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    Amatoxin-conjugates with improved linkers
    4.
    发明授权
    Amatoxin-conjugates with improved linkers 有权
    具有改良接头的氨氧化还原偶联物

    公开(公告)号：US09399681B2

    公开(公告)日：2016-07-26

    申请号：US13876829

    申请日：2011-09-29

    申请人： Jan Anderl ,  Werner Simon ,  Christoph Mueller

    发明人： Jan Anderl ,  Werner Simon ,  Christoph Mueller

    IPC分类号： A61K47/48 ,  C07K16/30

    CPC分类号： C07K16/30 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6855

    摘要： The invention relates to tumor therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by a linker comprising a urea moiety, which are useful in the treatment of cancer. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.

    摘要翻译： 本发明涉及肿瘤治疗。 在一个方面，本发明涉及阿莫地辛和靶结合部分的缀合物，例如， 通过包含尿素部分的接头连接的抗体，其可用于治疗癌症。 在另一方面，本发明涉及包含这种缀合物的药物组合物。

    Astaxanthin esters
    8.
    发明授权
    Astaxanthin esters 有权
    虾青素酯

    公开(公告)号：US07253297B2

    公开(公告)日：2007-08-07

    申请号：US10503696

    申请日：2003-01-29

    申请人： Arnold Gloor ,  Werner Simon

    发明人： Arnold Gloor ,  Werner Simon

    IPC分类号： C07C69/56 ,  C07C229/06 ,  C07C69/34 ,  A23L1/30

    CPC分类号： C07C403/24 ,  A23K20/174 ,  A23K20/179 ,  A23K50/80 ,  A23L5/44 ,  Y02A40/818

    摘要： Astaxanthin derivatives of the general formula (I) wherein R is in each case group —NH—CH(R1)—COOR2, —OR3 or —(Y)n-Z and R1, R2, R3, Y, Z and n are significances given in detail in the description, are novel compounds with improved stability during extrusion at the elevated temperatures as required in feed manufacture and during the storage of the manufactured feed and which accordingly are useful as pigmenting carotinoids for feed for aquatic animals. The derivatives are produced by reacting astaxanthin with the pertinent acid RCOOH as such or as its acid chloride RCOC1 or acid anhydride (RCO)2O, or, in the cases where R signifies a group —NH—CH(R1)—COOR2, with the appropriate N-carbonyl-amino acid ester of the formula OCNCH(R1)COOR2. The invention also concerns a formulation containing such an astaxanthin derivative as the pigmenting carotenoid for use in a feed for aquatic animals, a process for producing such a formulation by dissolving the astaxanthin derivative in a plant or vegetable oil or fat, or in an organic solvent, or in a mixture of both a plant or vegetable oil or fat and an organic solvent, emulsifying the solution with an aqueous solution of a protective colloid, at least partially removing the solvent and water to afford a concentrated emulsion, and spray-drying the concentrated emulsion to finally produce a formulation suitable for incorporation in a feed for aquatic animals, and a feed for aquatic animals containing such a pigmenting carotenoid.

    摘要翻译： 其中R在每种情况基团-NH-CH（R 1） - COOR 2， - 或 - 3）中的通式（I）的虾青素衍生物， 或者 - （Y）n -Z和R 1，R 2，R 3，Y， Z和n是在说明书中详细给出的意义，是在饲料生产和饲料生产过程中所需要的高温挤出时具有改进的稳定性的新型化合物，因此其可用作水生动物饲料的着色类胡萝卜素 。 衍生物通过使虾青素与相应的酸RCOOH本身反应或作为其酰氯RCOC1或酸酐（RCO）2 O 2反应而产生，或者在R表示基团-NH-CH （R 1） - COOR 2与适当的式OCNCH（R 1）H的N-羰基 - 氨基酸酯反应 > 2 。 本发明还涉及含有这样的虾青素衍生物作为水生动物饲料中着色的类胡萝卜素的制剂，通过将虾青素衍生物溶解在植物油或植物油或脂肪中或在有机溶剂中制备这种制剂的方法 ，或在植物油或植物油或脂肪与有机溶剂的混合物中，用保护胶体的水溶液乳化溶液，至少部分除去溶剂和水，得到浓缩乳液，并喷雾干燥 最终产生适于掺入水生动物饲料的制剂，以及含有这种着色类胡萝卜素的水生动物饲料。

    Filter for brewed beverages, especially coffee filter, and process for producing it
    10.
    发明授权
    Filter for brewed beverages, especially coffee filter, and process for producing it 失效
    过滤啤酒饮料，特别是咖啡过滤器，以及生产过程

    公开(公告)号：US5871644A

    公开(公告)日：1999-02-16

    申请号：US750350

    申请日：1997-03-11

    申请人： Werner Simon ,  Lutz Wittenschlaeger ,  Fred Bergmann

    发明人： Werner Simon ,  Lutz Wittenschlaeger ,  Fred Bergmann

    IPC分类号： A47J31/08 ,  B01D39/08

    CPC分类号： A47J31/08 ,  Y10T428/24992

    摘要： The invention relates to a filter for brewed beverages, especially a coffee filter, and a process for producing such a filter, in which a fibrous material has pores with an average pore width (d) of at least about 0.1 mm measured at a fiber density of about 50% of the original fiber density of the material. The average pore width (d) is preferably in a range from 0.1 mm to 0.7 mm approximately and more preferably in a range from 0.1 mm to 0.4 mm approximately. The material is preferably paper. The pores are also preferably made by piercing with needles or by subjecting the fibrous material to water jets, providing an irregular pore edge.

    摘要翻译： PCT No.PCT / EP96 / 01515 Sec。 371日期1997年3月11日 102（e）1997年3月11日PCT PCT 1996年4月9日PCT公布。 公开号WO96 / 32043 日期1996年10月17日本发明涉及一种用于酿造饮料，特别是咖啡过滤器的过滤器，以及一种生产这种过滤器的方法，其中纤维材料具有平均孔宽（d）至少为约0.1mm的孔 在原始纤维密度的约50％的纤维密度下测量。 平均孔宽（d）优选为0.1mm〜0.7mm左右，更优选为0.1mm〜0.4mm左右。 该材料最好是纸。 孔也优选通过用针刺或通过使纤维材料经受水射流而形成不规则孔边缘。