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公开(公告)号：US6020159A
公开(公告)日：2000-02-01
申请号：US910501
申请日：1997-08-04
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Martin Rosenberg , Julie M Pratt , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Martin Rosenberg , Julie M Pratt , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： C12N15/09 , A61K38/00 , A61K38/43 , A61K39/00 , A61K39/085 , A61K39/395 , A61P31/04 , C07K14/31 , C07K16/12 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/04 , C12N9/12 , C12N9/88 , C12N15/00 , C12N15/60 , C12R1/445 , C12P21/06 , C07H17/00
CPC分类号： C12N9/1205 , C07K14/31 , C12N9/00 , C12N9/0006 , C12N9/88 , A61K38/00 , A61K39/00
摘要： The invention provides 3-DEHYDROQUINATE SYNTHASE polypeptides and DNA (RNA) encoding 3-DEHYDROQUINATE SYNTHASE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing 3-DEHYDROQUINATE SYNTHASE polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了3-脱水氨基酸合成酶多肽和编码3-脱水氨基酸合成酶多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还提供了利用3-脱氢氨基酸合成酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US06232292B1
公开(公告)日：2001-05-15
申请号：US09398550
申请日：1999-09-17
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M. Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M. Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： C07K1400
CPC分类号： C12N9/1205 , A61K38/00 , A61K39/00 , C07K14/31 , C12N9/00 , C12N9/0006 , C12N9/88
摘要： The invention provides 3-DEHYDROQUINATE SYNTHASE polypeptides and DNA (RNA) encoding 3-DEHYDROQUINATE SYNTHASE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing 3-DEHYDROQUINATE SYNTHASE polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了3-脱水氨基酸合成酶多肽和编码3-脱水氨基酸合成酶多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还提供了利用3-脱氢氨基酸合成酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US06264955B1
公开(公告)日：2001-07-24
申请号：US09224502
申请日：1998-12-31
申请人： Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham
发明人： Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham
IPC分类号： A61K3902
CPC分类号： C07K16/1275 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K14/31 , C12N9/78 , C12Y305/04025
摘要： The invention provides Ferrichrome transport ATP-Binding Protein polypeptides and DNA (RNA) encoding Ferrichrome transport ATP-Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Ferrichrome transport ATP-Binding Protein polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了Ferrichrome转运ATP结合蛋白多肽和编码Ferrichrome转运ATP结合蛋白多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还提供了利用Ferrichrome转运ATP结合蛋白多肽筛选抗菌化合物的方法。
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公开(公告)号：US6107071A
公开(公告)日：2000-08-22
申请号：US910505
申请日：1997-08-04
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： G01N33/50 , A61K31/70 , A61K38/00 , A61K38/04 , A61K38/44 , A61K38/55 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07K14/31 , C07K16/12 , C12N1/00 , C12N1/21 , C12N9/00 , C12N9/04 , C12N9/12 , C12N9/14 , C12N9/88 , C12N15/00 , C12N15/09 , C12N15/31 , C12N15/53 , C12N15/54 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/19 , C12R1/44 , C12R1/445 , G01N33/15 , G01N33/53 , G01N33/569 , G01N33/573 , C07H21/04 , C12N1/20
CPC分类号： C12N9/0006 , C07K14/31 , C12N9/00 , C12N9/1205 , C12N9/88 , A61K38/00 , A61K39/00 , C07K2319/00 , Y10S435/883
摘要： The invention provides histidinol dehydrogenase polypeptides and DNA (RNA) encoding histidinol dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidinol dehydrogenase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供组氨醇脱氢酶多肽和编码组氨醇脱氢酶多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用组氨醇脱氢酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US06348582B1
公开(公告)日：2002-02-19
申请号：US08936165
申请日：1997-09-23
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto
IPC分类号： C07H2100
CPC分类号： C12N9/0006 , A61K38/00 , A61K39/00 , C07K14/31 , C07K2319/00 , C12N9/00 , C12N9/1205 , C12N9/88 , Y10S435/883
摘要： The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码这种多肽的新型多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用这些多肽筛选抗菌化合物的方法。
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公开(公告)号：US06248576B1
公开(公告)日：2001-06-19
申请号：US09493459
申请日：2000-01-28
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Riechard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M. Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Riechard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M. Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： C12N904
CPC分类号： C12N9/0006 , A61K38/00 , A61K39/00 , C07K14/31 , C07K2319/00 , C12N9/00 , C12N9/1205 , C12N9/88 , Y10S435/883
摘要： The invention provides histidinol dehydrogenase polypeptides and DNA (RNA) encoding histidinol dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidinol dehydrogenase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供组氨醇脱氢酶多肽和编码组氨醇脱氢酶多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用组氨醇脱氢酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US06248556B1
公开(公告)日：2001-06-19
申请号：US08879098
申请日：1997-06-19
申请人： Michael Terence Black , Martin Karl Russel Burnham , John Edward Hodgson , David Justin Charles Knowles , Richard O Nicholas , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Judith M Ward
发明人： Michael Terence Black , Martin Karl Russel Burnham , John Edward Hodgson , David Justin Charles Knowles , Richard O Nicholas , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Judith M Ward
IPC分类号： C12P2100
CPC分类号： C12N9/78 , A61K39/00 , C07K14/31 , C07K16/1275 , C12Y305/04025
摘要： The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.
摘要翻译： 本发明提供了ERA多肽和编码ERA多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还提供了利用ERA多肽以防止感染，特别是细菌感染的方法。
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公开(公告)号：US06465621B1
公开(公告)日：2002-10-15
申请号：US09631548
申请日：2000-08-03
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
IPC分类号： C07K1700
CPC分类号： C12N9/78 , A61K39/00 , C07K14/31 , C07K16/1275 , C12Y305/04025
摘要： The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.
摘要翻译： 本发明提供了ERA多肽和编码ERA多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还提供了利用ERA多肽以防止感染，特别是细菌感染的方法。
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公开(公告)号：US06228619B1
公开(公告)日：2001-05-08
申请号：US08948265
申请日：1997-10-09
申请人： Simon J Foster , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
发明人： Simon J Foster , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
IPC分类号： C12N1509
CPC分类号： C12Y302/01096 , A61K39/00 , A61K2039/53 , C07K14/31 , C07K16/1275 , C12N9/2402 , C12N9/78 , C12Y302/01023 , C12Y305/04025
摘要： The invention provides glucosaminidase polypeptides and DNA (RNA) encoding glucosaminidase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing glucosaminidase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了氨基葡糖苷酶多肽和编码氨基葡糖苷酶多肽的DNA（RNA），以及通过重组技术产生这种多肽的方法。 还提供了利用氨基葡糖苷酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US07250285B2
公开(公告)日：2007-07-31
申请号：US11403784
申请日：2006-04-13
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
CPC分类号： C12N9/1077 , A61K38/00 , A61K39/00 , C07K14/3156 , C07K2319/00 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002
摘要： The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码这种多肽的新型多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用这些多肽筛选抗菌化合物的方法。
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