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公开(公告)号：US08377926B2
公开(公告)日：2013-02-19
申请号：US13020947
申请日：2011-02-04
申请人： Francois Maltais , Guy W. Bemis , Tiansheng Wang , Juan-Miguel Jimenez , Luca Settimo , Stephen Young , Dean Boyall , Damien Fraysse , Christopher John Davis
发明人： Francois Maltais , Guy W. Bemis , Tiansheng Wang , Juan-Miguel Jimenez , Luca Settimo , Stephen Young , Dean Boyall , Damien Fraysse , Christopher John Davis
IPC分类号： A61K31/44 , C07D213/62
CPC分类号： C07D417/14 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/10 , C07D401/14 , C07D407/04 , C07D407/12
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20110183966A1
公开(公告)日：2011-07-28
申请号：US13020947
申请日：2011-02-04
申请人： Francois Maltais , Guy W. Bemis , Tiansheng Wang , Juan Miguel Jimenez , Luca Settimo , Stephen Young , Dean Boyall , Damien Fraysse , Christopher John Davis
发明人： Francois Maltais , Guy W. Bemis , Tiansheng Wang , Juan Miguel Jimenez , Luca Settimo , Stephen Young , Dean Boyall , Damien Fraysse , Christopher John Davis
IPC分类号： A61K31/551 , C07D401/06 , A61K31/444 , C07D401/14 , A61K31/496 , C07D491/048 , A61K31/4985 , C07D487/08 , A61K31/499 , A61K31/4545 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/28 , A61P1/00 , A61P29/00
CPC分类号： C07D417/14 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/10 , C07D401/14 , C07D407/04 , C07D407/12
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20110077237A1
公开(公告)日：2011-03-31
申请号：US12752283
申请日：2010-04-01
申请人： Juan-Miguel Jimenez , Guy W. Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
发明人： Juan-Miguel Jimenez , Guy W. Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
IPC分类号： A61K31/5513 , C07D401/06 , C07D401/14 , C07D417/14 , C07D409/06 , A61K31/444 , A61K31/496 , A61K31/4436 , A61K31/4439 , A61P25/28 , A61P25/16 , A61P25/18 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P1/00
CPC分类号： C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08741931B2
公开(公告)日：2014-06-03
申请号：US13442244
申请日：2012-04-09
申请人： Juan-Miguel Jimenez , Guy William Bemis , Francois Maltais , Tiansheng Wang , Ronald Marcellus Alphonsus Knegtel , Christopher John Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Paul Mortimore
发明人： Juan-Miguel Jimenez , Guy William Bemis , Francois Maltais , Tiansheng Wang , Ronald Marcellus Alphonsus Knegtel , Christopher John Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Paul Mortimore
IPC分类号： A61K31/444
CPC分类号： C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to compounds having formula: which are useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及具有下式的化合物：其可用作蛋白激酶的抑制剂。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20120214799A1
公开(公告)日：2012-08-23
申请号：US13442244
申请日：2012-04-09
申请人： Juan-Miguel Jimenez , Guy Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
发明人： Juan-Miguel Jimenez , Guy Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
IPC分类号： A61K31/551 , A61P25/28 , A61P25/14 , A61P25/16 , A61P25/00 , A61P25/18 , A61P7/00 , A61P9/00 , A61P9/10 , A61P29/00 , A61P1/00 , A61P35/00 , C07D401/06 , A61K31/444 , C07D401/14 , C07D417/14 , A61K31/496 , C07D409/06 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/497 , A61P3/10
CPC分类号： C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US08188071B2
公开(公告)日：2012-05-29
申请号：US12187909
申请日：2008-08-07
申请人： Juan-Miguel Jimenez , Guy Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
发明人： Juan-Miguel Jimenez , Guy Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
IPC分类号： A61K31/551
CPC分类号： C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to compounds useful as inhibitors of protein kinase of the following structural formula: The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作以下结构式的蛋白激酶抑制剂的化合物：本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20210040092A1
公开(公告)日：2021-02-11
申请号：US17083569
申请日：2020-10-29
申请人： Paul S. Charifson , Michael P. Clark , Upal K. Bandarage , Randy S. Bethiel , Michael J. Boyd , Ioana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brain Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
发明人： Paul S. Charifson , Michael P. Clark , Upal K. Bandarage , Randy S. Bethiel , Michael J. Boyd , Ioana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brain Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
IPC分类号： C07D471/04 , A61K31/506 , A61K45/06 , C07F9/6561 , A61K31/215 , A61K31/351 , A61K31/444 , A61K31/497
摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
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公开(公告)号：US20160355512A1
公开(公告)日：2016-12-08
申请号：US15177546
申请日：2016-06-09
申请人： Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , Michael J. Boyd , loana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brian Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
发明人： Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , Michael J. Boyd , loana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brian Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
IPC分类号： C07D471/04 , A61K31/351 , A61K31/215 , A61K31/497 , A61K31/506 , A61K31/444
CPC分类号： C07D471/04 , A61K31/215 , A61K31/351 , A61K31/444 , A61K31/497 , A61K31/506 , A61K45/06 , C07F9/6561
摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
摘要翻译： 或其药学上可接受的盐，其中结构式（I）的值如本文所述。 化合物由结构式（I）表示或其药学上可接受的盐，其中结构式（I）的值如本文所述。 药物组合物包含有效量的这种化合物或其药学上可接受的盐，以及药学上可接受的载体，佐剂或媒介物。
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公开(公告)号：US20090227607A1
公开(公告)日：2009-09-10
申请号：US12245069
申请日：2008-10-03
申请人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
发明人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
IPC分类号： A61K31/519 , C07D487/04 , C12N9/99
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20090088445A1
公开(公告)日：2009-04-02
申请号：US11732845
申请日：2007-04-05
申请人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
发明人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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