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    CLOSTRIDIAL TOXIN DERIVATIVES ABLE TO MODIFY PERIPHERAL SENSORY AFFERENT FUNCTIONS
    3.
    发明申请
    CLOSTRIDIAL TOXIN DERIVATIVES ABLE TO MODIFY PERIPHERAL SENSORY AFFERENT FUNCTIONS 审中-公开
    外用毒素衍生物可修改外周感觉功能

    公开(公告)号：US20120141511A1

    公开(公告)日：2012-06-07

    申请号：US13270662

    申请日：2011-10-11

    申请人： Keith Alan Foster ,  Michael John Duggan ,  Clifford Charles Shone

    发明人： Keith Alan Foster ,  Michael John Duggan ,  Clifford Charles Shone

    IPC分类号： A61K39/385 ,  C12P21/06 ,  A61K39/395 ,  A61P25/00 ,  C07K19/00 ,  C07K17/02

    CPC分类号： C07K14/48 ,  A61K38/4886 ,  A61K38/4893 ,  A61K47/62 ,  C07K14/33 ,  C07K2319/00 ,  Y10S424/832

    摘要： A novel agent for the targeted control of a mammalian cell activity can be used to control the interaction of particular cell types with their external environment. The agent has applications as a pharmaceutical for the treatment of a variety of disorders. An agent according to the invention comprises three Domains B, T and E, linked together in the following manner: Domain B-Domain T-Domain E where Domain B is the Binding Domain, which binds the agent to a Binding Site on the cell which undergoes endocytosis to produce an endosome; Domain T is the Translocation Domain, which translocates the agent from within the endosome across the endosomal membrane into the cytosol of the cell; and Domain E is the Effector Domain, which inhibits the ability of the Recyclable Membrane Vesicles to transport the Integral Membrane Proteins to the surface of the cell.

    摘要翻译： 用于靶向控制哺乳动物细胞活性的新型药剂可用于控制特定细胞类型与其外部环境的相互作用。 该试剂具有用作治疗各种疾病的药物的应用。 根据本发明的试剂包括以下列方式连接在一起的三个B区，T区和E区：域B域T域E，其中域B是结合域，其结合试剂到细胞上的结合位点 经历内吞以产生内体; 域T是易位结构域，其将来自内体的试剂从内体膜转移到细胞的胞质溶胶中; 并且E区是效应域，其抑制可循环膜囊泡将整合膜蛋白转运到细胞表面的能力。

    Clostridial toxin derivatives able to modify peripheral sensory afferent functions
    4.
    发明授权
    Clostridial toxin derivatives able to modify peripheral sensory afferent functions 失效
    能够修饰周围感觉传入功能的梭菌毒素衍生物

    公开(公告)号：US07892560B2

    公开(公告)日：2011-02-22

    申请号：US11819648

    申请日：2007-06-28

    申请人： Keith Alan Foster ,  Michael John Duggan ,  Clifford Charles Shone

    发明人： Keith Alan Foster ,  Michael John Duggan ,  Clifford Charles Shone

    IPC分类号： A61K38/16 ,  A61K38/18 ,  C07K14/33 ,  C07K14/485

    CPC分类号： C07K14/48 ,  A61K38/4886 ,  A61K38/4893 ,  A61K47/62 ,  C07K14/33 ,  C07K2319/00 ,  Y10S424/832

    摘要： This invention describes a novel agent for the targeted control of a mammalian cell activity, in particular the agent is used to control the interaction of particular cell types with their external environment. The agent has applications as a pharmaceutical for the treatment of a variety of disorders. An agent according to the invention comprises three Domains B, T and E linked together in the following manner: Domain B-Domain T-Domain E where Domain B is the Binding Domain which binds the agent to a Binding Site on the cell which undergoes endocytosis to produce an endosome, Domain T is the Translocation Domain which translocates the agent (with or without the Binding Site) from within the endosome across the endosomal membrane into the cytosol of the cell, Domain E is the Effector Domain which inhibits the ability of the Recyclable Membrane Vesicles to transport the Integral Membrane Proteins to the surface of the cell.

    摘要翻译： 本发明描述了用于靶向控制哺乳动物细胞活性的新型试剂，特别是该试剂用于控制特定细胞类型与其外部环境的相互作用。 该试剂具有用作治疗各种疾病的药物的应用。 根据本发明的药剂包含以下列方式连接在一起的三个B，T和E域：域B结构域T域E，其中B区是绑定结构域，该结合域将该试剂结合到经历内吞作用的细胞上的结合位点 为了产生一个内体，结构域T是易位区域，它将试剂（有或者没有结合位点）从内体内穿过内体膜转移到细胞的细胞溶质中，E区是抑制 可循环膜囊将整体膜蛋白转运至细胞表面。

    Clostridial toxin derivatives able to modify peripheral sensory afferent functions
    5.
    发明申请
    Clostridial toxin derivatives able to modify peripheral sensory afferent functions 失效
    能够修饰周围感觉传入功能的梭菌毒素衍生物

    公开(公告)号：US20090131645A1

    公开(公告)日：2009-05-21

    申请号：US11819648

    申请日：2007-06-28

    申请人： Keith Alan Foster ,  Michael John Duggan ,  Clifford Charles Shone

    发明人： Keith Alan Foster ,  Michael John Duggan ,  Clifford Charles Shone

    IPC分类号： C07K19/00 ,  C12N9/54 ,  C07H21/00

    CPC分类号： C07K14/48 ,  A61K38/4886 ,  A61K38/4893 ,  A61K47/62 ,  C07K14/33 ,  C07K2319/00 ,  Y10S424/832

    摘要： This invention describes a novel agent for the targeted control of a mammalian cell activity, in particular the agent is used to control the interaction of particular cell types with their external environment. The agent has applications as a pharmaceutical for the treatment of a variety of disorders. An agent according to the invention comprises three Domains B, T and E linked together in the following manner: Domain B-Domain T-Domain E where Domain B is the Binding Domain which binds the agent to a Binding Site on the cell which undergoes endocytosis to produce an endosome, Domain T is the Translocation Domain which translocates the agent (with or without the Binding Site) from within the endosome across the endosomal membrane into the cytosol of the cell, Domain E is the Effector Domain which inhibits the ability of the Recyclable Membrane Vesicles to transport the Integral Membrane Proteins to the surface of the cell.

    摘要翻译： 本发明描述了用于靶向控制哺乳动物细胞活性的新型试剂，特别是该试剂用于控制特定细胞类型与其外部环境的相互作用。 该试剂具有用作治疗各种疾病的药物的应用。 根据本发明的药剂包含以下列方式连接在一起的三个B，T和E域：域B结构域T域E，其中B区是绑定结构域，该结合域将该试剂结合到经历内吞作用的细胞上的结合位点 为了产生一个内体，结构域T是易位区域，它将试剂（有或者没有结合位点）从内体内穿过内体膜转移到细胞的细胞溶质中，E区是抑制 可循环膜囊将整体膜蛋白转运至细胞表面。

    Clostridial toxin derivatives able to modify peripheral sensory afferent functions
    6.
    发明申请
    Clostridial toxin derivatives able to modify peripheral sensory afferent functions 失效
    能够修饰周围感觉传入功能的梭菌毒素衍生物

    公开(公告)号：US20080319167A1

    公开(公告)日：2008-12-25

    申请号：US11819650

    申请日：2007-06-28

    申请人： Keith Alan Foster ,  Michael John Duggan ,  Clifford Charles Shone

    发明人： Keith Alan Foster ,  Michael John Duggan ,  Clifford Charles Shone

    IPC分类号： C07K14/33 ,  C07H21/00

    CPC分类号： C07K14/48 ,  A61K38/4886 ,  A61K38/4893 ,  A61K47/62 ,  C07K14/33 ,  C07K2319/00 ,  Y10S424/832

    摘要： This invention describes a novel agent for the targeted control of a mammalian cell activity, in particular the agent is used to control the interaction of particular cell types with their external environment. The agent has applications as a pharmaceutical for the treatment of a variety of disorders. An agent according to the invention comprises three Domains B, T and E linked together in the following manner: Domain B-Domain T-Domain E where Domain B is the Binding Domain which binds the agent to a Binding Site on the cell which undergoes endocytosis to produce an endosome, Domain T is the Translocation Domain which translocates the agent (with or without the Binding Site) from within the endosome across the endosomal membrane into the cytosol of the cell, Domain E is the Effector Domain which inhibits the ability of the Recyclable Membrane Vesicles to transport the Integral Membrane Proteins to the surface of the cell.

    摘要翻译： 本发明描述了用于靶向控制哺乳动物细胞活性的新型试剂，特别是该试剂用于控制特定细胞类型与其外部环境的相互作用。 该试剂具有用作治疗各种疾病的药物的应用。 根据本发明的药剂包含以下列方式连接在一起的三个B，T和E域：域B结构域T域E，其中B区是绑定结构域，该结合域将该试剂结合到经历内吞作用的细胞上的结合位点 为了产生一个内体，结构域T是易位区域，它将试剂（有或者没有结合位点）从内体内穿过内体膜转移到细胞的细胞溶质中，E区是抑制 可循环膜囊将整体膜蛋白转运至细胞表面。

    Clostridial toxin derivatives able to modify peripheral sensory afferent functions
    8.
    发明授权
    Clostridial toxin derivatives able to modify peripheral sensory afferent functions 失效
    能够修饰周围感觉传入功能的梭菌毒素衍生物

    公开(公告)号：US08158132B2

    公开(公告)日：2012-04-17

    申请号：US11234250

    申请日：2005-09-26

    申请人： Keith Alan Foster ,  Michael John Duggan ,  Clifford Charles Shone

    发明人： Keith Alan Foster ,  Michael John Duggan ,  Clifford Charles Shone

    IPC分类号： C07K14/33 ,  C07K14/48 ,  C07K14/70 ,  C07K19/00 ,  C12N15/62

    CPC分类号： C07K14/48 ,  A61K38/4886 ,  A61K38/4893 ,  A61K47/62 ,  C07K14/33 ,  C07K2319/00 ,  Y10S424/832

    摘要： This invention describes a novel agent for the targeted control of a mammalian cell activity, in particular the agent is used to control the interaction of particular cell types with their external environment. The agent has applications as a pharmaceutical for the treatment of a variety of disorders. An agent according to the invention comprises three Domains B, T and E linked together in the following manner: Domain B-Domain T-Domain E where Domain B is the Binding Domain which binds the agent to a Binding Site on the cell which undergoes endocytosis to produce an endosome, Domain T is the Translocation Domain which translocates the agent (with or without the Binding Site) from within the endosome across the endosomal membrane into the cytosol of the cell, Domain E is the Effector Domain which inhibits the ability of the Recyclable Membrane Vesicles to transport the Integral Membrane Proteins to the surface of the cell.

    摘要翻译： 本发明描述了用于靶向控制哺乳动物细胞活性的新型试剂，特别是该试剂用于控制特定细胞类型与其外部环境的相互作用。 该试剂具有用作治疗各种疾病的药物的应用。 根据本发明的药剂包含以下列方式连接在一起的三个B，T和E域：域B结构域T域E，其中B区是绑定结构域，该结合域将该试剂结合到经历内吞作用的细胞上的结合位点 为了产生内体，结构域T是易位区域，其将试剂（具有或不具有结合位点）从内体内穿过内体膜转移到细胞的细胞溶质中，域E是效应区，其抑制 可循环膜囊将整体膜蛋白转运至细胞表面。