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    Detection Method And Detection Device
    1.
    发明申请
    Detection Method And Detection Device 审中-公开

    公开(公告)号：US20190285545A1

    公开(公告)日：2019-09-19

    申请号：US16318315

    申请日：2017-07-11

    Applicant: KONICA MINOLTA, INC.

    Inventor： Fumio NAGAI ,  Tetsuya NODA ,  Kenichi KUBO

    IPC: G01N21/64 ,  G01N21/552 ,  G01N21/13 ,  G01N21/84

    Abstract: A light irradiation angle is set with respect to a first surface so as to detect only either first reflected light or second reflected light. Then, light is emitted from a light irradiation part at the set irradiation angle while a detection chip is kept in motion, either the first reflected light or the second reflected light is detected by a reflected light detection part, and positional information of the detection chip is acquired on the basis of the result of the detection of the first or second reflected light. The detection chip is moved, on the basis of the acquired positional information, to a detection position where detection of a substance to be detected is performed. While the detection chip is kept at the detection position, detection of the substance to be detected is performed through detection of sample light.

    MEASUREMENT METHOD
    3.
    发明申请
    MEASUREMENT METHOD 有权

    公开(公告)号：US20210285874A1

    公开(公告)日：2021-09-16

    申请号：US16328437

    申请日：2017-09-06

    Applicant: Konica Minolta, Inc.

    Inventor： Tetsuya NODA ,  Fumio NAGAI ,  Youichi AOKI ,  Makiko OTANI

    IPC: G01N21/552 ,  G01N21/49 ,  G01N33/543 ,  G01N21/64 ,  G01N33/49

    Abstract: A measurement chip including a prism, a metal film, and a capturing body is prepared. In a state in which a specimen is present on the metal film, scattered light obtained when first light which passes through the metal film and the specimen is scattered in the specimen when the first light is applied to the metal film from a prism side at a first incident angle smaller than a critical angle is detected. In a state in which a substance to be measured is captured by the capturing body and the specimen is not present on the metal film, a signal indicating an amount of the substance to be measured generated in the measurement chip when second light is applied to the metal film at a second incident angle not smaller than the critical angle from the prism side is detected. On the basis of a hematocrit value of the specimen determined from a light amount of the scattered light, a measurement value indicating the amount of the substance to be measured determined from the signal is corrected.

    MEASUREMENT METHOD, MEASUREMENT APPARATUS, AND MEASUREMENT SYSTEM
    4.
    发明申请
    MEASUREMENT METHOD, MEASUREMENT APPARATUS, AND MEASUREMENT SYSTEM 审中-公开

    公开(公告)号：US20200182784A1

    公开(公告)日：2020-06-11

    申请号：US16322832

    申请日：2017-08-01

    Applicant: Konica Minolta, Inc.

    Inventor： Fumio NAGAI ,  Tefsuya NODA ,  Hideyuki FUJll

    IPC: G01N21/41 ,  G01N33/49 ,  G01N21/64 ,  B01L3/00 ,  G01N33/543 ,  G01N33/553

    Abstract: A specimen containing a substance to be measured is introduced into a flow path of a measurement chip including a flow path which is a cavity for accommodating liquid and a reflecting unit which specularly reflects light which passes through the flow path so as to pass through the flow path again and a measurement value indicating an amount of the substance to be measured in the specimen is acquired. Then, second light acquired when first light including light of a wavelength absorbed by a red blood cell passes through the specimen in the flow path, is reflected by the reflecting unit, and passes through the specimen in the flow path again is detected in a state in which the specimen is present in the flow path. Next, a hematocrit value of the specimen is determined on the basis of a detection result of the second light. Next, a measurement value is corrected on the basis of the hematocrit value.

    MEASUREMENT METHOD
    5.
    发明申请
    MEASUREMENT METHOD 审中-公开

    公开(公告)号：US20190187125A1

    公开(公告)日：2019-06-20

    申请号：US16322190

    申请日：2017-08-09

    Applicant: Konica Minolta, Inc

    Inventor： Makiko OTANI ,  Tetsuya NODA ,  Fumio NAGAI

    IPC: G01N33/49 ,  G01N21/64 ,  G01N27/327

    CPC classification number: G01N33/49 ,  G01N21/6428 ,  G01N21/648 ,  G01N27/3274 ,  G01N2021/6439

    Abstract: A specimen containing blood is divided into a first specimen and a second specimen. The blood in the second specimen is hemolyzed. The first specimen containing a substance to be measured is introduced into an accommodating unit and a measurement value indicating an amount of the substance to be measured in the first specimen in a state in which the blood is not hemolyzed is acquired. In a state in which the second specimen in a state in which the blood is hemolyzed is present in the accommodating unit of a measurement chip, second light acquired when first light including light of a wavelength absorbed by a red blood cell passes through the second specimen in the accommodating unit is detected. On the basis of a detection result of the second light, a hematocrit value of the specimen is determined. The measurement value is corrected on the basis of the hematocrit value.

    Optical Sample Detection System
    6.
    发明申请
    Optical Sample Detection System 审中-公开

    公开(公告)号：US20180321152A1

    公开(公告)日：2018-11-08

    申请号：US15773910

    申请日：2016-10-25

    Applicant: KONICA MINOLTA, INC.

    Inventor： Fumio NAGAI ,  Tetsuya NODA

    IPC: G01N21/64 ,  G01N21/552

    CPC classification number: G01N21/648 ,  G01N21/553 ,  G01N21/6428 ,  G02B5/04

    Abstract: An optical sample detection system includes: a sensor chip including a dielectric member, a metal film adjacent to an upper surface of the dielectric member, a reaction layer adjacent to an upper surface of the metal film, and a lid member disposed on an upper surface of the reaction layer; a chip holding unit for holding the sensor chip; and a light projecting unit that irradiates the metal film with excitation light through the dielectric member. A sample is detected by irradiating the metal film with excitation light through the dielectric member. The lid member is wider than the dielectric member in an optical path cross section of the excitation light.

    DETECTION DEVICE
    7.
    发明申请
    DETECTION DEVICE 审中-公开

    公开(公告)号：US20180080873A1

    公开(公告)日：2018-03-22

    申请号：US15558526

    申请日：2016-03-08

    Applicant: KONICA MINOLTA, INC.

    Inventor： Tetsuya NODA ,  Fumio NAGAI ,  Nobuhiro YAMAUCHI ,  Yuichi KYOGOKU

    IPC: G01N21/64

    CPC classification number: G01N21/648 ,  G01N21/553 ,  G01N21/64 ,  G01N21/6428 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2201/0638 ,  G01N2201/0806

    Abstract: This detection device has a holder, light irradiation unit, angle adjustment unit, light receiving sensor, light receiving optical system, optical filter, and a control unit. The light receiving optical system guides light from a detection chip to the light receiving sensor. The optical filter is disposed in the light receiving optical system, blocks a part of plasmon scattered light, and passes, out of the light emitted from the detection chip, a part of the plasmon scattered light, and fluorescence emitted from a fluorescent material. The light receiving sensor detects the fluorescent light, and the part of the plasmon scattered light, which have been emitted from the detection chip and passed the optical filter. On the basis of the detection results of the plasmon scattered light, the control unit controls the angle adjustment unit, and adjusts the incident angle of the excitation light to a predetermined incident angle.

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