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    Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
    1.
    发明授权
    Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment 有权
    癌细胞抑制的癌细胞增殖抑制材料

    公开(公告)号：US06224912B1

    公开(公告)日：2001-05-01

    申请号：US09188476

    申请日：1998-11-09

    申请人： Shirin Asina ,  Kanti Jain ,  Albert L. Rubin ,  Barry Smith ,  Kurt Stenzel

    发明人： Shirin Asina ,  Kanti Jain ,  Albert L. Rubin ,  Barry Smith ,  Kurt Stenzel

    IPC分类号： A61K3512

    CPC分类号： A61K35/13 ,  A61K35/36 ,  C12N5/0693 ,  C12N11/04

    摘要： A material for suppressing proliferation of cancer cells is produced by entrapping cancer cells in a selectively-permeable structure such as a bead, and culturing the entrapped cells in a culture medium. Entrapment restricts growth of the cancel cells during culturing and causes the cells to produce in the culture medium a material having a molecular weight of at least about 30 kd that suppresses proliferation of cancer cells. The material is separated from the culture medium by filtering the medium through a filter that separates material having a molecular weight of at least about 30 kd from material having a molecular weight of less than 30 kd. The structure that entraps the cells may contain 10,000 to 500,000 cells.

    摘要翻译： 用于抑制癌细胞增殖的材料是通过将癌细胞包埋在选择性可渗透的结构如珠中产生的，并在培养基中培养包埋的细胞。 包埋限制培养过程中消除细胞的生长，并使细胞在培养基中产生抑制癌细胞增殖的至少约30kd分子量的材料。 通过过滤器将培养基与培养基分离，该过滤器将具有至少约30kd分子量的材料与分子量小于30kd的材料分离。 截留细胞的结构可能含有10,000至500,000个细胞。

    Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
    5.
    发明授权
    Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment 有权
    癌细胞抑制的癌细胞增殖抑制材料

    公开(公告)号：US06303151B1

    公开(公告)日：2001-10-16

    申请号：US09437193

    申请日：1999-11-09

    申请人： Shirin Asina ,  Kanti Jain ,  Albert L. Rubin ,  Barry Smith ,  Kurt Stenzel

    发明人： Shirin Asina ,  Kanti Jain ,  Albert L. Rubin ,  Barry Smith ,  Kurt Stenzel

    IPC分类号： A61K3512

    CPC分类号： C12N5/0693 ,  A61K35/13 ,  C12N11/04

    摘要： A material for suppressing proliferation of cancer cells is produced by entrapping cancer cells in a selectively-permeable structure such as a bead, and culturing the entrapped cells in a culture medium. Entrapment restricts growth of the cancel cells during culturing and causes the cells to produce in the culture medium a material having a molecular weight of at least about 30 kd as measured by filtration that suppresses proliferation of cancer cells. The material is separated from the culture medium by filtering the medium through a filter that separates material having a molecular weight of at least about 30 kd from material having a molecular weight of less than 30 kd. The structure that entraps the cells may contain 10,000 to 500,000 cells. The material or the structure containing the entrapped cells that produce the material can be administered to a subject to suppress cancer cell proliferation.

    摘要翻译： 用于抑制癌细胞增殖的材料是通过将癌细胞包埋在选择性可渗透的结构如珠中产生的，并在培养基中培养包埋的细胞。 包埋限制了培养过程中消除细胞的生长，并导致细胞在培养基中产生通过过滤测量的分子量至少为约30kd的材料，其抑制癌细胞的增殖。 通过过滤器将培养基与培养基分离，该过滤器将具有至少约30kd分子量的材料与分子量小于30kd的材料分离。 截留细胞的结构可能含有10,000至500,000个细胞。 可以向受试者施用含有产生该物质的包埋细胞的材料或结构，以抑制癌细胞增殖。

    Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
    9.
    再颁专利
    Preparation of agarose coated, solid agarose-collagen beads containing secretory cells 有权
    制备含有分泌细胞的琼脂糖包被的固体琼脂糖胶原珠

    公开(公告)号：USRE38027E1

    公开(公告)日：2003-03-11

    申请号：US09345196

    申请日：1999-06-30

    申请人： Kanti Jain ,  Albert L. Rubin ,  Barry Smith

    发明人： Kanti Jain ,  Albert L. Rubin ,  Barry Smith

    IPC分类号： A61K3512

    CPC分类号： A61K9/1652 ,  A61K9/1658 ,  A61K9/5036 ,  A61K35/39 ,  A61K38/00 ,  A61K2035/126 ,  C12N5/0012 ,  C12N5/0677 ,  C12N11/04 ,  C12N2533/54 ,  C12N2533/76

    摘要： Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid beads are formed from a suspension containing collagen, agarose and secretory cells such as pancreatic islets, the collagen is polymerized to form solid, agarose-collagen beads and the solid beads are coated with agarose. Coating is preferably by rolling the solid beads in about 5-10% agarose, contacting the rolled beads with mineral oil and washing oil from the beads. Beads containing secretory cells can be transplanted into a mammal to treat a condition caused by impaired secretory cell function.

    摘要翻译： 生物制剂如分泌细胞被包封在由琼脂糖或胶原 - 琼脂糖和明胶海绵 - 琼脂糖组合制成的亲水凝胶中。 在优选的实施方案中，半固体珠粒由含有胶原蛋白，琼脂糖和分泌细胞例如胰岛的悬浮液形成，胶原聚合形成固体，琼脂糖胶原珠粒，固体珠粒用琼脂糖涂覆。 涂覆优选通过在约5-10％的琼脂糖中滚动固体珠粒，使滚珠与矿物油接触并从珠粒洗涤油。 含有分泌细胞的珠可以移植到哺乳动物中以治疗由分泌细胞功能受损引起的病症。

    Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
    10.
    再颁专利
    Preparation of agarose coated, solid agarose-collagen beads containing secretory cells 有权
    制备含有分泌细胞的琼脂糖包被的固体琼脂糖胶原珠

    公开(公告)号：USRE39542E1

    公开(公告)日：2007-04-03

    申请号：US10336442

    申请日：2003-01-02

    申请人： Kanti Jain ,  Albert L. Rubin ,  Barry Smith

    发明人： Kanti Jain ,  Albert L. Rubin ,  Barry Smith

    IPC分类号： A61K35/12 ,  C12N11/02 ,  C12N11/10 ,  C12N5/00 ,  C12N5/08

    CPC分类号： C12N11/04 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/5036 ,  A61K35/39 ,  A61K38/00 ,  A61K2035/126 ,  C12N5/0012 ,  C12N5/0677 ,  C12N2533/54 ,  C12N2533/76

    摘要： Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid beads are formed from a suspension containing collagen, agarose and secretory cells such as pancreatic islets, the collagen is polymerized to form solid, agarose-collagen beads and the solid beads are coated with agarose. Coating is preferably by rolling the solid beads in about 5-10% agarose, contacting the rolled beads with mineral oil and washing oil from the beads. Beads containing secretory cells can be transplanted into a mammal to treat a condition caused by impaired secretory cell function.

    摘要翻译： 生物制剂如分泌细胞被包封在由琼脂糖或胶原 - 琼脂糖和明胶海绵 - 琼脂糖组合制成的亲水凝胶中。 在优选的实施方案中，半固体珠粒由含有胶原蛋白，琼脂糖和分泌细胞例如胰岛的悬浮液形成，胶原聚合形成固体，琼脂糖胶原珠粒，固体珠粒用琼脂糖涂覆。 涂覆优选通过在约5-10％的琼脂糖中滚动固体珠粒，使滚珠与矿物油接触并从珠粒洗涤油。 含有分泌细胞的珠可以移植到哺乳动物中以治疗由分泌细胞功能受损引起的病症。