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    Antibodies and their use
    1.
    发明授权
    Antibodies and their use 失效
    抗体及其用途

    公开(公告)号：US6113897A

    公开(公告)日：2000-09-05

    申请号：US580166

    申请日：1995-12-28

    申请人： Keld Dan.o slashed. ,  Ebbe R.o slashed.nne ,  Niels Behrendt ,  Vincent Ellis ,  Gunilla H.o slashed.yer-Hansen ,  Charles Pyke ,  Nils Bruenner

    发明人： Keld Dan.o slashed. ,  Ebbe R.o slashed.nne ,  Niels Behrendt ,  Vincent Ellis ,  Gunilla H.o slashed.yer-Hansen ,  Charles Pyke ,  Nils Bruenner

    IPC分类号： A61K38/00 ,  A61K38/18 ,  A61K38/49 ,  A61K38/55 ,  A61K39/395 ,  C07K14/705 ,  C07K16/28 ,  C12N9/72 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/574 ,  G01N33/86 ,  A61K51/00 ,  C12N9/68 ,  G01N33/53

    CPC分类号： C07K14/705 ,  A61K39/3955 ,  C07K16/28 ,  C07K16/2896 ,  C12N9/6462 ,  C12Q1/6886 ,  C12Y304/21073 ,  G01N33/5011 ,  G01N33/57446 ,  G01N33/86 ,  C07K2317/76 ,  C07K2317/77 ,  G01N2333/9723

    摘要： A monoclonal or polyclonal antibody directed against urokinase plasminogen activator receptor (u-PAR), or a subsequence, analogue or glycosylation variant thereof. Antibodies are disclosed which react with free u-PAR or with complexes between u-PA and u-PAR and which are capable of 1) catching u-PAR in ELISA, or 2) detecting u-PAR, e.g. in blotting, or 3) in radioimmunoprecipitation assay precipitate purified u-PAR in intact or fragment form, or 4) is useful for immunohistochemical detection of u-PAR, e.g. in immunostaining of cancer cells, such as in tissue sections at the invasive front, or 5) inhibits the binding of pro-u-PA and active u-PA and thereby inhibits cell surface plasminogen activation. Methods are disclosed 1) for detecting or quantifying u-PAR, 2) for targeting a diagnostic to a cell containing a u-PAR on the surface, 3) for preventing or counteracting proteolytic activity in a mammal. Methods for for selecting a substance suitable for inhibiting u-PA/u-PAR interaction, for preventing or counteracting localized proteolytical activity in a mammal, for inhibiting the invasion and/or metastasis comprise the use of the antibodies and of nude mice inoculated with human cancer cells which are known to invade and/or metastasize in mice and having a distinct color, f.x. obtained by means of an enzyme and a chromogenic substrate for the enzyme, the color being different from the cells of the mouse.

    摘要翻译： 针对尿激酶纤溶酶原激活剂受体（u-PAR）的单克隆或多克隆抗体或其子序列，类似物或糖基化变体。 公开了与游离u-PAR或与u-PA和u-PAR之间的复合物反应的抗体，其能够1）在ELISA中捕获u-PAR，或2）检测u-PAR，例如， 或3）在放射免疫沉淀测定中，沉淀纯化的u-PAR以完整或片段形式存在，或4）可用于u-PAR的免疫组织化学检测。 在诸如在侵入性前沿的组织切片中的癌细胞的免疫染色中，或5）抑制pro-u-PA和活性u-PA的结合，从而抑制细胞表面纤溶酶原激活。 公开了用于检测或定量u-PAR的方法，2）用于将诊断靶向到表面上含有u-PAR的细胞，3）用于预防或抵消哺乳动物中的蛋白水解活性。 用于选择适于抑制u-PA / u-PAR相互作用的物质，用于预防或抵消哺乳动物中局部蛋白质分解活性，抑制侵袭和/或转移的物质的方法包括使用抗体和接种人的裸鼠 已知在小鼠中侵入和/或转移并具有不同颜色的癌细胞，fx 通过酶和酶的显色底物获得，颜色不同于小鼠的细胞。

    Urokinase-type plasminogen activator receptor antibodies
    3.
    发明授权
    Urokinase-type plasminogen activator receptor antibodies 失效
    尿激酶型纤溶酶原激活物受体抗体

    公开(公告)号：US5519120A

    公开(公告)日：1996-05-21

    申请号：US85122

    申请日：1993-06-17

    申请人： Keld Dano ,  Ebbe Ronne ,  Niels Behrendt ,  Vincent Ellis ,  Gunilla Hoyer-Hansen ,  Charles Pyke ,  Nils Bruenner

    发明人： Keld Dano ,  Ebbe Ronne ,  Niels Behrendt ,  Vincent Ellis ,  Gunilla Hoyer-Hansen ,  Charles Pyke ,  Nils Bruenner

    IPC分类号： A61K38/00 ,  A61K38/18 ,  A61K38/49 ,  A61K38/55 ,  A61K39/395 ,  C07K14/705 ,  C07K16/28 ,  C12N9/72 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/574 ,  G01N33/86 ,  C07K16/40 ,  C07K16/00 ,  C07K16/18 ,  C12N5/12

    CPC分类号： C07K14/705 ,  A61K39/3955 ,  C07K16/28 ,  C07K16/2896 ,  C12N9/6462 ,  C12Q1/6886 ,  C12Y304/21073 ,  G01N33/5011 ,  G01N33/57446 ,  G01N33/86 ,  C07K2317/76 ,  C07K2317/77 ,  G01N2333/9723

    摘要： A monoclonal or polyclonal antibody directed against urokinase plasminogen activator receptor (u-PAR), or a subsequence, analogue or glycosylation variant thereof. Antibodies are disclosed which react with free u-PAR or with complexes between u-PA and u-PAR and which are capable of 1) catching u-PAR in ELISA, or 2) detecting u-PAR, e.g. in blotting, or 3) in radioimmunoprecipitation assay precipitate purified u-PAR in intact or fragment form, or 4) is useful for immunohistochemical detection of u-PAR, e.g. in immunostaining of cancer cells, such as in tissue sections at the invasive front, or 5) inhibits the binding of pro-u-PA and active u-PA and thereby inhibits cell surface plasminogen activation. Methods are disclosed 1) for detecting or quantifying u-PAR, 2) for targeting a diagnostic to a cell containing a u-PAR on the surface, 3) for preventing or counteracting proteolytic activity in a mammal. Methods for for selecting a substance suitable for inhibiting u-PA/u-PAR interaction, for preventing or counteracting localized proteolytical activity in a mammal, for inhibiting the invasion and/or metastasis comprise the use of the antibodies and of nude mice inoculated with human cancer cells which are known to invade and/or metastasize in mice and having a distinct color, f.x. obtained by means of an enzyme and a chromogenic substrate for the enzyme, the color being different from the cells of the mouse.

    摘要翻译： 针对尿激酶纤溶酶原激活剂受体（u-PAR）的单克隆或多克隆抗体或其子序列，类似物或糖基化变体。 公开了与游离u-PAR或与u-PA和u-PAR之间的复合物反应的抗体，其能够1）在ELISA中捕获u-PAR，或2）检测u-PAR，例如， 或3）在放射免疫沉淀测定中，沉淀纯化的u-PAR以完整或片段形式存在，或4）可用于u-PAR的免疫组织化学检测。 在诸如在侵入性前沿的组织切片中的癌细胞的免疫染色中，或5）抑制pro-u-PA和活性u-PA的结合，从而抑制细胞表面纤溶酶原激活。 公开了用于检测或定量u-PAR的方法，2）用于将诊断靶向到表面上含有u-PAR的细胞，3）用于预防或抵消哺乳动物中的蛋白水解活性。 用于选择适于抑制u-PA / u-PAR相互作用的物质，用于预防或抵消哺乳动物中局部蛋白质分解活性，抑制侵袭和/或转移的物质的方法包括使用抗体和接种人的裸鼠 已知在小鼠中侵入和/或转移并具有不同颜色的癌细胞，fx 通过酶和酶的显色底物获得，颜色不同于小鼠的细胞。

    Method for Cloning Avian-Derived Antibodies
    8.
    发明申请
    Method for Cloning Avian-Derived Antibodies 审中-公开
    克隆禽类衍生抗体的方法

    公开(公告)号：US20100069262A1

    公开(公告)日：2010-03-18

    申请号：US12549921

    申请日：2009-08-28

    申请人： Lars Soegaard Nielsen ,  Charles Pyke ,  Anne Marie V. Jensen ,  Klaus Koefoed ,  Allan Jensen ,  Mette Thorn

    发明人： Lars Soegaard Nielsen ,  Charles Pyke ,  Anne Marie V. Jensen ,  Klaus Koefoed ,  Allan Jensen ,  Mette Thorn

    IPC分类号： C40B40/08 ,  C40B50/06 ,  C12P19/34 ,  C12N15/74 ,  C12P21/02 ,  C12M1/00

    CPC分类号： C07K16/2875 ,  C07K16/00 ,  C12N15/1093 ,  C12Q2537/143

    摘要： The invention relates to a procedure for linking cognate pairs of VH and VL encoding sequences from a population of avian cells enriched in particular surface antigen markers. The linking procedure involves a multiplex molecular amplification procedure capable of linking nucleotide sequences of interest in connection with the amplification (multiplex PCR). The method is particularly advantageous for the generation of cognate pair libraries as well as combinatorial libraries of antibody variable region encoding sequences from chickens or other birds. The invention also provides methods for generation of chimeric human/avian antibodies and expression libraries generated by such methods.

    摘要翻译： 本发明涉及从富含特定表面抗原标记的禽类细胞群中连接VH和VL编码序列的同源对的方法。 连接方法涉及能够连接扩增（多重PCR）的感兴趣的核苷酸序列的多重分子扩增方法。 该方法特别有利于产生同源对文库以及来自鸡或其他鸟类的抗体可变区编码序列的组合文库。 本发明还提供用于产生嵌合人/禽抗体和通过这些方法产生的表达文库的方法。

    ANTI-CD5 ANTIBODIES
    9.
    发明申请
    ANTI-CD5 ANTIBODIES 审中-公开
    抗CD5抗体

    公开(公告)号：US20110250203A1

    公开(公告)日：2011-10-13

    申请号：US13061420

    申请日：2009-08-28

    申请人： Josephine L. K. Klitgaard ,  Charles Pyke ,  Mikke Wandahl Pedersen ,  Klaus Koefoed

    发明人： Josephine L. K. Klitgaard ,  Charles Pyke ,  Mikke Wandahl Pedersen ,  Klaus Koefoed

    IPC分类号： A61K39/395 ,  C12P21/00 ,  A61P35/00 ,  C40B40/02 ,  A61P19/02 ,  A61P35/02 ,  C07K16/28 ,  C12N5/071

    CPC分类号： C07K16/2896 ,  A61K2039/507 ,  C07K2317/92

    摘要： The present invention relates to the field of compositions comprising anti-CD5 antibodies. In particular, the present invention concerns an antibody composition comprising at least two anti-CD5 antibodies capable of binding distinct CD5 epitopes. The invention further concerns bi-specific molecules having the binding specificities of said antibody compositions. The invention also relates topharmaceutical compositions, use of antibody compositions and methods for manufacturing antibody compositions. The invention further relates to cell banks and a method for killing cells.

    摘要翻译： 本发明涉及包含抗CD5抗体的组合物领域。 特别地，本发明涉及包含至少两种能够结合不同CD5表位的抗CD5抗体的抗体组合物。 本发明还涉及具有所述抗体组合物的结合特异性的双特异性分子。 本发明还涉及药物组合物，抗体组合物的用途和制备抗体组合物的方法。 本发明还涉及细胞库和杀死细胞的方法。