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20 条记录 (耗时 0.028 秒)

    Non-manifold data structure based NC machining simulation system and method thereof
    1.
    发明授权
    Non-manifold data structure based NC machining simulation system and method thereof 失效
    基于非流形数据结构的NC加工仿真系统及其方法

    公开(公告)号：US5561601A

    公开(公告)日：1996-10-01

    申请号：US327253

    申请日：1994-10-21

    申请人： Keisuke Inoue ,  Hiroshi Masuda ,  Akira Okano

    发明人： Keisuke Inoue ,  Hiroshi Masuda ,  Akira Okano

    IPC分类号： G05B19/4069 ,  G06F19/00 ,  G06Q50/00 ,  G06Q50/04 ,  G06F15/62

    CPC分类号： G05B19/4069 ,  G05B2219/35349

    摘要： Use of a non-manifold data structure enables retention of not only the interfaces between an entity in the process of being cut and a non-entity, but also the interfaces between entities or non-entities. These interfaces include the surfaces of substances (the boundaries between an entity and a non-entity) at intermediate points in time during a machining process represented by a series of Boolean operations, and the final or in-process interfaces obtained when machining (Boolean operations) is performed in a different sequence, and hence procedures following this method enable simulation to be retried at a low computation cost after a machining procedure is modified.

    摘要翻译： 使用非歧管数据结构不仅可以保留被裁剪过程中的实体与非实体之间的接口，还可以保留实体或非实体之间的接口。 这些接口包括在由一系列布尔运算表示的加工过程中的中间点处的物质表面（实体和非实体之间的边界），以及加工时获得的最终或进程中的接口（布尔运算 ）以不同的顺序执行，因此遵循该方法的程序能够在修改加工程序之后以低计算成本重新进行仿真。

    Pharmaceutical composition for suppression of the expression of ATP citrate lyase and use thereof
    5.
    发明申请
    Pharmaceutical composition for suppression of the expression of ATP citrate lyase and use thereof 审中-公开
    用于抑制ATP柠檬酸裂合酶表达的药物组合物及其用途

    公开(公告)号：US20050096367A1

    公开(公告)日：2005-05-05

    申请号：US10997873

    申请日：2004-11-29

    申请人： Yoshiro Kitahara ,  Tomohisa Okutsu ,  Akira Mitsui ,  Akira Okano

    发明人： Yoshiro Kitahara ,  Tomohisa Okutsu ,  Akira Mitsui ,  Akira Okano

    IPC分类号： A61K31/00 ,  A61K31/175 ,  A61K31/198 ,  A61K31/426

    CPC分类号： A61K31/426 ,  A61K31/00 ,  A61K31/175 ,  A61K31/198

    摘要： The present invention provides a pharmaceutical composition for suppression of the expression of ATP citrate lyase, which contains a compound that suppresses the expression of ATP citrate lyase by the in vivo administration. The compounds suppress the expression of ATP citrate lyase by the in vivo administration include insulin secretagogues such as nateglinide. This pharmaceutical composition is effective in preventing, improving and treating metabolic syndrome, in particular, liver disorders related to abnormal lipid metabolism such as fatty liver and NASH.

    摘要翻译： 本发明提供抑制ATP柠檬酸裂合酶表达的药物组合物，其含有通过体内给药抑制ATP柠檬酸裂解酶的表达的化合物。 该化合物通过体内施用抑制ATP柠檬酸裂解酶的表达，包括胰岛素促分泌素如那格列奈。 该药物组合物可有效预防，改善和治疗代谢综合征，特别是与脂肪肝和NASH等脂代谢异常相关的肝脏疾病。

    Pharmaceutical composition for the treatment of non-alcoholic fatty liver disease
    8.
    发明申请
    Pharmaceutical composition for the treatment of non-alcoholic fatty liver disease 审中-公开
    用于治疗非酒精性脂肪性肝病的药物组合物

    公开(公告)号：US20060089412A1

    公开(公告)日：2006-04-27

    申请号：US11251932

    申请日：2005-10-18

    申请人： Fumihiko Takatsuki ,  Akira Okano

    发明人： Fumihiko Takatsuki ,  Akira Okano

    IPC分类号： A61K31/198

    CPC分类号： A61K31/198

    摘要： There is provided a method of preventing or treating non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis, which comprises administering a pharmaceutical composition comprising L-alanine as an active ingredient to a patient suffering from the disease. This pharmaceutical composition is safe and efficacious for prevention and/or therapeutic treatment of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis patients.

    摘要翻译： 提供了一种预防或治疗非酒精性脂肪肝病和/或非酒精性脂肪性肝炎的方法，其包括向患有该疾病的患者施用包含L-丙氨酸作为活性成分的药物组合物。 该药物组合物对于非酒精性脂肪性肝病或非酒精性脂肪性肝炎患者的预防和/或治疗性治疗是安全有效的。

    Culture and transportation of bovine embryos
    10.
    发明授权
    Culture and transportation of bovine embryos 失效
    牛胚胎的文化和运输

    公开(公告)号：US06238920B1

    公开(公告)日：2001-05-29

    申请号：US08018546

    申请日：1993-02-17

    申请人： Takashi Nagai ,  Akira Okano ,  Masashi Takahashi ,  Takayoshi Kariya ,  Hiroya Kadokawa ,  Hitomi Hirako ,  Masashige Kuwayama ,  Seizo Hamano

    发明人： Takashi Nagai ,  Akira Okano ,  Masashi Takahashi ,  Takayoshi Kariya ,  Hiroya Kadokawa ,  Hitomi Hirako ,  Masashige Kuwayama ,  Seizo Hamano

    IPC分类号： C12N502

    CPC分类号： A01N1/02 ,  A01N1/0226

    摘要： A method of culturing bovine embryos by culturing said bovine embryos in a medium containing thiol compound, and also a method of transporting bovine embryos by transporting said bovine embryos in a medium containing thiol compound are disclosed. According to the present invention, it is possible to culture bovine embryos up to blastocyst stage efficiently in the medium containing low molecular thiol compound without in vivo culture or coculture using feeder cells. Also when low molecular thiol compound is added to the transportation medium for bovine embryos, almost 100% embryos are still viable after long distant transportation.

    摘要翻译： 公开了一种通过在含有硫醇化合物的培养基中培养所述牛胚胎培养牛胚胎的方法，以及通过在含有硫醇化合物的培养基中转运所述牛胚胎来运输牛胚胎的方法。根据本发明， 在含有低分子硫醇化合物的培养基中有效培养牛胚胎至胚泡期，而不使用饲养细胞进行体内培养或共培养。 此外，当将低分子硫醇化合物加入到牛胚胎的运输介质中时，几乎100％的胚胎在远距离运输后仍然是可行的。