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14 条记录 (耗时 0.031 秒)

    DNA encoding flagellin and vector having the same
    1.
    发明授权
    DNA encoding flagellin and vector having the same 失效
    编码鞭毛蛋白的DNA和具有相同的载体

    公开(公告)号：US4886748A

    公开(公告)日：1989-12-12

    申请号：US24992

    申请日：1987-03-11

    申请人： Junichiro Asaka ,  Tamio Fujiwara ,  Takashi Fujiwara ,  Goro Kuwajima ,  Eiji Kondo ,  Masaru Shin

    发明人： Junichiro Asaka ,  Tamio Fujiwara ,  Takashi Fujiwara ,  Goro Kuwajima ,  Eiji Kondo ,  Masaru Shin

    IPC分类号： C07K14/02 ,  C07K14/245 ,  C12N15/31

    CPC分类号： C07K14/005 ,  C07K14/245 ,  C07K2319/00 ,  C07K2319/036 ,  C07K2319/40 ,  C12N2730/10122

    摘要： The whole DNA sequence coding for flagellin of E. coli (hag gene) cloned in phage .lambda. was determined. The hag gene is introduced into pBR322 and the region of the hag gene concerning the antigencity of flagella is lacked, into which linkers are inserted. Where the vector in which foreign DNA is inserted in the linker is introduced in E. coli forming no flagella, the E. coli can form flagella and possesses motility. The flagella comprises flagellin fused with foreign peptide encoded by the foreign DNA. Namely, the foreign peptide is excreted outside of bacteria. This system can be utilized in determination of epitope and preparation of antigen as well as excretion of peptide.

    摘要翻译： 测定克隆在噬菌体λ中的编码大肠杆菌鞭毛蛋白（hag基因）的整个DNA序列。 将hag基因导入pBR322，并且缺乏关于鞭毛抗原性的hag基因的区域，其中插入接头。 其中将外源DNA插入接头的载体导入大肠杆菌中，不形成鞭毛，大肠杆菌可形成鞭毛并具有动力。 鞭毛包括与外源DNA编码的外源肽融合的鞭毛蛋白。 即，外来肽在细菌外排出。 该系统可用于测定抗原的表位和制备以及肽的排泄。

    Easily openable sealed container
    3.
    发明授权
    Easily openable sealed container 失效
    易开封密封容器

    公开(公告)号：US4915289A

    公开(公告)日：1990-04-10

    申请号：US354315

    申请日：1989-03-08

    申请人： Yasushi Hatano ,  Tamio Fujiwara ,  Michio Watanabe ,  Hideo Kurashima ,  Kazuo Taira ,  Kazuma Kuse

    发明人： Yasushi Hatano ,  Tamio Fujiwara ,  Michio Watanabe ,  Hideo Kurashima ,  Kazuo Taira ,  Kazuma Kuse

    IPC分类号： B65D33/00 ,  B65D77/20 ,  B65D77/38

    CPC分类号： B65D77/2032 ,  B65D2577/205 ,  B65D2577/2066

    摘要： A container composed of a plurality of container materials the opposing parts of which are sealed by heat sealing, wherein at least an opening start part of the sealed portion is of a laminated structure consisting of the plurality of container materials and an intermediate material inserted therebetween. The intermediate material and one of the container materials are tightly sealed, and the intermediate material and another of the container materials are sealed easily peelably. The inside end edge of the easily peelable seal portion is positioned more toward the center of the container than the inside end edge of the tight seal portion. At an opening start position, the outside end edge of the easily peelable seal portion is positioned more toward the center of the container than the outside end edge of the tight seal portion, and the intermediate material is provided so as to jut outwwardly of a heat sealing flat portion of a container flange. The strength of peeling of this sealed container from its central side is high enough to withstand retorting or the like, and opening of the container from outside can be effected by hand accurately and stably.

    Benzolactam derivatives
    4.
    发明授权
    Benzolactam derivatives 失效
    苯内酰胺衍生物

    公开(公告)号：US5652232A

    公开(公告)日：1997-07-29

    申请号：US615286

    申请日：1996-05-24

    申请人： Koichi Shudo ,  Yasuyuki Endo ,  Tamio Fujiwara ,  Akihiko Sato

    发明人： Koichi Shudo ,  Yasuyuki Endo ,  Tamio Fujiwara ,  Akihiko Sato

    IPC分类号： C07D245/06 ,  A61K31/395

    CPC分类号： C07D245/06

    摘要： A benzolactam derivative represented by the following formula (I): ##STR1## wherein n represents an integer of from 1 to 3; R.sup.1 represents a straight- or branched-chain alkyl group or an aralkyl group; R.sup.2 represents a straight- or branched-chain alkyl group; R.sup.3 and R.sup.4 independently represent a hydrogen atom or a straight- or branched-chain alkyl group, and when R.sup.3 and R.sup.4 are adjacent each other on the phenyl group, they may be combined to form a cycloalkyl ring together with two carbon atoms of the phenyl group to which R.sup.3 and R.sup.4 bind, and said cycloalkyl ring may optionally have one or more substituents; and a anti-retroviral agent comprising the same as an active ingredient.

    摘要翻译： PCT No.PCT / JP94 / 01561 Sec。 371日期：1996年5月24日 102（e）日期1996年5月24日PCT 1994年9月22日PCT公布。 公开号WO95 / 09160 日期：1995年4月6日由下式（I）表示的苯并内酰胺衍生物：其中n表示1〜3的整数， R1表示直链或支链烷基或芳烷基; R2表示直链或支链烷基; R3和R4独立地表示氢原子或直链或支链烷基，当R3和R4在苯基上彼此相邻时，它们可以与苯基的两个碳原子一起形成环烷基环 R 3和R 4结合的基团，并且所述环烷基环可任选地具有一个或多个取代基; 和包含其作为活性成分的抗逆转录病毒剂。

    Packaging material comprising iron foil, and container and container lid composed thereof
    5.
    发明授权
    Packaging material comprising iron foil, and container and container lid composed thereof 失效
    包含铁箔的包装材料，以及由其组成的容器和容器盖

    公开(公告)号：US4686152A

    公开(公告)日：1987-08-11

    申请号：US799388

    申请日：1985-11-18

    申请人： Hiroshi Matsubayashi ,  Kazumi Hirota ,  Hisao Iwamoto ,  Tamio Fujiwara ,  Nobuyuki Sato ,  Tadahiko Katsura

    发明人： Hiroshi Matsubayashi ,  Kazumi Hirota ,  Hisao Iwamoto ,  Tamio Fujiwara ,  Nobuyuki Sato ,  Tadahiko Katsura

    IPC分类号： B32B15/08 ,  B65D1/28

    CPC分类号： B32B15/08 ,  B65D1/28 ,  Y10S220/917 ,  Y10S428/925 ,  Y10T428/12438 ,  Y10T428/12569 ,  Y10T428/12722 ,  Y10T428/12854 ,  Y10T428/12937

    摘要： Disclosed is a packaging material which comprises a laminate having an iron foil having a tensile strength (.sigma..sub.B) in the range represented by the following formula:100 kg/mm.sup.2 .gtoreq..sigma..sub.B .gtoreq.30 kg/mm.sup.2and a thickness (T) in the range represented by the following formula:120 .mu.m.gtoreq.T.gtoreq.15 .mu.mand being provided with a surface treatment layer containing metallic tin, metallic chromium or metallic nickel, and an organic resin covering having a total thickness (t) in the range represented by the following formula:T.sup.1/n C/.sigma..sub.B .gtoreq.t.gtoreq.3 .mu.mwherein n is 5.6 and C is 4630.A metal or pigment having an action of improving the processability, an anti-corrosive action and a hiding action is incorporated or contained in the organic resin coating layer. This packaging material is excellent in processability, corrosion resistance, storability, appearance characteristics and safety.

    摘要翻译： 公开了一种包装材料，其包括具有在下式表示的范围内的拉伸强度（σB）的铁箔的层压体：100kg / mm 2> / =σB> / = 30kg / mm 2，厚度（ T）在由下式表示的范围内：120μm/ = T> / =15μm，并且设置有包含金属锡，金属铬或金属镍的表面处理层和具有总共的金属铬的有机树脂覆盖物 由下式表示的范围内的厚度（t）：T1 / nC / sigma B> / = t> / =3μm其中n为5.6，C为4630.具有改善加工性能的作用的金属或颜料， 在有机树脂涂层中掺入或包含防腐蚀作用和隐藏作用。 该包装材料的加工性，耐腐蚀性，保存性，外观特性和安全性优异。

    Imidazole derivatives as anti-HIV agents
    6.
    发明授权
    Imidazole derivatives as anti-HIV agents 失效
    咪唑衍生物作为抗HIV剂

    公开(公告)号：US5910506A

    公开(公告)日：1999-06-08

    申请号：US809624

    申请日：1997-05-30

    申请人： Hirohiko Sugimoto ,  Tamio Fujiwara

    发明人： Hirohiko Sugimoto ,  Tamio Fujiwara

    IPC分类号： A61K31/4164 ,  A61K31/4178 ,  A61P31/18 ,  C07D233/54 ,  C07D233/58 ,  C07D233/60 ,  C07D233/64 ,  C07D233/84 ,  C07D401/04 ,  C07D401/06 ,  C07D409/04 ,  A01N43/50 ,  C07D233/28 ,  C07D233/40

    CPC分类号： C07D233/56 ,  C07D233/64 ,  C07D233/84 ,  C07D401/04 ,  C07D401/06 ,  C07D409/04

    摘要： An imidazole derivative represented by general formula (I) or a salt thereof, having the effect of specifically inhibiting the growth of HIV as a pathogenic virus and being reduced in toxicity. In said formula R.sup.1 represents hydrogen, C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.7 alkenyl, C.sub.4 -C.sub.12 cycloalkylalkyl, etc.; R.sup.2 represents C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 acyl, hydroxyiminomethyl, hydrazonomethyl or --(CH.sub.2)n--R.sup.4 (R.sup.4 being halogeno, alkoxy, hydroxy, etc.; and n being an integer of 1 to 3); R.sup.3 represents substituted or unsubstituted C.sub.1 -C.sub.6 alkyl; X and Y represent each independently hydrogen, C.sub.1 -C.sub.3 alkyl, halogeno, or nitro; and Z represents S, SO, SO.sub.2 or CH.sub.2. ##STR1##

    摘要翻译： PCT No.PCT / JP95 / 01936 Sec。 371日期1997年5月30日 102（e）日期1997年5月30日PCT提交1995年9月25日PCT公布。 WO96 / 10019 PCT出版物 日期：1996年5月4日由通式（I）表示的咪唑衍生物或其盐，具有特异性抑制作为致病病毒的HIV生长且毒性降低的作用。 在所述式中，R 1表示氢，C 1 -C 20烷基，C 2 -C 7烯基，C 4 -C 12环烷基烷基等; R 2表示C 1 -C 6烷基，C 1 -C 6酰基，羟基亚氨基甲基，亚肼基甲基或 - （CH 2）n -R 4（R 4为卤代，烷氧基，羟基等; n为1至3的整数）。 R 3表示取代或未取代的C 1 -C 6烷基; X和Y各自独立地表示氢，C1-C3烷基，卤代或硝基; Z表示S，SO，SO 2或CH 2。