公开(公告)号：US20110065749A1

公开(公告)日：2011-03-17

申请号：US12992681

申请日：2009-06-02

申请人： Kazuo Sakai

发明人： Kazuo Sakai

IPC分类号： A61K31/445 ,  A61K31/4453 ,  A61P25/24 ,  A61P25/18 ,  A61P25/22 ,  A61P25/28 ,  A61P25/32

CPC分类号： A61K31/445 ,  A61K31/4453 ,  A61K45/06 ,  C07D295/08 ,  A61K2300/00

摘要： A method of treating a mental disorder including administering to a patient in need thereof, an effective amount of a pharmaceutical composition including 1,1-diphenyl-4-piperidine-1-ylbuthan-1-ol or a pharmaceutically acceptable salt thereof. The mental disorder is depression, bipolar disorder, anxiety disorder, impulsive disorder, bulimia, panic disorder, social anxiety disorder, insomnia, attention deficit hyperactivity disorder (ADHD), schizophrenia, dementia, personality disorder, alcoholism, dissociative disorder, sleep apnea syndrome, or fibromyalgia. In a preferred embodiment, the mental disorder as a therapeutic target is fibromyalgia, chronic fatigue syndrome (CFS), or depression with pain, and the administration of the pharmaceutical composition is capable of reducing the pain caused by these diseases.

摘要翻译： 一种治疗精神障碍的方法，包括向有需要的患者施用有效量的包含1,1-二苯基-4-哌啶-1-基戊烷-1-醇或其药学上可接受的盐的药物组合物。 精神障碍是抑郁症，双相情感障碍，焦虑症，冲动性疾病，贪食症，惊恐障碍，社会焦虑症，失眠症，注意力缺陷多动障碍（ADHD），精神分裂症，痴呆，人格障碍，酒精中毒，解离障碍，睡眠呼吸暂停综合征， 或纤维肌痛。 在优选的实施方案中，作为治疗靶标的精神障碍是纤维肌痛，慢性疲劳综合征（CFS）或具有疼痛的抑郁症，并且药物组合物的施用能够减少由这些疾病引起的疼痛。

公开(公告)号：US20090203738A1

公开(公告)日：2009-08-13

申请号：US11992426

申请日：2006-09-22

申请人： Kazuo Sakai

发明人： Kazuo Sakai

IPC分类号： A61K31/4353 ,  A61K31/135

CPC分类号： A61K45/06 ,  A61K31/135 ,  A61K31/27 ,  A61K31/407 ,  A61K31/445 ,  A61K31/473 ,  A61K31/553 ,  A61K31/662

摘要： Provided is a pharmaceutical composition for the treatment of bulimia in which a cholinesterase inhibitor is combined with at least one member selected from the group consisting of sibutramine, a pharmacologically acceptable salt thereof, an active metabolite thereof, a prodrug thereof and a solvate thereof. The pharmaceutical composition is useful in treating bulimia and depression arising from bulimia.

摘要翻译： 本发明提供一种用于治疗贪食症的药物组合物，其中胆碱酯酶抑制剂与选自西布曲明，其药理学上可接受的盐，其活性代谢物，其前药及其溶剂合物中的至少一种组合。 药物组合物可用于治疗由食欲过盛引起的贪食症和抑郁症。

公开(公告)号：US20070053976A1

公开(公告)日：2007-03-08

申请号：US11523803

申请日：2006-09-20

申请人： Kazuo Sakai ,  John Ieni ,  Raymond Pratt

发明人： Kazuo Sakai ,  John Ieni ,  Raymond Pratt

IPC分类号： A61K31/165 ,  A61K31/137 ,  A61K31/381 ,  A61K31/405 ,  A61K9/20

CPC分类号： A61K45/06 ,  A61K31/137 ,  A61K31/165 ,  A61K31/381 ,  A61K31/405 ,  A61K2300/00

摘要： A novel antidepressant composition of a cholinesterase inhibitor in combination with a selective serotonin reuptake inhibitor, milnacipran or duloxetine is disclosed, which has a significantly high therapeutic effect as compared with conventional antidepressants. The therapeutic method using a cholinesterase inhibitor in combination with a selective serotonin reuptake inhibitor, milnacipran or duloxetine is beneficial for the treatment of depression, in particular, refractory depression.

摘要翻译： 公开了一种胆碱酯酶抑制剂与选择性5-羟色胺再摄取抑制剂米那普仑或度洛西汀组合的新型抗抑郁药组合物，其与常规抗抑郁药相比具有显着高的治疗效果。 使用胆碱酯酶抑制剂与选择性5-羟色胺再摄取抑制剂，米那普仑或度洛西汀组合的治疗方法有利于治疗抑郁症，特别是难治性抑郁症。

公开(公告)号：US07157843B2

公开(公告)日：2007-01-02

申请号：US10979112

申请日：2004-11-03

申请人： Takeo Ito ,  Hajime Tanaka ,  Tomoko Nakazawa ,  Taichiro Nakayama ,  Takaaki Shinohara ,  Yoichiro Nakayama ,  Kazuo Sakai

发明人： Takeo Ito ,  Hajime Tanaka ,  Tomoko Nakazawa ,  Taichiro Nakayama ,  Takaaki Shinohara ,  Yoichiro Nakayama ,  Kazuo Sakai

IPC分类号： H01J29/10 ,  H01J9/00 ,  B32B33/00

CPC分类号： H01J31/123 ,  H01J29/28 ,  H01J2329/28 ,  Y10T428/1476 ,  Y10T428/253 ,  Y10T428/265 ,  Y10T428/31681 ,  Y10T428/31692

摘要： A transfer film comprising a base film (11), a parting-agent layer (12), a protective film (13), and a metal film (14), the latter three being formed on the base film (11) in order, wherein the protective film (13) contains a softening agent such as a phosphate, an aliphatic monobasic acid ester, an aliphatic dibasic acid ester, or a dihydric alcohol ester. By using such a transfer film, a metal back layer is formed. Since the transfer layer of the transfer film has a surface resistivity of as high as 102–108 Ω/, the surface resistivity of the formed metal back layer is high, and discharge is suppressed.

摘要翻译： 一种转印膜，其包含基膜（11），脱模剂层（12），保护膜（13）和金属膜（14），后者三次依次形成在基膜（11）上， 其中，保护膜（13）含有磷酸盐，脂肪族一元酸酯，脂肪族二元酸酯，二元醇酯等软化剂。 通过使用这种转印膜，形成金属背层。 由于转印膜的转印层的表面电阻率高达10〜10 -8Ω，因此形成的金属背层的表面电阻率高， 并且放电被抑制。

公开(公告)号：US20050007034A1

公开(公告)日：2005-01-13

申请号：US10676974

申请日：2003-09-30

申请人： Toshio Kobayashi ,  Tetsuya Matsumoto ,  Tadashi Masuda ,  Hiroyuki Ikoshi ,  Kazuo Sakai ,  Kiyoshi Komatsu ,  Kiyomi Watanabe

发明人： Toshio Kobayashi ,  Tetsuya Matsumoto ,  Tadashi Masuda ,  Hiroyuki Ikoshi ,  Kazuo Sakai ,  Kiyoshi Komatsu ,  Kiyomi Watanabe

IPC分类号： H02M3/28 ,  H02M7/06 ,  H05B37/02

CPC分类号： H02M3/28 ,  H02M7/06

摘要： This discharge power supply apparatus is for supplying a D. C. voltage to a discharge load 6 and discharging the same. The discharge power supply apparatus includes an inverter circuit 2 that converts D. C. voltage to A. C. voltage; a transformer 3 having a primary winding 3a to which the A. C. voltage output by the inverter circuit 2 is supplied and a secondary winding 3b; a full-wave rectifier circuit 4 that has a plurality of diodes 4A to 4D and rectifies the A. C. voltage generated by the secondary winding 3b; and a trigger capacitor 7 connected in parallel to a part of the diodes of the full-wave rectifier circuit 4.

摘要翻译： 该放电电源装置用于向放电负载6提供D.C电压并对其放电。 放电电源装置包括将C.C.电压转换成A.C电压的反相电路2。 变压器3，其具有供给由逆变器电路2输出的A.C电压的初级绕组3a和次级绕组3b; 全波整流电路4具有多个二极管4A〜4D，对由次级绕组3b产生的A.C电压进行整流; 以及与全波整流电路4的二极管的一部分并联连接的触发电容器7。

公开(公告)号：US06665139B2

公开(公告)日：2003-12-16

申请号：US10022260

申请日：2001-12-20

申请人： Mikio Tokuyama ,  Hayato Shimizu ,  Satomitsu Imai ,  Shozo Saegusa ,  Masahiko Sega ,  Toshihisa Okazaki ,  Yuzo Yamaguchi ,  Masao Iwakura ,  Shigeo Nakamura ,  Kazuo Sakai ,  Shigenori Togashi ,  Masayuki Kaiho ,  Toshiaki Kobari

发明人： Mikio Tokuyama ,  Hayato Shimizu ,  Satomitsu Imai ,  Shozo Saegusa ,  Masahiko Sega ,  Toshihisa Okazaki ,  Yuzo Yamaguchi ,  Masao Iwakura ,  Shigeo Nakamura ,  Kazuo Sakai ,  Shigenori Togashi ,  Masayuki Kaiho ,  Toshiaki Kobari

IPC分类号： G11B3314

CPC分类号： G11B33/08 ,  G11B5/6005 ,  G11B25/043 ,  G11B33/1446

摘要： In a magnetic disc apparatus including a plurality of magnetic discs mounted on a spindle, arms supporting magnetic heads, a rotary actuator for the arms, and a housing having an arcuate-shaped shroud, the improvement wherein gaps between the shroud and the sides of outer peripheries of the magnetic discs are larger than 0.1 mm and less than 0.6 mm. An open space is located, downstream of the arms with respect to the air flow on surfaces of the magnetic discs, the open space being devoid of the shroud. An opening is provided in the shroud, upstream of the arms with respect to the air flow and having a greater width than a width of the gaps defined between the magnetic discs and the shroud, and a bypass channel is provided which communicates between the opening and open space.

摘要翻译： 在包括安装在主轴上的多个磁盘，支撑磁头的臂，用于臂的旋转致动器和具有弧形罩的壳体的磁盘装置中，改进之处在于罩与外侧之间的间隙 磁盘的周边大于0.1mm且小于0.6mm。 相对于磁盘表面上的气流，位于臂的下游的开放空间，开放空间没有护罩。 在护罩中，相对于空气流在臂的上游设置开口，并且具有比限定在磁盘和护罩之间的间隙的宽度更大的宽度，并且提供旁通通道，其在开口和 开放空间。

公开(公告)号：US6047052A

公开(公告)日：2000-04-04

申请号：US126638

申请日：1998-07-30

申请人： Kazuo Sakai ,  Katsumi Kishida ,  Tomoki Watanabe ,  Kouichi Maruyama

发明人： Kazuo Sakai ,  Katsumi Kishida ,  Tomoki Watanabe ,  Kouichi Maruyama

IPC分类号： H04L12/24 ,  H04L12/26 ,  H04M15/00

CPC分类号： H04L12/2697 ,  H04L12/24 ,  H04L41/00 ,  H04L43/10 ,  H04L43/50 ,  H04Q2213/13103 ,  H04Q2213/13242 ,  H04Q2213/13333

摘要： A data collection method and system is provided, by which blank time due to a time lag is not generated and a call probability to be broadcast can be calculated based on the number of potentially calling terminals which was counted as recently as possible. In the method, the center broadcasts to terminals a call probability and a control ID number which is increased by one for each broadcast. Each terminal calls up the center based on the received probability value, and if calling up, the terminal informs the center of terminal data and the received ID number. The center manages the probability value and the number of received calls for each ID.

摘要翻译： 提供了一种数据收集方法和系统，由此不产生由于时间滞后的空白时间，并且可以基于尽可能近地计数的潜在呼叫终端的数量来计算要广播的呼叫概率。 在该方法中，中心向终端广播呼叫概率和对于每个广播增加一个的控制ID号。 每个终端根据接收到的概率值来呼叫中心，并且如果呼叫，终端通知终端数据的中心和接收到的ID号。 中心管理每个ID的概率值和接收到的呼叫数。

公开(公告)号：US5423284A

公开(公告)日：1995-06-13

申请号：US209485

申请日：1994-03-14

申请人： Kohsuke Nishimura ,  Kazuo Sakai ,  Yasuyuki Nagao

发明人： Kohsuke Nishimura ,  Kazuo Sakai ,  Yasuyuki Nagao

IPC分类号： H01L21/365 ,  C30B25/02 ,  C30B25/14 ,  H01L33/28 ,  H01L33/30 ,  C30B25/04

CPC分类号： C30B25/02 ,  C30B29/48

摘要： A method which permits the growth of high-quality crystals of n-type II-VI compound semiconductors containing sulfur, by suppressing the reaction of a group III or VII element as a dopant with a group II material at low temperature. A raw material gas containing an organometallic material of the group III or organic material of the group VII is premixed with a raw material gas containing organic sulfur material, then the premixture is mixed with a raw material gas containing an organometallic material of the group II, and the mixture is used to grow a crystal of an n-type II-VI compound semiconductor on a semiconductor substrate by a metal organic vapor phase epitaxial growth method.

摘要翻译： 通过抑制III族或VII族元素作为掺杂剂与II族材料在低温下的反应，允许生长含有硫的n型II-VI化合物半导体的高质量晶体的方法。 将含有III族有机金属材料或VII族有机材料的原料气体与含有机硫材料的原料气体预混合，然后将预混合物与含有II族有机金属材料的原料气体混合， 并且通过金属有机气相外延生长法将混合物用于在半导体衬底上生长n型II-VI化合物半导体的晶体。

公开(公告)号：US5220472A

公开(公告)日：1993-06-15

申请号：US662619

申请日：1991-02-27

申请人： Tomomi Okamoto ,  Hiroaki Ono ,  Shinji Ozaki ,  Kazuo Sakai

发明人： Tomomi Okamoto ,  Hiroaki Ono ,  Shinji Ozaki ,  Kazuo Sakai

IPC分类号： G11B15/61

CPC分类号： G11B15/61

摘要： A surface of an upper rotary drum of a video tape recorder is machines such that it has a surface roughness in a range from 1 .mu.m to 2 .mu.m so as to enable a releasing of air on the upper rotary drum surface uniformly whereby a thickness of an air film between a magnetic tape and a head is uniformly reduced without affecting the tape running. The surface may be grooved concurrently with the roughened surface. A window is formed in rotary drum for receiving at least one magnetic head.

摘要翻译： 磁带录像机的上部旋转磁鼓的表面是机器，其表面粗糙度在1μm至2μm的范围内，以便均匀地释放上部旋转磁鼓表面上的空气，由此厚度 在磁带和磁头之间的气膜均匀地减小而不影响磁带的运行。 表面可以与粗糙表面同时开槽。 窗口形成在用于接收至少一个磁头的旋转磁鼓中。

公开(公告)号：US5217313A

公开(公告)日：1993-06-08

申请号：US678322

申请日：1991-04-30

申请人： Takashi Tamura ,  Masamitsu Nagahama ,  Koichi Enuma ,  Yoshihiro Wada ,  Masayuki Kawasaki ,  Kazuo Sakai ,  Kazunori Suzuki

发明人： Takashi Tamura ,  Masamitsu Nagahama ,  Koichi Enuma ,  Yoshihiro Wada ,  Masayuki Kawasaki ,  Kazuo Sakai ,  Kazunori Suzuki

IPC分类号： B43K8/00 ,  B43K23/08 ,  B43L13/02

CPC分类号： B43K8/00 ,  B43K23/08 ,  B43K7/005 ,  B43K8/003 ,  B43L13/024

摘要： This invention relates to a writing instrument wherein a temporary ink storage member made of a synthetic resin injection molded article is sandwiched between a pen tip and an ink tank. In the present invention, a flange portion for fitting to a predetermined apparatus, which is positioned around an outer peripheral portion of the temporary ink storage member, is formed integrally with a shaft made of a synthetic resin injection molded article. In embodiments of the invention, the temporary ink storage member is made flexible, the shaft is made of a material which is softer than that of the tip holder, and the tip holder is used as a writing thickness display member. The temporary ink storage member can be used as an ink color display member and a cap is used as an application display member. In other embodiment, the cap can be fitted selectively in accordance with types of writing instruments.

摘要翻译： PCT No.PCT / JP90 / 01239 Sec。 371日期：1991年4月30日 102（e）1991年4月30日PCT PCT 1990年9月27日PCT公布。 公开号WO91 / 04873 日本1991年04月18日。本发明涉及一种书写工具，其中由合成树脂注射成型制品制成的临时储墨构件夹在笔尖和墨水罐之间。 在本发明中，用于与位于临时储墨部件的外周部周围的规定装置嵌合的凸缘部与由合成树脂注射成型品构成的轴一体地形成。 在本发明的实施例中，临时储墨件制成柔性，该轴由比该刀片保持器更柔软的材料制成，并且刀片保持器用作书写厚度显示部件。 临时墨水存储构件可以用作墨水颜色显示构件，并且帽子用作应用显示构件。 在其他实施例中，可以根据书写工具的类型选择性地安装帽。