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    Diffusion-controlled dosage form and method of fabrication including three dimensional printing
    2.
    发明授权
    Diffusion-controlled dosage form and method of fabrication including three dimensional printing 有权
    扩散控制剂型和制造方法，包括三维印刷

    公开(公告)号：US08465777B2

    公开(公告)日：2013-06-18

    申请号：US13306393

    申请日：2011-11-29

    申请人： Chen-Chao Wang ,  Jaedeok Yoo ,  Esteban Bornancini ,  Willie J Roach ,  Monica Tejwani

    发明人： Chen-Chao Wang ,  Jaedeok Yoo ,  Esteban Bornancini ,  Willie J Roach ,  Monica Tejwani

    IPC分类号： A61K9/50

    CPC分类号： A61K9/00 ,  A61K9/2027 ,  A61K9/2077 ,  A61K9/2086 ,  A61K9/2095 ,  A61K31/137 ,  B29C64/153 ,  B33Y70/00 ,  B33Y80/00

    摘要： The invention includes a core-and-shell dosage form or unit in which the core contains API and in which the shell substantially governs the release such as by controlling diffusion of API through the shell. The shell may comprise a release-blocking polymer, and particles of a release-regulating polymer. The shell may be substantially impervious but the release-regulating polymer may become suitable to allow diffusion through it when activated. The core may include a buffer region between the shell and the API-containing portion of the core. The dosage form may include multiple units. The dosage form of the invention is capable of providing a release profile whose time scale can be adjusted by adjusting powder composition, and which may be approximately zero-order release. The invention further includes methods of manufacturing such a dosage form, such as three-dimensional printing.

    摘要翻译： 本发明包括核 - 壳剂型或单位，其中核包含API，并且其中壳基本上控制释放，例如通过控制API通过壳的扩散。 壳可以包含释放阻断聚合物和释放调节聚合物的颗粒。 壳可以是基本上不可渗透的，但是释放调节聚合物可能变得适合于在被激活时允许通过其扩散。 核心可以包括在壳体和核心的含API部分之间的缓冲区域。 剂型可以包括多个单位。 本发明的剂型能够提供释放曲线，其时间尺度可以通过调节粉末组成来调节，并且其可以大致零级释放。 本发明还包括制造这种剂型的方法，例如三维印刷。

    Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form
    5.
    发明授权
    Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form 有权
    药物递送装置的方法和形式，例如以口服剂型将毒性核心包封在无毒区域内

    公开(公告)号：US07875290B2

    公开(公告)日：2011-01-25

    申请号：US11246910

    申请日：2005-10-07

    申请人： Francis C. Payumo ,  Jill K. Sherwood ,  Donald C. Monkhouse ,  Jaedeok Yoo ,  Christopher M. Gaylo ,  Chen-Chao Wang ,  Michael J. Cima

    发明人： Francis C. Payumo ,  Jill K. Sherwood ,  Donald C. Monkhouse ,  Jaedeok Yoo ,  Christopher M. Gaylo ,  Chen-Chao Wang ,  Michael J. Cima

    IPC分类号： A61K31/4745 ,  A61K31/198 ,  A61K9/48

    CPC分类号： A61K9/2893 ,  A61K9/209 ,  A61K9/2886 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00

    摘要： A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isolation from the toxic or potent core. The drug in the toxic or potent core is incorporated into the dosage form via, for example, three-dimensional printing, as a solution, solubilization or suspension of solid particles in liquid, rather than by the more conventional handling and compressing of dry powder. This minimizes the likelihood of creating airborne particles of the toxic drug during manufacturing, hence controlling and minimizing the exposure of manufacturing personnel to the hazardous substance. Wet dispensing of the toxic or potent drug further provides greater bioavailability of the drug to the patient.

    摘要翻译： 药物递送装置，例如具有由无毒区域包封的毒性或有效核心的口服剂型（ODF）。 无毒区域可以是包括多层，涂层，壳及其组合的区域，其提供对有毒或有效的核心的保护和分离。 有毒或有效的核心中的药物通过例如三维印刷作为溶液，固体颗粒在液体中的溶解或悬浮而不是通过更常规的干粉处理和压缩而被并入到剂型中。 这最小化在制造过程中产生毒性药物的空气中颗粒的可能性，从而控制和最小化制造人员对有害物质的暴露。 有毒或有效的药物的湿分配进一步提供药物对患者更大的生物利用度。

    Diffusion-controlled dosage form and method of fabrication including three dimensional printing
    8.
    发明授权
    Diffusion-controlled dosage form and method of fabrication including three dimensional printing 有权
    扩散控制剂型和制造方法，包括三维印刷

    公开(公告)号：US08088415B2

    公开(公告)日：2012-01-03

    申请号：US10431353

    申请日：2003-05-06

    申请人： Chen-Chao Wang ,  Jaedeok Yoo ,  Esteban Bornancini ,  Willie J. Roach ,  Monica Rewachand Motwani

    发明人： Chen-Chao Wang ,  Jaedeok Yoo ,  Esteban Bornancini ,  Willie J. Roach ,  Monica Rewachand Motwani

    IPC分类号： A61K9/50

    CPC分类号： A61K9/00 ,  A61K9/2027 ,  A61K9/2077 ,  A61K9/2086 ,  A61K9/2095 ,  A61K31/137 ,  B29C64/153 ,  B33Y70/00 ,  B33Y80/00

    摘要： The invention includes a core-and-shell dosage form or unit in which the core contains API and in which the shell substantially governs the release such as by controlling diffusion of API through the shell. The shell may comprise a release-blocking polymer, and particles of a release-regulating polymer. The shell may be substantially impervious but the release-regulating polymer may become suitable to allow diffusion through it when activated. The core may include a buffer region between the shell and the API-containing portion of the core. The dosage form may include multiple units. The dosage form of the invention is capable of providing a release profile whose time scale can be adjusted by adjusting powder composition, and which may be approximately zero-order release. The invention further includes methods of manufacturing such a dosage form, such as three-dimensional printing.

    摘要翻译： 本发明包括核 - 壳剂型或单位，其中核包含API，并且其中壳基本上控制释放，例如通过控制API通过壳的扩散。 壳可以包含释放阻断聚合物和释放调节聚合物的颗粒。 壳可以是基本上不可渗透的，但是释放调节聚合物可能变得适合于在被激活时允许通过其扩散。 核心可以包括在壳体和核心的含API部分之间的缓冲区域。 剂型可以包括多个单位。 本发明的剂型能够提供释放曲线，其时间尺度可以通过调节粉末组成来调节，并且其可以大致零级释放。 本发明还包括制造这种剂型的方法，例如三维印刷。

    Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form
    9.
    发明授权
    Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form 有权
    药物递送装置的方法和形式，例如以口服剂型将毒性核心包封在无毒区域内

    公开(公告)号：US07276252B2

    公开(公告)日：2007-10-02

    申请号：US09861480

    申请日：2001-05-18

    申请人： Francis C. Payumo ,  Jill K. Sherwood ,  Donald C. Monkhouse ,  Jaedeok Yoo ,  Christopher M. Gaylo ,  Chen-Chao Wang ,  Michael J. Cima

    发明人： Francis C. Payumo ,  Jill K. Sherwood ,  Donald C. Monkhouse ,  Jaedeok Yoo ,  Christopher M. Gaylo ,  Chen-Chao Wang ,  Michael J. Cima

    IPC分类号： A61K9/26

    CPC分类号： A61K9/2893 ,  A61K9/209 ,  A61K9/2886 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00

    摘要： A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isolation from the toxic or potent core. The drug in the toxic or potent core is incorporated into the dosage form via, for example, three-dimensional printing, as a solution, solubilization or suspension of solid particles in liquid, rather than by the more conventional handling and compressing of dry powder. This minimizes the likelihood of creating airborne particles of the toxic drug during manufacturing, hence controlling and minimizing the exposure of manufacturing personnel to the hazardous substance. Wet dispensing of the toxic or potent drug further provides greater bioavailability of the drug to the patient.

    摘要翻译： 药物递送装置，例如具有由无毒区域包封的毒性或有效核心的口服剂型（ODF）。 无毒区域可以是包括多层，涂层，壳及其组合的区域，其提供对有毒或有效的核心的保护和分离。 有毒或有效的核心中的药物通过例如三维印刷作为溶液，固体颗粒在液体中的溶解或悬浮而不是通过更常规的干粉处理和压缩而被并入到剂型中。 这最小化在制造过程中产生毒性药物的空气中颗粒的可能性，从而控制和最小化制造人员对有害物质的暴露。 有毒或有效的药物的湿分配进一步提供药物对患者更大的生物利用度。