公开(公告)号：US08883210B1

公开(公告)日：2014-11-11

申请号：US13108856

申请日：2011-05-16

申请人： Katherine Gomes Truncale ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Eric Semler ,  Evangelia Chnari ,  Anouska Dasgupta ,  Judith Yannariello-Brown ,  Terri Riley

发明人： Katherine Gomes Truncale ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Eric Semler ,  Evangelia Chnari ,  Anouska Dasgupta ,  Judith Yannariello-Brown ,  Terri Riley

IPC分类号： A61K9/14 ,  A01N1/02 ,  A01N1/00 ,  C12N5/077 ,  C12N5/073 ,  A61K35/32

CPC分类号： C12N5/0654 ,  A61K35/32 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/19 ,  C12N5/0605 ,  C12N5/0653 ,  C12N5/0667 ,  C12N5/0668 ,  C12N2501/155 ,  C12N2533/90 ,  A61K2300/00

摘要： The disclosure provides implants containing a plurality of particles containing at least one population of viable tissuegenic cells adherent to and resident in the growth-conductive matrix or at least viable population of tissuegenic cells caused to be in contact with the growth-conductive matrix; methods to fabricate implants; methods of fabricating the implants; and use of the implants in tissue repair.

公开(公告)号：US20110060412A1

公开(公告)日：2011-03-10

申请号：US12875829

申请日：2010-09-03

申请人： Eric J. Semler ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Judith Yannariello-Brown ,  Katherine Gomes Truncale

发明人： Eric J. Semler ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Judith Yannariello-Brown ,  Katherine Gomes Truncale

IPC分类号： A61K35/32 ,  A61F2/08 ,  A61K9/00 ,  A61P19/04

CPC分类号： A61L27/3616 ,  A61F2/30756 ,  A61F2/3872 ,  A61F2002/30762 ,  A61K35/32 ,  A61K38/1841 ,  A61L27/225 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/38 ,  A61L27/3817 ,  A61L27/48 ,  A61L2430/06 ,  A61K2300/00

摘要： A meniscus repair composition for application to a meniscus injury to promote growth of new tissue at the meniscus injury site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 μm to about 500 μm; and a carrier comprising a solid fibrin web matrix. When introduced to a defect site in a meniscus, the composition is non-adhering to the defect site. A method for repairing a meniscus injury comprises administering a meniscus repair composition to the injury site.

摘要翻译： 提供一种用于应用于半月板损伤以促进半月板损伤部位新组织生长的半月板修复组合物。 组合物包含：约10至约50重量％的平均粒度为约10μm至约500μm的同种异体移植物弯月面颗粒; 和包含固体纤维蛋白网状基质的载体。 当引入弯液面中的缺陷部位时，组合物不粘附于缺陷部位。 修复半月板损伤的方法包括向损伤部位施用半月板修复组合物。

公开(公告)号：US20110059178A1

公开(公告)日：2011-03-10

申请号：US12875733

申请日：2010-09-03

申请人： Eric J. Semler ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Judith Yannariello-Brown ,  Katherine Gomes Truncale

发明人： Eric J. Semler ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Judith Yannariello-Brown ,  Katherine Gomes Truncale

IPC分类号： A61K9/14 ,  A61F2/08 ,  A61K35/34 ,  A61K35/12 ,  A61P21/00

CPC分类号： A61L27/3654 ,  A61F2/3872 ,  A61K35/32 ,  A61K35/34 ,  A61L27/3612 ,  A61L27/3834 ,  A61L27/48 ,  A61L2430/06

摘要： A meniscus repair composition for application to a meniscus defect site to promote growth of new tissue at the meniscus defect site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 μm to about 500 μm; a carrier selected from the group consisting of sodium hyaluronate, gelatin, collagen, polyethylene glycol, glycerin, carboxymethylcellulose, dextrose, blood derivatives, aqueous solutions thereof, and mixtures thereof; and a curing agent. The curing agent may be the carrier where the carrier is cross-linkable. When introduced to a defect site in a meniscus and cured, the composition will not flow away from the defect site, and the composition is non-adhering to the defect site after it is cured.

摘要翻译： 提供了一种应用于弯液面缺陷部位以促进新生组织在弯液面缺陷部位生长的半月板修复组合物。 组合物包含：约10至约50重量％的平均粒度为约10μm至约500μm的同种异体移植物弯月面颗粒; 选自透明质酸钠，明胶，胶原，聚乙二醇，甘油，羧甲基纤维素，葡萄糖，血液衍生物，其水溶液及其混合物的载体; 和固化剂。 固化剂可以是载体可交联的载体。 当引入弯液面中的缺陷部位并固化时，组合物不会从缺陷部位流出，并且组合物在固化后不粘附到缺陷部位。

公开(公告)号：US20060235534A1

公开(公告)日：2006-10-19

申请号：US11404806

申请日：2006-04-17

申请人： Arthur Gertzman ,  Barbara Merboth ,  Michael Schuler ,  Anton Steiner ,  Eric Semlar ,  Judith Yannariello-Brown

发明人： Arthur Gertzman ,  Barbara Merboth ,  Michael Schuler ,  Anton Steiner ,  Eric Semlar ,  Judith Yannariello-Brown

IPC分类号： A61F2/44

CPC分类号： A61F2/442 ,  A61B17/842 ,  A61F2/28 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/30062 ,  A61F2002/30075 ,  A61F2002/3008 ,  A61F2002/30136 ,  A61F2002/30153 ,  A61F2002/30172 ,  A61F2002/30177 ,  A61F2002/30181 ,  A61F2002/302 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30242 ,  A61F2002/30293 ,  A61F2002/30383 ,  A61F2002/30387 ,  A61F2002/30795 ,  A61F2002/30932 ,  A61F2002/30971 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2210/0004 ,  A61F2210/0061 ,  A61F2220/0025 ,  A61F2230/0004 ,  A61F2230/0019 ,  A61F2230/0052 ,  A61F2230/0056 ,  A61F2230/006 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61F2230/0071 ,  A61F2230/0091 ,  A61F2250/0098 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/3658 ,  A61L27/38 ,  A61L2400/16 ,  A61L2430/38 ,  Y10S623/919

摘要： A sterile implant for treatment of a spinal disc defect comprising an allograft cortical bone demineralized to a Type I collagen having a specific shape which is treated to eliminate osteoinductivity. The implant is lyophilized and compressed into smaller first shape which 20 to 80% from its original shape in at least one dimension and hardened. The implant expanding when hydrated into a second shape having the shape memory of the first shape and expanded in dimensional size from the first compressed shape.

摘要翻译： 一种用于治疗椎间盘缺损的无菌植入物，其包括脱矿质于具有特定形状的I型胶原的同种异体移植骨皮质骨，其经处理以消除骨诱导性。 将植入物冷冻干燥并压缩成较小的第一形状，其至少一个维度从原来的形状为20至80％，并硬化。 当植入物水合成具有第一形状的形状记忆并且从第一压缩形状扩大的尺寸尺寸的第二形状时，植入物膨胀。