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公开(公告)号：US06433142B1
公开(公告)日：2002-08-13
申请号：US07757022
申请日：1991-09-10
IPC分类号： C07K1452
摘要： Novel human megakaryocyte stimulating factors (MSFS) capable of stimulating the growth and development of colonies of megakaryocytes, pharmaceutical compositions containing same, and methods for their preparation and use are provided.
摘要翻译： 提供能够刺激巨核细胞集落生长发育的新型人类巨核细胞刺激因子（MSFS），含有其的药物组合物及其制备和使用方法。
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公开(公告)号：US07361738B2
公开(公告)日：2008-04-22
申请号：US11169232
申请日：2005-06-28
摘要： Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided.
摘要翻译： 人类巨核细胞刺激因子（MSF）的新型多肽。 提供含有其的药物组合物及其制备和使用方法。
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公开(公告)号：US07030223B2
公开(公告)日：2006-04-18
申请号：US10124557
申请日：2002-04-16
IPC分类号： C07K14/475 , C07K14/47 , C12N15/12 , C12P21/02
摘要： Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided.
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公开(公告)号：US5326558A
公开(公告)日：1994-07-05
申请号：US546114
申请日：1990-06-29
IPC分类号： A61K38/00 , A61P7/04 , C07K1/14 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/52 , C07K14/53 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12R1/19 , C07K15/00 , A61K37/02
CPC分类号： C07K14/53 , A61K38/00 , Y10S530/82 , Y10S530/827 , Y10S930/14 , Y10S930/145
摘要： A novel human megakaryocytopoietic factor capable of stimulating the growth and development of colonies of megakaryocytes is provided, including procedures for its purification and use as a pharmaceutical agent.
摘要翻译： 提供能够刺激巨核细胞集落生长发育的新型人类巨核细胞生成因子，包括其纯化和用作药剂的方法。
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公开(公告)号：US20060025570A1
公开(公告)日：2006-02-02
申请号：US11169232
申请日：2005-06-28
申请人： Katherine Turner , Steven Clark , Kenneth Jacobs , Rodney Hewick , Thomas Gesner
发明人： Katherine Turner , Steven Clark , Kenneth Jacobs , Rodney Hewick , Thomas Gesner
IPC分类号： A61K38/18 , C07K14/475
摘要： Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided.
摘要翻译： 人类巨核细胞刺激因子（MSF）的新型多肽。 提供含有它们的药物组合物及其制备和使用方法。
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公开(公告)号：US20130095184A1
公开(公告)日：2013-04-18
申请号：US12109897
申请日：2008-04-25
IPC分类号： A61K33/38 , A61K31/4174 , A61K38/14
CPC分类号： A61K33/38 , A01N59/16 , A61K9/0056 , A61K9/7023 , A61K31/4164 , A61K31/4174 , A61K31/437 , A61K38/14 , A61K45/06 , B82Y5/00 , Y02A50/469 , Y10S977/773 , Y10S977/915 , A01N25/12 , A01N25/26 , A01N25/34 , A01N2300/00 , A61K2300/00
摘要： Metal-containing materials, as well as their preparation, formulations, and use are disclosed.
摘要翻译： 公开了含金属材料及其制备，配方和用途。
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公开(公告)号：US08425880B1
公开(公告)日：2013-04-23
申请号：US12109897
申请日：2008-04-25
CPC分类号： A61K33/38 , A01N59/16 , A61K9/0056 , A61K9/7023 , A61K31/4164 , A61K31/4174 , A61K31/437 , A61K38/14 , A61K45/06 , B82Y5/00 , Y02A50/469 , Y10S977/773 , Y10S977/915 , A01N25/12 , A01N25/26 , A01N25/34 , A01N2300/00 , A61K2300/00
摘要： Metal-containing materials, as well as their preparation, formulations, and use are disclosed.
摘要翻译： 公开了含金属材料及其制备，配方和用途。
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公开(公告)号：USD446159S1
公开(公告)日：2001-08-07
申请号：US29117133
申请日：2000-01-18
申请人： Katherine Turner
设计人： Katherine Turner
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公开(公告)号：US20060165706A1
公开(公告)日：2006-07-27
申请号：US11321444
申请日：2005-12-29
申请人： Beatriz Carreno , Clive Wood , Katherine Turner , Mary Collins , Gary Gray , Donna Morris , Denise O'Hara , Paul Hinton , Naoya Tsurushita
发明人： Beatriz Carreno , Clive Wood , Katherine Turner , Mary Collins , Gary Gray , Donna Morris , Denise O'Hara , Paul Hinton , Naoya Tsurushita
IPC分类号： A61K39/395 , C07K16/46
CPC分类号： A61K51/1027 , A61K47/6827 , A61K47/6829 , A61K47/6849 , A61K2039/505 , C07K16/2818 , C07K2317/24 , C07K2317/34
摘要： The invention provides an antibody-toxic moiety conjugates comprising an antibody that specifically recognizes a molecule expressed on the surface of a T cell which is expressed only on T cells and is only expressed transiently on T cells upon T cell activation. Preferably, the T cell molecule is CTLA4. The invention further provides anti-CTLA4 antibodies and humanized forms thereof.
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公开(公告)号：US07034121B2
公开(公告)日：2006-04-25
申请号：US09772103
申请日：2001-01-26
申请人： Beatriz M. Carreno , Clive Wood , Katherine Turner , Mary Collins , Gary S. Gray , Donna Morris , Denise O'Hara , Paul R. Hinton , Naoya Tsurushita
发明人： Beatriz M. Carreno , Clive Wood , Katherine Turner , Mary Collins , Gary S. Gray , Donna Morris , Denise O'Hara , Paul R. Hinton , Naoya Tsurushita
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： A61K51/1027 , A61K47/6827 , A61K47/6829 , A61K47/6849 , A61K2039/505 , C07K16/2818 , C07K2317/24 , C07K2317/34
摘要： The invention provides an antibody-toxic moiety conjugates comprising an antibody that specifically recognizes a molecule expressed on the surface of a T cell which is expressed only on T cells and is only expressed transiently on T cells upon T cell activation. Preferably, the T cell molecule is CTLA4. The invention further provides anti-CTLA4 antibodies and humanized forms thereof.
摘要翻译： 本发明提供了一种抗体毒性部分缀合物，其包含特异性识别仅在T细胞上表达的T细胞表面上表达的分子并且仅在T细胞活化时在T细胞上瞬时表达的抗体。 优选地，T细胞分子是CTLA4。 本发明进一步提供抗CTLA4抗体及其人源化形式。
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