公开(公告)号：US08883210B1

公开(公告)日：2014-11-11

申请号：US13108856

申请日：2011-05-16

申请人： Katherine Gomes Truncale ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Eric Semler ,  Evangelia Chnari ,  Anouska Dasgupta ,  Judith Yannariello-Brown ,  Terri Riley

发明人： Katherine Gomes Truncale ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Eric Semler ,  Evangelia Chnari ,  Anouska Dasgupta ,  Judith Yannariello-Brown ,  Terri Riley

IPC分类号： A61K9/14 ,  A01N1/02 ,  A01N1/00 ,  C12N5/077 ,  C12N5/073 ,  A61K35/32

CPC分类号： C12N5/0654 ,  A61K35/32 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/19 ,  C12N5/0605 ,  C12N5/0653 ,  C12N5/0667 ,  C12N5/0668 ,  C12N2501/155 ,  C12N2533/90 ,  A61K2300/00

摘要： The disclosure provides implants containing a plurality of particles containing at least one population of viable tissuegenic cells adherent to and resident in the growth-conductive matrix or at least viable population of tissuegenic cells caused to be in contact with the growth-conductive matrix; methods to fabricate implants; methods of fabricating the implants; and use of the implants in tissue repair.

公开(公告)号：US20110059178A1

公开(公告)日：2011-03-10

申请号：US12875733

申请日：2010-09-03

申请人： Eric J. Semler ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Judith Yannariello-Brown ,  Katherine Gomes Truncale

发明人： Eric J. Semler ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Judith Yannariello-Brown ,  Katherine Gomes Truncale

IPC分类号： A61K9/14 ,  A61F2/08 ,  A61K35/34 ,  A61K35/12 ,  A61P21/00

CPC分类号： A61L27/3654 ,  A61F2/3872 ,  A61K35/32 ,  A61K35/34 ,  A61L27/3612 ,  A61L27/3834 ,  A61L27/48 ,  A61L2430/06

摘要： A meniscus repair composition for application to a meniscus defect site to promote growth of new tissue at the meniscus defect site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 μm to about 500 μm; a carrier selected from the group consisting of sodium hyaluronate, gelatin, collagen, polyethylene glycol, glycerin, carboxymethylcellulose, dextrose, blood derivatives, aqueous solutions thereof, and mixtures thereof; and a curing agent. The curing agent may be the carrier where the carrier is cross-linkable. When introduced to a defect site in a meniscus and cured, the composition will not flow away from the defect site, and the composition is non-adhering to the defect site after it is cured.

摘要翻译： 提供了一种应用于弯液面缺陷部位以促进新生组织在弯液面缺陷部位生长的半月板修复组合物。 组合物包含：约10至约50重量％的平均粒度为约10μm至约500μm的同种异体移植物弯月面颗粒; 选自透明质酸钠，明胶，胶原，聚乙二醇，甘油，羧甲基纤维素，葡萄糖，血液衍生物，其水溶液及其混合物的载体; 和固化剂。 固化剂可以是载体可交联的载体。 当引入弯液面中的缺陷部位并固化时，组合物不会从缺陷部位流出，并且组合物在固化后不粘附到缺陷部位。

公开(公告)号：US20110060412A1

公开(公告)日：2011-03-10

申请号：US12875829

申请日：2010-09-03

申请人： Eric J. Semler ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Judith Yannariello-Brown ,  Katherine Gomes Truncale

发明人： Eric J. Semler ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Judith Yannariello-Brown ,  Katherine Gomes Truncale

IPC分类号： A61K35/32 ,  A61F2/08 ,  A61K9/00 ,  A61P19/04

CPC分类号： A61L27/3616 ,  A61F2/30756 ,  A61F2/3872 ,  A61F2002/30762 ,  A61K35/32 ,  A61K38/1841 ,  A61L27/225 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/38 ,  A61L27/3817 ,  A61L27/48 ,  A61L2430/06 ,  A61K2300/00

摘要： A meniscus repair composition for application to a meniscus injury to promote growth of new tissue at the meniscus injury site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 μm to about 500 μm; and a carrier comprising a solid fibrin web matrix. When introduced to a defect site in a meniscus, the composition is non-adhering to the defect site. A method for repairing a meniscus injury comprises administering a meniscus repair composition to the injury site.

摘要翻译： 提供一种用于应用于半月板损伤以促进半月板损伤部位新组织生长的半月板修复组合物。 组合物包含：约10至约50重量％的平均粒度为约10μm至约500μm的同种异体移植物弯月面颗粒; 和包含固体纤维蛋白网状基质的载体。 当引入弯液面中的缺陷部位时，组合物不粘附于缺陷部位。 修复半月板损伤的方法包括向损伤部位施用半月板修复组合物。

公开(公告)号：US08435551B2

公开(公告)日：2013-05-07

申请号：US12508892

申请日：2009-07-24

申请人： Eric J. Semler ,  Roman Shikhanovich ,  Alex B. Callahan ,  Katherine Gomes Truncale ,  Judith I. Yannariello-Brown ,  Yen-Chen Huang

发明人： Eric J. Semler ,  Roman Shikhanovich ,  Alex B. Callahan ,  Katherine Gomes Truncale ,  Judith I. Yannariello-Brown ,  Yen-Chen Huang

IPC分类号： A61F2/28

CPC分类号： A61F2/28 ,  A61F2/30756 ,  A61F2/3859 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/302 ,  A61F2002/30224 ,  A61F2002/30354 ,  A61F2002/30759 ,  A61F2002/30764 ,  A61F2002/30932 ,  A61F2220/0033 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61K35/32 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1875 ,  A61L27/3608 ,  A61L27/3654 ,  A61L27/446 ,  A61L27/48 ,  A61K2300/00

摘要： The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.

摘要翻译： 本发明涉及一种软骨软骨修复组件，其包括成形的同种异体移植物构建体，其包括不平衡的杠铃形圆柱形松质骨主要构件，其形成有具有较小直径的圆柱形杆的矿化圆柱形基部，其通向软化的第二圆柱形部分。 矿化的环形支撑构件被迫超过压缩的软化的第二软化环形构件的孔以使其适配于杆的周围，一个环表面邻近底表面到第二圆柱形部分，并且相对的环表面邻近 矿化圆柱形基部的上表面。

公开(公告)号：US20100015202A1

公开(公告)日：2010-01-21

申请号：US12508892

申请日：2009-07-24

申请人： Eric J. Semler ,  Roman Shikhanovich ,  Alex B. Callahan ,  Katherine Gomes Truncale ,  Judith I. Yannariello-Brown ,  Yen-Chen Huang

发明人： Eric J. Semler ,  Roman Shikhanovich ,  Alex B. Callahan ,  Katherine Gomes Truncale ,  Judith I. Yannariello-Brown ,  Yen-Chen Huang

IPC分类号： A61F2/00 ,  A61F2/28 ,  A61K35/32 ,  A61P19/00

CPC分类号： A61F2/28 ,  A61F2/30756 ,  A61F2/3859 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/302 ,  A61F2002/30224 ,  A61F2002/30354 ,  A61F2002/30759 ,  A61F2002/30764 ,  A61F2002/30932 ,  A61F2220/0033 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61K35/32 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1875 ,  A61L27/3608 ,  A61L27/3654 ,  A61L27/446 ,  A61L27/48 ,  A61K2300/00

摘要： The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.

摘要翻译： 本发明涉及一种软骨软骨修复组件，其包括成形的同种异体移植物构建体，其包括不平衡的杠铃形圆柱形松质骨主要构件，其形成有具有较小直径的圆柱形杆的矿化圆柱形基部，其通向软化的第二圆柱形部分。 矿化的环形支撑构件被迫超过压缩的软化的第二软化环形构件的孔以使其适配于杆的周围，一个环表面邻近底表面到第二圆柱形部分，并且相对的环表面邻近 矿化圆柱形基部的上表面。

公开(公告)号：US20120251609A1

公开(公告)日：2012-10-04

申请号：US13074571

申请日：2011-03-29

申请人： Yen-Chen Huang ,  Moon Hae Sunwoo ,  Arthur A. Gertzman

发明人： Yen-Chen Huang ,  Moon Hae Sunwoo ,  Arthur A. Gertzman

IPC分类号： A61K35/14 ,  A61P19/08 ,  A61F2/28 ,  A61K35/16 ,  A61K35/32

CPC分类号： A61L27/3608 ,  A61F2/28 ,  A61F2310/00359 ,  A61K31/728 ,  A61K35/14 ,  A61K35/19 ,  A61K35/28 ,  A61K35/32 ,  A61K35/33 ,  A61K35/36 ,  A61K38/18

摘要： A demineralized cancellous bone matrix comprising a cancellous bone matrix that has been demineralized is described herein. The demineralized cancellous bone matrix is rigid and has certain dimensions, including a certain length. Implants comprising at least one demineralized cancellous bone matrix are also described. Also disclosed are methods for treating bone having a void or defect in a patient using at least one demineralized cancellous bone matrix. In addition, methods of making a demineralized cancellous bone matrix are disclosed.

摘要翻译： 本文描述了包含已经脱矿质的松质骨基质的软化松质骨基质。 脱矿质松质骨基质是刚性的，具有一定的尺寸，包括一定的长度。 还描述了包含至少一种脱矿质松质骨基质的植入物。 还公开了使用至少一种脱矿质松质骨基质治疗患有空隙或缺损的骨的方法。 此外，公开了制备脱矿质松质骨基质的方法。

公开(公告)号：US20090291112A1

公开(公告)日：2009-11-26

申请号：US12322996

申请日：2009-02-09

申请人： Katherine G. Truncale ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W. Tomford ,  Judith I. Yannariello-Brown ,  Yen-Chen Huang

发明人： Katherine G. Truncale ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W. Tomford ,  Judith I. Yannariello-Brown ,  Yen-Chen Huang

IPC分类号： A61F2/28 ,  A61K38/18 ,  A61K38/00 ,  A61K35/32 ,  A61K35/28 ,  A61K38/28

CPC分类号： A61F2/28 ,  A61F2/30756 ,  A61F2/3859 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30004 ,  A61F2002/30062 ,  A61F2002/30136 ,  A61F2002/30224 ,  A61F2002/30233 ,  A61F2002/3024 ,  A61F2002/30299 ,  A61F2002/30327 ,  A61F2002/30764 ,  A61F2002/30785 ,  A61F2002/4645 ,  A61F2210/0004 ,  A61F2230/0004 ,  A61F2230/0069 ,  A61F2230/0093 ,  A61F2250/0014 ,  A61F2250/0039 ,  A61F2310/00365 ,  A61F2310/00383 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3804 ,  A61L27/48 ,  A61L2430/06 ,  C08L89/00

摘要： An allograft osteochondral plug is combined with a mixture that includes freeze-milled cartilage particles, and such combination is used to repair defects in articular cartilage. The plug includes an subchondral bone portion and an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans. At least a portion of the plug has a lateral dimension selected to form an interference fit against a tissue layer exposed as a result of a bore formed in a defect area in articular cartilage of a host. The cartilage particle mixture is placed adjacent at least a portion of the plug for promoting cartilage cell migration into (i.e., from the adjacent host cartilage) and proliferation in the bore, and for enhancing tissue integration between the plug and patient (i.e., host) tissue when the plug is inserted into the bore. Methods for surgical implantation of the plug into a patient are also disclosed.

摘要翻译： 同种异体骨软骨塞与包括冷冻研磨的软骨颗粒的混合物组合，并且这种组合用于修复关节软骨中的缺陷。 塞子包括软骨下骨部分和整合的上覆软骨帽，其被处理以除去细胞碎片和蛋白聚糖。 插塞的至少一部分具有选择的横向尺寸，以形成对由于在主体的关节软骨中的缺陷区域中形成的孔而暴露的组织层的干涉配合。 将软骨颗粒混合物放置在插塞的至少一部分附近，用于促进软骨细胞迁移（即，从相邻的宿主软骨）和孔中的增殖，并且用于增强插塞和患者（即宿主）之间的组织整合， 当插头插入孔中时的组织。 还公开了将插塞外科植入患者体内的方法。

公开(公告)号：US20090319045A1

公开(公告)日：2009-12-24

申请号：US12381072

申请日：2009-03-05

申请人： Katherine G. Truncale ,  Eric J. Semler ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W. Tomford ,  Roman Shikhanovich ,  Alex B. Callahan ,  Judith I. Yannariello-Brown ,  Morris L. Jacobs ,  John C. Munson ,  Yen-Chen Huang

发明人： Katherine G. Truncale ,  Eric J. Semler ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W. Tomford ,  Roman Shikhanovich ,  Alex B. Callahan ,  Judith I. Yannariello-Brown ,  Morris L. Jacobs ,  John C. Munson ,  Yen-Chen Huang

IPC分类号： A61F2/28 ,  A61F2/02

CPC分类号： A61F2/30756 ,  A61B17/00491 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/3859 ,  A61F2/3872 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/2842 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30227 ,  A61F2002/30233 ,  A61F2002/30235 ,  A61F2002/30327 ,  A61F2002/30331 ,  A61F2002/30354 ,  A61F2002/30387 ,  A61F2002/30448 ,  A61F2002/30459 ,  A61F2002/30461 ,  A61F2002/30492 ,  A61F2002/30604 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30772 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30795 ,  A61F2002/3085 ,  A61F2002/30932 ,  A61F2002/3096 ,  A61F2002/4635 ,  A61F2002/4646 ,  A61F2002/4649 ,  A61F2210/0004 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2230/0069 ,  A61F2250/0039 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2430/06 ,  C08L89/00

摘要： Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct includes a base member, a cap member and at least one pin that secures the cap member to the base member. The base member may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member includes a blind bore and first and second through-going transverse bores in opposite sides of a wall of the base member. The cap member includes an upper section that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem depending from the upper section that is dimensioned to be received in and by the blind bore of the base member. The stem includes a transverse through-going bore, which may be aligned with the transverse through-going bores of the base member to receive the pin therein when the construct has been assembled. The cap member is at least partially formed of demineralized allograft cancellous bone, into which a mixture containing lyophilized, freeze-milled allograft cartilage particles may be infused for the repair of articular cartilage defects. The cartilage particles have a size within a range of from about 10 microns to about 210 microns.

摘要翻译： 公开了至少部分由同种异体移植松质骨构成的构造物，以及可用于修复关节软骨缺损的构建体的软骨颗粒。 多件式构件包括底座构件，帽构件以及将盖构件固定到基座构件的至少一个销。 基部构件可以由矿化松质骨构成，并且当外科医生切割相邻软骨缺损区域中的孔时，用于替代被去除的软骨下骨。 基部构件包括盲孔以及在基部构件的壁的相对侧中的第一和第二穿过横向孔。 盖构件包括具有与患者周围的关节软骨层的厚度相似的厚度的上部部分和从上部部分延伸的杆部，该上部部分的尺寸设计成被接纳在基部构件的盲孔内和通过该盲孔。 所述杆包括横向通孔，所述横向通孔可以与所述基部构件的横向贯穿孔对齐，以在所述构造件已经组装时将其插入其中。 盖构件至少部分地由软化的同种异体移植松质骨形成，含有冻干的冷冻研磨的同种异体移植软骨颗粒的混合物可以被注入其中，用于修复关节软骨缺损。 软骨颗粒的尺寸在约10微米至约210微米的范围内。

公开(公告)号：US20100274362A1

公开(公告)日：2010-10-28

申请号：US12657207

申请日：2010-01-14

申请人： Avner Yayon ,  Katherine G. Truncale ,  Hilla Barkay-Olami ,  Alex B. Callahan ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Morris L. Jacobs ,  John C. Munson ,  Eric J. Semler ,  Roman Shikhanovich ,  Baruch Stern ,  Moon Hae Sunwoo ,  William W. Tomford ,  Judith I. Yannariello-Brown

发明人： Avner Yayon ,  Katherine G. Truncale ,  Hilla Barkay-Olami ,  Alex B. Callahan ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Morris L. Jacobs ,  John C. Munson ,  Eric J. Semler ,  Roman Shikhanovich ,  Baruch Stern ,  Moon Hae Sunwoo ,  William W. Tomford ,  Judith I. Yannariello-Brown

IPC分类号： A61F2/02 ,  A61K9/19 ,  A61K9/00 ,  A61K38/18 ,  A61P19/00

CPC分类号： A61K9/19 ,  A61K35/32 ,  A61K38/1825 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/602

摘要： Mixtures, such as gels or pastes, comprising freeze-milled cartilage particles and exogenous growth factors are used for repairing chondral defects. Such mixtures may be applied to constructs comprising cancellous bone for implantation at the defect site. Suitable growth factors include variants of FGF-2, particularly variants that include a sole amino acid substitution for asparagine at amino acid 111 of the β8-β9 loop of the FGF-2 peptide. Such FGF-2 variants are released slowly and continuously at a constant rate from cartilage pastes. In other embodiments, the amino acid substituted for asparigine is glycine. Other variants that may be used include FGF-9 variants having truncated chains and a sole amino acid substitution in the β8-β9 loop of the FGF-9 peptide either for tryptophan at amino acid 144 or for asparagine at amino acid 143.

摘要翻译： 使用包含冷冻研磨的软骨颗粒和外源生长因子的混合物，例如凝胶或糊剂来修复软骨缺陷。 可以将这样的混合物施用于包含用于在缺损部位植入的松质骨的构建体。 合适的生长因子包括FGF-2的变体，特别是包括在FGF-2肽的8-＆amp; B9环的氨基酸111处的天冬酰胺的唯一氨基酸取代的变体。 这样的FGF-2变体以软骨糊剂的恒定速率缓慢且连续地释放。 在其它实施方案中，取代天冬酰胺的氨基酸是甘氨酸。 可以使用的其它变体包括FGF-9变体，其具有截短的链和唯一的氨基酸取代在FGF-9肽的8-＆Bgr9环中，对于在氨基酸144处的色氨酸或在氨基酸143处的天冬酰胺 。

公开(公告)号：US20090184656A1

公开(公告)日：2009-07-23

申请号：US12053624

申请日：2008-03-24

申请人： Yen-Chen Huang ,  Chia-Hung Sun ,  Huang-Ti Lin ,  Yuan-Pin Cho

发明人： Yen-Chen Huang ,  Chia-Hung Sun ,  Huang-Ti Lin ,  Yuan-Pin Cho

IPC分类号： H05B37/02

CPC分类号： H05B41/2855 ,  H05B41/282 ,  Y02B20/183

摘要： A lamp current balance and feedback system and related method are disclosed for balancing the input and output currents of a lamp by making use of a lamp current balance and feedback mechanism. The operation of the lamp current balance and feedback mechanism includes coupling the input current of the lamp for generating a first balance current by a first transformer, coupling the output current of the lamp for generating a second balance current by a second transformer, coupling the first and second transformers for substantially equalizing the first and second balance currents, generating a feedback signal based on the first or second balance current by a feedback circuit, generating a pulse width modulation signal based on the feedback signal by a pulse width modulation signal generation circuit, and driving the input and output currents of the lamp based on the pulse width modulation signal by a driving circuit.

摘要翻译： 公开了一种灯电流平衡和反馈系统及相关方法，用于通过利用灯电流平衡和反馈机构平衡灯的输入和输出电流。 灯电流平衡和反馈机构的操作包括耦合用于由第一变压器产生第一平衡电流的灯的输入电流，通过第二变压器耦合用于产生第二平衡电流的灯的输出电流，将第一 以及第二变压器，用于基本上均衡所述第一和第二平衡电流，通过反馈电路产生基于所述第一或第二平衡电流的反馈信号，通过脉宽调制信号产生电路产生基于所述反馈信号的脉宽调制信号， 并且通过驱动电路基于脉宽调制信号驱动灯的输入和输出电流。