02014 , C12Y401/99005 , Y02P20/52
摘要： The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently produce alkanes, and in particular the use of such organisms for the commercial production of alkanes and related molecules. Other materials, methods, and compositions are also described.
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公开(公告)号：US20150337320A1
公开(公告)日：2015-11-26
申请号：US14668775
申请日：2015-03-25
发明人： Eric James Devroe , David Arthur Berry , Noubar Boghos Afeyan , Dan Eric Robertson , Frank Anthony Skraly , Christian Perry Ridley
CPC分类号： C12N15/70 , C12N9/1205 , C12N15/52 , C12P5/00 , C12P7/00 , C12P19/00 , C12Y207/01019
摘要： The present disclosure identifies pathways and mechanisms to confer photoautotrophic properties to a heterotrophic organism. The resultant engineered cell or organism will uniquely enable efficient conversion of carbon dioxide and light into biomass and carbon-based products of interest.
摘要翻译： 本公开标识了赋予异养生物体的光自养性质的途径和机制。 所得到的工程细胞或生物将独特地使二氧化碳和光有效转化成生物质和基于碳的产品。
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9.发明申请Methods and Compositions for the Recombinant Biosynthesis of Fatty Acids and Esters 审中-公开脂肪酸和酯的重组生物合成的方法和组合物公开(公告)号：US20150082691A1
公开(公告)日：2015-03-26
申请号：US14559168
申请日：2014-12-03
发明人： David Arthur Berry , Noubar Boghos Afeyan , Frank Anthony Skraly , Christian Perry Ridley , Dan Eric Robertson , Regina Wilpiszeski , Martha Sholl
IPC分类号： C10L1/02
CPC分类号： C10L1/026 , C10L2200/0476 , C10L2270/026 , C12N15/79 , C12P7/649 , C12Y602/01003 , Y02E50/13 , Y02E50/17
摘要： The present disclosure identifies methods and compositions for modifying photoautotrophic organisms, such that the organisms efficiently convert carbon dioxide and light into compounds such as esters and fatty acids. In certain embodiments, the compounds produced are secreted into the medium used to culture the organisms.
摘要翻译： 本公开内容确定了修饰光自养生物的方法和组合物，使得生物有效地将二氧化碳和光转化为化合物如酯和脂肪酸。 在某些实施方案中，所生产的化合物分泌到用于培养生物体的培养基中。
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