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    DIAGNOSTIC AGENT FOR INFECTIOUS DISEASES
    1.
    发明申请
    DIAGNOSTIC AGENT FOR INFECTIOUS DISEASES 审中-公开
    感染性疾病诊断剂

    公开(公告)号：US20120219500A1

    公开(公告)日：2012-08-30

    申请号：US13504318

    申请日：2010-10-25

    申请人： Kazuhisa Sakurai ,  Akio Nagano

    发明人： Kazuhisa Sakurai ,  Akio Nagano

    IPC分类号： A61K51/04 ,  G01N33/569 ,  C07F5/00 ,  C07D233/91 ,  C07D233/95 ,  C07D233/94 ,  A61K49/00

    CPC分类号： G01N33/52 ,  A61K51/0453 ,  A61K51/0455 ,  A61K51/0463 ,  C12Q1/025 ,  C12Q1/18 ,  G01N33/569 ,  G01N2333/205 ,  G01N2333/35

    摘要： A diagnostic agent for infectious diseases which is capable of distinguishing among different kinds of bacterial species and which allows simple and non-invasive measurement and/or imaging in a short period of time is provided; and a screening method for a therapeutic agent for infectious diseases caused by microorganisms are provided.A diagnostic agent for infectious diseases caused by nitroimidazole susceptible microorganisms, containing an imidazole derivative or a fused imidazole derivative having at least one nitro group on an imidazole ring, or a labeled form thereof as an active ingredient is provided.

    摘要翻译： 提供能够区分不同种类的细菌种类并且允许在短时间内进行简单和非侵入性测量和/或成像的感染性疾病诊断剂; 并提供了由微生物引起的感染性疾病的治疗剂的筛选方法。 提供了由咪唑衍生物或咪唑环上具有至少一个硝基的稠合咪唑衍生物或其标记形式作为有效成分的由硝基咪唑易感微生物引起的感染性疾病的诊断剂。

    DIAGNOSTIC AGENT AND THERAPEUTIC AGENT FOR DISEASE ASSOCIATED WITH HEPATOCYTE GROWTH FACTOR RECEPTOR
    2.
    发明申请
    DIAGNOSTIC AGENT AND THERAPEUTIC AGENT FOR DISEASE ASSOCIATED WITH HEPATOCYTE GROWTH FACTOR RECEPTOR 审中-公开
    与肝细胞生长因子受体相关的疾病诊断药物和治疗药物

    公开(公告)号：US20090169473A1

    公开(公告)日：2009-07-02

    申请号：US12091299

    申请日：2006-10-24

    申请人： Tsunehiko Nishimura ,  Akio Nagano

    发明人： Tsunehiko Nishimura ,  Akio Nagano

    IPC分类号： A61K51/08 ,  A61K49/00 ,  A61K38/16

    CPC分类号： G01N33/74 ,  A61K38/1833 ,  A61K51/088 ,  G01N33/57484 ,  G01N2333/4753 ,  G01N2800/323

    摘要： Disclosed is a diagnostic agent which is useful for imaging the site of application at which the highest therapeutic effect is expected (i.e., the site where an HGF receptor is expressed) in the therapy of an ischemic disease with an HGF plasmid for the purpose of promoting the angiogenesis with good efficiency.The diagnostic agent is for a disease associated with a hepatocyte growth factor receptor. wherein the drug includes: a labeled product of a partial polypeptide of hepatocyte growth factor containing a heparin-binding domain; or a labeled product of a polypeptide which consisting of an amino acid sequence in which one or several amino acid residues are substituted, deleted or added to the amino acid sequence of the partial polypeptide and having a heparin-binding activity.

    摘要翻译： 公开了一种诊断剂，其用于对用于促进HGF质粒的缺血性疾病的治疗中期望具有最高治疗效果（即HGF受体表达的部位）的应用部位的成像 血管生成效率高。 诊断剂用于与肝细胞生长因子受体相关的疾病。 其中所述药物包括：含有肝素结合结构域的肝细胞生长因子的部分多肽的标记产物; 或多肽的标记产物，其由一个或多个氨基酸残基被取代，缺失或添加到部分多肽的氨基酸序列中并且具有肝素结合活性的氨基酸序列组成。

    Ultrasonic wave generator
    5.
    发明授权
    Ultrasonic wave generator 失效
    超声波发生器

    公开(公告)号：US3967143A

    公开(公告)日：1976-06-29

    申请号：US513752

    申请日：1974-10-10

    申请人： Akinori Watanabe ,  Katsuhide Tanoshima ,  Takao Ando ,  Akira Tohama ,  Akio Nagano

    发明人： Akinori Watanabe ,  Katsuhide Tanoshima ,  Takao Ando ,  Akira Tohama ,  Akio Nagano

    IPC分类号： B06B1/02 ,  H01L41/04

    CPC分类号： B06B1/0261 ,  B06B1/0276 ,  B06B2201/55

    摘要： The ultrasonic wave generator of the present invention always drives a transducer with the resonant frequency f.sub.o of the transducer. Although the resonant frequency f.sub.o changes due to the temperature change etc., the driving frequency automatically follows the change of the resonant frequency f.sub.o. The control of the driving frequency is performed by means of a feed-back loop including a voltage controlled oscillator and means for applying a control signal to said voltage controlled oscillator according to the amplitude and/or phase of the driving signal of the transducer.

    摘要翻译： 本发明的超声波发生器总是驱动具有换能器的谐振频率fo的换能器。 虽然谐振频率fo由于温度变化等而变化，但驱动频率自动跟随谐振频率fo的变化。 驱动频率的控制通过包括压控振荡器的反馈回路和根据换能器的驱动信号的幅度和/或相位向所述压控振荡器施加控制信号的装置来执行。