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    Microarray bioprobe device integrated with an amplifier having bottom-gate thin film transistors
    4.
    发明授权
    Microarray bioprobe device integrated with an amplifier having bottom-gate thin film transistors 有权
    与具有底栅薄膜晶体管的放大器集成的微阵列生物探针器件

    公开(公告)号：US08007726B2

    公开(公告)日：2011-08-30

    申请号：US11806786

    申请日：2007-06-04

    申请人： Jium-Ming Lin ,  Li-Chern Pan ,  Po-Wei Lin

    发明人： Jium-Ming Lin ,  Li-Chern Pan ,  Po-Wei Lin

    IPC分类号： G01N27/00 ,  G01N7/00 ,  G01N15/06

    CPC分类号： G01N27/4145 ,  G01N27/4148

    摘要： The present invention provides a microarray bioprobe device integrated with an amplifier having bottom-gate thin film transistors. The present invention utilizes a micro-electro-mechanical process as well as a semiconductor process to integrate microarray bioprobes and an amplifier having bottom-gate thin film transistors on a flexible substrate. As such, a signal obtained by the microarray bioprobes can be amplified nearby to improve the signal-to-noise ratio and impedance matching. The microarray bioprobes are formed on the flexible substrate such that the present microarray bioprobe device can be disposed to conform to the profile of a living body's portion so as to improve electrical contact between the bioprobes and the living body's portion.

    摘要翻译： 本发明提供了一种与具有底栅薄膜晶体管的放大器集成的微阵列生物探针器件。 本发明利用微机电工艺以及半导体工艺将微阵列生物探针和具有底栅薄膜晶体管的放大器集成在柔性衬底上。 因此，通过微阵列生物探针获得的信号可以在附近放大，以提高信噪比和阻抗匹配。 微阵列生物探针形成在柔性基底上，使得本发明的微阵列生物探针装置可以被设置成符合活体部分的轮廓，以改善生物探针与生物体部分之间的电接触。

    Microarray bioprobe device integrated with a semiconductor amplifier module on a flexible substrate
    5.
    发明授权
    Microarray bioprobe device integrated with a semiconductor amplifier module on a flexible substrate 失效
    微阵列生物探针器件与柔性基板上的半导体放大器模块集成

    公开(公告)号：US07805175B2

    公开(公告)日：2010-09-28

    申请号：US11545687

    申请日：2006-10-11

    申请人： Jium Ming Lin ,  Li-Chern Pan ,  Po-Wei Lin

    发明人： Jium Ming Lin ,  Li-Chern Pan ,  Po-Wei Lin

    IPC分类号： A61B5/04

    CPC分类号： B01J19/0046 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00653

    摘要： The present invention provides a microarray bioprobe device integrated with a semiconductor amplifier module, which integrates micro array biological probes and thin film transistors on a flexible substrate by Micro-Electro-Mechanical System (MEMS) processes and semiconductor processes. A signal from the microarray bioprobe device is amplified through a near amplifier to increase signal-to-noise ratio and impendence matching. The micro array biological probes of the present invention are produced on the flexible substrate such that the micro array biological probes can be disposed to conform to the profile of a living body's portion and improving contact between the probes and living body's portion.

    摘要翻译： 本发明提供了一种与半导体放大器模块集成的微阵列生物探针器件，该半导体放大器模块通过微电子机械系统（MEMS）工艺和半导体工艺在柔性衬底上集成微阵列生物探针和薄膜晶体管。 来自微阵列生物探针器件的信号通过近放大器放大，以增加信噪比和阻抗匹配。 本发明的微阵列生物探针在柔性基板上制造，使得微阵列生物探针可以被设置成符合生物体部分的轮廓并改善探针与活体部分之间的接触。

    Microarray bioprobe device integrated with an amplifier having bottom-gate thin film transistors
    6.
    发明申请
    Microarray bioprobe device integrated with an amplifier having bottom-gate thin film transistors 有权
    与具有底栅薄膜晶体管的放大器集成的微阵列生物探针器件

    公开(公告)号：US20080297135A1

    公开(公告)日：2008-12-04

    申请号：US11806786

    申请日：2007-06-04

    申请人： Jium-Ming Lin ,  Li-Chern Pan ,  Po-Wei Lin

    发明人： Jium-Ming Lin ,  Li-Chern Pan ,  Po-Wei Lin

    IPC分类号： G01N27/00

    CPC分类号： G01N27/4145 ,  G01N27/4148

    摘要： The present invention provides a microarray bioprobe device integrated with an amplifier having bottom-gate thin film transistors. The present invention utilizes a micro-electro-mechanical process as well as a semiconductor process to integrate microarray bioprobes and an amplifier having bottom-gate thin film transistors on a flexible substrate. As such, a signal obtained by the microarray bioprobes can be amplified nearby to improve the signal-to-noise ratio and impedance matching. The microarray bioprobes are formed on the flexible substrate such that the present microarray bioprobe device can be disposed to conform to the profile of a living body's portion so as to improve electrical contact between the bioprobes and the living body's portion.

    摘要翻译： 本发明提供了一种与具有底栅薄膜晶体管的放大器集成的微阵列生物探针器件。 本发明利用微机电工艺以及半导体工艺将微阵列生物探针和具有底栅薄膜晶体管的放大器集成在柔性衬底上。 因此，通过微阵列生物探针获得的信号可以在附近放大，以提高信噪比和阻抗匹配。 微阵列生物探针形成在柔性基底上，使得本发明的微阵列生物探针装置可以被设置成符合活体部分的轮廓，以改善生物探针与生物体部分之间的电接触。

    Bone implants
    7.
    发明授权
    Bone implants 有权
    骨植入物

    公开(公告)号：US08323348B2

    公开(公告)日：2012-12-04

    申请号：US11063074

    申请日：2005-02-22

    申请人： Wen-Fu T. Lai ,  Li-Chern Pan ,  Pau-Yee Lim ,  Jung-Chou Oung ,  Chun-Wei Chen

    发明人： Wen-Fu T. Lai ,  Li-Chern Pan ,  Pau-Yee Lim ,  Jung-Chou Oung ,  Chun-Wei Chen

    IPC分类号： A61F2/28

    CPC分类号： A61L27/50 ,  A61L27/06 ,  A61L27/24 ,  A61L27/34 ,  A61L2430/02 ,  C08L89/06

    摘要： This invention relates to a bone implant that includes a bioinert substrate covered with a ceramic layer containing a plurality of indentations. The total surface area of the indentations is 30-70% of the total surface area of the ceramic layer. This invention also relates to a method of preparing such a bone implant. The method includes: (1) affixing a ceramic layer on the surface of a bioinert substrate; (2) forming a plurality of indentations in the ceramic layer, wherein the total surface area of the indentations is 30-70% of the total surface area of the ceramic layer; and (3) immobilizing a biopolymer onto the ceramic layer via covalent bonding.

    摘要翻译： 本发明涉及一种骨植入体，其包括用包含多个凹陷的陶瓷层覆盖的生物惰性基底。 压痕的总表面积为陶瓷层总表面积的30-70％。 本发明还涉及一种制备这种骨植入物的方法。 该方法包括：（1）在生物惰性基材的表面上固定陶瓷层; （2）在陶瓷层中形成多个凹陷，其中凹陷的总表面积为陶瓷层的总表面积的30-70％; 和（3）通过共价键将生物聚合物固定在陶瓷层上。

    Bone implants
    8.
    发明申请
    Bone implants 有权
    骨植入物

    公开(公告)号：US20060190091A1

    公开(公告)日：2006-08-24

    申请号：US11063074

    申请日：2005-02-22

    申请人： Wen-Fu Lai ,  Li-Chern Pan ,  Pau-Yee Lim ,  Jung-Chou Oung ,  Chun-Wei Chen

    发明人： Wen-Fu Lai ,  Li-Chern Pan ,  Pau-Yee Lim ,  Jung-Chou Oung ,  Chun-Wei Chen

    IPC分类号： A61F2/28

    CPC分类号： A61L27/50 ,  A61L27/06 ,  A61L27/24 ,  A61L27/34 ,  A61L2430/02 ,  C08L89/06

    摘要： This invention relates to a bone implant that includes a bioinert substrate covered with a ceramic layer containing a plurality of indentations. The total surface area of the indentations is 30-70% of the total surface area of the ceramic layer. This invention also relates to a method of preparing such a bone implant. The method includes: (1) affixing a ceramic layer on the surface of a bioinert substrate; (2) forming a plurality of indentations in the ceramic layer, wherein the total surface area of the indentations is 30-70% of the total surface area of the ceramic layer; and (3) immobilizing a biopolymer onto the ceramic layer via covalent bonding.

    摘要翻译： 本发明涉及一种骨植入物，其包括用包含多个凹陷的陶瓷层覆盖的生物惰性基底。 压痕的总表面积为陶瓷层总表面积的30-70％。 本发明还涉及一种制备这种骨植入物的方法。 该方法包括：（1）在生物惰性基材的表面上固定陶瓷层; （2）在陶瓷层中形成多个凹陷，其中凹陷的总表面积为陶瓷层的总表面积的30-70％; 和（3）通过共价键将生物聚合物固定在陶瓷层上。

    METHOD USING MICROFLUIDIC CHIP TO SORT HIGH MOTILITY SPERM
    9.
    发明申请
    METHOD USING MICROFLUIDIC CHIP TO SORT HIGH MOTILITY SPERM 审中-公开
    使用微流控芯片排除高电流密度的方法

    公开(公告)号：US20100291535A1

    公开(公告)日：2010-11-18

    申请号：US12546267

    申请日：2009-08-24

    申请人： Da-Jeng Yao ,  Tsung-Lin Wu ,  Fan-Gang Tseng ,  Li-Chern Pan ,  Hong-Yuan Huang

    发明人： Da-Jeng Yao ,  Tsung-Lin Wu ,  Fan-Gang Tseng ,  Li-Chern Pan ,  Hong-Yuan Huang

    IPC分类号： A01N1/02

    CPC分类号： C12N5/0612

    摘要： The present invention discloses a method using a microfluidic chip to sort high motility sperm. In the present invention, sperm and a medium are respectively injected into a microchannel of a microfluidic chip via several inlets. Owing to the characteristic of microfluidics, the sperm and the medium form a sperm laminar flow and medium laminar flow in the microchannels; the sperm laminar flow and the medium laminar flow are parallel to each other. The higher motile sperm may pass through at least one laminar flow within a limited time, whereby different motility levels of sperm can be respectively collected from different outlets.

    摘要翻译： 本发明公开了一种使用微流体芯片分选高活力精子的方法。 在本发明中，通过多个入口将精子和培养基分别注入微流体芯片的微通道。 由于微流体的特点，精子和培养基在微通道中形成精子层流和中层流; 精子层流和介质层流彼此平行。 较高活动精子可以在有限的时间内通过至少一个层流，从而可以从不同的出口分别收集精子的不同运动水平。