公开(公告)号：US08801781B2

公开(公告)日：2014-08-12

申请号：US11260013

申请日：2005-10-26

申请人： Juan Tabernero ,  Pablo Artal ,  Patricia Piers

发明人： Juan Tabernero ,  Pablo Artal ,  Patricia Piers

IPC分类号： A61F2/16 ,  A61B3/00

CPC分类号： A61B3/0025 ,  A61F2/1613

摘要： When fitting a patient for an intraocular lens, a series of measurements is taken on the patient's eye that determines a required lens power. Next, a range of preferred shape factors may be found, which determine the base (i.e., spherical) radii of the two lens surfaces, essentially independent of the lens power. The preferred shape factor adjusts the third-order coma of the lens to largely offset the coma of the cornea, so that the image at the retina has a reduced amount of third-order coma. Once a preferred shape factor is determined, the base radii of curvature of the anterior and posterior surfaces are determined from the shape factor and the lens power by algebraic formulas. Finally, one or more aspheric terms are added to one or both of the surfaces in the lens, so that the spherical aberration of the lens largely offsets the spherical aberration of the cornea.

摘要翻译： 当将患者安装在眼内透镜上时，对患者的眼睛进行一系列测量，以确定所需的镜片功率。 接下来，可以找到一系列优选的形状因子，其确定两个透镜表面的基本（即球面）半径，基本上与透镜功率无关。 优选的形状因子调整透镜的三阶彗差以大大抵消角膜的昏迷，使得视网膜上的图像具有减少的三次彗差。 一旦确定了优选的形状因子，则根据形状因子和透镜功率通过代数公式确定前表面和后表面的基本曲率半径。 最后，一个或多个非球面术语被添加到透镜中的一个或两个表面，使得透镜的球面像差大大抵消了角膜的球面像差。

公开(公告)号：US20070093891A1

公开(公告)日：2007-04-26

申请号：US11260013

申请日：2005-10-26

申请人： Juan Tabernero ,  Pablo Artal ,  Patricia Piers

发明人： Juan Tabernero ,  Pablo Artal ,  Patricia Piers

IPC分类号： A61F2/16 ,  A61F9/013

CPC分类号： A61B3/0025 ,  A61F2/1613

摘要： When fitting a patient for an intraocular lens, a series of measurements is taken on the patient's eye that determines a required lens power. Next, a range of preferred shape factors may be found, which determine the base (i.e., spherical) radii of the two lens surfaces, essentially independent of the lens power. The preferred shape factor adjusts the third-order coma of the lens to largely offset the coma of the cornea, so that the image at the retina has a reduced amount of third-order coma. Once a preferred shape factor is determined, the base radii of curvature of the anterior and posterior surfaces are determined from the shape factor and the lens power by algebraic formulas. Finally, one or more aspheric terms are added to one or both of the surfaces in the lens, so that the spherical aberration of the lens largely offsets the spherical aberration of the cornea.

摘要翻译： 当将患者安装在眼内透镜上时，对患者的眼睛进行一系列测量，以确定所需的镜片功率。 接下来，可以找到一系列优选的形状因子，其确定两个透镜表面的基本（即球面）半径，基本上与透镜功率无关。 优选的形状因子调整透镜的三阶彗差以大大抵消角膜的昏迷，使得视网膜上的图像具有减少的三次彗差。 一旦确定了优选的形状因子，则根据形状因子和透镜功率通过代数公式确定前表面和后表面的基本曲率半径。 最后，一个或多个非球面术语被添加到透镜中的一个或两个表面，使得透镜的球面像差大大抵消了角膜的球面像差。

公开(公告)号：US20070258044A1

公开(公告)日：2007-11-08

申请号：US11742996

申请日：2007-05-01

申请人： Sverker Norrby ,  Pablo Artal ,  Patricia Piers ,  Marrie Mooren

发明人： Sverker Norrby ,  Pablo Artal ,  Patricia Piers ,  Marrie Mooren

IPC分类号： A61B3/107

CPC分类号： A61B3/0025 ,  A61F2/1637 ,  A61F2240/002 ,  G02C7/02 ,  G02C7/028 ,  G02C2202/06 ,  G02C2202/22

摘要： The present invention discloses methods of obtaining ophthalmic lens capable of reducing the aberrations of the eye comprising the steps of characterizing at least one corneal surface as a mathematical model, calculating the resulting aberrations of said corneal surface(s) by employing said mathematical model, selecting the optical power of the intraocular lens. From this information, an ophthalmic lens is modeled so a wavefront arriving from an optical system comprising said lens and corneal model obtains reduced aberrations in the eye. Also disclosed are ophthalmic lenses as obtained by the methods which are capable reducing aberrations of the eye.

摘要翻译： 本发明公开了获得能够减少眼睛像差的眼镜的方法，包括以下步骤：将至少一个角膜表面表征为数学模型，通过使用所述数学模型计算所得到的所述角膜表面的像差，选择 眼内透镜的光学功率。 根据该信息，对眼科镜进行建模，使得从包括所述透镜和角膜模型的光学系统到达的波前获得眼睛中的减少的像差。 还公开了通过能够减少眼睛畸变的方法获得的眼科镜片。

公开(公告)号：US20070121064A1

公开(公告)日：2007-05-31

申请号：US11619098

申请日：2007-01-02

申请人： Sverker Norrby ,  Pablo Artal ,  Patricia Piers ,  Marrie Van Der Mooren

发明人： Sverker Norrby ,  Pablo Artal ,  Patricia Piers ,  Marrie Van Der Mooren

IPC分类号： G02C7/02

CPC分类号： A61B3/0025 ,  A61F2/1637 ,  A61F2240/002 ,  G02C7/02 ,  G02C7/028 ,  G02C2202/06 ,  G02C2202/22

摘要： The present invention discloses methods of obtaining ophthalmic lens capable of reducing the aberrations of the eye comprising the steps of characterizing at least one corneal surface as a mathematical model, calculating the resulting aberrations of said corneal surface(s) by employing said mathematical model, selecting the optical power of the intraocular lens. From this information, an ophthalmic lens is modeled so a wavefront arriving from an optical system comprising said lens and corneal model obtains reduced aberrations in the eye. Also disclosed are ophthalmic lenses as obtained by the methods which are capable reducing aberrations of the eye.

公开(公告)号：US07677725B2

公开(公告)日：2010-03-16

申请号：US11099342

申请日：2005-04-05

申请人： Patricia Piers ,  Henk Weeber

发明人： Patricia Piers ,  Henk Weeber

IPC分类号： G02C7/02

CPC分类号： A61F2/1613 ,  A61F2/1637 ,  A61F2/1654 ,  A61F2/1659 ,  A61F2240/002 ,  G02B3/04 ,  G02B5/1814 ,  G02B27/0012 ,  G02B27/0037 ,  G02B27/4211 ,  G02C7/02 ,  G02C7/027 ,  G02C7/028 ,  G02C2202/20 ,  G02C2202/22

摘要： A method of designing an aspheric ophthalmic lens with both refractive and diffractive powers that is capable of reducing chromatic aberration and at least one monochromatic aberration of an eye comprises combining aspherical refractive and diffractive surfaces, selecting an appropriate eye model, establishing a design lens having at least one aspheric surface with a capacity to reduce monochromatic aberration in said eye model, establishing a diffractive lens element that corrects for chromatic aberration of the model eye; and adjusting the lens surface design in order to obtain a suitably high polychromatic image quality in a form that is weighted to comply with a spectral merit function.

摘要翻译： 设计具有能够减少色差和眼睛的至少一个单色像差的折射率和衍射光焦度的非球面眼镜片的方法包括组合非球面折射和衍射表面，选择合适的眼睛模型，建立具有 至少一个具有降低所述眼睛模型中的单色像差的能力的非球面表面，建立校正模型眼的色差的衍射透镜元件; 并且调整透镜表面设计以便以加权以符合光谱优点函数的形式获得适当高的多色图像质量。

公开(公告)号：US20070002444A1

公开(公告)日：2007-01-04

申请号：US11099342

申请日：2005-04-05

申请人： Patricia Piers ,  Henk Weeber

发明人： Patricia Piers ,  Henk Weeber

IPC分类号： G02B27/44

CPC分类号： A61F2/1613 ,  A61F2/1637 ,  A61F2/1654 ,  A61F2/1659 ,  A61F2240/002 ,  G02B3/04 ,  G02B5/1814 ,  G02B27/0012 ,  G02B27/0037 ,  G02B27/4211 ,  G02C7/02 ,  G02C7/027 ,  G02C7/028 ,  G02C2202/20 ,  G02C2202/22

摘要： A method of designing an aspheric ophthalmic lens with both refractive and diffractive powers that is capable of reducing chromatic aberration and at least one monochromatic aberration of an eye comprises combining aspherical refractive and diffractive surfaces, selecting an appropriate eye model, establishing a design lens having at least one aspheric surface with a capacity to reduce monochromatic aberration in said eye model, establishing a diffractive lens element that corrects for chromatic aberration of the model eye; and adjusting the lens surface design in order to obtain a suitably high polychromatic image quality in a form that is weighted to comply with a spectral merit function.

摘要翻译： 设计具有能够减少色差和眼睛的至少一个单色像差的折射率和衍射光焦度的非球面眼镜片的方法包括组合非球面折射和衍射表面，选择合适的眼睛模型，建立具有 至少一个具有降低所述眼睛模型中的单色像差的能力的非球面表面，建立校正模型眼的色差的衍射透镜元件; 并且调整透镜表面设计以便以加权以符合光谱优点函数的形式获得适当高的多色图像质量。

公开(公告)号：US20070106380A1

公开(公告)日：2007-05-10

申请号：US11564783

申请日：2006-11-29

申请人： Thomas Terwee ,  Hendrick Weeber ,  Patricia Piers

发明人： Thomas Terwee ,  Hendrick Weeber ,  Patricia Piers

IPC分类号： A61F2/16 ,  A61F9/013

CPC分类号： A61F2/1613 ,  A61F9/0017 ,  A61L27/18 ,  A61L2430/16 ,  Y10S623/907 ,  C08L83/04

摘要： A method for implanting an intraocular lens into the eye of a subject includes placing the intraocular lens into the eye of a subject and administering a drug in an amount sufficient to maintain an accommodative state of the eye. The method further includes permitting at least a portion of the intraocular lens to become coupled to at least a portion of the eye while maintaining the eye in the accommodative state. In certain embodiments, the method may include forming an intraocular lens while maintaining an accommodative state of the eye. In such embodiments, the method may exclude permitting at least a portion of the intraocular lens to become coupled to at least a portion of the capsular bag.

摘要翻译： 将眼内透镜植入受试者的眼睛中的方法包括将眼内透镜放置在受试者的眼睛中并施用足以维持眼睛调节状态的量的药物。 该方法还包括允许眼内透镜的至少一部分变得耦合到眼睛的至少一部分，同时将眼睛保持在调节状态。 在某些实施例中，该方法可以包括在保持眼睛调节状态的同时形成眼内透镜。 在这样的实施例中，该方法可以排除允许眼内透镜的至少一部分变得联接到囊袋的至少一部分。

公开(公告)号：US20060244906A1

公开(公告)日：2006-11-02

申请号：US11426196

申请日：2006-06-23

申请人： Patricia Piers ,  Hendrik Weeber ,  Sverker Norrby

发明人： Patricia Piers ,  Hendrik Weeber ,  Sverker Norrby

IPC分类号： G02C7/04

CPC分类号： A61F2/1618 ,  A61B3/0025 ,  A61F2/1613 ,  A61F2/1637 ,  A61F2/164 ,  A61F2/1654 ,  A61F2002/1696 ,  A61F2240/002 ,  G01J9/00 ,  G02C7/027 ,  G02C7/028 ,  G02C7/041 ,  G02C7/06 ,  G02C2202/20 ,  G02C2202/22

摘要： A method of designing a multifocal ophthalmic lens with one base focus and at least one additional focus, capable of reducing aberrations of the eye for at least one of the foci after its implantation, comprising the steps of: (i) characterizing at least one corneal surface as a mathematical model; (ii) calculating the resulting aberrations of said corneal surface(s) by employing said mathematical model; (iii) modelling the multifocal ophthalmic lens such that a wavefront arriving from an optical system comprising said lens and said at least one corneal surface obtains reduced aberrations for at least one of the foci. There is also disclosed a method of selecting a multifocal intraocular lens, a method of designing a multifocal ophthalmic lens based on corneal data from a group of patients, and a multifocal ophthalmic lens.

公开(公告)号：US20060158611A1

公开(公告)日：2006-07-20

申请号：US11375410

申请日：2006-03-13

申请人： Patricia Piers ,  Sverker Norrby

发明人： Patricia Piers ,  Sverker Norrby

IPC分类号： G02C7/02

CPC分类号： A61F2/1637 ,  A61B3/1015 ,  A61B3/107 ,  A61F2/1602 ,  A61F2240/002 ,  G02C2202/22

摘要： An intraocular lens comprises optical part configured to be implanted in an eye of a subject. The intraocular lens further comprises at least one aspheric surface configured, in combination with a lens in the capsular bag of an eye, to reduce an aberration of a wavefront passing the eye. The aberrations may include astigmatism, coma, and/or spherical aberrations. An aberration of the intraocular lens may be expressed as a linear combination of Zernike polynomial terms that may include a Zernike coefficient a11. The Zernike coefficient a11 may be selected to reduce a spherical aberration of a wavefront passing the eye and/or to compensate for an average value resulting from a predetermined number of estimations of the Zernike coefficient a11 in a population of corneas and capsular bag lenses.

摘要翻译： 眼内透镜包括被配置为植入对象的眼睛中的光学部件。 眼内透镜还包括与眼睛囊袋中的透镜组合配置的至少一个非球面，以减少通过眼睛的波前的像差。 像差可能包括散光，昏迷和/或球面像差。 眼内透镜的像差可以表示为可以包括泽尼克系数α1的Zernike多项式项的线性组合。 可以选择泽尼克系数α11，以减少通过眼睛的波前的球面像差和/或补偿由预定数量的Zernike系数的估计导致的平均值 11个角膜和囊袋透镜群体。

公开(公告)号：US20070188700A1

公开(公告)日：2007-08-16

申请号：US11734238

申请日：2007-04-11

申请人： Patricia Piers ,  Hendrik Weeber ,  Sverker Norrby

发明人： Patricia Piers ,  Hendrik Weeber ,  Sverker Norrby

IPC分类号： G02C7/04

CPC分类号： A61F2/1618 ,  A61B3/0025 ,  A61F2/1613 ,  A61F2/1616 ,  A61F2/1637 ,  A61F2/164 ,  A61F2/1654 ,  A61F2002/1681 ,  A61F2002/1696 ,  A61F2240/001 ,  A61F2240/002 ,  G01J9/00 ,  G02C7/028 ,  G02C7/041 ,  G02C7/042 ,  G02C7/044 ,  G02C7/06 ,  G02C2202/20 ,  G02C2202/22

摘要： A method of designing a multifocal ophthalmic lens with one base focus and at least one additional focus, capable of reducing aberrations of the eye for at least one of the foci after its implantation, comprising the steps of: (i) characterizing at least one corneal surface as a mathematical model; (ii) calculating the resulting aberrations of said corneal surface(s) by employing said mathematical model; (iii) modeling the multifocal ophthalmic lens such that a wavefront arriving from an optical system comprising said lens and said at least one corneal surface obtains reduced aberrations for at least one of the foci. There is also disclosed a method of selecting a multifocal intraocular lens, a method of designing a multifocal ophthalmic lens based on corneal data from a group of patients, and a multifocal ophthalmic lens.

摘要翻译： 一种设计具有一个基底焦点和至少一个附加焦点的多焦点眼科镜片的方法，其能够在其植入之后减少至少一个焦点的眼睛的像差，包括以下步骤：（i）表征至少一个角膜 表面作为数学模型; （ii）通过使用所述数学模型来计算所得到的所述角膜表面的像差; （iii）对多焦点眼科镜片进行建模，使得从包括所述透镜和所述至少一个角膜表面的光学系统到达的波前获得至少一个焦点的减少的像差。 还公开了一种选择多焦点眼内透镜的方法，基于来自一组患者的角膜数据设计多焦点眼科镜片的方法和多焦点眼科镜片。