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    Cancer gene therapeutic drug
    2.
    发明申请
    Cancer gene therapeutic drug 审中-公开
    癌症基因治疗药

    公开(公告)号：US20070134202A1

    公开(公告)日：2007-06-14

    申请号：US10576047

    申请日：2003-10-15

    申请人： Katsuyuki Hamada ,  Akinobu Goto ,  Toshiro Shirakawa

    发明人： Katsuyuki Hamada ,  Akinobu Goto ,  Toshiro Shirakawa

    IPC分类号： A61K48/00 ,  C12N15/86

    CPC分类号： C12N7/00 ,  A61K31/409 ,  A61K35/761 ,  A61K38/193 ,  A61K48/0058 ,  A61K2039/5256 ,  A61K2039/57 ,  C07K14/475 ,  C12N15/85 ,  C12N15/86 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2830/85 ,  A61K2300/00

    摘要： A cancer gene therapeutic drug of the present invention comprises a combination of: a virus for immunological treatment to be administered for inducing a CTL reaction within a living body to administration of a carrier cell; and a carrier cell to be infected with an oncolytic virus before the administration so as to make the oncolytic virus act on a tumor cell within the living body. For example, A549 cell can be used as the carrier cell. Non-proliferative adenovirus inactivated by UV irradiation can be used as the virus for immunological treatment, and a proliferative adenovirus having a tumor-specific promoter can be used as the oncolytic virus, for example.

    摘要翻译： 本发明的癌症基因治疗药物包含以下组合：用于在活体内诱导CTL反应而施用的用于免疫治疗的病毒，用于施用载体细胞; 以及在施用前被感染有溶瘤病毒的载体细胞，以使得溶瘤病毒作用于活体内的肿瘤细胞。 例如，可以使用A549细胞作为载体细胞。 通过UV辐射灭活的非增殖性腺病毒可以用作免疫治疗的病毒，例如可以使用具有肿瘤特异性启动子的增殖性腺病毒作为溶瘤病毒。

    Gene expression base sequences for therapeutic use and drugs for gene therapy
    3.
    发明授权
    Gene expression base sequences for therapeutic use and drugs for gene therapy 失效
    用于治疗用途的基因表达碱基序列和用于基因治疗的药物

    公开(公告)号：US06815430B1

    公开(公告)日：2004-11-09

    申请号：US09958021

    申请日：2002-01-07

    申请人： Kazuhiro Yuda ,  Katsuhiko Akiyama ,  Takeshi Goto ,  Katsuyuki Hamada

    发明人： Kazuhiro Yuda ,  Katsuhiko Akiyama ,  Takeshi Goto ,  Katsuyuki Hamada

    IPC分类号： C07H2104

    CPC分类号： C07K14/4731 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4748 ,  C12N15/63

    摘要： The base sequence for the expression of a therapeutic gene and the medicament for gene therapy are disclosed. There is also disclosed the base sequence for the expression of a therapeutic gene, said sequence being shown in any one of from (a) to (d) and capable of directing the expression of the therapeutic gene specifically to squamous epithelium: (a) the base sequence set forth in SEQ ID NO:1 in the Sequence Listing; (b) the base sequence set forth in SEQ ID NO:18 in the Sequence Listing; (c) the base sequence set forth in SEQ ID NO:17 in the Sequence Listing; and (d) the base sequence set forth in SEQ ID NO:16 in the Sequence Listing. Moreover, there is disclosed the medicament for gene therapy containing a therapeutic gene downstream any of the above-mentioned base sequences, capable of directing the expression of the therapeutic gene specifically to squamous epithelium.

    摘要翻译： 公开了用于表达治疗基因的碱基序列和用于基因治疗的药物。 还公开了用于表达治疗基因的碱基序列，所述序列显示为（a）至（d）中任一项，并且能够将治疗基因的表达特异性指导至鳞状上皮细胞：（a） 碱基序列;（b）序列表中SEQ ID NO：18所示的碱基序列;（c）SEQ ID NO：17所示的碱基序列， 序列表 和（d）序列表中SEQ ID NO：16所示的碱基序列。此外，公开了含有上述碱基序列下游的治疗基因的基因治疗药物，其能够指导 该治疗基因专门用于鳞状上皮细胞。

    Tumor-specific promotor and use thereof
    4.
    发明授权
    Tumor-specific promotor and use thereof 有权
    肿瘤特异性启动子及其用途

    公开(公告)号：US07321030B2

    公开(公告)日：2008-01-22

    申请号：US10489258

    申请日：2002-01-30

    申请人： Katsuyuki Hamada

    发明人： Katsuyuki Hamada

    IPC分类号： C07H21/04 ,  C12N15/36

    CPC分类号： C12N15/86 ,  A61K35/761 ,  A61K45/06 ,  A61K48/00 ,  C12N15/85 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2830/85 ,  A61K2300/00

    摘要： A promoter domain of 1816 bp or 441 bp in the upstream side of exon 1B of IAI.3B gene has a specifically high promoter activity in ovarian cancer cells. An adenovirus having this promoter domain inserted in the E1 domain thereof exhibits a specifically high cell proliferation inhibitory effect on ovarian cancer cells. Thus, it is efficacious in gene therapy for ovarian cancer.

    摘要翻译： IAI.3B基因外显子1B上游侧的1816bp或441bp的启动子结构域在卵巢癌细胞中具有特异性的启动子活性。 具有插入其E1结构域中的该启动子结构域的腺病毒对卵巢癌细胞具有特异性高的细胞增殖抑制作用。 因此，在卵巢癌的基因治疗中是有效的。

    Log in-out system for logic apparatus
    5.
    发明授权
    Log in-out system for logic apparatus 失效
    逻辑设备登录系统

    公开(公告)号：US4145749A

    公开(公告)日：1979-03-20

    申请号：US836077

    申请日：1977-09-23

    申请人： Tatsuro Yoshimura ,  Takamitsu Tsuchimoto ,  Katsuyuki Hamada

    发明人： Tatsuro Yoshimura ,  Takamitsu Tsuchimoto ,  Katsuyuki Hamada

    IPC分类号： G06F13/42 ,  G06F7/76 ,  G01R15/00 ,  G11C7/00 ,  G11C17/00

    CPC分类号： G06F7/76

    摘要： A plurality of logic circuits having log in-out functions are connected in sequence. A clock distribution circuit is connected to each sequential logic circuit via a corresponding one of a plurality of bidirectional lines. A mode designation signal is supplied in common to each sequential logic circuit and the clock distribution circuit. A sequential logic circuit selection signal, which selects one of the sequential logic circuits, is supplied to the clock distribution circuit. A clock signal is supplied from the clock distribution circuit to each sequential logic circuit via the bidirectional lines in the clock mode. Log in data is supplied from the clock distribution circuit to the sequential logic circuit via a specific bidirectional line in accordance with the sequential logic circuit selection signal in the log in mode. Log out data is supplied to the clock distribution circuit from the sequential logic circuit in the log out mode via a specific bidirectional line in accordance with the sequential logic circuit selection signal.

    摘要翻译： 具有登录功能的多个逻辑电路依次连接。 时钟分配电路通过多条双向线路中的相应一条连接到每个顺序逻辑电路。 模式指定信号被共同地提供给每个顺序逻辑电路和时钟分配电路。 选择顺序逻辑电路之一的顺序逻辑电路选择信号被提供给时钟分配电路。 在时钟模式下，时钟信号经由双向线从时钟分配电路提供给每个顺序逻辑电路。 根据登录模式中的顺序逻辑电路选择信号，通过特定双向线将登录数据从时钟分配电路提供给顺序逻辑电路。 根据顺序逻辑电路选择信号，经由特定的双向线路，从注销模式的顺序逻辑电路将注销数据提供给时钟分配电路。

    Semiconductor device
    7.
    发明授权
    Semiconductor device 失效
    半导体器件

    公开(公告)号：US4197555A

    公开(公告)日：1980-04-08

    申请号：US925788

    申请日：1978-07-18

    申请人： Takao Uehara ,  Takamitsu Tsuchimoto ,  Katsuyuki Hamada ,  Hideo Masuzawa ,  Makoto Mukai

    发明人： Takao Uehara ,  Takamitsu Tsuchimoto ,  Katsuyuki Hamada ,  Hideo Masuzawa ,  Makoto Mukai

    IPC分类号： H01L23/528 ,  H01L23/538 ,  H01L23/48

    CPC分类号： H01L23/528 ,  H01L23/5384 ,  H01L2924/0002

    摘要： An electronic device which includes at least one semiconductor chip with at least one circuit element thereon and connection patterns thereon being connected to the circuit element or elements. The connection patterns comprise a lower connection pattern, which is standardized and widely applicable to many kinds of circuits, and an upper connection pattern, which is positioned on the upper side of said lower connection pattern. The upper connection pattern and the lower connection pattern are connected in conformity with the desired circuit to be obtained.

    摘要翻译： 一种电子设备，其包括至少一个其上具有至少一个电路元件的半导体芯片及其上的连接图案连接到电路元件。 连接图案包括标准化并广泛适用于多种电路的下连接图案，以及位于所述下连接图案的上侧的上连接图案。 上连接图案和下连接图案根据要获得的期望电路连接。