-
1.发明公开公开(公告)号：US20240164718A1
公开(公告)日：2024-05-23
申请号：US18509843
申请日：2023-11-15
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/11 , A61B5/113
CPC分类号： A61B5/6844 , A61B5/0002 , A61B5/0205 , A61B5/1118 , A61B5/1126 , A61B5/113 , A61B5/02438 , A61B2562/0219
摘要： A system includes a monitoring device including an accelerometer, an on-board electronic processor, and a wireless transmitter or transceiver. The monitoring device configured to be attached to a patient and the accelerometer configured to measure accelerometer data. The on-board electronic processor of the monitoring device performs a health status monitoring method including analyzing the accelerometer data to determine respiration rate data for the patient or an indication that respiration rate data cannot be determined from the accelerometer data; determining whether the monitoring device is attached to the patient based at least on the whether the analyzing determines that respiration rate data cannot be determined; and one of (i) displaying health status information for the patient generated from the accelerometer data and the determined respiration rate data; or (ii) displaying an indication that the monitoring device is not attached to the patient.
-
公开(公告)号：US11309059B2
公开(公告)日：2022-04-19
申请号：US14785400
申请日：2014-04-24
发明人： Wilhelmus Franciscus Johannes Verhaegh , Hendrik Jan Van Ooijen , Anja Van De Stolpe , Marcia Alves De Inda
摘要： A method for determining a risk score that indicates a risk that a clinical event will occur within a certain period of time. The risk score is based at least in part on a combination of inferred activities of two or more cellular signaling pathways in a tissue and/or cells and/or a body fluid of a subject. The cellular signaling pathways comprise a Wnt pathway, an ER pathway, an HH pathway, and/or an AR pathway. The risk score is defined such that the indicated risk that the clinical event will occur within the certain period of time decreases with an increasing PER and increases with an increasing max(PWnt, PHH), wherein PER, PWnt, and PHH denote the inferred activity of the ER pathway, the Wnt pathway, and the HH pathway, respectively.
-
公开(公告)号：US20210158900A1
公开(公告)日：2021-05-27
申请号：US16624526
申请日：2018-06-25
摘要： A method (100) comprising: (i) providing (104, 106) a reference data set for a first gene expression platform and a training data set for a second platform; (iii) computing (108) a boundary expression level that distinguishes between the subtypes; (iv) generating (1 10) a confusion matrix; (v) determining (112) an effectiveness of the gene markers to discriminate between the subtypes; (vi) filtering (114) any gene marker with an expression level below a threshold or with determined effectiveness below a threshold; (v) calculating (118) a mean and/or median expression level for each subtype, and comparing them to generate an expression level change; (vi) comparing (118) the expression level change to a reference expression level change; and (vii) selecting (120) the gene marker if the generated expression level change and the reference expression level change are changed in the same direction; and (viii) providing (124) the selected gene markers via a user interface.
-
公开(公告)号：US20190100790A1
公开(公告)日：2019-04-04
申请号：US16145263
申请日：2018-09-28
发明人： Anja Van De Stolpe , Laurentius Henricus Franciscus Maria Holtzer , Wilhelmus Franciscus Johannes Verhaegh
IPC分类号： C12Q1/6809 , C12Q1/686 , C12Q1/6851 , G06F19/24 , G06F19/20 , G06F19/12 , G06F17/18
摘要： A bioinformatics process which provides an improved means to detect a Notch cellular signaling pathway in a subject, such as a human, based on the expression levels of at least three unique target genes of the Notch cellular signaling pathway measured in a sample. The invention includes an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method. Kits are also provided for measuring expression levels of unique sets of Notch cellular signaling pathway target genes.
-
公开(公告)号：US11908549B2
公开(公告)日：2024-02-20
申请号：US16646187
申请日：2018-09-21
摘要： The invention relates to a computer-implemented Bayesian inference method for performing Bayesian inference in a Bayesian network, which includes a continuous child node (3) and its discrete parent node (2) having two states. Being provided with a calibrated continuous probability distribution of the observations of the child node (3) for each of the two states of the parent node (2), the inferring for a new observation of the child node (3) for which the state of the parent node (2) is not known of the probability of at least a first state of the parent node (2) makes use of masses of portions of the probability distributions that depend on a locational relationship of the probability distributions and the value of the new observation. This may ensure that the inferred probability of the first state of the parent node (2) monotonically changes with monotonically changing values of the new observation.
-
公开(公告)号：US11674185B2
公开(公告)日：2023-06-13
申请号：US16864518
申请日：2020-05-01
IPC分类号： C12Q1/6886 , C12Q1/6809
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16
摘要： The present application mainly relates to a method for determining a prognosis for a subject diagnosed with high-grade serous ovarian cancer. The method comprises determining the prognosis based on activities of at least two cellular signaling pathways including a phosphatidylinositide 3-kinase (PI3K) pathway and a nuclear factor-kappa B (NFkB or NFκB) pathway in a sample of the subject. The present application also relates to a method for identifying a subject diagnosed with high-grade serous ovarian cancer that will be suitable for a PI3K pathway targeting therapy or an NFkB pathway targeting therapy. The method comprises identifying the subject based on activities of at least two cellular signaling pathways including a PI3K pathway and an NFkB pathway in a sample of the subject. The present application further relates to corresponding apparatuses, non-transitory storage media, computer programs and kits.
-
7.发明申请ASSESSMENT OF CELLULAR SIGNALING PATHWAY ACTIVITY USING PROBABILISTIC MODELING OF TARGET GENE EXPRESSION 审中-公开使用目标基因表达的概念建模评估细胞信号途径活动公开(公告)号：US20140156200A1
公开(公告)日：2014-06-05
申请号：US14233546
申请日：2012-07-19
发明人： Wilhelmus Franciscus Johannes Verhaegh , Anja Van De Stolpe , Hendrik Jan Van Ooijen , Kalyana Chakravarth Dulla , Marcia Alves De Inda , Ralf Hoffmann
CPC分类号： G16B5/00 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G16B20/00 , G16B25/00 , G16B40/00 , C12Q2537/165
摘要： The present application mainly relates to specific methods for inferring activity of one or more cellular signaling pathway(s) in tissue of a medical subject based at least on the expression level(s) of one or more target gene(s) of the cellular signaling pathway(s) measured in an extracted sample of the tissue of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.
摘要翻译： 本申请主要涉及至少基于细胞信号的一个或多个目标基因的表达水平来推断医学对象组织中的一种或多种细胞信号传导途径的活性的具体方法 在医学对象的组织的提取样本中测量的路径，包括被配置为执行这种方法的数字压缩器和存储可由数字处理装置执行以执行这种方法的指令的非暂时性存储介质的装置。
-
公开(公告)号：US20240105333A1
公开(公告)日：2024-03-28
申请号：US17767938
申请日：2020-10-13
摘要： The present invention relates to monitoring a patients response to therapy. In order to facilitate monitoring a patients response to therapy, a method is provided to identify groups of trends in each of genetic changes with similar genetic changes over time and to analyse these groups to determine the patients response to therapy.
-
公开(公告)号：US11640845B2
公开(公告)日：2023-05-02
申请号：US14922506
申请日：2015-10-26
发明人： Hendrik Jan Van Ooijen , Wilhelmus Franciscus Johannes Verhaegh , Anne Godefrida Catharina Van Brussel , Janneke Wrobel , Robert Van Gog
IPC分类号： G16B5/00 , G16B25/10 , G16H50/20 , G16H50/30 , G16B5/20 , G16B30/00 , G16B20/00 , G16B20/30 , G16B20/20 , C12Q1/6883 , C12Q1/6886
摘要： A bioinformatics method for determining a risk score that indicates a risk that a subject will experience a negative clinical event within a certain period of time. The risk score is based on a combination of activities of two or more cellular signaling pathways in a subject, such as a human, wherein the specific cellular signaling pathways are the PI3K pathway and one or more of a Wnt pathway, an ER pathway, and an HH pathway. The invention also includes an apparatus with a digital processor configured to perform such a method, to a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and to a computer program comprising program code means for causing a digital processing device to perform such a method. The invention achieves advanced prognosis of negative clinical events, for example, disease progression, recurrence, development of metastasis, or even death.
-
公开(公告)号：US20230028306A1
公开(公告)日：2023-01-26
申请号：US17777713
申请日：2020-11-17
IPC分类号： G06T7/00
摘要： The present invention relates to an apparatus (10) for diagnostic image acquisition, comprising: an input unit (20); a processing unit (30); and an output unit (40). The input unit is configured to receive a data value relating to at least one biomarker in a measurement blood sample of a patient. The processing unit is configured to determine a time to acquire a diagnostic image of the patient, wherein the determination comprises utilization of the data value. The output unit is configured to output an indication of the time to acquire the diagnostic image of the patient.
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.015 秒)
