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    Cancer gene therapeutic drug
    2.
    发明申请
    Cancer gene therapeutic drug 审中-公开
    癌症基因治疗药

    公开(公告)号：US20070134202A1

    公开(公告)日：2007-06-14

    申请号：US10576047

    申请日：2003-10-15

    申请人： Katsuyuki Hamada ,  Akinobu Goto ,  Toshiro Shirakawa

    发明人： Katsuyuki Hamada ,  Akinobu Goto ,  Toshiro Shirakawa

    IPC分类号： A61K48/00 ,  C12N15/86

    CPC分类号： C12N7/00 ,  A61K31/409 ,  A61K35/761 ,  A61K38/193 ,  A61K48/0058 ,  A61K2039/5256 ,  A61K2039/57 ,  C07K14/475 ,  C12N15/85 ,  C12N15/86 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2830/85 ,  A61K2300/00

    摘要： A cancer gene therapeutic drug of the present invention comprises a combination of: a virus for immunological treatment to be administered for inducing a CTL reaction within a living body to administration of a carrier cell; and a carrier cell to be infected with an oncolytic virus before the administration so as to make the oncolytic virus act on a tumor cell within the living body. For example, A549 cell can be used as the carrier cell. Non-proliferative adenovirus inactivated by UV irradiation can be used as the virus for immunological treatment, and a proliferative adenovirus having a tumor-specific promoter can be used as the oncolytic virus, for example.

    摘要翻译： 本发明的癌症基因治疗药物包含以下组合：用于在活体内诱导CTL反应而施用的用于免疫治疗的病毒，用于施用载体细胞; 以及在施用前被感染有溶瘤病毒的载体细胞，以使得溶瘤病毒作用于活体内的肿瘤细胞。 例如，可以使用A549细胞作为载体细胞。 通过UV辐射灭活的非增殖性腺病毒可以用作免疫治疗的病毒，例如可以使用具有肿瘤特异性启动子的增殖性腺病毒作为溶瘤病毒。

    Apparatus for cell culture
    3.
    发明申请
    Apparatus for cell culture 失效
    细胞培养装置

    公开(公告)号：US20050176138A1

    公开(公告)日：2005-08-11

    申请号：US11048559

    申请日：2005-02-01

    申请人： Takahiro Nishimoto ,  Yoshiaki Hamada ,  Seiichi Sakuramoto ,  Keiichi Yokouchi ,  Akinobu Goto ,  Toshiro Shirakawa

    发明人： Takahiro Nishimoto ,  Yoshiaki Hamada ,  Seiichi Sakuramoto ,  Keiichi Yokouchi ,  Akinobu Goto ,  Toshiro Shirakawa

    IPC分类号： C12M1/00 ,  C12M1/02 ,  C12M3/00

    CPC分类号： C12M47/02 ,  C12M23/50 ,  C12M33/06 ,  C12M37/00 ,  C12M41/48

    摘要： An object of the present invention is to provide an apparatus for cell culture exhibiting favorable property to occupy little space and economical efficiency, capable of reducing the working labor, faulty manipulation and the like, and of promoting the prevention of contamination, which is suitable for small scale cell culture at an experimental level on research, in particular. The present invention is an apparatus for cell culture wherein at least a medium replacement process and a passage culture process can be executed, and characterized by including an aspirator unit for drawing a liquid, a chemical liquid supply unit for supplying a medium, a liquid for detachment, a washing liquid and the like, a pipetting unit for quantitatively aspirating and discharging the liquid, a centrifugal unit for separating cells from the cell suspension in a centrifuge tube, and a handling unit for moving a culture vessel and the centrifuge tube to each unit; and all units being constructed such that they can be stored in a clean bench. Further, according to the present invention, the apparatus may include a clean bench having a sterile operation space, and the aforementioned units may be stored within the sterile operation space in a removable manner.

    摘要翻译： 本发明的目的是提供一种细胞培养装置，其具有良好的性能，占用空间少，经济效益好，能够减少劳动力，操作不良等，促进防止污染，适用于 特别是在实验水平的小规模细胞培养研究。 本发明是一种用于细胞培养的装置，其中至少可以执行培养基更换过程和通道培养过程，其特征在于包括用于抽取液体的抽吸单元，用于供给培养基的药液供应单元，用于 洗涤液等，用于定量抽吸和排出液体的移液单元，用于在离心管中从细胞悬浮液中分离细胞的离心单元和用于将培养容器和离心管移动到每个的操作单元 单元; 并且所有单元被构造成使得它们可以被存储在干净的工作台中。 此外，根据本发明，该装置可以包括具有无菌操作空间的清洁台，并且上述单元可以以可移除的方式存储在无菌操作空间内。

    Apparatus for cell culture
    4.
    发明授权
    Apparatus for cell culture 失效
    细胞培养装置

    公开(公告)号：US07419819B2

    公开(公告)日：2008-09-02

    申请号：US11048559

    申请日：2005-02-01

    申请人： Takahiro Nishimoto ,  Yoshiaki Hamada ,  Seiichi Sakuramoto ,  Keiichi Yokouchi ,  Akinobu Goto ,  Toshiro Shirakawa

    发明人： Takahiro Nishimoto ,  Yoshiaki Hamada ,  Seiichi Sakuramoto ,  Keiichi Yokouchi ,  Akinobu Goto ,  Toshiro Shirakawa

    IPC分类号： C12M1/36 ,  C12M1/38 ,  C12M3/00

    CPC分类号： C12M47/02 ,  C12M23/50 ,  C12M33/06 ,  C12M37/00 ,  C12M41/48

    摘要： Apparatus for cell culture occupying little space, providing economical efficiency, reducing working labor, faulty manipulation, and promoting the prevention of contamination, which is suitable for small scale cell culture . The apparatus permits the execution of at least a medium replacement process and a passage culture process, and includes an aspirator unit for drawing a liquid, a chemical liquid supply unit for supplying a medium, a liquid for detachment, a washing liquid, a pipetting unit for quantitatively aspirating and discharging the liquid, a centrifugal unit for separating cells from the cell suspension in a centrifuge tube, and a handling unit for moving a culture vessel and the centrifuge tube to each unit. All units being constructed for storage in a clean bench. The apparatus may include a clean bench having a sterile operation space, and the aforementioned units may be removably stored within the sterile operation space.

    摘要翻译： 细胞培养装置空间小，提供经济效益，减少工作劳动，错误操作，促进防止污染，适用于小规模细胞培养。 该装置允许至少执行介质置换处理和通道培养处理，并且包括用于抽取液体的抽吸单元，用于供给介质的药液供应单元，用于分离的液体，洗涤液，移液单元 用于定量抽吸和排出液体;离心机，用于将细胞从离心管中的细胞悬浮液中分离;以及处理单元，用于将培养容器和离心管移动到每个单元。 所有单位正在建造中，用于存放在干净的工作台上。 该设备可以包括具有无菌操作空间的清洁台，并且上述单元可以可移除地存储在无菌操作空间内。