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公开(公告)号：US06354810B1
公开(公告)日：2002-03-12
申请号：US09583785
申请日：2000-05-31
IPC分类号： F04B129
CPC分类号： F16K15/025 , F04B27/1036 , F04B27/1804 , F04B49/225 , Y10T137/7738 , Y10T137/7925
摘要： A variable capacity type compressor has a swash plate, pistons reciprocating in the cylinder bores, a suction chamber, and a discharge chamber. A check valve arranged in the compressor. The check valve has a valve seat member having a flow passage and a valve seat, a case attached to the valve seat member, and a valve element arranged in the case for cooperation with the valve seat. The case has a communication hole formed therethrough to allow the gas to flow from the flow passage through the communication hole to the outside circuit. An annular groove is formed in the outer peripheral surface of the valve element to allow a leaking gas to flow from the clearance space between the valve element and the valve housing to the exterior of the valve housing.
摘要翻译： 可变容量型压缩机具有斜盘，活塞在气缸孔中往复运动，吸入室和排出室。 设置在压缩机中的止回阀。 止回阀具有具有流路和阀座的阀座构件，附接到阀座构件的壳体和布置在壳体中用于与阀座配合的阀元件。 壳体具有穿过其形成的连通孔，以允许气体从流动通道通过连通孔流到外部回路。 在阀元件的外周面形成有环状的槽，使泄漏的气体从阀体与阀壳体之间的间隙空气流向阀壳体的外部。
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2.发明授权Compressor control valve with two independently operated check valves, wherein the crank chamber pressure is the control pressure, and the monitor pressure is the suction pressure 失效具有两个独立操作止回阀的压缩机控制阀，其中曲柄室压力为控制压力，监测压力为吸入压力公开(公告)号：US06514049B2
公开(公告)日：2003-02-04
申请号：US09922399
申请日：2001-08-03
申请人： Minoru Mera , Hideki Mizutani , Kazuya Kimura , Masahiro Kawaguchi , Takeshi Imanishi , Hiroaki Kayukawa
发明人： Minoru Mera , Hideki Mizutani , Kazuya Kimura , Masahiro Kawaguchi , Takeshi Imanishi , Hiroaki Kayukawa
IPC分类号： F04B126
CPC分类号： F04B27/1804 , F04B2027/1813 , F04B2027/1827 , F04B2027/1831 , F04B2027/1859 , Y10T137/87499 , Y10T137/87507
摘要： A control valve is used in connection with a variable displacement compressor that varies the discharge capacity by controlling an inclination of a cam plate located in a crank chamber. The inclination of the cam plate is variable based on crank chamber pressure caused by refrigerant in the crank chamber. Monitor pressure is monitored at a predetermined point in a refrigerant circuit for causing a change in the crank chamber pressure and ultimately varying the discharge capacity. The control valve has a housing, an internal control valve mechanism and an external control valve mechanism. The internal control valve mechanism is located inside the valve housing and has a first valve body and a first reacting member. The first reacting member is connected to the first valve body for reacting to the monitor pressure to cause a change in the crank chamber pressure. The external control valve mechanism is located inside the valve housing and has a second valve body and a second reacting member. The second reacting member is for reacting to an external signal to cause the second valve body to change in the crank chamber pressure. The internal control valve mechanism and the external control valve mechanism operate independently with each other.
摘要翻译： 控制阀与可变排量压缩机结合使用，其通过控制位于曲柄室中的凸轮板的倾角来改变排出容量。 凸轮板的倾斜度基于由曲柄室中的制冷剂引起的曲轴室压力而变化。 在制冷剂回路中的预定点处监视压力，以使曲轴室压力发生变化并最终改变放电容量。 控制阀具有壳体，内部控制阀机构和外部控制阀机构。 内部控制阀机构位于阀壳体内部并具有第一阀体和第一反作用构件。 第一反应构件连接到第一阀体，用于对监测压力作出反应以引起曲柄室压力的变化。 外部控制阀机构位于阀壳体内部并具有第二阀体和第二反作用构件。 第二反应构件用于使外部信号反应，使第二阀体改变曲柄室压力。 内部控制阀机构和外部控制阀机构彼此独立运行。
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公开(公告)号：US06337141B1
公开(公告)日：2002-01-08
申请号：US09464775
申请日：1999-12-16
申请人： Toyokazu Yamada , Soo-Myung Hong , Masanori Akiduki , Takashi Kokubo , Hiroaki Kayukawa , Hideki Mizutani , Manabu Sugiura , Takeshi Imanishi
发明人： Toyokazu Yamada , Soo-Myung Hong , Masanori Akiduki , Takashi Kokubo , Hiroaki Kayukawa , Hideki Mizutani , Manabu Sugiura , Takeshi Imanishi
IPC分类号： C23C406
CPC分类号： C23C4/06 , C23C4/04 , F04B27/086 , F04B27/1054 , F05C2201/021 , F05C2201/903 , F05C2203/06 , F05C2253/12 , Y10S428/937 , Y10T428/12063 , Y10T428/12139 , Y10T428/12167 , Y10T428/12174 , Y10T428/1275 , Y10T428/12757 , Y10T428/12764
摘要： The seizure resistance of an Al-based flame-sprayed layer formed on the swash plate of a swash-plate type comressor is increased to such a level comparable to that of a flame-sprayed bronze layer. The Al-based flame-sprayed layer of the present invention contains: from 12 to 60% of Si and granular Si particles dispersed in the matrix thereof, and at least one dispersing phase of graphite carbon, amorphous carbon and carbon, the crystallizing degree of which is between the graphite carbon and amorphous carbon, and MoS2.
摘要翻译： 形成在旋转斜盘式压缩机的旋转斜盘上的Al系火焰喷涂层的耐发泡性提高到与火焰喷镀的青铜层相当的水平。 本发明的Al系火焰喷涂层含有12〜60％的分散在基体中的Si和粒状Si粒子，以及石墨碳，无定形碳和碳的至少一种分散相，其结晶度为 在石墨碳和无定形碳之间，和MoS2。
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公开(公告)号：US07994145B2
公开(公告)日：2011-08-09
申请号：US11700361
申请日：2007-01-31
申请人： Takeshi Imanishi , Satoshi Obika
发明人： Takeshi Imanishi , Satoshi Obika
摘要： Oligonucleotide analogues which have anti-sense or anti-gene activity, as well as in vivo stability, or pharmaceutically acceptable salts thereof. The oligonucleotide analogues have one or more structural units represented by the following formula (1a): provided that when the oligonucleotide has two or more structural units of formula (1a), each B is the same or different, wherein B represents a purin-9-yl group or a 2-oxo-1,2-dihydropyrimidin-1-yl group.
摘要翻译： 具有反义或抗基因活性的寡核苷酸类似物，以及体内稳定性或其药学上可接受的盐。 寡核苷酸类似物具有一个或多个由下式（1a）表示的结构单元：条件是当寡核苷酸具有两个或更多个式（1a）的结构单元时，每个B相同或不同，其中B表示嘌呤-9 - 基或2-氧代-1,2-二氢嘧啶-1-基。
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公开(公告)号：US6043060A
公开(公告)日：2000-03-28
申请号：US308367
申请日：1999-05-18
申请人： Takeshi Imanishi
发明人： Takeshi Imanishi
IPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , C12N15/113
CPC分类号： C12N15/113 , C07H19/10 , C07H19/20 , C07H21/00 , C12N2310/3231
摘要： An oligonucleotide analog or an antisense molecule, which is minimally hydrolyzable with an enzyme in vivo, has a high sense strand binding ability, and is easily synthesized, is provided. It is an oligo- or polynucleotide analog containing one or more monomer units being nucleotide analogs of the general formula: ##STR1## where B may be identical or different, and is a pyrimidine or purine nucleic acid base, or a derivative thereof.
摘要翻译： PCT No.PCT / JP97 / 04187 Sec。 371日期1999年5月18日 102（e）日期1999年5月18日PCT 1997年11月18日PCT公布。 公开号WO98 / 22489 日期1998年5月28日在体内用酶最低限度地水解的寡核苷酸类似物或反义分子具有高有义链结合能力，容易合成。 它是含有一个或多个单体单元的寡核苷酸或多核苷酸类似物，其是通式的核苷酸类似物：其中B可以相同或不同，并且是嘧啶或嘌呤核酸碱基或其衍生物。
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公开(公告)号：US20110009471A1
公开(公告)日：2011-01-13
申请号：US12804500
申请日：2010-07-22
申请人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
发明人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
IPC分类号： A61K31/7088 , A61K31/7084 , A61P29/00 , A61P17/06 , A61P31/18 , A61P31/22 , A61P31/16 , A61P35/00 , C07H21/04 , C12P19/34 , G01N33/50
摘要： A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.
摘要翻译： 一种用于预防或治疗哺乳动物的疾病，其可通过所述哺乳动物体内的寡核苷酸类似物或其药理学上可接受的盐的药理学上有用的反义或反应活性可预防或治疗的疾病，所述方法包括向需要的所述哺乳动物施用 这样的预防或治疗药物有效量的包含两个或多个核苷单位的寡核苷酸类似物，其中所述核苷单元中的至少一个是式（2）的结构：其中A是亚甲基; 和B是未取代的嘌呤-9-基，未取代的2-氧代 - 嘧啶-1-基或取代的嘌呤-9-基; 或其药理学上可接受的盐。
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公开(公告)号：US07816333B2
公开(公告)日：2010-10-19
申请号：US11881775
申请日：2007-07-27
申请人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
发明人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
摘要： A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.
摘要翻译： 一种用于预防或治疗哺乳动物的疾病，其可通过所述哺乳动物体内的寡核苷酸类似物或其药理学上可接受的盐的药理学上有用的反义或反应活性可预防或治疗的疾病，所述方法包括向需要的所述哺乳动物施用 这样的预防或治疗药物有效量的包含两个或多个核苷单位的寡核苷酸类似物，其中所述核苷单元中的至少一个是式（2）的结构：其中A是亚甲基; 和B是未取代的嘌呤-9-基，未取代的2-氧代 - 嘧啶-1-基或取代的嘌呤-9-基; 或其药理学上可接受的盐。
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公开(公告)号：US20090149404A1
公开(公告)日：2009-06-11
申请号：US11881775
申请日：2007-07-27
申请人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
发明人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
IPC分类号： A61K31/7084 , C12Q1/68 , C07H21/00
摘要： A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.
摘要翻译： 一种用于预防或治疗哺乳动物的疾病，其可通过所述哺乳动物体内的寡核苷酸类似物或其药理学上可接受的盐的药理学上有用的反义或反应活性可预防或治疗的疾病，所述方法包括向需要的所述哺乳动物施用 这样的预防或治疗药物有效量的包含两个或多个核苷单位的寡核苷酸类似物，其中所述核苷单元中的至少一个是式（2）的结构：其中A是亚甲基; 和B是未取代的嘌呤-9-基，未取代的2-氧代 - 嘧啶-1-基或取代的嘌呤-9-基; 或其药理学上可接受的盐。
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公开(公告)号：US20070270370A1
公开(公告)日：2007-11-22
申请号：US11700361
申请日：2007-01-31
申请人： Takeshi Imanishi , Satoshi Obika
发明人： Takeshi Imanishi , Satoshi Obika
IPC分类号： A61K31/7088 , A61P17/00 , A61P17/06 , A61P31/04 , A61P31/12 , A61P31/16 , A61P31/18 , A61P35/00 , A61P43/00 , C07H21/00
摘要： Oligonucleotide analogues which have anti-sense or anti-gene activity, as well as in vivo stability, or pharmaceutically acceptable salts thereof. The oligonucleotide analogues have one or more structural units represented by the following formula (1a): provided that when the oligonucleotide has two or more structural units of formula (1a), each B is the same or different, wherein B represents a purin-9-yl group or a 2-oxo-1,2-dihydropyrimidin-1-yl group.
摘要翻译： 具有反义或抗基因活性的寡核苷酸类似物，以及体内稳定性或其药学上可接受的盐。 寡核苷酸类似物具有一个或多个由下式（1a）表示的结构单元：条件是当寡核苷酸具有两个或更多个式（1a）的结构单元时，每个B相同或不同，其中B表示嘌呤-9 - 基或2-氧代-1,2-二氢嘧啶-1-基。
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10.发明申请Nucloeside analogues and oligonucleotide derivative comprising nucleotide analogue thereof 有权核苷酸类似物和包含其核苷酸类似物的寡核苷酸衍生物公开(公告)号：US20060166908A1
公开(公告)日：2006-07-27
申请号：US10504165
申请日：2003-02-13
申请人： Takeshi Imanishi , Satoshi Obika
发明人： Takeshi Imanishi , Satoshi Obika
IPC分类号： A61K48/00 , C07F9/6512 , C07H21/02
摘要： Compounds of the following general formula (1) and salts thereof: where A represents a direct bond, an alkylene group having 1 to 4 carbon atoms, etc.; B represents an aromatic heterocyclic group which may have a substituent, etc.; R1, R2, R3 and R4 each represent a hydrogen atom, a protective group for an amino group, a protective group for a hydroxyl group, a phosphate group, or —P(R7)R8 [where R7 and R8 each represent a hydroxyl group, a protected hydroxyl group, a mercapto group, a protected mercapto group, etc.]. These compounds are useful as oligonucleotide analogues useful for the antisense method, and as nucleoside analogues for producing their intermediates.
摘要翻译： 下列通式（1）的化合物及其盐：其中A表示直接键，含有1至4个碳原子的亚烷基等; B表示可具有取代基的芳香族杂环基等。 R 1，R 2，R 3和R 4各自表示氢原子，保护基为 氨基，羟基的保护基，磷酸基或-P（R 7）R 8 [其中R 7和/ R 8各自表示羟基，被保护的羟基，巯基，保护的巯基等〕。 这些化合物可用作用于反义方法的寡核苷酸类似物，以及用作产生其中间体的核苷类似物。
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