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1.发明授权公开(公告)号：US09078712B2
公开(公告)日：2015-07-14
申请号：US12610020
申请日：2009-10-30
申请人： Jusong Xia , Hai H. Trieu , William F. McKay , Newton H. Metcalf, Jr. , Nikolas F. Kerr , Drew Amery
发明人： Jusong Xia , Hai H. Trieu , William F. McKay , Newton H. Metcalf, Jr. , Nikolas F. Kerr , Drew Amery
IPC分类号： A61K9/00 , A61K31/496 , A61K31/65 , A61K47/00 , A61B17/80 , A61B17/70 , A61K47/24 , A61K47/32 , A61K47/34 , A61B17/00
CPC分类号： A61B17/8042 , A61B17/7059 , A61B2017/00004 , A61B2017/00951 , A61K9/0024 , A61K47/24 , A61K47/32 , A61K47/34
摘要： A drug-eluting device comprising a drug-eluting matrix containing at least one elutable drug, a method of manufacturing a preformed drug-eluting device, and an implant kit comprising the same.
摘要翻译： 一种药物洗脱装置，其包括含有至少一种可洗脱药物的药物洗脱基质，制备预成型药物洗脱装置的方法和包含该药物洗脱液的植入试剂盒。
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公开(公告)号：US20100247600A1
公开(公告)日：2010-09-30
申请号：US12610005
申请日：2009-10-30
申请人： Jusong Xia , Hai H. Trieu , William F. McKay , Newton H. Metcalf, JR. , Nikolas F. Kerr , Drew Amery
发明人： Jusong Xia , Hai H. Trieu , William F. McKay , Newton H. Metcalf, JR. , Nikolas F. Kerr , Drew Amery
IPC分类号： A61K9/00 , A61K47/32 , A61K47/30 , A61K47/42 , A61P31/00 , A61K47/38 , A61K31/65 , A61K31/496
CPC分类号： A61L31/16 , A61B17/70 , A61L31/04 , A61L31/10 , A61L2300/404 , A61L2400/10
摘要： A drug-eluting implant cover fabricated from a drug-eluting biocompatible matrix containing at least one elutable drug, a drug-eluting implant cover kit containing at least one drug-eluting implant cover, and a method of manufacturing the same.
摘要翻译： 药物洗脱植入物盖，其由含有至少一种可洗脱药物的药物洗脱生物相容性基质制备，药物洗脱植入物覆盖试剂盒含有至少一种药物洗脱植入物盖，及其制备方法。
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3.发明申请公开(公告)号：US20100266657A1
公开(公告)日：2010-10-21
申请号：US12610020
申请日：2009-10-30
申请人： Jusong Xia , Hai H. Trieu , William F. McKay , Newton H. Metcalf, JR. , Nikolas F. Kerr , Drew Amery
发明人： Jusong Xia , Hai H. Trieu , William F. McKay , Newton H. Metcalf, JR. , Nikolas F. Kerr , Drew Amery
IPC分类号： A61K9/00 , A61K47/30 , A61K47/32 , A61K47/42 , A61P19/00 , A61K47/36 , A61K47/38 , A61K31/65 , A61K31/496 , B05D3/00
CPC分类号： A61B17/8042 , A61B17/7059 , A61B2017/00004 , A61B2017/00951 , A61K9/0024 , A61K47/24 , A61K47/32 , A61K47/34
摘要： A drug-eluting device comprising a drug-eluting matrix containing at least one elutable drug, a method of manufacturing a preformed drug-eluting device, and an implant kit comprising the same.
摘要翻译： 一种药物洗脱装置，其包括含有至少一种可洗脱药物的药物洗脱基质，制备预成型药物洗脱装置的方法和包含该药物洗脱液的植入试剂盒。
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公开(公告)号：US20110184245A1
公开(公告)日：2011-07-28
申请号：US12695211
申请日：2010-01-28
申请人： Jusong Xia , Joseph Jude Saladino , Jeff R. Justis , Newton H. Metcalf, JR. , Greg C. Marik , Nikolas F. Kerr , Hai H. Trieu
发明人： Jusong Xia , Joseph Jude Saladino , Jeff R. Justis , Newton H. Metcalf, JR. , Greg C. Marik , Nikolas F. Kerr , Hai H. Trieu
IPC分类号： A61B1/32
CPC分类号： A61B1/32 , A61B17/0206 , A61B46/17 , A61B2017/00022 , A61B2017/00115 , A61B2017/00119 , A61B2017/00199 , A61B2017/00221 , G06F19/00
摘要： An apparatus for monitoring the characteristics of tissue adjacent a surgical site and communicating that information to a health care provider includes a retractor, a sensor, and a processing system. The sensor is disposed on the retractor and is configured to measure a parameter indicative of at least one characteristic of the tissue adjacent the first or the second blade. The processing system is in communication with the sensor and configured and arranged to receive information from the sensor indicative of the measured parameter. It includes a threshold stored therein indicative of excessive trauma to the tissue and it is configured in a manner such that it compares the received information to the stored threshold and communicates information to the health care provider regarding the comparison.
摘要翻译： 用于监测邻近手术部位的组织的特征并将该信息传达给医疗保健提供者的装置包括牵开器，传感器和处理系统。 传感器设置在牵开器上并被配置成测量指示邻近第一或第二叶片的组织的至少一个特征的参数。 处理系统与传感器通信并被配置和布置成从传感器接收指示测量参数的信息。 它包括存储在其中的阈值，其指示对组织的过度创伤，并且其被配置为使得其将所接收的信息与存储的阈值进行比较，并且将信息与卫生保健提供者进行比较。
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公开(公告)号：US08376937B2
公开(公告)日：2013-02-19
申请号：US12695211
申请日：2010-01-28
申请人： Jusong Xia , Joseph Jude Saladino , Jeff R. Justis , Newton H. Metcalf, Jr. , Greg C. Marik , Nikolas F. Kerr , Hai H. Trieu
发明人： Jusong Xia , Joseph Jude Saladino , Jeff R. Justis , Newton H. Metcalf, Jr. , Greg C. Marik , Nikolas F. Kerr , Hai H. Trieu
IPC分类号： A61B1/32
CPC分类号： A61B1/32 , A61B17/0206 , A61B46/17 , A61B2017/00022 , A61B2017/00115 , A61B2017/00119 , A61B2017/00199 , A61B2017/00221 , G06F19/00
摘要： An apparatus for monitoring the characteristics of tissue adjacent a surgical site and communicating that information to a health care provider includes a retractor, a sensor, and a processing system. The sensor is disposed on the retractor and is configured to measure a parameter indicative of at least one characteristic of the tissue adjacent the first or the second blade. The processing system is in communication with the sensor and configured and arranged to receive information from the sensor indicative of the measured parameter. It includes a threshold stored therein indicative of excessive trauma to the tissue and it is configured in a manner such that it compares the received information to the stored threshold and communicates information to the health care provider regarding the comparison.
摘要翻译： 用于监测邻近手术部位的组织的特征并将该信息传达给医疗保健提供者的装置包括牵开器，传感器和处理系统。 传感器设置在牵开器上并被配置成测量指示邻近第一或第二叶片的组织的至少一个特征的参数。 处理系统与传感器通信并被配置和布置成从传感器接收指示测量参数的信息。 它包括存储在其中的阈值，其指示对组织的过度创伤，并且其被配置为使得其将所接收的信息与存储的阈值进行比较，并且将信息传达给医疗保健提供者以关于比较。
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公开(公告)号：US20100268278A1
公开(公告)日：2010-10-21
申请号：US12424083
申请日：2009-04-15
申请人： Kevin T. FOLEY , Regis W. Haid , Newton H. Metcalf, JR. , Bradley J. Coates , David Alan Sharp , Chris Michael Diaz , Virginia Leigh Richardson , Jeff R. Justis , Hai H. Trieu , Jeffrey H. Nycz , Greg C. Marik , Troy D. Drewry , Richard J. Thiele , Gary S. Lindemann
发明人： Kevin T. FOLEY , Regis W. Haid , Newton H. Metcalf, JR. , Bradley J. Coates , David Alan Sharp , Chris Michael Diaz , Virginia Leigh Richardson , Jeff R. Justis , Hai H. Trieu , Jeffrey H. Nycz , Greg C. Marik , Troy D. Drewry , Richard J. Thiele , Gary S. Lindemann
CPC分类号： A61B17/7059
摘要： Various embodiments of a vertebral tension band assembly and associated connection structure are provided. The tension band assemblies may be attached to vertebral bodies to, for example, connect one vertebrae to another, retain the band in approximately a preferred position by application of tension to the band during insertion and/or limit, impede, inhibit, reduce or interfere with the separation from one vertebra to another and may further block, impede, interfere with, inhibit, reduce or present an obstacle to dislodgement of a spinal implant from between the vertebrae to which it is attached. Flexible band portions of the assemblies may be treated and/or configured to promote bony integration between the band and the associated vertebrae, limit tissue adhesion to the band, and/or to elute a therapeutic substance from the installed band to the surgical site.
摘要翻译： 提供了椎体张力带组件和相关连接结构的各种实施例。 张力带组件可以附接到椎体以例如将一个椎骨连接到另一个椎骨，通过在插入期间施加张力并且/或限制，阻止，抑制，减少或干扰，将带保持在大致优选的位置 具有从一个椎骨到另一个椎骨的分离，并且可以进一步阻止，阻碍，干扰，抑制，减少或呈现脊柱植入物从其所连接的椎骨之间移动的障碍。 组件的柔性带部分可以被处理和/或构造成促进带和相关椎骨之间的骨整合，限制组织对带的粘附，和/或将治疗物质从所安装的带中洗脱到手术部位。
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7.发明授权Allogenic/xenogenic implants and methods for augmenting or repairing intervertebral discs 有权同种异体植入物和增强或修复椎间盘的方法公开(公告)号：US07309359B2
公开(公告)日：2007-12-18
申请号：US10645006
申请日：2003-08-21
IPC分类号： A61F2/44
CPC分类号： A61L27/3683 , A61F2/08 , A61F2/442 , A61F2002/30075 , A61F2002/30214 , A61F2002/30224 , A61F2002/30293 , A61F2002/30448 , A61F2002/30459 , A61F2002/30461 , A61F2002/30677 , A61F2002/30971 , A61F2002/4435 , A61F2002/444 , A61F2002/445 , A61F2210/0061 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0067 , A61F2230/0069 , A61F2230/0091 , A61L27/3604 , A61L27/3612 , A61L27/3658 , A61L2430/38 , Y10S623/908 , Y10S623/919 , Y10S623/923
摘要： Allogenic or xenogenic materials are used to provide intervertebral disc nucleus implants and/or annular plugs. The allogenic or xenogenic materials comprise natural disc annulus material, which may have a portion of the anterior longitudinal ligament attached. The tissue may be used “as is” without an additional core or covering, or it may be used in combination with other materials. The material may be rolled, folded, layered and/or sutured, stapled, or glued to provide a solid plug of natural biological material. The implant may be provided as a dehydrated, substantially rod-shaped segment having a diameter less than the diameter of the hydrated material, and may have one or more ends of the dehydrated rod terminate with a further reduced diameter portion, preferably a point.
摘要翻译： 同种异体或异种材料用于提供椎间盘核植入物和/或环形塞。 同种异体或异种材料包括天然椎间盘环形材料，其可以具有连接的前纵韧带的一部分。 组织可以“原样”使用而没有附加的芯或覆盖物，或者可以与其它材料组合使用。 该材料可以被卷起，折叠，分层和/或缝合，缝合或胶合以提供天然生物材料的固体塞子。 植入物可以被提供为具有直径小于水合材料直径的脱水的，基本上为棒状的段，并且可以具有脱水杆的一个或多个端部以另外的直径缩小部分，优选地点终止。
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8.发明授权Methods for augmenting or repairing intervertebral discs with allogenic/xenogenic implants 有权用同种异体/异种植入物增强或修复椎间盘的方法公开(公告)号：US09011543B2
公开(公告)日：2015-04-21
申请号：US11930557
申请日：2007-10-31
CPC分类号： A61L27/3683 , A61F2/08 , A61F2/442 , A61F2002/30075 , A61F2002/30214 , A61F2002/30224 , A61F2002/30293 , A61F2002/30448 , A61F2002/30459 , A61F2002/30461 , A61F2002/30677 , A61F2002/30971 , A61F2002/4435 , A61F2002/444 , A61F2002/445 , A61F2210/0061 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0067 , A61F2230/0069 , A61F2230/0091 , A61L27/3604 , A61L27/3612 , A61L27/3658 , A61L2430/38 , Y10S623/908 , Y10S623/919 , Y10S623/923
摘要： Allogenic or xenogenic materials are used to provide intervertebral disc nucleus implants and/or annular plugs. The allogenic or xenogenic materials comprise natural disc annulus material, which may have a portion of the anterior longitudinal ligament attached. The tissue may be used “as is” without an additional core or covering, or it may be used in combination with other materials. The material may be rolled, folded, layered and/or sutured, stapled, or glued to provide a solid plug of natural biological material. The implant may be provided as a dehydrated, substantially rod-shaped segment having a diameter less than the diameter of the hydrated material, and may have one or more ends of the dehydrated rod terminate with a further reduced diameter portion, preferably a point.
摘要翻译： 同种异体或异种材料用于提供椎间盘核植入物和/或环形塞。 同种异体或异种材料包括天然椎间盘环形材料，其可以具有连接的前纵韧带的一部分。 组织可以“原样”使用而没有附加的芯或覆盖物，或者可以与其它材料组合使用。 该材料可以被卷起，折叠，分层和/或缝合，装订或胶合以提供天然生物材料的固体塞子。 植入物可以被提供为具有直径小于水合材料直径的脱水的，基本上为棒状的段，并且可以具有脱水杆的一个或多个端部以另外的直径缩小部分，优选地点终止。
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9.发明授权Method of implanting natural tissue within the vertebral disc nucleus space using a drawstring 有权使用束带将椎体间隙内的天然组织植入的方法公开(公告)号：US07887593B2
公开(公告)日：2011-02-15
申请号：US10666900
申请日：2003-09-18
申请人： William F. McKay , Hai H. Trieu
发明人： William F. McKay , Hai H. Trieu
IPC分类号： A61F2/44
CPC分类号： A61L31/18 , A61B2017/564 , A61F2/08 , A61F2/30767 , A61F2/441 , A61F2/442 , A61F2/4601 , A61F2002/30075 , A61F2002/3008 , A61F2002/30224 , A61F2002/30459 , A61F2002/30461 , A61F2002/30588 , A61F2002/30599 , A61F2002/30677 , A61F2002/444 , A61F2002/445 , A61F2002/4495 , A61F2210/0061 , A61F2220/0066 , A61F2220/0075 , A61F2230/0069 , A61F2250/0063 , A61F2250/0098 , A61F2310/00365 , A61L27/3604 , A61L27/3629 , A61L27/3658 , A61L27/3683 , A61L27/50 , A61L31/005 , A61L31/14 , A61L2430/24 , A61L2430/38 , Y10S623/908
摘要： Materials and methods for repairing or replacing an intervertebral disc or disc nucleus using natural biological tissue. The tissue may be used alone without an additional core material, or it may be used to encapsulate an elastomeric or hydrogel core. When used alone the tissue may be rolled, folded, braided, or layered to provide a solid plug of natural biological material. When used to encapsulate an elastomeric or hydrogel core the tissue acts as a constraining jacket to support the core. The natural tissue implants may further include a drawstring to assist in folding the implant when the device is implanted in an intervertebral disc space. Multiple units of the natural tissue implants may be used together.
摘要翻译： 使用天然生物组织修复或更换椎间盘或椎间盘核的材料和方法。 组织可以单独使用而不需要额外的芯材料，或者可以用于包封弹性体或水凝胶核。 当单独使用时，组织可以被卷起，折叠，编织或分层以提供天然生物材料的固体塞子。 当用于包封弹性体或水凝胶芯时，组织用作约束护套以支撑芯。 天然组织植入物可以进一步包括当将该装置植入椎间盘空间时有助于折叠植入物的束带。 天然组织植入物的多个单位可以一起使用。
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10.发明授权公开(公告)号：US09414864B2
公开(公告)日：2016-08-16
申请号：US12409089
申请日：2009-04-15
申请人： Hai H. Trieu
发明人： Hai H. Trieu
CPC分类号： A61B17/7059 , A61B17/8042 , A61B2017/00004 , A61B2017/00951 , A61K9/0024 , A61K47/24 , A61K47/32 , A61K47/34
摘要： An anterior spinal plate has affixed to at least a portion of a surface thereof at least one preformed drug-eluting device fabricated from a drug-eluting matrix containing at least one elutable drug.
摘要翻译： 前脊椎板已经固定在其表面的至少一部分上，至少一个预先形成的药物洗脱装置由含有至少一种可洗脱药物的药物洗脱基质制备。
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