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1.发明申请Benzyl Piperidine Compounds as Lysophosphatidic Acid (LPA) Receptor Antagonist 有权苄基哌啶化合物作为溶血磷脂酸（LPA）受体拮抗剂公开(公告)号：US20150011557A1
公开(公告)日：2015-01-08
申请号：US14344267
申请日：2012-09-07
申请人： Kai Schiemann , Wolfgang Staehle , Michael Busch , Dirk Wienke , Oliver Poeschke , Christa Burger
发明人： Kai Schiemann , Wolfgang Staehle , Michael Busch , Dirk Wienke , Oliver Poeschke , Christa Burger
IPC分类号： C07D487/04 , A61K31/454 , C07D471/04 , A61K31/4545 , A61K31/4985 , A61K31/4525 , C07D409/04 , A61K31/4535 , C07D401/14 , C07D401/04 , C07D405/04
CPC分类号： C07D487/04 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4985 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D471/04
摘要： The invention provides novel substituted benzyl piperidine compounds according to Formula (I) as lysophosphatidic acid (LPA) receptor antagonists, their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.
摘要翻译： 本发明提供了作为溶血磷脂酸（LPA）受体拮抗剂的式（I）的新型取代的苄基哌啶化合物，其用于治疗增殖性或炎性疾病如癌症，纤维化或关节炎的制备和用途。
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公开(公告)号：US20110230471A1
公开(公告)日：2011-09-22
申请号：US13131696
申请日：2009-11-05
申请人： Wolfgang Staehle , Ingo Kober , Kai Schiemann , Melanie Schultz , Dirk Wienke
发明人： Wolfgang Staehle , Ingo Kober , Kai Schiemann , Melanie Schultz , Dirk Wienke
IPC分类号： A61K31/538 , C07D471/04 , A61K31/496 , A61K31/551 , A61K31/5377 , A61K31/4745 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds of the formula (I), in which R1, R2, R3, R4, R5, D, Z, X, Y, m and p have the meanings indicated in Claim 1, can and be employed for the treatment of tumours.
摘要翻译： 式（I）的化合物，其中R 1，R 2，R 3，R 4，R 5，D，Z，X，Y，m和p具有权利要求1所述的含义，可用于治疗肿瘤。
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![2, 5-DIAMINO-SUBSTITUTED PYRIDO [4, 3-D] PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER](/abs-image/US/2011/09/29/US20110237583A1/abs.jpg.150x150.jpg)
3.发明申请2, 5-DIAMINO-SUBSTITUTED PYRIDO [4, 3-D] PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER 有权2，5-二氨基取代的吡啶[4,3-D]吡啶类作为对癌症的自身免疫抑制剂公开(公告)号：US20110237583A1
公开(公告)日：2011-09-29
申请号：US13132181
申请日：2009-11-03
申请人： Kai Schiemann , Melanie Schultz , Wolfgang Staehle , Ingo Kober , Dirk Wienke , Mireille Krier
发明人： Kai Schiemann , Melanie Schultz , Wolfgang Staehle , Ingo Kober , Dirk Wienke , Mireille Krier
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/519 , C12N9/99 , A61P35/00 , A61P35/02 , A61P9/10 , A61P9/00 , A61P27/02 , A61P29/00 , A61P19/02 , A61P25/28 , A61P37/06 , A61P17/02
CPC分类号： C07D471/04
摘要： The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
摘要翻译： 本发明涉及作为自分泌激素抑制剂的式（I）的吡啶并嘧啶衍生物，以及这些化合物用于治疗和/或预防生理和/或病理生理条件的用途，其由增加的溶血磷酸引起，介导和/或增殖 水平和/或激活自分泌素，特别是不同的癌症。
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4.发明授权Benzyl piperidine compounds as lysophosphatidic acid (LPA) receptor antagonist 有权苄基哌啶化合物作为溶血磷脂酸（LPA）受体拮抗剂公开(公告)号：US09527850B2
公开(公告)日：2016-12-27
申请号：US14344267
申请日：2012-09-07
申请人： Kai Schiemann , Wolfgang Staehle , Michael Busch , Dirk Wienke , Oliver Poeschke , Christa Burger
发明人： Kai Schiemann , Wolfgang Staehle , Michael Busch , Dirk Wienke , Oliver Poeschke , Christa Burger
IPC分类号： C07D401/14 , A61K31/45 , C07D487/04 , C07D403/04 , C07D471/04 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4985 , C07D401/04 , C07D405/04 , C07D409/04
CPC分类号： C07D487/04 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4985 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D471/04
摘要： The invention provides novel substituted benzyl piperidine compounds according to Formula (I) as lysophosphatidic acid (LPA) receptor antagonists, their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.
摘要翻译： 本发明提供了作为溶血磷脂酸（LPA）受体拮抗剂的式（I）的新型取代的苄基哌啶化合物，其用于治疗增殖性或炎性疾病如癌症，纤维化或关节炎的制备和用途。
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公开(公告)号：US08859775B2
公开(公告)日：2014-10-14
申请号：US13820304
申请日：2011-08-05
申请人： Kai Schiemann , Wolfgang Staehle , Dirk Wienke
发明人： Kai Schiemann , Wolfgang Staehle , Dirk Wienke
IPC分类号： C07D515/02 , A61K31/437 , A61K45/00 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , A61K31/437 , A61K45/00 , C07D487/04
摘要： The present invention relates to novel pyrazolopyridinone derivatives according to formula (I) and a process of manufacturing thereof. These pyrazolopyridinone derivatives can be used as LPA receptor antagonists for the treatment of various herein disclosed diseases.
摘要翻译： 本发明涉及式（I）的新型吡唑并吡喃酮衍生物及其制备方法。 这些吡唑并吡喃酮衍生物可用作LPA受体拮抗剂，用于治疗本发明的各种疾病。
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![2, 5-diamino-substituted pyrido [4, 3-D] pyrimidines as autotaxin inhibitors against cancer](/abs-image/US/2013/09/10/US08530650B2/abs.jpg.150x150.jpg)
6.发明授权2, 5-diamino-substituted pyrido [4, 3-D] pyrimidines as autotaxin inhibitors against cancer 有权2,5-二氨基取代的吡啶并[4,3-D]嘧啶作为抗癌药的自分泌抑素公开(公告)号：US08530650B2
公开(公告)日：2013-09-10
申请号：US13132181
申请日：2009-11-03
申请人： Kai Schiemann , Melanie Schultz , Wolfgang Staehle , Ingo Kober , Dirk Wienke , Mireille Krier
发明人： Kai Schiemann , Melanie Schultz , Wolfgang Staehle , Ingo Kober , Dirk Wienke , Mireille Krier
IPC分类号： C07D487/04 , A61K31/5025
CPC分类号： C07D471/04
摘要： The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
摘要翻译： 本发明涉及作为自分泌激素抑制剂的式（I）的吡啶并嘧啶衍生物，以及这些化合物用于治疗和/或预防生理和/或病理生理条件的用途，其由增加的溶血磷酸引起，介导和/或增殖 水平和/或激活自分泌素，特别是不同的癌症。
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公开(公告)号：US20130165478A1
公开(公告)日：2013-06-27
申请号：US13820304
申请日：2011-08-05
申请人： Kai Schiemann , Wolfgang Staehle , Dirk Wienke
发明人： Kai Schiemann , Wolfgang Staehle , Dirk Wienke
IPC分类号： C07D471/04 , A61K45/00 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K45/00 , C07D487/04
摘要： The present invention relates to novel pyrazolopyridinone derivatives according to formula (I) and a process of manufacturing thereof. These pyrazolopyridinone derivatives can be used as LPA receptor antagonists for the treatment of various herein disclosed diseases.
摘要翻译： 本发明涉及式（I）的新型吡唑并吡喃酮衍生物及其制备方法。 这些吡唑并吡喃酮衍生物可用作LPA受体拮抗剂，用于治疗本发明的各种疾病。
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公开(公告)号：US20120252815A1
公开(公告)日：2012-10-04
申请号：US13516370
申请日：2010-11-18
申请人： Frank Stieber , Dirk Wienke
发明人： Frank Stieber , Dirk Wienke
IPC分类号： A61K31/454 , A61K31/496 , C07D417/14 , A61K31/4545 , A61K31/5377 , C07D221/20 , A61K31/438 , C07C49/333 , A61P35/00 , A61P9/10 , A61P27/02 , A61P29/00 , A61P19/02 , A61P25/28 , A61P9/00 , A61P17/02 , A61P37/06 , C07D417/04
CPC分类号： C07D249/06 , C07D263/32 , C07D277/28 , C07D277/40 , C07D417/04 , C07D417/14
摘要： The present invention relates to compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, M1, M2, M3, Y1, Y2, V, W, n, m and o have the gleanings given herein, and physiologically acceptable salts, derivatives, prodrugs, solvates, tautomers and stereoisomers thereof, including mixtures thereof in all ratios, for use in the treatment of diseases which are influenced by inhibition of Sph kinase 1.
摘要翻译： 本发明涉及式（I）化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，R13，R14，R15，R16，R17，M1 ，M2，M3，Y1，Y2，V，W，n，m和o具有本文给出的收集，以及生理上可接受的盐，衍生物，前药，溶剂合物，互变异构体和立体异构体，包括其所有比例的混合物， 受Sph激酶1抑制影响的疾病的治疗。
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公开(公告)号：US20120252789A1
公开(公告)日：2012-10-04
申请号：US13515598
申请日：2010-11-22
申请人： Frank Stieber , Dirk Wienke
发明人： Frank Stieber , Dirk Wienke
IPC分类号： A61K31/496 , C07D403/04 , A61K31/506 , A61K31/53 , C07D295/205 , A61K31/495 , A61K31/497 , C07D413/14 , A61K31/5377 , A61K31/55 , A61K31/551 , A61P35/00 , A61P29/00 , A61P9/00 , A61P13/12 , A61P1/16 , A61P9/10 , A61P17/06 , A61P1/00 , A61P13/08 , A61P13/00 , A61P15/00 , A61P35/02 , A61P37/06 , A61P19/02 , A61P11/06 , A61P37/08 , A61P11/00 , A61P17/08 , A61P3/10 , A61P37/00 , A61P17/10 , A61P17/00 , A61P27/02 , C07F5/02 , C07D401/14 , C07D213/65 , C07D213/61 , C07D401/04
CPC分类号： C07D295/088 , A61K31/444 , C07B2200/05 , C07D213/61 , C07D213/65 , C07D213/74 , C07D239/42 , C07D241/20 , C07D251/22 , C07D295/033 , C07D295/096 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/14 , C07F5/025
摘要： The present invention relates to compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, M1, M2, M3, M4, Y1, Y2, V, W, n, m and o have the meanings given in Claim 1, and physiologically acceptable salts, derivatives, prodrugs, solvates, tautomers and stereoisomers thereof, including mixtures thereof in all ratios, for use in the treatment of diseases which are influenced by inhibition of Sph kinase 1.
摘要翻译： 本发明涉及式（I）化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，R13，R14，R15，R16，R17，M1 ，M2，M3，M4，Y1，Y2，V，W，n，m和o具有权利要求1中给出的含义，以及生理上可接受的盐，衍生物，前药，溶剂合物，互变异构体和立体异构体，包括其所有比例的混合物 用于治疗受Sph激酶1抑制影响的疾病。
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公开(公告)号：US09062015B2
公开(公告)日：2015-06-23
申请号：US13515598
申请日：2010-11-22
申请人： Frank Stieber , Dirk Wienke
发明人： Frank Stieber , Dirk Wienke
IPC分类号： C07D401/04 , C07D401/14 , A61K31/444 , A61K31/496 , A61P19/02 , C07D295/088 , C07D213/61 , C07D213/65 , C07D213/74 , C07D239/42 , C07D241/20 , C07D251/22 , C07D295/033 , C07D295/096 , C07D403/04 , C07D413/14 , C07F5/02
CPC分类号： C07D295/088 , A61K31/444 , C07B2200/05 , C07D213/61 , C07D213/65 , C07D213/74 , C07D239/42 , C07D241/20 , C07D251/22 , C07D295/033 , C07D295/096 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/14 , C07F5/025
摘要： The present invention relates to compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, M1, M2, M3, M4, Y1, Y2, V, W, n, m and o have the meanings given in Claim 1, and physiologically acceptable salts, derivatives, prodrugs, solvates, tautomers and stereoisomers thereof, including mixtures thereof in all ratios, for use in the treatment of diseases which are influenced by inhibition of Sph kinase 1.
摘要翻译： 本发明涉及式（I）化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，R13，R14，R15，R16，R17，M1 ，M2，M3，M4，Y1，Y2，V，W，n，m和o具有权利要求1中给出的含义，以及生理上可接受的盐，衍生物，前药，溶剂合物，互变异构体和立体异构体，包括其所有比例的混合物 用于治疗受Sph激酶1抑制影响的疾病。
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