摘要:
The present invention provides a useful and highly safe agent for the treatment of chronic obstructive pulmonary disease, which contains, as the effective ingredient, at least one compound selected from the group consisting of thiazole derivatives and salts thereof represented by the general formula (1), wherein, R1 is a phenyl group which may have 1 to 3 lower alkoxy groups as the substituents on the phenyl ring; R2 is a pyridyl group which may have 1 to 3 carboxyl groups as the substituents on the pyridine ring.
摘要翻译:本发明提供了用于治疗慢性阻塞性肺疾病的有用和高度安全的药物,其包含作为有效成分的至少一种选自由通式(1)表示的噻唑衍生物及其盐的化合物, 其中,R 1是可以具有1〜3个低级烷氧基作为苯环上的取代基的苯基; R 2是可以具有1至3个羧基作为吡啶环上的取代基的吡啶基。
摘要:
The present invention provides a useful and highly safe agent for the treatment of chronic obstructive pulmonary disease, which contains, as the effective ingredient, at least one compound selected from the group consisting of thiazole derivatives and salts thereof represented by the general formula (1), wherein, R1 is a phenyl group which may have 1 to 3 lower alkoxy groups as the substituents on the phenyl ring; R2 is a pyridyl group which may have 1 to 3 carboxyl groups as the substituents on the pyridine ring.
摘要:
A reflection unit reflects an image indicated on an indicator and projects the image on a combiner to indicate a virtual image of the image at a position viewable for a user. A stepping motor rotates the reflection unit to move the virtual image continuously in a predetermined section of the combiner. A control unit controls a driving power of the stepping motor such that a smoothness parameter becomes less than a predetermined value. The smoothness parameter is defined by a division of a difference between the maximum speed of the virtual image and an average speed of the virtual image, when the virtual image moves continuously in the predetermined section, by the average speed.
摘要:
The invention provides a way of producing a natural immunologically active state in a person by subjecting him to an apheresis procedure with bioincompatible biomaterials for about one hour. To safely control the immunological shock induced by this procedure, the person is put under general anesthesia for about six hours, including the apheresis time and at least an additional five hours thereafter. This immunological activation is useful for treating malignant tumors and diseases related to immunosuppression, such as AIDS. The invention also provides for the use of an apheresis column containing a blood perfusion filter with bioincompatible materials for treating malignant tumors and infectious diseases.
摘要:
The invention provides a way of producing a natural immunologically active state in a person by subjecting him to an apheresis procedure with bioincompatible biomaterials for about one hour. To safely control the immunological shock induced by this procedure, the person is put under general anesthesia for about six hours, including the apheresis time and at least an additional five hours thereafter. This immunological activation is useful for treating malignant tumors and diseases related to immunosuppression, such as AIDS. The invention also provides for the use of an apheresis column containing a blood perfusion filter with bioincompatible materials for treating malignant tumors and infectious diseases.
摘要:
The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.
摘要:
A hollow portion is provided on the core of an inner shaft (2) to form an oil feed port (3), a plurality of oil feed holes (4) which are connected with both of the outer peripheral face of the inner shaft (2) within a range (L) of the bearing surface of the inner shaft (2) and the oil feed port (3) are radially provided in a line , and axial oil grooves (5) each of which includes an inner shaft surface side opening portion (4a) of the oil feed hole (4) are provided on the outer peripheral face of the inner shaft to form a contra-rotating bearing device for a contra-rotating propeller which causes the inner shaft (2) and an outer shaft (2) to contra-rotate mutually. In place of the oil grooves, a plurality of concave-convex portions may be formed in the axial direction of a contra-rotating bearing on the inner peripheral face of the bearing and circular portions may be provided on both axial ends of the concavo-convex portions to form the contra-rotating bearing device for a contra-rotating propeller. Thus, a sufficient oil film is formed on the bearing surface of the contra-rotating bearing in an area where the inner shaft and the outer shaft rotate in mutually opposite directions at almost equal speeds so that an excellent bearing function can be obtained.
摘要:
A microneedle array is provided which has (1) the strength to withstand insertion into the skin surface layer and/or stratum corneum, (2) the fineness and flexibility to cause no pain or bleeding in the skin surface layer and/or stratum corneum at the insertion site of the microneedles, and (3) solubility or biodegradability of the microneedle portions under the skin. The microneedle array is produced by forming microneedles using proteoglycan as a base material.
摘要:
The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.
摘要:
An object of the present invention is to provide a novel microneedle array that has (1) the strength to withstand insertion into the skin surface layer and/or stratum corneum, (2) the fineness and flexibility to cause no pain or bleeding in the skin surface layer and/or stratum corneum at the insertion site of the microneedles, and (3) solubility or biodegradability of the microneedle portions under the skin.[Method for Achieving the Object]The microneedle array is produced by forming microneedles using proteoglycan as a base material.