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公开(公告)号：US20130053388A1
公开(公告)日：2013-02-28
申请号：US13560122
申请日：2012-07-27
申请人： Juan-Miguel Jimenez , Luca Settimo , Damien Fraysse , Guy Brenchley , Christopher John Davis , Andrew W. Miller
发明人： Juan-Miguel Jimenez , Luca Settimo , Damien Fraysse , Guy Brenchley , Christopher John Davis , Andrew W. Miller
IPC分类号： A61K31/4985 , A61P37/06 , A61P29/00 , A61P35/00 , A61P11/06 , A61P19/04 , A61P19/02 , A61P25/00 , A61P3/10 , A61P1/00 , A61P35/02 , C07D487/04 , A61P17/06
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08809335B2
公开(公告)日：2014-08-19
申请号：US13560131
申请日：2012-07-27
申请人： Juan-Miguel Jimenez , Luca Settimo , Damien Fraysse , Guy Brenchley , Christopher John Davis , Andrew W. Miller
发明人： Juan-Miguel Jimenez , Luca Settimo , Damien Fraysse , Guy Brenchley , Christopher John Davis , Andrew W. Miller
IPC分类号： A61K31/497
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08895740B2
公开(公告)日：2014-11-25
申请号：US13560122
申请日：2012-07-27
申请人： Juan-Miguel Jimenez , Luca Settimo , Damien Fraysse , Guy Brenchley , Christopher John Davis , Andrew W. Miller
发明人： Juan-Miguel Jimenez , Luca Settimo , Damien Fraysse , Guy Brenchley , Christopher John Davis , Andrew W. Miller
IPC分类号： C07D487/04 , A61K31/4985
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20130053394A1
公开(公告)日：2013-02-28
申请号：US13560131
申请日：2012-07-27
申请人： Juan-Miguel Jimenez , Luca Settimo , Damien Fraysse , Guy Brenchley , Christopher John Davis , Andrew W. Miller
发明人： Juan-Miguel Jimenez , Luca Settimo , Damien Fraysse , Guy Brenchley , Christopher John Davis , Andrew W. Miller
IPC分类号： A61K31/519 , A61P37/00 , A61P29/00 , A61P35/00 , A61P11/06 , A61P35/02 , A61P19/02 , A61P25/00 , A61P3/10 , A61P1/00 , A61P37/06 , C07D487/04 , A61P17/06
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20130053395A1
公开(公告)日：2013-02-28
申请号：US13560119
申请日：2012-07-27
申请人： Juan-Miguel Jimenez , Julian M.C. Golec , Luca Settimo , Damien Fraysse , Guy Brenchley , Dean Boyall , Heather Twin , Stephen Young , Andrew W. Miller , Christopher John Davis , Philip N. Collier
发明人： Juan-Miguel Jimenez , Julian M.C. Golec , Luca Settimo , Damien Fraysse , Guy Brenchley , Dean Boyall , Heather Twin , Stephen Young , Andrew W. Miller , Christopher John Davis , Philip N. Collier
IPC分类号： A61K31/496 , A61P37/06 , A61P29/00 , A61P35/00 , A61P11/06 , A61P19/04 , A61P19/02 , A61P25/00 , A61P3/10 , A61P1/00 , A61P35/02 , C07D471/04 , A61P17/06
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08569337B2
公开(公告)日：2013-10-29
申请号：US12670989
申请日：2010-01-27
申请人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Christopher John Davis , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
发明人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Christopher John Davis , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , A61K31/496 , A61K31/506 , C07D239/24 , C07D241/10 , C07D519/00
摘要： The present invention relates to compounds of tri-cyclic pyrazolopyridine useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions containing such compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的三环吡唑并吡啶化合物。 本发明还提供含有这些化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08377926B2
公开(公告)日：2013-02-19
申请号：US13020947
申请日：2011-02-04
申请人： Francois Maltais , Guy W. Bemis , Tiansheng Wang , Juan-Miguel Jimenez , Luca Settimo , Stephen Young , Dean Boyall , Damien Fraysse , Christopher John Davis
发明人： Francois Maltais , Guy W. Bemis , Tiansheng Wang , Juan-Miguel Jimenez , Luca Settimo , Stephen Young , Dean Boyall , Damien Fraysse , Christopher John Davis
IPC分类号： A61K31/44 , C07D213/62
CPC分类号： C07D417/14 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/10 , C07D401/14 , C07D407/04 , C07D407/12
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20110183966A1
公开(公告)日：2011-07-28
申请号：US13020947
申请日：2011-02-04
申请人： Francois Maltais , Guy W. Bemis , Tiansheng Wang , Juan Miguel Jimenez , Luca Settimo , Stephen Young , Dean Boyall , Damien Fraysse , Christopher John Davis
发明人： Francois Maltais , Guy W. Bemis , Tiansheng Wang , Juan Miguel Jimenez , Luca Settimo , Stephen Young , Dean Boyall , Damien Fraysse , Christopher John Davis
IPC分类号： A61K31/551 , C07D401/06 , A61K31/444 , C07D401/14 , A61K31/496 , C07D491/048 , A61K31/4985 , C07D487/08 , A61K31/499 , A61K31/4545 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/28 , A61P1/00 , A61P29/00
CPC分类号： C07D417/14 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/10 , C07D401/14 , C07D407/04 , C07D407/12
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08741931B2
公开(公告)日：2014-06-03
申请号：US13442244
申请日：2012-04-09
申请人： Juan-Miguel Jimenez , Guy William Bemis , Francois Maltais , Tiansheng Wang , Ronald Marcellus Alphonsus Knegtel , Christopher John Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Paul Mortimore
发明人： Juan-Miguel Jimenez , Guy William Bemis , Francois Maltais , Tiansheng Wang , Ronald Marcellus Alphonsus Knegtel , Christopher John Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Paul Mortimore
IPC分类号： A61K31/444
CPC分类号： C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to compounds having formula: which are useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及具有下式的化合物：其可用作蛋白激酶的抑制剂。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20110060013A1
公开(公告)日：2011-03-10
申请号：US12601026
申请日：2009-11-20
申请人： Michael Paul Mortimore , Christopher John Davis , Julian M.C. Golec , John Studley , Daniel David Robinson
发明人： Michael Paul Mortimore , Christopher John Davis , Julian M.C. Golec , John Studley , Daniel David Robinson
IPC分类号： A61K31/4439 , C07D401/14 , C07D417/14 , A61P35/00
CPC分类号： C07D401/14 , C07D417/14
摘要： The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译： 本发明涉及可用作Aurora蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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