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    Labeling Reagent Containing A Molecularly Targeted Drug
    3.
    发明申请
    Labeling Reagent Containing A Molecularly Targeted Drug 审中-公开

    公开(公告)号：US20170205417A1

    公开(公告)日：2017-07-20

    申请号：US15327782

    申请日：2015-07-21

    Applicant: KONICA MINOLTA, INC.

    Inventor： Takuji AIMIYA ,  Naoko FURUSAWA

    IPC: G01N33/574 ,  C07D401/14 ,  G01N33/58

    CPC classification number: G01N33/57438 ,  A61K49/00 ,  C07D401/14 ,  G01N33/48 ,  G01N33/582

    Abstract: An object of the present invention is to provide a labeling agent which exhibits excellent binding to a target molecule in a bioassay or histological staining method that relates to a compound containing a nitrogen-containing aromatic ring.The labeling agent according to the present invention is a labeling agent having a structure in which a molecular target drug, which is a compound containing a nitrogen atom-containing aromatic ring, is bound with a label via a divalent linking group, wherein one end of the divalent linking group is bound to a carbon atom of the nitrogen atom-containing aromatic ring. The label is preferably a fluorescent substance-integrated nanoparticle, and the nitrogen atom-containing aromatic ring is preferably a pyridine ring.

    PHOSPHOR INTEGRATED DOTS NANOPARTICLES AND LABELING AGENT USING SAME
    5.
    发明申请
    PHOSPHOR INTEGRATED DOTS NANOPARTICLES AND LABELING AGENT USING SAME 审中-公开

    公开(公告)号：US20180362770A1

    公开(公告)日：2018-12-20

    申请号：US16061986

    申请日：2016-12-06

    Applicant: Konica Minolta, Inc.

    Inventor： Takuji AIMIYA ,  Kensaku TAKANASHI

    IPC: C09B67/02 ,  C09B67/08 ,  C09B19/00 ,  C09B29/08 ,  C09B11/24 ,  C08J7/12 ,  C08K5/00 ,  C08L101/02

    Abstract: The present invention provides a nanoparticle containing a hydrophobic fluorescent substance accumulated therein and a thermosetting resin as a matrix, which nanoparticle, when used for labeling of a biological substance such as a protein or nucleic acid, has brightness sufficient for allowing pathological diagnosis using a fluorescence image obtained thereby. The present invention is a phosphor integrated dots nanoparticles wherein a thermosetting resin contains a structural unit formed from a raw material containing a hydrophobic substituent, and wherein a fluorescent substance is accumulated in the nanoparticle at least by hydrophobic interaction, preferably further by stacking interaction, with the hydrophobic substituent of the thermosetting resin.

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