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公开(公告)号：US08741931B2
公开(公告)日：2014-06-03
申请号：US13442244
申请日：2012-04-09
申请人： Juan-Miguel Jimenez , Guy William Bemis , Francois Maltais , Tiansheng Wang , Ronald Marcellus Alphonsus Knegtel , Christopher John Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Paul Mortimore
发明人： Juan-Miguel Jimenez , Guy William Bemis , Francois Maltais , Tiansheng Wang , Ronald Marcellus Alphonsus Knegtel , Christopher John Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Paul Mortimore
IPC分类号： A61K31/444
CPC分类号： C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to compounds having formula: which are useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及具有下式的化合物：其可用作蛋白激酶的抑制剂。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08377926B2
公开(公告)日：2013-02-19
申请号：US13020947
申请日：2011-02-04
申请人： Francois Maltais , Guy W. Bemis , Tiansheng Wang , Juan-Miguel Jimenez , Luca Settimo , Stephen Young , Dean Boyall , Damien Fraysse , Christopher John Davis
发明人： Francois Maltais , Guy W. Bemis , Tiansheng Wang , Juan-Miguel Jimenez , Luca Settimo , Stephen Young , Dean Boyall , Damien Fraysse , Christopher John Davis
IPC分类号： A61K31/44 , C07D213/62
CPC分类号： C07D417/14 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/10 , C07D401/14 , C07D407/04 , C07D407/12
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20110183966A1
公开(公告)日：2011-07-28
申请号：US13020947
申请日：2011-02-04
申请人： Francois Maltais , Guy W. Bemis , Tiansheng Wang , Juan Miguel Jimenez , Luca Settimo , Stephen Young , Dean Boyall , Damien Fraysse , Christopher John Davis
发明人： Francois Maltais , Guy W. Bemis , Tiansheng Wang , Juan Miguel Jimenez , Luca Settimo , Stephen Young , Dean Boyall , Damien Fraysse , Christopher John Davis
IPC分类号： A61K31/551 , C07D401/06 , A61K31/444 , C07D401/14 , A61K31/496 , C07D491/048 , A61K31/4985 , C07D487/08 , A61K31/499 , A61K31/4545 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/28 , A61P1/00 , A61P29/00
CPC分类号： C07D417/14 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/10 , C07D401/14 , C07D407/04 , C07D407/12
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20120214799A1
公开(公告)日：2012-08-23
申请号：US13442244
申请日：2012-04-09
申请人： Juan-Miguel Jimenez , Guy Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
发明人： Juan-Miguel Jimenez , Guy Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
IPC分类号： A61K31/551 , A61P25/28 , A61P25/14 , A61P25/16 , A61P25/00 , A61P25/18 , A61P7/00 , A61P9/00 , A61P9/10 , A61P29/00 , A61P1/00 , A61P35/00 , C07D401/06 , A61K31/444 , C07D401/14 , C07D417/14 , A61K31/496 , C07D409/06 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/497 , A61P3/10
CPC分类号： C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US20110077237A1
公开(公告)日：2011-03-31
申请号：US12752283
申请日：2010-04-01
申请人： Juan-Miguel Jimenez , Guy W. Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
发明人： Juan-Miguel Jimenez , Guy W. Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
IPC分类号： A61K31/5513 , C07D401/06 , C07D401/14 , C07D417/14 , C07D409/06 , A61K31/444 , A61K31/496 , A61K31/4436 , A61K31/4439 , A61P25/28 , A61P25/16 , A61P25/18 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P1/00
CPC分类号： C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08188071B2
公开(公告)日：2012-05-29
申请号：US12187909
申请日：2008-08-07
申请人： Juan-Miguel Jimenez , Guy Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
发明人： Juan-Miguel Jimenez , Guy Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
IPC分类号： A61K31/551
CPC分类号： C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to compounds useful as inhibitors of protein kinase of the following structural formula: The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作以下结构式的蛋白激酶抑制剂的化合物：本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08569337B2
公开(公告)日：2013-10-29
申请号：US12670989
申请日：2010-01-27
申请人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Christopher John Davis , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
发明人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Christopher John Davis , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , A61K31/496 , A61K31/506 , C07D239/24 , C07D241/10 , C07D519/00
摘要： The present invention relates to compounds of tri-cyclic pyrazolopyridine useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions containing such compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的三环吡唑并吡啶化合物。 本发明还提供含有这些化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20130053395A1
公开(公告)日：2013-02-28
申请号：US13560119
申请日：2012-07-27
申请人： Juan-Miguel Jimenez , Julian M.C. Golec , Luca Settimo , Damien Fraysse , Guy Brenchley , Dean Boyall , Heather Twin , Stephen Young , Andrew W. Miller , Christopher John Davis , Philip N. Collier
发明人： Juan-Miguel Jimenez , Julian M.C. Golec , Luca Settimo , Damien Fraysse , Guy Brenchley , Dean Boyall , Heather Twin , Stephen Young , Andrew W. Miller , Christopher John Davis , Philip N. Collier
IPC分类号： A61K31/496 , A61P37/06 , A61P29/00 , A61P35/00 , A61P11/06 , A61P19/04 , A61P19/02 , A61P25/00 , A61P3/10 , A61P1/00 , A61P35/02 , C07D471/04 , A61P17/06
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20120136000A1
公开(公告)日：2012-05-31
申请号：US12670989
申请日：2010-01-27
申请人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
发明人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
IPC分类号： A61K31/496 , A61K31/497 , A61K31/437 , A61K31/506 , A61P37/00 , A61P29/00 , A61P35/00 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/00 , A61P3/10 , A61P1/00 , A61P37/06 , A61P35/02 , A61P19/04 , C07D471/04
CPC分类号： C07D471/04 , A61K31/496 , A61K31/506 , C07D239/24 , C07D241/10 , C07D519/00
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US09067932B2
公开(公告)日：2015-06-30
申请号：US13014505
申请日：2011-01-26
申请人： Dean Boyall , Guy Brenchley , Chris Davis , Damien Fraysse , Julian Golec , Juan-Miguel Jimenez , Andrew Miller , Luca Settimo , Heather Twin , Stephen Young
发明人： Dean Boyall , Guy Brenchley , Chris Davis , Damien Fraysse , Julian Golec , Juan-Miguel Jimenez , Andrew Miller , Luca Settimo , Heather Twin , Stephen Young
IPC分类号： C07D471/04 , A61K31/496 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496
摘要： The present invention relates to compounds of pyrazolopyridine derivatives useful as inhibitors of protein kinase. In one embodiment the compounds of the present invention are represented by the following structural formula: or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的吡唑并吡啶衍生物的化合物。 在一个实施方案中，本发明的化合物由以下结构式表示：或其药学上可接受的盐。
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