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1.发明申请Polycationically Charged Polymer and the Use of the Same as a Carrier for Nucleic Acid 有权聚阳离子充电聚合物及其作为核酸载体的用途公开(公告)号：US20080249049A1
公开(公告)日：2008-10-09
申请号：US11884146
申请日：2006-02-08
申请人： Kazunori Kataoka , Keiji Itaka , Nobuhiro Nishiyama , Shigeto Fukushima , Woo-Dong Jang , Kanjiro Miyata , Masataka Nakanishi , Shunsaku Asano , Naoki Kanayama
发明人： Kazunori Kataoka , Keiji Itaka , Nobuhiro Nishiyama , Shigeto Fukushima , Woo-Dong Jang , Kanjiro Miyata , Masataka Nakanishi , Shunsaku Asano , Naoki Kanayama
CPC分类号： A61K48/0041 , A61K47/60 , A61K47/6455 , C08G18/0814 , C08G63/6854 , C08G69/10 , C08G73/028 , C08G73/0293 , C12N15/88
摘要： A composition for the delivery of nucleic acid to target cells or tissues, which comprises polycationically charged polymer as a carrier of nucleic acid is provided. Said polycationically charged polymer is a polymer which may comprise a charged polymer segment having a main chain based on poly(amino acid), polysaccharide, polyester, polyether, polyurethane or vinyl polymer and having, as a side chain, a group of formula —NH—(CH2)a—(NH(CH2)2)e—NH2 (wherein a and e independently denote an integer of 1 to 5) which is connected to said main chain either directly or via a linker. This composition is low-toxic, and has a high efficiency in introducing nucleic acid into cells.
摘要翻译： 提供了用于将核酸递送至靶细胞或组织的组合物，其包含作为核酸载体的聚阳离子带电聚合物。 所述聚阳离子带电聚合物是聚合物，其可以包含带有聚合物链段，该聚合物链段具有基于聚（氨基酸），多糖，聚酯，聚醚，聚氨酯或乙烯基聚合物的主链，并且具有作为侧链的式-NH - （CH 2）2 - （NH（CH 2）2） - （CH 2） 其中a和e独立地表示1〜5的整数），其直接或通过连接体与所述主链连接。 该组合物是低毒的，并且在将核酸引入细胞中具有高效率。
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2.发明授权Polycationically charged polymer and the use of the same as a carrier for nucleic acid 有权聚阳离子电荷的聚合物和其作为核酸的载体的使用公开(公告)号：US07829657B2
公开(公告)日：2010-11-09
申请号：US11884146
申请日：2006-02-08
申请人： Kazunori Kataoka , Keiji Itaka , Nobuhiro Nishiyama , Shigeto Fukushima , Woo-Dong Jang , Kanjiro Miyata , Masataka Nakanishi , Shunsaku Asano , Naoki Kanayama
发明人： Kazunori Kataoka , Keiji Itaka , Nobuhiro Nishiyama , Shigeto Fukushima , Woo-Dong Jang , Kanjiro Miyata , Masataka Nakanishi , Shunsaku Asano , Naoki Kanayama
IPC分类号： C08G69/08
CPC分类号： A61K48/0041 , A61K47/60 , A61K47/6455 , C08G18/0814 , C08G63/6854 , C08G69/10 , C08G73/028 , C08G73/0293 , C12N15/88
摘要： Disclosed is a composition for the delivery of nucleic acid to target cells or tissues, which comprises a polycationically charged polymer as a carrier of nucleic acid. The polycationically charged polymer is a polymer which may comprise a charged polymer segment having a main chain based on poly(amino acid), polysaccharide, polyester, polyether, polyurethane or vinyl polymer and having, as a side chain, a group of formula —NH—(CH2)a—(NH(CH2)2)e—NH2 (wherein a and e independently denote an integer of 1 to 5) which is connected to the main chain either directly or via a linker. The disclosed composition has low toxicity, and has a high efficiency in introducing nucleic acid into cells.
摘要翻译： 公开了用于将核酸递送至靶细胞或组织的组合物，其包含作为核酸载体的聚阳离子带电聚合物。 聚阳离子带电聚合物是聚合物，其可以包含具有基于聚（氨基酸），多糖，聚酯，聚醚，聚氨酯或乙烯基聚合物的主链的带电聚合物链段，并且具有作为侧链的式-NH基团 - （CH 2）a - （NH（CH 2）2）e-NH 2（其中a和e独立地表示1至5的整数），其直接或通过连接体与主链连接。 所公开的组合物具有低毒性，并且在将核酸引入细胞中具有高效率。
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3.发明授权公开(公告)号：US09278075B2
公开(公告)日：2016-03-08
申请号：US13979546
申请日：2012-01-16
申请人： Kazunori Kataoka , Ronald James Christie , Nobuhiro Nishiyama , Kanjiro Miyata , Shigeto Fukushima , Yu Matsumoto , Takahiro Nomoto , Yasuki Kato
发明人： Kazunori Kataoka , Ronald James Christie , Nobuhiro Nishiyama , Kanjiro Miyata , Shigeto Fukushima , Yu Matsumoto , Takahiro Nomoto , Yasuki Kato
IPC分类号： A61K9/50 , A61K38/19 , A61K31/713 , A61K31/711 , A61K9/107 , A61K47/48
CPC分类号： A61K9/5031 , A61K9/107 , A61K31/711 , A61K31/713 , A61K38/193 , A61K47/60 , A61K47/6455
摘要： A composition of matter for use in encapsulating a drug is expressed by formula (1) or formula (2): wherein R1 and R2 are each independently a hydrogen atom or a substituted or unsubstituted, linear or branched alkyl group having 1 to 12 carbon atoms; A is a hydrophilic polymer chain; L1 and L3 are each a linking group; B is a cation-containing group; R3 is a side chain of an amino acid; z is an integer of 5 to 500; x is an integer of 40% or more of z; y is 0 or a positive integer; z-x-y is 0 or a positive integer; p is an integer of 1 to 10; and q is an integer of 1 to 10.
摘要翻译： 用于包封药物的物质组合物由式（1）或式（2）表示：其中R 1和R 2各自独立地为氢原子或具有1至12个碳原子的取代或未取代的直链或支链烷基 ; A是亲水性聚合物链; L1和L3各自是连接基团; B是含阳离子基团; R3是氨基酸的侧链; z为5〜500的整数。 x是z的40％以上的整数; y为0或正整数; z-x-y为0或正整数; p为1〜10的整数。 q为1〜10的整数。
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公开(公告)号：US07780957B2
公开(公告)日：2010-08-24
申请号：US10556058
申请日：2004-05-07
CPC分类号： C08G69/10 , A61K9/1075 , A61K47/645 , A61K47/6907 , C08G69/48 , C08G81/00 , C12N15/87
摘要： The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA.
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5.发明申请PARTICLE COMPOSITION AND PHARMACEUTICAL COMPOSITION USING PARTICLE COMPOSITION 有权颗粒组合物和使用颗粒组合物的药物组合物公开(公告)号：US20140017328A1
公开(公告)日：2014-01-16
申请号：US13979546
申请日：2012-01-16
申请人： Kazunori Kataoka , Ronald James Christie , Nobuhiro Nishiyama , Kanjiro Miyata , Shigeto Fukushima , Yu Matsumoto , Takahiro Nomoto , Yasuki Kato
发明人： Kazunori Kataoka , Ronald James Christie , Nobuhiro Nishiyama , Kanjiro Miyata , Shigeto Fukushima , Yu Matsumoto , Takahiro Nomoto , Yasuki Kato
IPC分类号： A61K9/50 , A61K38/19 , A61K31/713
CPC分类号： A61K9/5031 , A61K9/107 , A61K31/711 , A61K31/713 , A61K38/193 , A61K47/60 , A61K47/6455
摘要： A composition of matter for use in encapsulating a drug is expressed by formula (1) or formula (2): wherein R1 and R2 are each independently a hydrogen atom or a substituted or unsubstituted, linear or branched alkyl group having 1 to 12 carbon atoms; A is a hydrophilic polymer chain; L1 and L3 are each a linking group; B is a cation-containing group; R3 is a side chain of an amino acid; z is an integer of 5 to 500; x is an integer of 40% or more of z; y is 0 or a positive integer; z-x-y is 0 or a positive integer; p is an integer of 1 to 10; and q is an integer of 1 to 10.
摘要翻译： 用于包封药物的物质组合物由式（1）或式（2）表示：其中R 1和R 2各自独立地为氢原子或具有1至12个碳原子的取代或未取代的直链或支链烷基 ; A是亲水性聚合物链; L1和L3各自是连接基团; B是含阳离子基团; R3是氨基酸的侧链; z为5〜500的整数。 x是z的40％以上的整数; y为0或正整数; z-x-y为0或正整数; p为1〜10的整数。 q为1〜10的整数。
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公开(公告)号：US20070059271A1
公开(公告)日：2007-03-15
申请号：US10556058
申请日：2004-05-07
IPC分类号： A61K31/787 , C08L71/02
CPC分类号： C08G69/10 , A61K9/1075 , A61K47/645 , A61K47/6907 , C08G69/48 , C08G81/00 , C12N15/87
摘要： The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA.
摘要翻译： 本发明提供由聚（乙二醇）链段和具有至少一种特定胺残基的侧链的聚（氨基酸衍生物）链段形成的嵌段共聚物。 本发明还提供了这种共聚物与多核苷酸等的聚离子配合物。 这些嵌段共聚物可用作体内递送活性物质如DNA的载体。
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公开(公告)号：US08318205B2
公开(公告)日：2012-11-27
申请号：US12656307
申请日：2010-01-25
IPC分类号： A61K9/14
CPC分类号： C08G69/10 , A61K9/1075 , A61K47/645 , A61K47/6907 , C08G69/48 , C08G81/00 , C12N15/87
摘要： The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA.
摘要翻译： 本发明提供由聚（乙二醇）链段和具有至少一种特定胺残基的侧链的聚（氨基酸衍生物）链段形成的嵌段共聚物。 本发明还提供了这种共聚物与多核苷酸等的聚离子配合物。 这些嵌段共聚物可用作体内递送活性物质如DNA的载体。
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公开(公告)号：US20100137512A1
公开(公告)日：2010-06-03
申请号：US12656307
申请日：2010-01-25
IPC分类号： A61K47/48
CPC分类号： C08G69/10 , A61K9/1075 , A61K47/645 , A61K47/6907 , C08G69/48 , C08G81/00 , C12N15/87
摘要： The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA.
摘要翻译： 本发明提供由聚（乙二醇）链段和具有至少一种特定胺残基的侧链的聚（氨基酸衍生物）链段形成的嵌段共聚物。 本发明还提供了这种共聚物与多核苷酸等的聚离子配合物。 这些嵌段共聚物可用作体内递送活性物质如DNA的载体。
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9.发明授权Anionic polymer, polyion complex and ternary polymer composite using anionic polymer, and pharmaceutical composition 有权阴离子聚合物，聚离子络合物和三元聚合物复合材料使用阴离子聚合物，以及药物组成公开(公告)号：US08450282B2
公开(公告)日：2013-05-28
申请号：US13386554
申请日：2010-07-23
申请人： Kazunori Kataoka , Atsushi Ishii , Hiroyasu Takemoto , Masataka Nakanishi , Nobuhiro Nishiyama , Kanjiro Miyata
发明人： Kazunori Kataoka , Atsushi Ishii , Hiroyasu Takemoto , Masataka Nakanishi , Nobuhiro Nishiyama , Kanjiro Miyata
IPC分类号： A61K38/00 , C07K14/72 , C07K14/705
CPC分类号： C08L79/02 , C08G69/10 , C08G73/0206 , C08G73/028 , C08L77/04
摘要： There are provided an anionic polymer, a polyion complex, and a ternary polymer composite, each of which is stable in a biological environment and is capable of realizing small RNA delivery without causing any undesired immune response. An anionic polymer according to an embodiment of the invention includes: a main chain which includes repeating units having carboxyl groups; and a side chain which is linked with part of the carboxyl groups in the main chain and is represented by the following formula: -A-B—X where: A represents a residue having one or more aminoethyl bonds; B represents an in vivo cleavable bond; and X represents a small RNA. A polyion complex according to an embodiment of the invention includes the anionic polymer as described above and a cationic polymer. A ternary polymer composite according to an embodiment of the invention includes the polyion complex as described above and a charge conversional polymer.
摘要翻译： 提供阴离子聚合物，聚离子络合物和三元聚合物复合材料，其中每一种在生物环境中都是稳定的并且能够实现小的RNA递送而不引起任何不期望的免疫应答。 根据本发明实施方案的阴离子聚合物包括：主链，其包含具有羧基的重复单元; 和与主链中部分羧基连接并由下式表示的侧链：-A-B-X其中：A表示具有一个或多个氨基乙基的残基; B代表体内可剪切键; X表示小RNA。 根据本发明实施方案的聚离子络合物包括如上所述的阴离子聚合物和阳离子聚合物。 根据本发明实施方案的三元聚合物复合物包括如上所述的聚离子络合物和电荷转移聚合物。
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10.发明申请ANIONIC POLYMER, POLYION COMPLEX AND TERNARY POLYMER COMPOSITE USING ANIONIC POLYMER, AND PHARMACEUTICAL COMPOSITION 有权使用阴离子聚合物和药物组合物的阴离子聚合物，聚合物和季铵盐聚合物复合物公开(公告)号：US20120196810A1
公开(公告)日：2012-08-02
申请号：US13386554
申请日：2010-07-23
申请人： Kazunori Kataoka , Atsushi Ishii , Hiroyasu Takemoto , Masataka Nakanishi , Nobuhiro Nishiyama , Kanjiro Miyata
发明人： Kazunori Kataoka , Atsushi Ishii , Hiroyasu Takemoto , Masataka Nakanishi , Nobuhiro Nishiyama , Kanjiro Miyata
CPC分类号： C08L79/02 , C08G69/10 , C08G73/0206 , C08G73/028 , C08L77/04
摘要： There are provided an anionic polymer, a polyion complex, and a ternary polymer composite, each of which is stable in a biological environment and is capable of realizing small RNA delivery without causing any undesired immune response. An anionic polymer according to an embodiment of the invention includes: a main chain which includes repeating units having carboxyl groups; and a side chain which is linked with part of the carboxyl groups in the main chain and is represented by the following formula: -A-B—X where : A represents a residue having one or more aminoethyl bonds; B represents an in vivo cleavable bond; and X represents a small RNA. A polyion complex according to an embodiment of the invention includes the anionic polymer as described above and a cationic polymer. A ternary polymer composite according to an embodiment of the invention includes the polyion complex as described above and a charge conversional polymer.
摘要翻译： 提供阴离子聚合物，聚离子络合物和三元聚合物复合材料，其中每一种在生物环境中都是稳定的并且能够实现小的RNA递送而不引起任何不期望的免疫应答。 根据本发明实施方案的阴离子聚合物包括：主链，其包含具有羧基的重复单元; 和与主链中部分羧基连接并由下式表示的侧链：-A-B-X其中：A表示具有一个或多个氨基乙基的残基; B代表体内可剪切键; X表示小RNA。 根据本发明实施方案的聚离子络合物包括如上所述的阴离子聚合物和阳离子聚合物。 根据本发明实施方案的三元聚合物复合物包括如上所述的聚离子络合物和电荷转移聚合物。
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