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    Methods of predicting dose of drug and program for predicting dose of drug
    3.
    发明授权
    Methods of predicting dose of drug and program for predicting dose of drug 失效
    预测药物剂量的方法和预测药物剂量的程序

    公开(公告)号：US07925520B2

    公开(公告)日：2011-04-12

    申请号：US12015449

    申请日：2008-01-16

    申请人： Kentaro Kogure ,  Kaoru Kigasawa ,  Naoki Nakamura

    发明人： Kentaro Kogure ,  Kaoru Kigasawa ,  Naoki Nakamura

    IPC分类号： A61M31/00 ,  G06Q10/00

    CPC分类号： A61N1/0428 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/325 ,  G06F19/00 ,  G06Q50/22

    摘要： A migration M of a drug ion in a membrane type iontophoresis device for administering the drug ion through a first ion exchange membrane is predicted on the basis of a migration C of the drug ion from the first ion exchange membrane to the outside of the device in the case where a voltage is applied to an electrode by using the device under such a condition that the first ion exchange membrane is not brought into contact with the skin of a living organism and a migration R of the drug ion to a liposome caused by mixing a liposome solution having a predetermined concentration and a drug solution containing a predetermined concentration of the drug ion.

    摘要翻译： 基于从第一离子交换膜向装置外部的药物离子的迁移C，预测用于通过第一离子交换膜施用药物离子的膜型离子电渗疗装置中的药物离子的迁移M 在第一离子交换膜不与活体的皮肤接触的状态下，通过使用该装置向电极施加电压的情况以及由混合引起的药物离子向脂质体的迁移R 具有预定浓度的脂质体溶液和含有预定浓度的药物离子的药物溶液。

    METHODS OF PREDICTING DOSE OF DRUG AND PROGRAM FOR PREDICTING DOSE OF DRUG
    4.
    发明申请
    METHODS OF PREDICTING DOSE OF DRUG AND PROGRAM FOR PREDICTING DOSE OF DRUG 失效
    药物剂量预测方法和预防药物剂量方案

    公开(公告)号：US20080208106A1

    公开(公告)日：2008-08-28

    申请号：US12015449

    申请日：2008-01-16

    申请人： Kentaro Kogure ,  Kaoru Kigasawa ,  Naoki Nakamura

    发明人： Kentaro Kogure ,  Kaoru Kigasawa ,  Naoki Nakamura

    IPC分类号： A61N1/30

    CPC分类号： A61N1/0428 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/325 ,  G06F19/00 ,  G06Q50/22

    摘要： A migration M of a drug ion in a membrane type iontophoresis device for administering the drug ion through a first ion exchange membrane is predicted on the basis of a migration C of the drug ion from the first ion exchange membrane to the outside of the device in the case where a voltage is applied to an electrode by using the device under such a condition that the first ion exchange membrane is not brought into contact with the skin of a living organism and a migration R of the drug ion to a liposome caused by mixing a liposome solution having a predetermined concentration and a drug solution containing a predetermined concentration of the drug ion.

    摘要翻译： 基于从第一离子交换膜向装置外部的药物离子的迁移C，预测用于通过第一离子交换膜施用药物离子的膜型离子电渗疗装置中的药物离子的迁移M 在第一离子交换膜不与活体的皮肤接触的状态下，通过使用该装置向电极施加电压的情况以及由混合引起的药物离子向脂质体的迁移R 具有预定浓度的脂质体溶液和含有预定浓度的药物离子的药物溶液。

    COMPOSTIONS AND METHODS FOR IONTOPHORESIS DELIVERY OF ACTIVE INGREDIENTS THROUGH HAIR FOLLICLES
    5.
    发明申请
    COMPOSTIONS AND METHODS FOR IONTOPHORESIS DELIVERY OF ACTIVE INGREDIENTS THROUGH HAIR FOLLICLES 审中-公开
    组合物和方法通过头发手段输送活性成分进行静脉输送

    公开(公告)号：US20080193514A1

    公开(公告)日：2008-08-14

    申请号：US11929451

    申请日：2007-10-30

    申请人： Kentaro Kogure ,  Masahiko Yamamoto ,  Hideyoshi Harashima

    发明人： Kentaro Kogure ,  Masahiko Yamamoto ,  Hideyoshi Harashima

    IPC分类号： A61K9/127

    CPC分类号： A61N1/0448 ,  A61K9/0009 ,  A61K9/1272 ,  A61N1/0444

    摘要： Systems, devices, and methods for delivering one or more active ingredients to deep regions of hair follicles and intradermal tissues in the vicinity of hair follicles. In some embodiments, a composition is provided including an active ingredient carried in a liposome. The liposome includes a cationic lipid and an amphiphilic glycerophospholipid having a saturated fatty acid moiety and unsaturated fatty acid moiety.

    摘要翻译： 将一种或多种活性成分递送到毛囊附近的毛囊和皮内组织的深部区域的系统，装置和方法。 在一些实施方案中，提供了包含在脂质体中携带的活性成分的组合物。 脂质体包括阳离子脂质和具有饱和脂肪酸部分和不饱和脂肪酸部分的两亲性甘油磷脂。

    Method for coating particle with lipid film
    6.
    发明授权
    Method for coating particle with lipid film 失效
    用脂质膜包覆颗粒的方法

    公开(公告)号：US08097276B2

    公开(公告)日：2012-01-17

    申请号：US11795513

    申请日：2006-01-18

    申请人： Kentaro Kogure ,  Arisa Minoura ,  Hideyoshi Harashima

    发明人： Kentaro Kogure ,  Arisa Minoura ,  Hideyoshi Harashima

    IPC分类号： A61K9/127 ,  A01N25/26 ,  G01N33/00

    CPC分类号： A61K9/127 ,  B01J13/02 ,  B01J13/04

    摘要： A method for coating an object, i.e. a particle, with two sheets of lipid film having a space formed there between. In the method for coating a particle having a positive electrostatic-charging property with two sheets of lipid film, the particle having a positive electrostatic-charging property is brought into contact with a plurality of SUV type liposomes having a negative electrostatic-charging property to form a complex having a negative electrostatic-charging property containing the particle having a positive electrostatic-charging property and the SUV type liposomes having a negative electrostatic-charging property coupled electrostatically with the particle having a positive electrostatic-charging property, and then the complex having a negative electrostatic-charging property is treated with cation.

    摘要翻译： 一种用两层脂质膜涂覆物体即颗粒的方法，所述脂质膜在其间形成有空间。 在利用两片脂质膜涂布具有正静电充电性的颗粒的方法中，具有正静电带电性的颗粒与多个具有负静电充电性质的SUV型脂质体接触以形成 具有含有具有正静电充电性的颗粒的负静电充电性的复合物和具有负静电充电性能的SUV型脂质体与具有正静电充电性质的颗粒静电耦合，然后该络合物具有 用阳离子处理负静电充电性能。

    Polyarginine-modified liposome having nuclear entry ability
    8.
    发明申请
    Polyarginine-modified liposome having nuclear entry ability 失效
    具有核进入能力的聚精氨酸改性脂质体

    公开(公告)号：US20070059353A1

    公开(公告)日：2007-03-15

    申请号：US11396081

    申请日：2006-03-31

    申请人： Hideyoshi Harashima ,  Shiroh Futaki ,  Kentaro Kogure

    发明人： Hideyoshi Harashima ,  Shiroh Futaki ,  Kentaro Kogure

    IPC分类号： A61K48/00 ,  A61K9/127 ,  C12N15/88

    CPC分类号： C12N15/88 ,  A61K9/1273 ,  A61K47/34 ,  A61K47/645 ,  A61K47/6911 ,  C07K1/1077

    摘要： With the object of providing a liposome having cellular and nuclear entry ability, to achieve this object, a liposome is provided having on its surface a peptide comprising multiple consecutive arginine residues, and specifically a liposome is provided wherein the peptide is modified with a hydrophobic group or hydrophobic compound and the hydrophobic group or hydrophobic compound is inserted into a lipid bilayer so that the peptide is exposed on the surface of the bilayer.

    摘要翻译： 为了提供具有细胞和核进入能力的脂质体，为了达到这个目的，提供了一种脂质体，其表面上含有多个连续的精氨酸残基的肽，特别是提供一种脂质体，其中肽用疏水基团修饰 或疏水性化合物，并且将疏水基团或疏水性化合物插入脂质双层中，使得该肽暴露在双层的表面上。

    NANOPARTICLES CONTAINING pH-RESPONSIVE PEPTIDE
    10.
    发明申请
    NANOPARTICLES CONTAINING pH-RESPONSIVE PEPTIDE 有权
    含有pH响应肽的纳米颗粒

    公开(公告)号：US20140044778A1

    公开(公告)日：2014-02-13

    申请号：US14113411

    申请日：2012-04-24

    申请人： Kentaro Kogure ,  Susumu Hama

    发明人： Kentaro Kogure ,  Susumu Hama

    IPC分类号： A61K9/127 ,  A61K38/02

    CPC分类号： A61K38/02 ,  A61K38/03 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K38/16 ,  A61K47/6911 ,  A61K47/6913 ,  C07K2/00 ,  C07K7/06 ,  C07K14/00

    摘要： The present invention provides a nanoparticle and cell induction agent, capable of releasing a target substance in a weakly acidic pH environment. Specifically, the present invention provides a nanoparticle comprising a peptide and a particle-forming component, the particle-forming component forming a liposome or a micelle, the peptide having a sequence with 2 to 8 units starting with His (histidine) and ending with an acidic amino acid, wherein each of the units may be identical or different.

    摘要翻译： 本发明提供能够在弱酸性pH环境中释放目标物质的纳米粒子和细胞诱导剂。 具体而言，本发明提供了包含肽和成像成分的纳米粒子，形成粒子的成分构成脂质体或胶束，所述肽具有从His（组氨酸）开始的2〜8个单元的序列，以 酸性氨基酸，其中每个单元可以相同或不同。