公开(公告)号：US5645072A

公开(公告)日：1997-07-08

申请号：US535929

申请日：1995-09-28

申请人： Karla D. Thrall ,  Donald V. Kenny ,  George W. R. Endres ,  Daniel R. Sisk

发明人： Karla D. Thrall ,  Donald V. Kenny ,  George W. R. Endres ,  Daniel R. Sisk

IPC分类号： A61B5/08 ,  G01N33/00 ,  G01N33/497 ,  A61B5/09

CPC分类号： A61B5/0813 ,  G01N33/0009 ,  G01N33/497

摘要： The apparatus of the present invention is a combination of a breath interface and an external exposure dosimeter interface to a chemical analysis device, all controlled by an electronic processor for quantitatively analyzing chemical analysis data from both the breath interface and the external exposure dosimeter for determining internal tissue dose. The method of the present invention is a combination of steps of measuring an external dose, measuring breath content, then analyzing the external dose and breath content and determining internal tissue dose.

摘要翻译： 本发明的装置是呼吸界面和化学分析装置的外部曝光剂量计界面的组合，全部由电子处理器控制，用于定量分析来自呼吸界面和外部曝光剂量计的化学分析数据，用于确定内部 组织剂量。 本发明的方法是测量外部剂量，测量呼吸含量，然后分析外部剂量和呼吸含量并确定内部组织剂量的步骤的组合。

公开(公告)号：US20140249102A1

公开(公告)日：2014-09-04

申请号：US13173262

申请日：2011-06-30

申请人： Tatiana G. Levitskaia ,  Karla D. Thrall ,  James M. Peterson ,  Glen E. Fryxell ,  Charles A. Timchalk ,  Barbara J. Tarasevich

发明人： Tatiana G. Levitskaia ,  Karla D. Thrall ,  James M. Peterson ,  Glen E. Fryxell ,  Charles A. Timchalk ,  Barbara J. Tarasevich

IPC分类号： A61K31/722 ,  A61K9/00 ,  A61K45/06 ,  A61K31/734

CPC分类号： A61K31/722 ,  A61K9/0014 ,  A61K31/734 ,  A61K45/06 ,  A61L15/28 ,  A61L15/42 ,  A61L15/44 ,  A61L24/0021 ,  A61L26/0023 ,  A61L26/0066 ,  G21F9/002 ,  G21F9/28

摘要： A topical applicator composition and process are described that decorporate radionuclides from radiologically-contaminated dermal surfaces and that further promote healing. The topical applicator includes a decorporation agent mixed with a plasticizing agent that forms a covering when applied to the dermal surface that decorporates radionuclides and minimizes their systemic migration. The topical applicator formulations can be delivered in conjunction with bandages and other application dressings.

摘要翻译： 描述了一种局部施用组合物和方法，其将放射性核素从放射性污染的皮肤表面分解，并进一步促进愈合。 局部施用器包括与增塑剂混合的脱落剂，当增塑剂施用于真皮表面并形成放射性核素并使其全身迁移最小化时形成覆盖物。 局部给药制剂可以与绷带和其它应用敷料一起递送。

公开(公告)号：US20100280393A1

公开(公告)日：2010-11-04

申请号：US12772530

申请日：2010-05-03

申请人： Tatiana G. Levitskaia ,  James E. Morris ,  Karla D. Thrall ,  Samuel A. Bryan ,  James M. Peterson

发明人： Tatiana G. Levitskaia ,  James E. Morris ,  Karla D. Thrall ,  Samuel A. Bryan ,  James M. Peterson

IPC分类号： A61B6/00 ,  G06F19/00

CPC分类号： A61B5/0059 ,  A61B5/0075 ,  A61B5/441 ,  A61B5/444 ,  A61B5/445 ,  G01N21/49 ,  G01N2021/4709

摘要： Non-invasive methods and systems are described for rapidly measuring in-vivo dose, severity, and progression of injury after exposure to damaging phenomena, such as ionizing radiation, chemical burns, or electrical burns. Optical reflectance backscattering spectroscopy is applied to identify and characterize the effects of such phenomena on an individual's whole body and in localized areas.

摘要翻译： 描述了非侵入性方法和系统，用于在暴露于诸如电离辐射，化学灼伤或电灼伤的损坏现象之后快速测量体内剂量，严重性和损伤进展。 应用光学反射后向散射光谱法来识别和表征这种现象对个体全身和局部区域的影响。

公开(公告)号：US06699384B1

公开(公告)日：2004-03-02

申请号：US09667034

申请日：2000-09-20

申请人： Yuehe Lin ,  Wendy D. Bennett ,  Charles Timchalk ,  Karla D. Thrall

发明人： Yuehe Lin ,  Wendy D. Bennett ,  Charles Timchalk ,  Karla D. Thrall

IPC分类号： G01N27327

CPC分类号： B01F13/0064 ,  B01D61/28 ,  B01D63/08 ,  B01D63/081 ,  B01F5/0475 ,  B01F5/048 ,  B01F5/0604 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0094 ,  B01F2215/0431 ,  B01J19/0093 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/10 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0439

摘要： Microanalytical systems based on a microfluidics/electrochemical detection scheme are described. Individual modules, such as microfabricated piezoelectrically actuated pumps and a microelectrochemical cell were integrated onto portable platforms. This allowed rapid change-out and repair of individual components by incorporating “plug and play” concepts now standard in PC's. Different integration schemes were used for construction of the microanalytical systems based on microfluidics/electrochemical detection. In one scheme, all individual modules were integrated in the surface of the standard microfluidic platform based on a plug-and-play design. Microelectrochemical flow cell which integrated three electrodes based on a wall-jet design was fabricated on polymer substrate. The microelectrochemical flow cell was then plugged directly into the microfluidic platform. Another integration scheme was based on a multilayer lamination method utilizing stacking modules with different functionality to achieve a compact microanalytical device. Application of the microanalytical system for detection of lead in, for example, river water and saliva samples using stripping voltammetry is described.

摘要翻译： 描述了基于微流体/电化学检测方案的微量分析系统。 单个模块，如微加压压电泵和微电化学电池集成到便携式平台上。 这允许通过在PC中组合“即插即用”概念来快速更换和修复各个组件。 基于微流体/电化学检测的微分析系统的构建使用了不同的集成方案。 在一个方案中，基于即插即用设计将所有单个模块集成在标准微流体平台的表面中。 在聚合物基板上制造基于壁喷射设计集成三个电极的微电化学流动池。 然后将微电化学流动池直接插入微流体平台。 另一种集成方案基于利用具有不同功能的堆叠模块的多层层压方法来实现紧凑的微量分析装置。 描述了使用溶出伏安法在例如河水和唾液样品中检测铅的微量分析系统的应用。