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    Alternate soaking apparatus and method for treatment of tissue materials
    1.
    发明申请
    Alternate soaking apparatus and method for treatment of tissue materials 审中-公开
    替代浸泡装置和组织材料处理方法

    公开(公告)号：US20050053671A1

    公开(公告)日：2005-03-10

    申请号：US10927054

    申请日：2004-08-27

    申请人： Junzo Tanaka ,  Masataka Sakane ,  Hironobu Fukuzaki ,  Yoshikane Yokoyama ,  Kunihiro Ota ,  Masanori Kikuchi ,  Toshiyuki Ikoma ,  Isamu Yamaguchi

    发明人： Junzo Tanaka ,  Masataka Sakane ,  Hironobu Fukuzaki ,  Yoshikane Yokoyama ,  Kunihiro Ota ,  Masanori Kikuchi ,  Toshiyuki Ikoma ,  Isamu Yamaguchi

    IPC分类号： A61L27/32 ,  A61L27/36 ,  A61K33/42

    CPC分类号： A61L27/3683 ,  A61L27/32 ,  A61L2430/40

    摘要： The alternate soaking apparatus for treatment of tissue materials has a plurality of chemical liquid containers, a treatment container for soaking and treating a tissue material, a plurality of liquid feed tubes for providing fluid communication between the corresponding chemical liquid containers and the treatment container to introduce the respective chemical liquids into the treatment container, a liquid discharge tube for discharging the chemical liquids in the treatment container, and control means for controllably opening and closing the liquid feed tubes and the liquid discharge tube to allow the plurality of chemical liquids to be contained in the treatment container individually and alternately. A tissue material is treated using the above alternate soaking apparatus under the condition that one of chemical liquids is an aqueous solution containing calcium, and another one of chemical liquids is an aqueous solution containing phosphoric acid, so as to form a calcium phosphate compound on the surface of and in the inside of the treated tissue material. The present invention allows a ligament material and to be automatically synthesized with a calcium phosphate-based compound in a shorter time-period by a limited number of members during the operation while securing an aseptic condition.

    摘要翻译： 用于处理组织材料的替代浸泡装置具有多个化学液体容器，用于浸泡和处理组织材料的处理容器，用于在相应的化学液体容器和处理容器之间提供流体连通的多个液体进料管以引入 进入处理容器的各化学液体，用于排出处理容器中的化学液体的液体排出管，以及用于可控地打开和关闭液体进料管和液体排出管以允许容纳多种化学液体的控制装置 在处理容器中单独地和交替地。 使用上述替代均热装置在化学液体是含有钙的水溶液的条件下处理组织材料，另一种化学液体是含有磷酸的水溶液，以便在其上形成磷酸钙化合物 处理过的组织材料的表面和内部。 本发明允许韧带材料，并且在确保无菌条件的同时在操作期间由有限数量的构件在较短的时间段内以磷酸钙基化合物自动合成。

    Porous composite containing calcium phosphate and process for producing the same
    4.
    发明授权
    Porous composite containing calcium phosphate and process for producing the same 有权
    含磷酸钙的多孔复合材料及其制备方法

    公开(公告)号：US08039090B2

    公开(公告)日：2011-10-18

    申请号：US10558245

    申请日：2004-05-26

    申请人： Katsumi Kawamura ,  Takehiko Nakajima ,  Daisuke Shoji ,  Junzo Tanaka ,  Masanori Kikuchi ,  Toshiyuki Ikoma

    发明人： Katsumi Kawamura ,  Takehiko Nakajima ,  Daisuke Shoji ,  Junzo Tanaka ,  Masanori Kikuchi ,  Toshiyuki Ikoma

    IPC分类号： B32B3/00

    CPC分类号： A61L27/56 ,  A61L27/12 ,  A61L27/425 ,  Y10T428/24752

    摘要： A porous composite comprising a porous layer containing a calcium phosphate ceramic, and a dense layer formed on part of the porous layer and having a smaller average pore size than that of the porous layer. The porous composite can be produced by (1) introducing a slurry containing a calcium phosphate ceramic/collagen composite and collagen into a molding die having a high thermal conductivity, (2) rapidly freezing and drying the slurry in the molding die, to form a porous body comprising a porous layer and a dense layer formed on the porous layer, (3) cross-linking collagen in the porous body, and (4) removing the dense layer except for a portion thereof on a surface coming into contact with a soft tissue when implanted in a human body, so that the porous layer is exposed.

    摘要翻译： 一种多孔复合体，其包含含有磷酸钙陶瓷的多孔层，以及形成在所述多孔层的一部分上并且具有比所述多孔层的平均孔径更小的致密层。 多孔复合材料可以通过（1）将含有磷酸钙陶瓷/胶原复合材料和胶原的浆料引入到具有高导热性的成型模具中，（2）快速冷冻并干燥成型模具中的浆料，从而形成 多孔体包括多孔层和形成在多孔层上的致密层，（3）在多孔体中交联胶原，以及（4）在与柔软接触的表面上去除除了其一部分之外的致密层 植入人体时的组织，使得多孔层被暴露。

    Porous composite containing calcium phosphate and process for producing the same
    7.
    发明申请
    Porous composite containing calcium phosphate and process for producing the same 有权
    含磷酸钙的多孔复合材料及其制备方法

    公开(公告)号：US20060292350A1

    公开(公告)日：2006-12-28

    申请号：US10558245

    申请日：2004-05-26

    申请人： Katsumi Kawamura ,  Takehiko Nakajima ,  Daisuke Shoji ,  Junzo Tanaka ,  Masanori Kikuchi ,  Toshiyuki Ikoma

    发明人： Katsumi Kawamura ,  Takehiko Nakajima ,  Daisuke Shoji ,  Junzo Tanaka ,  Masanori Kikuchi ,  Toshiyuki Ikoma

    IPC分类号： B32B3/00

    CPC分类号： A61L27/56 ,  A61L27/12 ,  A61L27/425 ,  Y10T428/24752

    摘要： A porous composite comprising a porous layer containing a calcium phosphate ceramic, and a dense layer formed on part of the porous layer and having a smaller average pore size than that of the porous layer. The porous composite can be produced by (1) introducing a slurry containing a calcium phosphate ceramic/collagen composite and collagen into a molding die having a high thermal conductivity, (2) rapidly freezing and drying the slurry in the molding die, to form a porous body comprising a porous layer and a dense layer formed on the porous layer, (3) cross-linking collagen in the porous body, and (4) removing the dense layer except for a portion thereof on a surface coming into contact with a soft tissue when implanted in a human body, so that the porous layer is exposed.

    摘要翻译： 一种多孔复合体，其包含含有磷酸钙陶瓷的多孔层，以及形成在所述多孔层的一部分上并且具有比所述多孔层的平均孔径更小的致密层。 多孔复合材料可以通过（1）将含有磷酸钙陶瓷/胶原复合材料和胶原的浆料引入到具有高导热性的成型模具中，（2）快速冷冻并干燥成型模具中的浆料，从而形成 多孔体包括多孔层和形成在多孔层上的致密层，（3）在多孔体中交联胶原，以及（4）在与柔软接触的表面上去除除了其一部分之外的致密层 植入人体时的组织，使得多孔层被暴露。

    Drug-containing sustained release microparticle, process for producing the same and preparation containing the microparticle
    10.
    发明授权
    Drug-containing sustained release microparticle, process for producing the same and preparation containing the microparticle 失效
    含药缓释微粒，其制造方法和含有微粒的制剂

    公开(公告)号：US08313767B2

    公开(公告)日：2012-11-20

    申请号：US12837810

    申请日：2010-09-02

    申请人： Yutaka Mizushima ,  Yasuaki Ogawa ,  Junzo Tanaka ,  Toshiyuki Ikoma

    发明人： Yutaka Mizushima ,  Yasuaki Ogawa ,  Junzo Tanaka ,  Toshiyuki Ikoma

    IPC分类号： A61K9/22 ,  A61K9/14 ,  A61K33/30 ,  A61K38/00 ,  A61K31/70 ,  A61K31/7088 ,  A61K31/56 ,  A61K31/315

    CPC分类号： A61K31/00 ,  A61K9/1611 ,  A61K33/30 ,  A61K33/42 ,  A61K45/06 ,  A61K2300/00

    摘要： Sustained release microparticles suitable for various types of drugs, or drug-containing sustained release microparticles capable of sustained release of drugs over a period of three days or more and capable of inhibiting initial burst release; a process for producing the same; and preparations containing the microparticles are disclosed. The drug-containing sustained release microparticles comprise a drug other than human growth hormone and a porous apatite derivative, and optionally include a water-soluble bivalent metal compound. The drug-containing sustained release microparticles can be produced by dispersing under agitation microparticles of a porous apatite derivative in an aqueous solution containing a drug so that the aqueous solution infiltrates into the porous apatite derivative; optionally adding an aqueous solution containing a water-soluble bivalent metal compound that may infiltrate into the porous apatite derivative; further adding additives such as a stabilizer to the mixture; and effecting lyophilization or vacuum drying.

    摘要翻译： 适用于各种类型药物的持续释放微粒，或能够在三天或更长时间内持续释放药物并且能够抑制初始爆发释放的药物持续释放微粒; 其制造方法; 并且公开了含有微粒的制剂。 含药物的缓释微粒包含除人生长激素以外的药物和多孔磷灰石衍生物，任选地包含水溶性二价金属化合物。 含药缓释微粒可以通过将多孔磷灰石衍生物的微粒分散在含有药物的水溶液中分散而制成，使得水溶液渗透到多孔磷灰石衍生物中; 任选地加入含有可渗透到多孔磷灰石衍生物中的水溶性二价金属化合物的水溶液; 进一步向混合物中加入稳定剂等添加剂; 并进行冻干或真空干燥。