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    METHOD FOR OBTAINING INFORMATION AND DEVICE THEREFOR
    6.
    发明申请
    METHOD FOR OBTAINING INFORMATION AND DEVICE THEREFOR 有权
    获取信息的方法及其设备

    公开(公告)号：US20080179512A1

    公开(公告)日：2008-07-31

    申请号：US12017584

    申请日：2008-01-22

    申请人： Manabu Komatsu ,  Hiroyuki Hashimoto ,  Yohei Murayama ,  Kazuhiro Ban

    发明人： Manabu Komatsu ,  Hiroyuki Hashimoto ,  Yohei Murayama ,  Kazuhiro Ban

    IPC分类号： B01D59/44

    CPC分类号： H01J49/142

    摘要： A method for obtaining information on a mass of an object by time-of-flight mass spectrometry. This method includes placing colloidal metal particles for promoting ionization of the object inside the object at a depth ranging from 0.1 nm to 100 nm in opposition to a primary beam for the ionization; irradiating the object with the primary beam selected from the group of ions, neutral particles, and electrons, which can be focused, pulsed, and are capable of scanning, and laser beams, which can be focused, pulsed, and are capable of scanning to ionize a constituent of the object and to allow the ionized constituent to fly out of the object; and obtaining information on the mass of the flying constituent of the object by time-of-flight mass spectrometry.

    摘要翻译： 一种通过飞行时间质谱法获得物体质量信息的方法。 该方法包括将胶体金属颗粒放置在与离子化的主光束相反的0.1nm至100nm范围内的物体内部物体的离子化; 用可以被聚焦，脉冲和能够扫描的离子，中性粒子和电子组中选择的主要束照射物体，以及可以被聚焦，脉冲且能够扫描的激光束 电离物体的成分并使离子化成分从物体飞出; 并通过飞行时间质谱法获得关于物体飞行成分质量的信息。

    Method for treating living samples and analyzing the same
    7.
    发明授权
    Method for treating living samples and analyzing the same 有权
    处理活体样本并进行分析的方法

    公开(公告)号：US09086404B2

    公开(公告)日：2015-07-21

    申请号：US11867276

    申请日：2007-10-04

    申请人： Manabu Komatsu ,  Hiroyuki Hashimoto ,  Kazuhiro Ban ,  Yohei Murayama

    发明人： Manabu Komatsu ,  Hiroyuki Hashimoto ,  Kazuhiro Ban ,  Yohei Murayama

    IPC分类号： G01N33/50 ,  G01N35/10

    CPC分类号： G01N33/5082 ,  G01N35/1002 ,  G01N2035/1041

    摘要： A method is provided by which a reagent is provided to a living sample, including contacting a thin-film containing a porous body with a living sample containing cells or tissues, and discharging a solution containing at least one or more reagents to a non-contact side of the thin-film by ink-jet to provide the solution to the specific area of the living sample through pores on the thin-film, wherein the smaller diameter of the pores on the porous body relative to the diameter of cells in the living sample enables the reagent to be provided to each individual cell separately. According to this method, the reagent and the reaction product can be fixed while maintaining positioning information of the target substance in the living sample, as a pretreatment for analyzing with high positioning accuracy the target substance in each individual cell in the living sample.

    摘要翻译： 提供了一种将试剂提供给活体样品的方法，包括使含有多孔体的薄膜与含有细胞或组织的活体样品接触，并将含有至少一种或多种试剂的溶液排出至非接触 通过喷墨使薄膜的一侧通过薄膜上的孔提供到活体样品的特定区域的溶液，其中多孔体上的孔的直径相对于活体中细胞的直径较小 样品使得可以分别向每个单独的细胞提供试剂。 根据该方法，可以在维持活体样品中的目标物质的定位信息的同时固定试剂和反应产物，作为用于以高定位精度分析活体样品中各个细胞中的目标物质的预处理。

    Method for obtaining information and device therefor
    8.
    发明授权
    Method for obtaining information and device therefor 有权
    获取信息的方法及其设备

    公开(公告)号：US07851749B2

    公开(公告)日：2010-12-14

    申请号：US12017584

    申请日：2008-01-22

    申请人： Manabu Komatsu ,  Hiroyuki Hashimoto ,  Yohei Murayama ,  Kazuhiro Ban

    发明人： Manabu Komatsu ,  Hiroyuki Hashimoto ,  Yohei Murayama ,  Kazuhiro Ban

    IPC分类号： H01J49/00

    CPC分类号： H01J49/142

    摘要： A method for obtaining information on a mass of an object by time-of-flight mass spectrometry. This method includes placing colloidal metal particles for promoting ionization of the object inside the object at a depth ranging from 0.1 nm to 100 nm in opposition to a primary beam for the ionization; irradiating the object with the primary beam selected from the group of ions, neutral particles, and electrons, which can be focused, pulsed, and are capable of scanning, and laser beams, which can be focused, pulsed, and are capable of scanning to ionize a constituent of the object and to allow the ionized constituent to fly out of the object; and obtaining information on the mass of the flying constituent of the object by time-of-flight mass spectrometry.

    摘要翻译： 一种通过飞行时间质谱法获得物体质量信息的方法。 该方法包括将胶体金属颗粒放置在与离子化的主光束相反的0.1nm至100nm范围内的物体内部物体的离子化; 用可以被聚焦，脉冲和能够扫描的离子，中性粒子和电子组中选择的主要束照射物体，以及可以被聚焦，脉冲且能够扫描的激光束 电离物体的成分并使离子化成分从物体飞出; 并通过飞行时间质谱法获得关于物体飞行成分质量的信息。

    Information obtaining method
    9.
    发明授权
    Information obtaining method 有权
    信息获取方法

    公开(公告)号：US07795579B2

    公开(公告)日：2010-09-14

    申请号：US12120512

    申请日：2008-05-14

    申请人： Manabu Komatsu ,  Hiroyuki Hashimoto ,  Yohei Murayama ,  Kazuhiro Ban

    发明人： Manabu Komatsu ,  Hiroyuki Hashimoto ,  Yohei Murayama ,  Kazuhiro Ban

    IPC分类号： B01D59/44

    CPC分类号： H01J49/145

    摘要： An information obtaining method for obtaining information about a mass of a component of an analyte using a time of flight mass spectrometer and obtaining information about a distribution state of the component based on the obtained information about the mass includes the step of: (1) adding a self-reactive substance to the analyte on a base to facilitate ionization of the component; (2) irradiating the analyte with a primary beam in the presence of the self-reactive substance, thereby ionizing the components and allowing resulting ions to fly; (3) obtaining information about mass of the flying ions using the time of flight mass spectrometer; and (4) obtaining information about the distribution state of the component on the base based on the information about the mass.

    摘要翻译： 使用飞行时间质谱仪获取关于分析物的成分的质量的信息的信息获取方法，基于获得的关于质量的信息获得关于部件的分布状态的信息，包括以下步骤：（1）添加 对基底上的分析物的自反应物质，以促进组分的离子化; （2）在存在自反应物质的情况下用主光束照射分析物，从而电离成分并允许所得离子飞行; （3）使用飞行时间质谱仪获取关于飞行离子质量的信息; 和（4）基于关于质量的信息获得关于组件在基础上的分布状态的信息。