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    Antibodies and their use
    3.
    发明授权
    Antibodies and their use 失效
    抗体及其用途

    公开(公告)号：US6113897A

    公开(公告)日：2000-09-05

    申请号：US580166

    申请日：1995-12-28

    申请人： Keld Dan.o slashed. ,  Ebbe R.o slashed.nne ,  Niels Behrendt ,  Vincent Ellis ,  Gunilla H.o slashed.yer-Hansen ,  Charles Pyke ,  Nils Bruenner

    发明人： Keld Dan.o slashed. ,  Ebbe R.o slashed.nne ,  Niels Behrendt ,  Vincent Ellis ,  Gunilla H.o slashed.yer-Hansen ,  Charles Pyke ,  Nils Bruenner

    IPC分类号： A61K38/00 ,  A61K38/18 ,  A61K38/49 ,  A61K38/55 ,  A61K39/395 ,  C07K14/705 ,  C07K16/28 ,  C12N9/72 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/574 ,  G01N33/86 ,  A61K51/00 ,  C12N9/68 ,  G01N33/53

    CPC分类号： C07K14/705 ,  A61K39/3955 ,  C07K16/28 ,  C07K16/2896 ,  C12N9/6462 ,  C12Q1/6886 ,  C12Y304/21073 ,  G01N33/5011 ,  G01N33/57446 ,  G01N33/86 ,  C07K2317/76 ,  C07K2317/77 ,  G01N2333/9723

    摘要： A monoclonal or polyclonal antibody directed against urokinase plasminogen activator receptor (u-PAR), or a subsequence, analogue or glycosylation variant thereof. Antibodies are disclosed which react with free u-PAR or with complexes between u-PA and u-PAR and which are capable of 1) catching u-PAR in ELISA, or 2) detecting u-PAR, e.g. in blotting, or 3) in radioimmunoprecipitation assay precipitate purified u-PAR in intact or fragment form, or 4) is useful for immunohistochemical detection of u-PAR, e.g. in immunostaining of cancer cells, such as in tissue sections at the invasive front, or 5) inhibits the binding of pro-u-PA and active u-PA and thereby inhibits cell surface plasminogen activation. Methods are disclosed 1) for detecting or quantifying u-PAR, 2) for targeting a diagnostic to a cell containing a u-PAR on the surface, 3) for preventing or counteracting proteolytic activity in a mammal. Methods for for selecting a substance suitable for inhibiting u-PA/u-PAR interaction, for preventing or counteracting localized proteolytical activity in a mammal, for inhibiting the invasion and/or metastasis comprise the use of the antibodies and of nude mice inoculated with human cancer cells which are known to invade and/or metastasize in mice and having a distinct color, f.x. obtained by means of an enzyme and a chromogenic substrate for the enzyme, the color being different from the cells of the mouse.

    摘要翻译： 针对尿激酶纤溶酶原激活剂受体（u-PAR）的单克隆或多克隆抗体或其子序列，类似物或糖基化变体。 公开了与游离u-PAR或与u-PA和u-PAR之间的复合物反应的抗体，其能够1）在ELISA中捕获u-PAR，或2）检测u-PAR，例如， 或3）在放射免疫沉淀测定中，沉淀纯化的u-PAR以完整或片段形式存在，或4）可用于u-PAR的免疫组织化学检测。 在诸如在侵入性前沿的组织切片中的癌细胞的免疫染色中，或5）抑制pro-u-PA和活性u-PA的结合，从而抑制细胞表面纤溶酶原激活。 公开了用于检测或定量u-PAR的方法，2）用于将诊断靶向到表面上含有u-PAR的细胞，3）用于预防或抵消哺乳动物中的蛋白水解活性。 用于选择适于抑制u-PA / u-PAR相互作用的物质，用于预防或抵消哺乳动物中局部蛋白质分解活性，抑制侵袭和/或转移的物质的方法包括使用抗体和接种人的裸鼠 已知在小鼠中侵入和/或转移并具有不同颜色的癌细胞，fx 通过酶和酶的显色底物获得，颜色不同于小鼠的细胞。

    Hydrophobic u-PAR binding site
    4.
    发明授权
    Hydrophobic u-PAR binding site 失效
    疏水性u-PAR结合位点

    公开(公告)号：US6025142A

    公开(公告)日：2000-02-15

    申请号：US458585

    申请日：1995-06-02

    申请人： Ulrich Pessara ,  Ulrich Weidle ,  Bernhard Konig ,  Ulrich Kohnert ,  Ilse Bartke ,  Keld Dan.o slashed. ,  Michael Ploug ,  Vincent Ellis

    发明人： Ulrich Pessara ,  Ulrich Weidle ,  Bernhard Konig ,  Ulrich Kohnert ,  Ilse Bartke ,  Keld Dan.o slashed. ,  Michael Ploug ,  Vincent Ellis

    IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P7/02 ,  A61P9/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C12N15/02 ,  C12N15/09 ,  C12P21/08 ,  C12R1/91 ,  G01N33/574 ,  G01N33/577

    CPC分类号： C07K16/2896 ,  A61K38/00

    摘要： The invention relates to an antibody which inhibits the binding between u-PA and u-PAR to an extent of at least 90% in an assay as defined in the specification, or an active fragment or immunological equivalent of said antibody. Examples of such antibodies are deposited Jul. 7, 1994 at Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSM) with accession numbers DSM ACC2178 and DSM ACC2179 under the terms and conditions of the Budapest Treaty. The invention furthermore relates to a method for detecting or quantifying u-PAR or a glycosylation variant of u-PAR in a sample by use of an antibody according to the invention.Furthermore, the invention relates to a method for the manufacture of a therapeutic agent for preventing or counteracting localized proteolytic activity using of an antibody of the invention as well as to use of an antibody according to the invention for the preparation of a diagnostic agent which is capable of targeting a diagnostic to a cell that contains a u-PAR on the surface.

    摘要翻译： 本发明涉及在本说明书中定义的测定中抑制u-PA和u-PAR之间的结合至少90％的抗体或所述抗体的活性片段或免疫相当的抗体。 这种抗体的实例在1994年7月7日在德国知识产权组织（DSM）保藏号为DSM ACC2178和DSM ACC2179的情况下，根据布达佩斯条约的条款和条件。 本发明还涉及通过使用本发明的抗体来检测或定量样品中u-PAR或u-PAR的糖基化变体的方法。 此外，本发明涉及一种制备用于使用本发明的抗体预防或抵消局部蛋白水解活性的治疗剂的方法，以及使用根据本发明的抗体制备诊断剂，其为 能够将诊断定位到表面上含有u-PAR的细胞。

    Urokinase-type plasminogen activator receptor antibodies
    5.
    发明授权
    Urokinase-type plasminogen activator receptor antibodies 失效
    尿激酶型纤溶酶原激活物受体抗体

    公开(公告)号：US5519120A

    公开(公告)日：1996-05-21

    申请号：US85122

    申请日：1993-06-17

    申请人： Keld Dano ,  Ebbe Ronne ,  Niels Behrendt ,  Vincent Ellis ,  Gunilla Hoyer-Hansen ,  Charles Pyke ,  Nils Bruenner

    发明人： Keld Dano ,  Ebbe Ronne ,  Niels Behrendt ,  Vincent Ellis ,  Gunilla Hoyer-Hansen ,  Charles Pyke ,  Nils Bruenner

    IPC分类号： A61K38/00 ,  A61K38/18 ,  A61K38/49 ,  A61K38/55 ,  A61K39/395 ,  C07K14/705 ,  C07K16/28 ,  C12N9/72 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/574 ,  G01N33/86 ,  C07K16/40 ,  C07K16/00 ,  C07K16/18 ,  C12N5/12

    CPC分类号： C07K14/705 ,  A61K39/3955 ,  C07K16/28 ,  C07K16/2896 ,  C12N9/6462 ,  C12Q1/6886 ,  C12Y304/21073 ,  G01N33/5011 ,  G01N33/57446 ,  G01N33/86 ,  C07K2317/76 ,  C07K2317/77 ,  G01N2333/9723

    摘要： A monoclonal or polyclonal antibody directed against urokinase plasminogen activator receptor (u-PAR), or a subsequence, analogue or glycosylation variant thereof. Antibodies are disclosed which react with free u-PAR or with complexes between u-PA and u-PAR and which are capable of 1) catching u-PAR in ELISA, or 2) detecting u-PAR, e.g. in blotting, or 3) in radioimmunoprecipitation assay precipitate purified u-PAR in intact or fragment form, or 4) is useful for immunohistochemical detection of u-PAR, e.g. in immunostaining of cancer cells, such as in tissue sections at the invasive front, or 5) inhibits the binding of pro-u-PA and active u-PA and thereby inhibits cell surface plasminogen activation. Methods are disclosed 1) for detecting or quantifying u-PAR, 2) for targeting a diagnostic to a cell containing a u-PAR on the surface, 3) for preventing or counteracting proteolytic activity in a mammal. Methods for for selecting a substance suitable for inhibiting u-PA/u-PAR interaction, for preventing or counteracting localized proteolytical activity in a mammal, for inhibiting the invasion and/or metastasis comprise the use of the antibodies and of nude mice inoculated with human cancer cells which are known to invade and/or metastasize in mice and having a distinct color, f.x. obtained by means of an enzyme and a chromogenic substrate for the enzyme, the color being different from the cells of the mouse.

    摘要翻译： 针对尿激酶纤溶酶原激活剂受体（u-PAR）的单克隆或多克隆抗体或其子序列，类似物或糖基化变体。 公开了与游离u-PAR或与u-PA和u-PAR之间的复合物反应的抗体，其能够1）在ELISA中捕获u-PAR，或2）检测u-PAR，例如， 或3）在放射免疫沉淀测定中，沉淀纯化的u-PAR以完整或片段形式存在，或4）可用于u-PAR的免疫组织化学检测。 在诸如在侵入性前沿的组织切片中的癌细胞的免疫染色中，或5）抑制pro-u-PA和活性u-PA的结合，从而抑制细胞表面纤溶酶原激活。 公开了用于检测或定量u-PAR的方法，2）用于将诊断靶向到表面上含有u-PAR的细胞，3）用于预防或抵消哺乳动物中的蛋白水解活性。 用于选择适于抑制u-PA / u-PAR相互作用的物质，用于预防或抵消哺乳动物中局部蛋白质分解活性，抑制侵袭和/或转移的物质的方法包括使用抗体和接种人的裸鼠 已知在小鼠中侵入和/或转移并具有不同颜色的癌细胞，fx 通过酶和酶的显色底物获得，颜色不同于小鼠的细胞。

    Power management for electronic devices
    8.
    发明申请
    Power management for electronic devices 有权
    电子设备电源管理

    公开(公告)号：US20070054651A1

    公开(公告)日：2007-03-08

    申请号：US11516375

    申请日：2006-09-06

    申请人： Michael Farmer ,  Vincent Ellis ,  Kenneth Carpenter

    发明人： Michael Farmer ,  Vincent Ellis ,  Kenneth Carpenter

    IPC分类号： H04B1/16 ,  H04B1/06

    CPC分类号： H04B1/1615 ,  H04W52/0274 ,  Y02D70/164 ,  Y02D70/40 ,  Y10T307/773

    摘要： A cordless electronic device with power management system and method is provided that includes an outer surface, a power consumption circuit operable to consume power and for use in a cordless electronic device, a power supply circuit operable to regulate the power from a power source used to power the power consumption circuit of the cordless electronic device, a power control circuit operable to receive an input signal and to place the power consumption circuit in a lower or higher power state upon receipt of the input signal, a presence sensor operable to detect the presence of a user and to provide a presence sensor input signal to the power control circuit to place the power consumption circuit in the higher power state.

    摘要翻译： 提供具有电源管理系统和方法的无绳电子设备，其包括外表面，可操作以消耗电力并用于无绳电子设备的功耗电路，电源电路，其可操作以调节来自用于 为无绳电子设备的功率消耗电路供电;功率控制电路，其可操作以接收输入信号并且在接收到所述输入信号时将所述功率消耗电路置于较低或较高功率状态;存在传感器，其可操作以检测所述存在 并且向功率控制电路提供存在传感器输入信号以将功率消耗电路置于较高功率状态。

    Electromagnetically transparent fluidic operators for remote operation of electric switches and method of adapting electric switches for remote, fluidic operation
    9.
    依法登记的发明
    Electromagnetically transparent fluidic operators for remote operation of electric switches and method of adapting electric switches for remote, fluidic operation 失效
    用于电气开关远程操作的电磁透明流体操作器和用于远程，流动操作的适配电开关的方法

    公开(公告)号：USH1832H

    公开(公告)日：2000-02-01

    申请号：US668454

    申请日：1996-06-03

    申请人： Vincent Ellis

    发明人： Vincent Ellis

    IPC分类号： H01H3/24 ,  H01H35/34

    CPC分类号： H01H3/24

    摘要： An electromagnetically transparent fluidic operator for adapting a conventional, mechanically operated electric switch to remote, fluidic operation includes a non-metallic housing for being rigidly attached to the electric switch with a chamber in the housing aligned with a mechanical actuator of the electric switch and a non-metallic, expandable reservoir mounted by the housing. The reservoir includes a nipple rigidly attached to the housing and a deformable diaphragm forming a seal with the nipple and being disposed in the chamber close to the mechanical actuator. The reservoir is pressurized with fluid from a remote location causing the diaphragm to deform and the reservoir to expand thereby applying a positive pressure or operating force against the mechanical actuator to operate the electric switch. A method of adapting an electric switch for remote, fluidic operation includes the steps of rigidly attaching the housing to a selected electric switch such that the chamber in the housing is aligned with the mechanical actuator, positioning the diaphragm in the chamber close to the mechanical actuator, rigidly attaching the nipple to the housing, establishing a seal between the nipple and the diaphragm to form a fluid-tight reservoir and supplying fluid to the reservoir to deform the diaphragm and apply the operating force against the mechanical actuator.

    摘要翻译： 用于使传统的机械操作的电开关适应远程流动操作的电磁透明流体操作器包括用于刚性地附接到电开关的非金属壳体，壳体中的腔室与电开关的机械致动器对准， 由壳体安装的非金属可膨胀油箱。 储存器包括刚性地连接到壳体的乳头和与乳头形成密封的可变形隔膜，并且设置在靠近机械致动器的腔室中。 储存器被来自远程位置的流体加压，导致隔膜变形并且储存器膨胀，从而对机械致动器施加正压或操作力以操作电开关。 适用于远程流动操作的电开关的方法包括将壳体刚性地附接到所选择的电开关的步骤，使得壳体中的室与机械致动器对准，将隔膜定位在靠近机械致动器的腔室中 将乳头刚性地连接到壳体上，在乳头和隔膜之间建立密封，以形成流体密封的储存器并将流体供应到储存器以使隔膜变形并将操作力施加到机械致动器上。

    Multiple plasma channel high output variable electro-acoustic pulse source
    10.
    发明授权
    Multiple plasma channel high output variable electro-acoustic pulse source 失效
    多等离子体通道高输出可变电声脉冲源

    公开(公告)号：US5903518A

    公开(公告)日：1999-05-11

    申请号：US30521

    申请日：1998-02-23

    申请人： Bruce Benwell ,  Dave DeTroye ,  Harold E. Boesch ,  Vincent Ellis

    发明人： Bruce Benwell ,  Dave DeTroye ,  Harold E. Boesch ,  Vincent Ellis

    IPC分类号： G01V1/157 ,  G10K15/06 ,  G01S15/00

    CPC分类号： G01V1/157 ,  G10K15/06

    摘要： An acoustic impulse source has been developed and used to simulate the highcoustic output of detonation driven acoustic sources. While detonation driven acoustic sources are capable of producing large acoustic signals (>160 dB) at 10s and 100s of meters from the source, their laboratory use is limited due to the combustion byproducts. The present invention is capable of reproducing the downrange detonative source acoustic signals (170 dB) at short range, on the order of 1 meter, without noxious or large thermal byproducts. The present invention relies on the plasma formation resulting from electrical arc discharge in air to generate thermal impulses and the resultant acoustic signals. Utilizing multiple plasma channels and timing control of the formation of said channels, the present invention achieves increased efficiency and the ability to tailor the acoustic output signal to match the desired detonation source characteristic output.

    摘要翻译： 已经开发了一种声脉冲源，用于模拟爆震驱动声源的高声输出。 虽然爆震驱动的声源能够在距离源10秒和100米的距离处产生大的声信号（> 160 dB），但由于燃烧副产物，其实验室使用受到限制。 本发明能够在短距离范围内再现约1米的低频爆震源声学信号（170dB），没有有害或大的热副产物。 本发明依赖于由空气中的电弧放电产生的等离子体形成以产生热脉冲和所产生的声信号。 利用多个等离子体通道和所述通道的形成的定时控制，本发明实现了提高的效率和定制声输出信号以匹配期望的爆震源特性输出的能力。