公开(公告)号：US08357168B2

公开(公告)日：2013-01-22

申请号：US11850424

申请日：2007-09-05

Applicant: Thomas G. Wilson ,  Keith Collins ,  Robert T. Potash ,  Andrew Carter

Inventor： Thomas G. Wilson ,  Keith Collins ,  Robert T. Potash ,  Andrew Carter

IPC: A61B17/58 ,  A61B17/60 ,  A61F2/00

CPC classification number: A61M5/46 ,  A61B17/8808 ,  A61B17/8827 ,  A61F2/4611 ,  A61F2002/3085 ,  A61F2002/444

Abstract: A kit for injecting a biomaterial into an intradiscal space accessed through an opening in the disc annulus comprises a plurality of needles, each sized for introduction through the annulus opening with a passageway for injecting the biomaterial therethrough, and each including a distal end to be disposed within the intradiscal space when the needle extends through the annulus opening. Each needle includes a stop affixed thereto at different pre-determined distances from the distal end to define the location of the distal end within the intradiscal space when the needle extends through the opening in the annulus. The kit further includes a plurality of seals defining a bore for sliding engagement with a needle, each of the plurality of seals including a sealing face for engaging the annulus around the needle. Each sealing face defines a differently configured area of contact, such as circular, elliptical, tapered and threaded.

Abstract translation: 用于将生物材料注入通过椎间盘环中的开口进入的椎间盘内空间的套件包括多个针，每个针的尺寸适于通过环形开口引入，用于将生物材料注射通过其中的通道，并且每个针包括待设置的远端 当针穿过环形开口时，在椎间盘内空间内。 每个针包括一个固定在其上的止挡件，其距离远端的预定距离不同，以限定当针穿过环形空间中的开口时的椎间盘内空间内的远端位置。 套件还包括限定用于与针滑动接合的孔的多个密封件，所述多个密封件中的每一个密封件包括用于与环周围的环接合的密封面。 每个密封面限定不同的接触面积，例如圆形，椭圆形，锥形和螺纹。

公开(公告)号：US07837733B2

公开(公告)日：2010-11-23

申请号：US11170588

申请日：2005-06-29

Applicant: Keith Collins ,  Thomas S. Wilson ,  Jared Walkenhorst ,  Andrew Carter ,  Mark D. LoGuidice

Inventor： Keith Collins ,  Thomas S. Wilson ,  Jared Walkenhorst ,  Andrew Carter ,  Mark D. LoGuidice

IPC: A61F2/44

CPC classification number: A61F2/4657 ,  A61B17/70 ,  A61B17/8811 ,  A61B17/8827 ,  A61B2017/0256 ,  A61B2017/564 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61M29/02

Abstract: A method for treating a spinal disc comprises the steps of: determining the integrity of the annulus by subjecting the annulus to a first pressure applied internally of the annulus; providing access to the nucleus pulposus through the annulus without removing any tissue from the annulus or from the nucleus pulposus; and sealably injecting curable biomaterial through the annulus access directly into the nucleus pulposus at a second pressure correlated with the first pressure. The integrity of the annulus may be determined by a pre-operative discogram using a contrast medium that has a viscosity substantially similar to the viscosity of the biomaterial to be injected. The curable biomaterial may be injected under a pressure sufficient to distract opposing vertebral bodies communicating with the disc space.

Abstract translation: 一种用于治疗脊椎椎间盘的方法包括以下步骤：通过使所述环对所述环的内部施加第一压力来确定所述环的完整性; 提供通过环的进入髓核而不从环或髓核中去除任何组织; 并且以与第一压力相关的第二压力将可固化生物材料密封地注射通过环带进入直接进入髓核。 可以通过使用具有与待注射的生物材料的粘度基本相似的粘度的造影剂的术前放射图来确定环的完整性。 可固化生物材料可以在足以分散与椎间盘间隙连通的相对椎体的压力下注射。

公开(公告)号：US20080045897A1

公开(公告)日：2008-02-21

申请号：US11836511

申请日：2007-08-09

Applicant: Keith Collins ,  Thomas Wilson ,  Jared Walkenhorst ,  Dennis Lee ,  Andrew Carter ,  John Pafford ,  Mark LaGuidice ,  Lance Middleton ,  Lawrence Boyd

Inventor： Keith Collins ,  Thomas Wilson ,  Jared Walkenhorst ,  Dennis Lee ,  Andrew Carter ,  John Pafford ,  Mark LaGuidice ,  Lance Middleton ,  Lawrence Boyd

IPC: A61M29/02

CPC classification number: A61F2/4657 ,  A61B17/70 ,  A61B17/8811 ,  A61B17/8827 ,  A61B2017/0256 ,  A61B2017/564 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61M29/02

Abstract: A vented needle is provided for sealably injecting biomaterial into an intradiscal space interiorly of the annulus of a spinal disc and for providing an exhaust for the intradiscal space. The vented needle comprises a compressible seal body for pressing against an outer surface of the annulus, and a needle extending through the seal. The needle may be configured to connect to a syringe for pressure injection of the biomaterial. The seal includes a vent extending therethrough with an opening for communication with the intradiscal space and an opening for the discharge of excess biomaterial filling the intradiscal space. A kit of parts is also provided for use in the treatment of a spinal disc, the kit comprising the vented needle and an inflatable trial device. The trial device is removably introduced into the intradiscal space and inflated to determine the available size of said intradiscal space.

Abstract translation: 提供通气针，用于将生物材料密封地注入脊椎盘环形内部的椎间盘内空间，并为椎间盘内空间提供排气。 排气针包括用于压靠环形空间的外表面的可压缩密封体和延伸穿过密封件的针。 针可以被配置为连接到注射器以用于压力注射生物材料。 密封件包括通过其延伸的通气口，其具有用于与椎间盘内空间连通的开口和用于排出填充椎间盘内空间的多余生物材料的开口。 还提供了一套用于治疗脊椎盘的部件，该试剂盒包括通气针和可充气试验装置。 试验装置可移除地引入椎间盘内空间并膨胀以确定所述椎间盘内空间的可用尺寸。

公开(公告)号：US08337557B2

公开(公告)日：2012-12-25

申请号：US11170657

申请日：2005-06-29

Applicant: Keith Collins ,  Thomas G. Wilson ,  Andrew Carter

Inventor： Keith Collins ,  Thomas G. Wilson ,  Andrew Carter

IPC: A61F2/44

CPC classification number: A61F2/4657 ,  A61B17/70 ,  A61B17/8811 ,  A61B17/8827 ,  A61B2017/0256 ,  A61B2017/564 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61M29/02

Abstract: A kit of parts is provided that comprises: a cannula, the distal end of the cannula adapted to be inserted through the disc annulus; an injection needle, the distal end adapted to be inserted into the proximal end of the cannula and configured for relatively close sliding fit therewithin; and a syringe for containing a quantity of curable biomaterial, the syringe adapted to be coupled to the proximal end of the needle and to inject the biomaterial into the needle under pressure. The kit may further comprise a quantity of curable biomaterial that is selected to have upon curing strong adhesive properties such as a protein polymer.

Abstract translation: 提供了一套零件，其包括：插管，插管的远端适于插入穿过盘环; 注射针，所述远端适于插入所述套管的近端并且被配置为在其中相对较紧的滑动配合; 以及用于容纳一定量的可固化生物材料的注射器，所述注射器适于联接到所述针的近端并且在压力下将所述生物材料注射到所述针中。 该试剂盒还可以包含一定量的可固化生物材料，其被选择为在固化强粘合性能如蛋白质聚合物时具有。

公开(公告)号：US07789913B2

公开(公告)日：2010-09-07

申请号：US11170577

申请日：2005-06-29

Applicant: Keith Collins ,  Thomas G. Wilson ,  Jared Walkenhorst ,  Dennis Lee ,  Andrew Carter ,  John Pafford ,  Mark D. LoGuidice ,  Lance Middleton ,  Lawrence Boyd

Inventor： Keith Collins ,  Thomas G. Wilson ,  Jared Walkenhorst ,  Dennis Lee ,  Andrew Carter ,  John Pafford ,  Mark D. LoGuidice ,  Lance Middleton ,  Lawrence Boyd

IPC: A61F2/44

CPC classification number: A61F2/4657 ,  A61B17/70 ,  A61B17/8811 ,  A61B17/8827 ,  A61B2017/0256 ,  A61B2017/564 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61M29/02

Abstract: A method for treating a diseased or damaged spinal disc comprises the steps of: (a) providing access to the nucleus pulposus through the annulus; (b) removing at least a portion of the nucleus pulposus to create an intradiscal space; determining the size of the intradiscal space; and (c) sealably introducing under pressure a curable biomaterial through the annulus directly into the intradiscal space. The method may include the additional steps of applying a force to distract the opposing vertebral bodies about the intradiscal space and then removing the distraction force after the biomaterial has cured. The step of determining the size of the intradiscal space may be accomplished by expanding a compliant balloon within the intradiscal space using a contrast medium capable of visualization under fluoroscopy. The curable material is sealably introduced through a vented needle inserted through the opening. The curable biomaterial is introduced until a quantity of the material flows into the vent.

Abstract translation: 用于治疗患病或损伤的椎间盘的方法包括以下步骤：（a）通过所述环提供进入髓核的通路; （b）去除髓核的至少一部分以产生椎间盘内空间; 确定椎间盘内空间的大小; 和（c）在压力下可密封地将可固化生物材料通过环形物直接引入椎间盘内空间。 该方法可以包括额外的步骤：施加力以分散相对的椎体围绕椎间盘内空间，然后在生物材料固化后去除牵引力。 确定椎间盘内空间大小的步骤可以通过使用能够在荧光透视下可视化的造影剂来扩展椎间盘内空间内的顺应气囊来实现。 可固化材料通过穿过开口插入的通气针密封地引入。 引入可固化的生物材料，直到一定量的材料流入通气口。

公开(公告)号：US07722579B2

公开(公告)日：2010-05-25

申请号：US11170010

申请日：2005-06-29

Applicant: Keith Collins ,  Lawrence Boyd ,  Andrew Carter ,  Dennis Lee ,  John Pafford ,  Jared Walkenhorst ,  Thomas G. Wilson ,  Mark D. LoGuidice ,  Lance Middlelton

Inventor： Keith Collins ,  Lawrence Boyd ,  Andrew Carter ,  Dennis Lee ,  John Pafford ,  Jared Walkenhorst ,  Thomas G. Wilson ,  Mark D. LoGuidice ,  Lance Middlelton

IPC: A61M25/00

CPC classification number: A61F2/4657 ,  A61B17/70 ,  A61B17/8811 ,  A61B17/8827 ,  A61B2017/0256 ,  A61B2017/564 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61M29/02

Abstract: A vented needle assembly is provided for sealably injecting biomaterial into an intradiscal space interiorly of the annulus of a spinal disc and for providing an exhaust for the intradiscal space. The vented needle assembly comprises a compressible seal body for pressing against an outer surface of the annulus, and a needle extending through the seal. The needle may be configured to connect to a syringe for pressure injection of the biomaterial. The seal includes a vent extending therethrough with an opening for communication with the intradiscal space and an opening for the discharge of excess biomaterial filling the intradiscal space. A kit of parts is also provided for use in the treatment of a spinal disc, the kit comprising the vented needle assembly and an inflatable trial device. The trial device is removably introduced into the intradiscal space and inflated to determine the available size of the intradiscal space.

Abstract translation: 提供了一种排气针组件，用于将生物材料密封地注入椎间盘环的内部的椎间盘内空间，并为椎间盘内空间提供排气。 排气针组件包括用于压靠环形空间的外表面的可压缩密封体和延伸穿过密封件的针。 针可以被配置为连接到注射器以用于压力注射生物材料。 密封件包括通过其延伸的通气口，其具有用于与椎间盘内空间连通的开口和用于排出填充椎间盘内空间的多余生物材料的开口。 还提供了一套用于治疗脊椎盘的部件，该套件包括通气针组件和可充气试验装置。 试验装置可拆卸地引入椎间盘内空间并充气以确定椎间盘内空间的可用尺寸。

公开(公告)号：US20080071281A1

公开(公告)日：2008-03-20

申请号：US11850424

申请日：2007-09-05

Applicant: Thomas Wilson ,  Keith Collins ,  Robert Potash ,  Andrew Carter

Inventor： Thomas Wilson ,  Keith Collins ,  Robert Potash ,  Andrew Carter

IPC: A61F2/46

CPC classification number: A61M5/46 ,  A61B17/8808 ,  A61B17/8827 ,  A61F2/4611 ,  A61F2002/3085 ,  A61F2002/444

Abstract: A kit for injecting a biomaterial into an intradiscal space accessed through an opening in the disc annulus comprises a plurality of needles, each sized for introduction through the annulus opening with a passageway for injecting the biomaterial therethrough, and each including a distal end to be disposed within the intradiscal space when the needle extends through the annulus opening. Each needle includes a stop affixed thereto at different pre-determined distances from the distal end to define the location of the distal end within the intradiscal space when the needle extends through the opening in the annulus. The kit further includes a plurality of seals defining a bore for sliding engagement with a needle, each of the plurality of seals including a sealing face for engaging the annulus around the needle. Each sealing face defines a differently configured area of contact, such as circular, elliptical, tapered and threaded.

Abstract translation: 用于将生物材料注入通过椎间盘环中的开口进入的椎间盘内空间的套件包括多个针，每个针的尺寸适于通过环形开口引入，用于将生物材料注射通过其中的通道，并且每个针包括待设置的远端 当针穿过环形开口时，在椎间盘内空间内。 每个针包括一个固定在其上的止挡件，其距离远端的预定距离不同，以限定当针穿过环形空间中的开口时的椎间盘内空间内的远端的位置。 套件还包括限定用于与针滑动接合的孔的多个密封件，所述多个密封件中的每一个密封件包括用于与环周围的环接合的密封面。 每个密封面限定不同的接触面积，例如圆形，椭圆形，锥形和螺纹。

公开(公告)号：US20060009851A1

公开(公告)日：2006-01-12

申请号：US11170588

申请日：2005-06-29

Applicant: Keith Collins ,  Thomas Wilson ,  Jared Walkenhorst ,  Andrew Carter ,  Mark LoGuidice

Inventor： Keith Collins ,  Thomas Wilson ,  Jared Walkenhorst ,  Andrew Carter ,  Mark LoGuidice

IPC: A61F2/44 ,  A61F2/46 ,  A61B17/88

CPC classification number: A61F2/4657 ,  A61B17/70 ,  A61B17/8811 ,  A61B17/8827 ,  A61B2017/0256 ,  A61B2017/564 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61M29/02

Abstract: A method for treating a spinal disc having an outer relatively intact annulus defining a disc space and an inner defective nucleus pulposus within the disc space, comprises the steps of: determining the integrity of the annulus by subjecting the annulus to a first pressure applied internally of the annulus; providing access to the nucleus pulposus through the annulus without removing any tissue from the annulus or from the nucleus pulposus; and sealably injecting curable biomaterial through the annulus access directly into the nucleus pulposus at a second pressure correlated with the first pressure. The integrity of the annulus may be determined by a pre-operative discogram using a contrast medium that has a viscosity substantially similar to the viscosity of the biomaterial to be injected. The needle is placed initially within the center of the nucleus pulposus and then withdrawn during the injection to approximately the inner border of the annulus. The second pressure is then maintained until the biomaterial is substantially cured. In steps, the curable biomaterial has strong adhesive properties and is capable of injection under pressure to fill fissures in the nucleus pulposus. The curable biomaterial may be injected under a pressure sufficient to distract opposing vertebral bodies communicating with the disc space.

Abstract translation: 一种用于治疗脊椎盘的方法，所述脊椎盘具有限定椎间盘空间的外部相对完整的环和在椎间盘空间内的内部有缺陷的髓核，包括以下步骤：通过使所述环具有内部施加的第一压力来确定环的完整性 环带 提供通过环的进入髓核而不从环或髓核中去除任何组织; 并且以与第一压力相关的第二压力将可固化生物材料密封地注射通过环带进入直接进入髓核。 可以通过使用具有与待注射的生物材料的粘度基本相似的粘度的造影剂的术前放射图来确定环的完整性。 针最初放置在髓核的中心之内，然后在注射期间将针排出到大致环形的内边缘。 然后维持第二压力直到生物材料基本固化。 在步骤中，可固化生物材料具有很强的粘合性能，并且能够在压力下注射以填充髓核中的裂缝。 可固化生物材料可以在足以分散与椎间盘间隙连通的相对椎体的压力下注射。

公开(公告)号：US08690883B2

公开(公告)日：2014-04-08

申请号：US11969303

申请日：2008-01-04

Applicant: Keith Collins ,  Thomas G. Wilson ,  Spanky A. Raymond

Inventor： Keith Collins ,  Thomas G. Wilson ,  Spanky A. Raymond

IPC: A61B17/58 ,  A61B17/60 ,  A61F2/00 ,  A61M5/178 ,  A61M5/00

CPC classification number: A61B17/8811 ,  A61B17/8816 ,  A61F2/4611 ,  A61F2/4657 ,  A61F2/4684 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4628 ,  A61F2002/4663

Abstract: An assembly for sealably injecting a fluent material into an intradiscal space accessed through an opening in the annulus of a spinal disc comprises a cannula having a passageway for injecting the fluent material therethrough into the intradiscal space, a seal having a sealing surface for sealing engagement with the outer surface of the disc annulus and defining a central opening for, and an articulating joint defined between the central opening of the seal and the cannula configured to permit relative articulation between the components. The assembly may further comprise an anchor element extending through the central opening of the seal, the anchor element including an elongated threaded body sized for threaded engagement within the opening in the disc annulus and having a head configured to engage a distal end of the cannula.

Abstract translation: 用于将流体材料密封地注入通过脊椎盘环的开口进入的椎间盘内空间的组件包括具有用于将流体通过其注入椎间盘内空间的通道的套管，密封件，具有用于与 所述盘环的外表面和限定在所述密封件的所述中心开口和所述套管之间限定的中心开口，所述关节接头被构造成允许所述部件之间的相对铰接。 组件还可以包括延伸穿过密封件的中心开口的锚固元件，锚定元件包括细长螺纹体，其尺寸适于螺旋接合在盘环空间内的开口内，并具有构造成接合套管远端的头部。

公开(公告)号：US20110176382A1

公开(公告)日：2011-07-21

申请号：US12688513

申请日：2010-01-15

Applicant: Keith Collins

Inventor： Keith Collins

IPC: B01F13/00

CPC classification number: B01F5/0685 ,  B01F13/002 ,  B01F13/0023 ,  B01F15/0205 ,  B01F15/0212 ,  B01F15/0225 ,  B01F2215/0034

Abstract: A syringe-to-syringe mixing apparatus comprises first and second syringes adapted to be coupled at their respective outlets to fluidly connect the syringes. The first syringe includes a plunger having a hollow plunger barrel and a distal end defining a lumen therethrough. The lumen is initially closed by a septum, which in one embodiment is an elastomeric stopper mounted over the end of the plunger. The mixing apparatus further includes a third syringe slidably disposed within the plunger barrel. The third syringe includes a hollow needle adapted to pierce the septum to allow fluid from the third syringe to be injected into fluid within the coupled first and second syringes.

Abstract translation: 注射器 - 注射器混合装置包括适于在其各自出口连接以流体连接注射器的第一和第二注射器。 第一注射器包括具有中空柱塞筒的柱塞和限定通过其的腔的远端。 管腔最初由隔膜封闭，在一个实施例中，隔膜安装在柱塞的端部上。 混合装置还包括可滑动地设置在柱塞筒内的第三注射器。 第三注射器包括适于刺穿隔膜以允许来自第三注射器的流体被注入耦合的第一和第二注射器内的流体的中空针头。