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1.发明申请公开(公告)号：US20130046225A1
公开(公告)日：2013-02-21
申请号：US13394765
申请日：2010-10-07
申请人： Kazuhide Ohta , Hiroshi Miyamoto , Junji Takaba , Ako Nose
发明人： Yukihiko Nose , Kazuhide Ohta , Hiroshi Miyamoto , Junji Takaba
CPC分类号： A61K31/727 , A61K31/135 , A61M1/14 , A61M1/16 , A61M1/3486 , A61M1/3496 , A61M1/3621 , B01D15/00 , B01J20/00 , B01J20/22 , B01J2220/4825 , B01J2220/4831 , A61K2300/00
摘要： The invention provides a way of producing a natural immunologically active state in a person by subjecting him to an apheresis procedure with bioincompatible biomaterials for about one hour. To safely control the immunological shock induced by this procedure, the person is put under general anesthesia for about six hours, including the apheresis time and at least an additional five hours thereafter. This immunological activation is useful for treating malignant tumors and diseases related to immunosuppression, such as AIDS. The invention also provides for the use of an apheresis column containing a blood perfusion filter with bioincompatible materials for treating malignant tumors and infectious diseases.
摘要翻译： 本发明提供了一种通过使他与生物相容性生物材料进行约1小时的分离程序来在人体内产生天然的免疫活性状态的方法。 为了安全地控制由该程序引起的免疫休克，将该人全身麻醉约6小时，包括分离时间，此后至少另外5小时。 这种免疫激活可用于治疗恶性肿瘤和与免疫抑制相关的疾病，如艾滋病。 本发明还提供使用含有血液灌注过滤器的生物相容性材料用于治疗恶性肿瘤和感染性疾病的单采血液柱。
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2.发明授权公开(公告)号：US08926543B2
公开(公告)日：2015-01-06
申请号：US13394765
申请日：2010-10-07
申请人： Kazuhide Ohta , Hiroshi Miyamoto , Junji Takaba , Ako Nosé
发明人： Yukihiko Nosé , Kazuhide Ohta , Hiroshi Miyamoto , Junji Takaba
IPC分类号： A61M1/16 , A61M1/36 , A61K31/727 , A61M1/14 , A61K31/135 , A61M1/34 , B01J20/00 , B01D15/00 , B01J20/22
CPC分类号： A61K31/727 , A61K31/135 , A61M1/14 , A61M1/16 , A61M1/3486 , A61M1/3496 , A61M1/3621 , B01D15/00 , B01J20/00 , B01J20/22 , B01J2220/4825 , B01J2220/4831 , A61K2300/00
摘要： The invention provides a way of producing a natural immunologically active state in a person by subjecting him to an apheresis procedure with bioincompatible biomaterials for about one hour. To safely control the immunological shock induced by this procedure, the person is put under general anesthesia for about six hours, including the apheresis time and at least an additional five hours thereafter. This immunological activation is useful for treating malignant tumors and diseases related to immunosuppression, such as AIDS. The invention also provides for the use of an apheresis column containing a blood perfusion filter with bioincompatible materials for treating malignant tumors and infectious diseases.
摘要翻译： 本发明提供了一种通过使他与生物相容性生物材料进行约1小时的分离程序来在人体内产生天然的免疫活性状态的方法。 为了安全地控制由该程序引起的免疫休克，将该人全身麻醉约6小时，包括分离时间，此后至少另外5小时。 这种免疫激活可用于治疗恶性肿瘤和与免疫抑制相关的疾病，如艾滋病。 本发明还提供使用含有血液灌注过滤器的生物相容性材料用于治疗恶性肿瘤和感染性疾病的单采血液柱。
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公开(公告)号：US09850840B2
公开(公告)日：2017-12-26
申请号：US14900792
申请日：2013-06-26
CPC分类号： F02D41/126 , F01N3/08 , F01N13/009 , F01N2560/025 , F01N2560/14 , F01N2900/0416 , F02D41/1439 , F02D41/1441 , F02D41/1456 , F02D41/1495
摘要： An electronic control unit (ECU) of an internal combustion engine, which includes an air-fuel ratio sensor arranged at a downstream side of an exhaust purification catalyst, is configured to judge if a state of the air-fuel ratio sensor is normal or abnormal based on the first characteristic of change of air-fuel ratio and, if a judgment cannot be made based on the first characteristic, the ECU is configured to judge if the state of the air-fuel ratio sensor is normal or abnormal based on a second characteristic of change of air-fuel ratio. As a result, it is possible to suppress the effects of the change of state of the exhaust purification catalyst while accurately diagnosing the abnormality of deterioration of response of a downstream side air-fuel ratio sensor.
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公开(公告)号：US09719449B2
公开(公告)日：2017-08-01
申请号：US14900645
申请日：2013-06-26
CPC分类号： F02D41/1495 , F01N3/10 , F01N11/007 , F01N13/009 , F01N2550/02 , F01N2900/0416 , F01N2900/1624 , F02D41/0295 , F02D41/123 , F02D41/1441 , F02D41/1454 , F02D2041/228 , F02D2200/0814 , F02D2200/0816 , Y02T10/47
摘要： An internal combustion engine comprises an exhaust purification catalyst arranged in an exhaust passage of the internal combustion engine and being able to store oxygen in inflowing exhaust gas and an air-fuel ratio sensor arranged at a downstream side of the exhaust purification catalyst in a direction of exhaust flow and detecting an air-fuel ratio of exhaust gas flowing out from the exhaust purification catalyst and stops or decreases a feed of fuel to a combustion chamber as fuel cut control. The abnormality diagnosis system calculates a characteristic of change of an air-fuel ratio based on an output air-fuel ratio output from the air-fuel ratio sensor at the time when the output air-fuel ratio first passes a part of an air-fuel ratio region of a stoichiometric air-fuel ratio or more after an end of the fuel cut control, and diagnoses abnormality of the air-fuel ratio sensor based on the characteristic of change of the air-fuel ratio. As a result, the diagnosis system can diagnose the abnormality of deterioration of response of the downstream side air-fuel ratio sensor when necessary without fail when performing fuel cut control.
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5.发明授权公开(公告)号：US08833348B2
公开(公告)日：2014-09-16
申请号：US13194923
申请日：2011-07-30
申请人： Yasushi Iwazaki , Hiroshi Miyamoto
发明人： Yasushi Iwazaki , Hiroshi Miyamoto
CPC分类号： F02D41/1456 , F02D41/0085 , F02D41/1401 , F02D41/1441 , F02D41/182 , F02D41/2454 , F02D2041/1432 , F02D2200/101
摘要： A fuel injection amount control system acquires a pre-correction air-fuel ratio imbalance index value that increases as the degree of ununiformity in the air-fuel ratio among cylinders increases, based on an output value of an upstream air-fuel ratio sensor, and obtains a value (intake air amount correlation value) corresponding to the intake air amount and a value (engine speed correlation value) corresponding to the engine speed over a period in which the pre-correction air-fuel ratio imbalance index value is acquired. Also, a post-correction air-fuel ratio imbalance index value is acquired by correcting the pre-correction air-fuel ratio imbalance index value based on the intake air amount correlation value and the engine speed correlation value, and the air-fuel ratio of the engine is controlled based on the post-correction air-fuel ratio imbalance index value.
摘要翻译： 燃料喷射量控制系统获取基于上游空燃比传感器的输出值随着气缸中的空燃比的不均匀度增加而增加的预校正空燃比不平衡指数值，以及 获取与获取预校正空燃比不平衡指数值的期间对应的与进气量对应的值（进气量相关值）和与发动机转速对应的值（发动机转速相关值）。 此外，通过基于进气量相关值和发动机转速相关值校正预校正空燃比不平衡指数值来获取校正后空燃比不平衡指数值，并且， 基于校正后的空燃比不平衡指数值来控制发动机。
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6.发明申请公开(公告)号：US20140129116A1
公开(公告)日：2014-05-08
申请号：US14072374
申请日：2013-11-05
IPC分类号： F02D41/02
CPC分类号： F02D41/1495 , F02D41/1441 , F02D41/1498 , F02D2250/24
摘要： An inter-cylinder air-fuel ratio variation abnormality detection apparatus for a multicylinder internal combustion engine according to the present invention detects variation abnormality based on a rotational fluctuation of the internal combustion engine. Number-of-rotations feedback control is preformed to make the number of rotations of the internal combustion engine equal to a predetermined target number of rotations. The amount of power generated by a power generation device driven by the internal combustion engine is controlled so as to bring the load on the internal combustion engine into a target range when the abnormality detection is carried out.
摘要翻译： 根据本发明的用于多缸内燃机的缸内空燃比变化异常检测装置基于内燃机的旋转波动检测变化异常。 进行转数反馈控制以使内燃机的转数等于预定的目标转数。 控制由内燃机驱动的发电装置产生的动力量，以便在执行异常检测时使内燃机的负荷达到目标范围。
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7.发明授权公开(公告)号：US08700290B2
公开(公告)日：2014-04-15
申请号：US13185015
申请日：2011-07-18
申请人： Hiroshi Miyamoto , Yasushi Iwazaki
发明人： Hiroshi Miyamoto , Yasushi Iwazaki
CPC分类号： F02D41/1495 , F02D41/0037 , F02D41/0085 , F02D41/1441 , F02D41/1456 , F02D41/2441 , F02D41/2454
摘要： When the ratio of the amount of vaporized fuel (purge amount) to be introduced into an intake passage of an engine from a fuel tank through a purge passage pipe, a purge control valve, etc. to the total amount of fuel (total fuel amount) to be supplied to the engine is large, an abnormality determination system acquires, as a parameter Pon, the air-fuel ratio imbalance index value that increases as the difference between the air-fuel ratios of the respective cylinders increases. When the purge amount is small relative to the total fuel amount, the determination system acquires the air-fuel ratio imbalance index value as a parameter Poff. When the difference between the parameters Pon and Poff is less than a predetermined value and at least one of these parameters is greater than a predetermined threshold value, the determination system determines that an inter-cylinder air intake amount variation abnormality is occurring.
摘要翻译： 当要从燃料箱通过吹扫通道管，净化控制阀等引入发动机的进气通道中的汽化燃料量（吹扫量）与燃料总量的比例（总燃料量 ），异常判定系统作为参数Pon获取随着各气缸的空燃比的差增大而增加的空燃比不平衡指数值。 当清除量相对于总燃料量小时，确定系统获取作为参数Poff的空燃比不平衡指数值。 当参数Pon和Poff之间的差小于预定值并且这些参数中的至少一个大于预定阈值时，确定系统确定发生了气缸间进气量变化异常。
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8.发明授权公开(公告)号：US08560208B2
公开(公告)日：2013-10-15
申请号：US13505849
申请日：2009-11-05
IPC分类号： B60T7/12
CPC分类号： F02D41/0085 , F02D41/0065 , F02D41/1454 , Y02T10/47
摘要： An inter-cylinder air-fuel ratio imbalance determination apparatus (determination apparatus) according to the present invention obtains, as an “EGR supplying state imbalance determination parameter”, a value corresponding to a differential value d(abyfs)dt of a detected air-fuel ratio abyfs represented by an output value of an air-fuel ratio sensor when an EGR gas is being supplied, and obtains, as an “EGR stop state imbalance determination parameter”, a value corresponding to a differential value d(abyfs)dt when an EGR gas supply is being stopped. The determination apparatus obtains an “EGR-causing imbalance determination parameter Pegr” by subtracting the EGR stop state imbalance determination parameter Poff from the EGR supplying state imbalance determination parameter Pon, and determines that an inter-cylinder air-fuel ratio imbalance state has occurred due to the supply of the EGR gas when the parameter Pegr is larger than a threshold Pegrth.
摘要翻译： 根据本发明的气缸内空燃比不平衡判定装置（判定装置），作为“EGR供给状态不平衡判定参数”，获得与检测到的空气 - 燃料比不平衡判定装置的差分值d（abyfs）dt对应的值， 在EGR气体供给时由空燃比传感器的输出值表示的燃料比abyfs，作为“EGR停止状态不平衡判定参数”，获得与差分值d（abyfs）dt对应的值 正在停止EGR气体供应。 确定装置通过从EGR供应状态不平衡确定参数Pon中减去EGR停止状态不平衡确定参数Poff而获得“EGR导致不平衡确定参数Pegr”，并且确定缸间空燃比不平衡状态已经发生 当参数Pegr大于阈值Pegrth时，供应EGR气体。
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9.发明申请公开(公告)号：US20130261934A1
公开(公告)日：2013-10-03
申请号：US13871249
申请日：2013-04-26
IPC分类号： F02D41/00
CPC分类号： F02D41/00 , F02D41/0042 , F02D41/0085 , F02D41/1454 , F02D41/2441 , F02D41/2454
摘要： An apparatus for determining an air-fuel ratio imbalance among cylinders based on an output value of an air-fuel ratio sensor, an imbalance determination parameter which becomes larger or smaller as a difference among air-fuel ratios becomes larger, and performs determining an air-fuel ratio imbalance among cylinders based on a result of a comparison between the imbalance determination parameter and a imbalance determination threshold. The determining apparatus calculates a purge correction coefficient which compensates for a change in the air-fuel ratio due to an evaporated fuel gas which is generated in a fuel tank, while the evaporated fuel gas is being introduced into an intake passage, and corrects a fuel injection amount with the purge correction coefficient FPG.
摘要翻译： 一种用于基于空燃比传感器的输出值来确定气缸之间的空燃比不平衡的装置，作为空燃比之差变大或变小的不平衡确定参数变大，并且执行空气 - 基于不平衡确定参数和不平衡确定阈值之间的比较的结果，气缸之间的燃料比不平衡。 确定装置计算净化校正系数，其补偿由于在燃料箱中产生的蒸发燃料气体而引起的空燃比的变化，同时蒸发的燃料气体被引入进气通道中，并且校正燃料 喷射量与净化校正系数FPG。
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10.发明申请公开(公告)号：US20130253802A1
公开(公告)日：2013-09-26
申请号：US13827660
申请日：2013-03-14
IPC分类号： F02D43/04
CPC分类号： F02D43/04 , F02D41/008 , F02D41/1456 , F02D41/1495 , F02D2041/001 , F02D2250/34
摘要： An air-fuel ratio imbalance detection apparatus includes an air-fuel ratio sensor that is arranged in an exhaust passage of an internal combustion engine and that includes an electrode and a diffusion layer provided on the electrode; an estimating unit configured to estimate or detect an output variation amount that is an amount of variation in an output of the air-fuel ratio sensor due to an influence of a pressure pulsation of exhaust gas from the internal combustion engine; and a determination unit configured to determine whether there is an air-fuel ratio imbalance among cylinders of the internal combustion engine, on the basis of the output variation amount and a determination value based on the output of the air-fuel ratio sensor.
摘要翻译： 空燃比不平衡检测装置包括：空燃比传感器，其设置在内燃机的排气通路中，并且包括设置在电极上的电极和扩散层; 估计单元，其被配置为估计或检测作为所述空燃比传感器的输出的变化量的输出变化量，所述输出变化量是由于来自所述内燃机的废气的压力脉动的影响; 以及确定单元，被配置为基于所述输出变化量和基于所述空燃比传感器的输出的确定值来确定所述内燃机的气缸中是否存在空燃比不平衡。
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