利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

35 条记录 (耗时 0.033 秒)

    Epitope directed selection of antibodies to murine tissue factor
    1.
    发明授权
    Epitope directed selection of antibodies to murine tissue factor 有权
    表位定向选择抗小鼠组织因子的抗体

    公开(公告)号：US07514539B2

    公开(公告)日：2009-04-07

    申请号：US11112481

    申请日：2005-04-22

    申请人： Karyn O'Neil ,  Raymond Sweet

    发明人： Karyn O'Neil ,  Raymond Sweet

    IPC分类号： C07K16/00

    CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76

    摘要： A tissue factor antibody which binds to non-human tissue factor and is useful as a surrogate in preclinical testing where the human therapeutic tissue factor candidate antibody does not interact with the homolog target protein in a manner that would provide meaningful information about treatment efficacy or safety.

    摘要翻译： 结合非人组织因子的组织因子抗体并且可用作临床前测试中的替代物，其中人治疗组织因子候选抗体不以与提供关于治疗功效或安全性的有意义的信息的方式与同源物靶蛋白相互作用 。

    Solution phase biopanning method using engineered decoy proteins
    2.
    发明授权
    Solution phase biopanning method using engineered decoy proteins 有权
    使用工程诱饵蛋白的溶液相生物淘选方法

    公开(公告)号：US07790405B2

    公开(公告)日：2010-09-07

    申请号：US11112701

    申请日：2005-04-22

    申请人： Karyn O'Neil ,  Raymond Sweet ,  George Heavner

    发明人： Karyn O'Neil ,  Raymond Sweet ,  George Heavner

    IPC分类号： G01N33/53

    CPC分类号： C07K16/00 ,  A61K2039/505 ,  C07K16/005 ,  C07K16/244 ,  C07K16/36 ,  C07K2299/00 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  G01N33/6845 ,  G01N33/6854

    摘要： The invention relates to a method of directing selection of biological therapeutic molecules to specific functional domains of the target biologic molecule. Selection is directed by the use of closely related molecules, where one is a decoy and the other contains the targeted domain or epitope. The invention is based on the use of physical data, which may be combined with derived data, to ascertain that the decoy and the target differ only in the specific functional domain or epitope where the binding will be directed.

    摘要翻译： 本发明涉及将生物治疗分子选择指向靶生物分子的特定功能结构域的方法。 选择是通过使用紧密相关的分子来引导的，其中一个是诱饵，另一个包含靶向结构域或表位。 本发明基于物理数据的使用，其可以与衍生数据组合，以确定诱饵和靶标仅在绑定将被引导的特定功能域或表位上不同。

    Fibronectin type III domain based scaffold compositions, methods and uses
    5.
    发明授权
    Fibronectin type III domain based scaffold compositions, methods and uses 有权
    纤连蛋白III型结构域的支架组合物，方法和用途

    公开(公告)号：US09200059B2

    公开(公告)日：2015-12-01

    申请号：US13595484

    申请日：2012-08-27

    申请人： Steve Jacobs ,  Karyn O'Neil

    发明人： Steve Jacobs ,  Karyn O'Neil

    IPC分类号： C40B50/06 ,  C07K14/78

    CPC分类号： C07K14/78 ,  C40B40/08 ,  C40B50/06

    摘要： A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.

    摘要翻译： 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。 特别地，已经鉴定了结合IgG的蛋白质支架分子可用于诊断和/或治疗应用。

    Fibronectin type III domain based scaffold compositions, methods and uses
    6.
    发明授权
    Fibronectin type III domain based scaffold compositions, methods and uses 有权
    纤连蛋白III型结构域的支架组合物，方法和用途

    公开(公告)号：US08293482B2

    公开(公告)日：2012-10-23

    申请号：US12704824

    申请日：2010-02-12

    申请人： Steven Jacobs ,  Karyn O'Neil

    发明人： Steven Jacobs ,  Karyn O'Neil

    IPC分类号： C07K16/00 ,  G01N33/53

    CPC分类号： C12N15/1044 ,  A61K38/00 ,  C07K14/78 ,  C40B40/08 ,  C40B50/06

    摘要： A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG based on the consensus sequence have been identified as useful for diagnostic and/or therapeutic applications.

    摘要翻译： 基于来自人纤连蛋白的第十纤维连接蛋白III型（FN3）重复共有序列的蛋白质支架，包括编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备和使用的方法具有诊断和/ 或治疗组合物，方法和装置。 特别地，已经鉴定了基于共有序列与IgG结合的蛋白质支架分子对于诊断和/或治疗应用是有用的。