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1.发明授权Method for treating insulin sensitivity by long-acting GLP-1 receptor mimetibody agonists 有权用长效GLP-1受体模拟体激动剂治疗胰岛素敏感性的方法公开(公告)号：US07833531B2
公开(公告)日：2010-11-16
申请号：US11962214
申请日：2007-12-21
CPC分类号： A61K38/26 , G01N2800/044
摘要： The present invention provides to at least one novel human GLP-1 receptor agonist, or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 receptor agonist, or specified portion or variant, GLP-1 receptor agonist, or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including the use of long acting GLP-1 receptor agonists to improve insulin sensitivity or lipid profiles in obesity and related therapeutic and/or diagnostic compositions, methods and devices.
摘要翻译： 本发明提供至少一种新型人GLP-1受体激动剂或特定部分或变体，包括编码至少一种GLP-1受体激动剂或特定部分或变体GLP-1受体激动剂的分离核酸，或 特定部分或变体，载体，宿主细胞，转基因动物或植物，及其制备和使用方法，包括使用长效GLP-1受体激动剂来改善肥胖中的胰岛素敏感性或脂质分布以及相关的治疗和/或诊断 组合物，方法和装置。
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2.发明申请USE OF LONG-ACTING GLP-1 RECEPTOR AGONISTS TO IMPROVE INSULIN SENSITIVITY AND LIPID PROFILES 有权使用长效GLP-1受体激动剂来提高胰岛素敏感性和脂质谱公开(公告)号：US20090098108A1
公开(公告)日：2009-04-16
申请号：US11962214
申请日：2007-12-21
IPC分类号： A61K38/00 , A61P3/00 , A61K38/04 , A61K38/16 , A61K31/7088 , A61K39/395 , C12N5/00 , G01N33/53
CPC分类号： A61K38/26 , G01N2800/044
摘要： The present invention provides to at least one novel human GLP-1 receptor agonist, or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 receptor agonist, or specified portion or variant, GLP-1 receptor agonist, or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including the use of long acting GLP-1 receptor agonists to improve insulin sensitivity or lipid profiles in obesity and related therapeutic and/or diagnostic compositions, methods and devices.
摘要翻译： 本发明提供至少一种新型人GLP-1受体激动剂或特定部分或变体，包括编码至少一种GLP-1受体激动剂或特定部分或变体GLP-1受体激动剂的分离核酸，或 特定部分或变体，载体，宿主细胞，转基因动物或植物，及其制备和使用方法，包括使用长效GLP-1受体激动剂来改善肥胖中的胰岛素敏感性或脂质分布以及相关的治疗和/或诊断 组合物，方法和装置。
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公开(公告)号：US20060115475A1
公开(公告)日：2006-06-01
申请号：US11291140
申请日：2005-11-30
申请人： Jill Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill Giles-Komar , Theresa Goletz , David Knight , Roberta Lamb , Mouhamadou Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
发明人： Jill Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill Giles-Komar , Theresa Goletz , David Knight , Roberta Lamb , Mouhamadou Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译： Toll样受体3（TLR3）拮抗剂，编码TLR3拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。
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4.发明申请Toll Like Receptor 3 Antagonists, Methods and Uses 审中-公开Toll Like Receptor 3 Antagonists，Methods and Uses公开(公告)号：US20120189643A1
公开(公告)日：2012-07-26
申请号：US13412259
申请日：2012-03-05
申请人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
发明人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , C12N1/21 , A61P3/10 , C12P21/00 , C12N5/16 , A61P29/00 , A61P1/00 , A61P11/00 , C07K16/28 , C12N5/10
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/74 , C07K2317/76
摘要： Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译： Toll样受体3（TLR3）拮抗剂，编码TLR3拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。
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公开(公告)号：US08153583B2
公开(公告)日：2012-04-10
申请号：US11291140
申请日：2005-11-30
申请人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
发明人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists, and methods of making and using the foregoing are disclosed.
摘要翻译： 公开了Toll样受体3（TLR3）拮抗剂，编码TLR3拮抗剂的多核苷酸，以及制备和使用前述物质的方法。
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公开(公告)号：US20070298492A1
公开(公告)日：2007-12-27
申请号：US11809866
申请日：2007-06-01
CPC分类号： C07K14/47 , A01K2217/05 , A01K2267/03 , Y10S530/84
摘要： This invention relates to a novel PTH gene. The invention further relates to methods of screening, diagnosis and development of therapies for bone related disorders.
摘要翻译： 本发明涉及一种新的PTH基因。 本发明还涉及筛选，诊断和开发用于骨相关疾病的疗法的方法。
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7.发明申请Implantable pump for protein delivery for obesity control by drug infusion into the brain 有权用于通过药物输注到大脑中进行肥胖控制的蛋白质递送的可植入泵公开(公告)号：US20070082843A1
公开(公告)日：2007-04-12
申请号：US11245653
申请日：2005-10-07
CPC分类号： A61K38/34 , A61K47/6811 , A61K47/6849
摘要： Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.
摘要翻译： 提供了通过将药物输注泵手术植入受试者的部位来抑制食欲的方法和组合物，并且在受试者的中枢神经系统中输送食欲抑制剂的稳定的悬浮液。 食欲抑制剂与中枢神经系统中的神经细胞上的靶受体结合并改变受体功能以抑制食欲。
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8.发明授权Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases 有权Toll样受体3拮抗剂用于治疗代谢和心血管疾病公开(公告)号：US08460659B2
公开(公告)日：2013-06-11
申请号：US13230060
申请日：2011-09-12
申请人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Raymond Sweet , Fang Teng , Alexey Teplyakov , Linda Wu , Sheng-Jiun Wu
发明人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Raymond Sweet , Fang Teng , Alexey Teplyakov , Linda Wu , Sheng-Jiun Wu
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00 , C07K16/18 , C07K16/28
CPC分类号： C07K16/2896 , C07K16/28 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译： 公开了Toll样受体3（TLR3）抗体拮抗剂，编码TLR3抗体拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。
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9.发明申请TOLL-LIKE RECEPTOR 3 ANTAGONISTS FOR THE TREATMENT OF METABOLIC AND CARDIOVASCULAR DISEASES 有权TOLL-LIKE受体3治疗代谢性和心脏血管疾病的拮抗剂公开(公告)号：US20120064095A1
公开(公告)日：2012-03-15
申请号：US13230060
申请日：2011-09-12
申请人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Raymond Sweet , Fang Teng , Alexey Teplyakov , Linda Wu , Sheng-Jiun Wu
发明人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Raymond Sweet , Fang Teng , Alexey Teplyakov , Linda Wu , Sheng-Jiun Wu
CPC分类号： C07K16/2896 , C07K16/28 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译： 公开了Toll样受体3（TLR3）抗体拮抗剂，编码TLR3抗体拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。
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公开(公告)号：US07560112B2
公开(公告)日：2009-07-14
申请号：US11413561
申请日：2006-04-28
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： A61K39/395 , C07K16/24 , C12N5/12
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有在诊断和/或治疗组合物中的应用 ，方法和设备。
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