公开(公告)号：US06382238B2

公开(公告)日：2002-05-07

申请号：US09801896

申请日：2001-03-09

申请人： Ken Ishii ,  Tsuneyuki Okabe ,  Yuji Kawano ,  Michio Yamaji

发明人： Ken Ishii ,  Tsuneyuki Okabe ,  Yuji Kawano ,  Michio Yamaji

IPC分类号： F17D106

CPC分类号： F16K27/003 ,  Y10T137/5283 ,  Y10T137/87885

摘要： Lower members of each of lines A, B, C, D, E, P are mounted on a subbase panel 3 with screws, upper members 11, 12, 13, 14, 15, 16, 17, 18, 19 of each line are mounted on the lower members with screws, and the subbase panels 3 is mounted on a single main base panel 2. Channel connecting element 50 is removable upward.

摘要翻译： 线A，B，C，D，E，P中的每一个的下部构件用螺钉安装在底座面板3上，每条线的上部构件11,12,13,14,15,16,17,18,19 用螺钉安装在下部构件上，底座面板3安装在单个主底板2上。通道连接元件50可向上移动。

公开(公告)号：US10130398B2

公开(公告)日：2018-11-20

申请号：US15329740

申请日：2015-06-29

申请人： KYOCERA Medical Corporation ,  Ken Ishii ,  Morio Matsumoto ,  Yoshiaki Toyama

发明人： Ken Ishii ,  Morio Matsumoto ,  Yoshiaki Toyama ,  Masaki Atarashi ,  Junji Ito

IPC分类号： A61B17/70 ,  A61B17/86 ,  A61B17/88

摘要： A vertebral surgery instrument includes: an engagement part for engaging with a pair of opposing parts provided on or attached to a vertebral implant in a state in which the vertebral implant is fixed to a vertebra, the pair of opposing parts forming a slit into which a fixation rod for fixing a plurality of vertebrae to each other is to be inserted; and a pair of guide parts that are provided integrally with or attached to the engagement part. The pair of guide parts are formed extending so as to separate from each other toward a side on which the fixation rod is to be inserted, in a state in which the engagement part is engaged with the pair of opposing parts, and the slit and a guide passage that is formed between the pair of guide parts are in communication with each other.

公开(公告)号：US20130008222A1

公开(公告)日：2013-01-10

申请号：US13635476

申请日：2011-03-18

申请人： Takahiro Ota ,  Daisuke Ogura ,  Atsushi Sugai ,  Ken Ishii

发明人： Takahiro Ota ,  Daisuke Ogura ,  Atsushi Sugai ,  Ken Ishii

IPC分类号： B21D11/20 ,  B32B1/00

CPC分类号： B21D11/08 ,  B21D11/02 ,  B21D11/206 ,  Y10T428/1241

摘要： Provided is a molding method for a plate-shaped workpiece including forming a concave portion (11) at one surface (1a) of a plate-shaped workpiece (1), and bending the plate-shaped workpiece (1) having the concave portion (11) such that the one surface (1a) becomes a concave surface and a rear surface (1b) thereof becomes a convex surface.

摘要翻译： 本发明提供一种板状工件的成型方法，其包括在板状工件（1）的一个表面（1a）处形成凹部（11），并弯曲具有凹部的板状工件（1） 11），使得一个表面（1a）变成凹面，并且其后表面（1b）变为凸面。

公开(公告)号：US20120128725A1

公开(公告)日：2012-05-24

申请号：US13312260

申请日：2011-12-06

申请人： Shizuo Akira ,  Ken Ishii ,  Cevayir Coban

发明人： Shizuo Akira ,  Ken Ishii ,  Cevayir Coban

IPC分类号： A61K31/555 ,  C12N5/071 ,  A61K38/02

CPC分类号： A61K39/015 ,  A01K2267/0387 ,  A61K2039/572 ,  G01N33/56905 ,  G01N2333/445 ,  G01N2333/70596 ,  G01N2500/10 ,  Y02A50/58

摘要： The instant invention is to provide a method for detecting and measuring malaria infection utilizing the induction by hemozoin (HZ); a method for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection using the method for detecting and measuring; and a means for regulating the induction of innate immunity using the HZ, synthetic HZ, or derivatives thereof as an adjuvant or immunostimulant. Malaria infection is detected and measured of by detecting and measuring HZ-induced, TLR9-mediated, and MyD88-dependent innate immune activity. The detection and measurement of malaria infection can be used to diagnose malaria infection. The method for detecting and measuring is also used for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection. Further, HZ, synthetic HZ, or derivatives thereof are used as an adjuvant or immunostimulant to regulate HZ-induced innate immune induction.

摘要翻译： 本发明是提供一种利用血红素（HZ）的诱导检测和测量疟疾感染的方法; 使用检测和测量方法筛选疟疾感染疫苗的方法和用于疟疾感染的预防或治疗剂; 以及使用HZ，合成HZ或其衍生物作为佐剂或免疫刺激剂来调节诱导天然免疫的方法。 通过检测和测量HZ诱导的TLR9介导的和MyD88依赖性先天免疫活性来检测和测量疟疾感染。 疟疾感染的检测和测量可用于诊断疟疾感染。 用于检测和测量的方法也用于筛选疟疾感染的疫苗和用于疟疾感染的预防或治疗剂。 此外，HZ，合成HZ或其衍生物用作佐剂或免疫刺激剂以调节HZ诱导的先天免疫诱导。

公开(公告)号：US20120064132A1

公开(公告)日：2012-03-15

申请号：US13321215

申请日：2010-05-19

申请人： Mamoru Aizawa ,  Tomoyuki Hoshikawa ,  Ken Ishii ,  Haruki Funao

发明人： Mamoru Aizawa ,  Tomoyuki Hoshikawa ,  Ken Ishii ,  Haruki Funao

IPC分类号： A61K9/00 ,  A61P31/04 ,  C07F1/10 ,  A61K31/6615 ,  C07F9/117

CPC分类号： A61L27/12 ,  A61L27/54 ,  A61L29/02 ,  A61L29/16 ,  A61L31/026 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/112 ,  A61L2300/404 ,  A61L2300/606

摘要： An object of the present invention is to provide an antibacterial medical equipment which has sufficient antibacterial activity in vivo and is excellent in compatibility with living tissues, and also can maintain antibacterial activity over a long period and has high safety.An antibacterial medical equipment characterized in that inositol phosphate is bonded to a Ca compound of a medical equipment whose surface is at least coated with a layer of the Ca compound, or a medical equipment comprising the Ca compound. The antibacterial medical equipment as described above, wherein silver ions are bonded to the inositol phosphate. A method for producing an antibacterial medical equipment, which comprises bringing a medical equipment whose surface is at least coated with a layer of a Ca compound, or a medical equipment comprising a Ca compound into contact with an aqueous solution of inositol phosphate to obtain an antibacterial medical equipment in which inositol phosphate is bonded to the Ca compound. The method for producing an antibacterial medical equipment, wherein inositol phosphate is bonded to the Ca compound and then the Ca compound is brought into contact with an aqueous solution containing silver ions to obtain an antibacterial medical equipment in which silver ions are bonded to the inositol phosphate.

摘要翻译： 本发明的目的在于提供一种在体内具有足够的抗菌活性并且与活组织相容性优异的抗菌医疗设备，并且能够长时间保持抗菌活性且安全性高。 一种抗菌医疗设备，其特征在于磷酸肌醇与其表面至少涂覆有Ca化合物层的医疗设备的Ca化合物或包含Ca化合物的医疗设备结合。 如上所述的抗菌医疗设备，其中银离子与磷酸肌醇结合。 一种抗菌医疗设备的制造方法，其特征在于，将表面至少涂覆有Ca化合物的医疗器械，或包含Ca化合物的医疗器械与磷酸肌醇水溶液接触，得到抗菌剂 磷酸肌醇与Ca化合物结合的医疗设备。 生产抗菌医疗设备的方法，其中将磷酸肌醇与Ca化合物接合，然后使Ca化合物与含有银离子的水溶液接触，得到银离子与磷酸肌醇结合的抗菌医疗设备 。

公开(公告)号：US07960356B2

公开(公告)日：2011-06-14

申请号：US11131672

申请日：2005-05-17

申请人： Dennis Klinman ,  Daniela Verthelyi ,  Ken Ishii ,  James J. Mond ,  Mayda Gursel

发明人： Dennis Klinman ,  Daniela Verthelyi ,  Ken Ishii ,  James J. Mond ,  Mayda Gursel

IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K45/00 ,  A61K47/00 ,  A61K31/70 ,  A61K9/127 ,  A01N43/04

CPC分类号： A61K39/008 ,  A61K31/7088 ,  A61K39/39 ,  A61K2039/55561 ,  C07H21/04 ,  Y02A50/41 ,  A61K2300/00

摘要： D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5′ X1X2X3Pu1 Py2 CpG Pu3 Py4 X4X5X6(W)M (G)N-3′ wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.

摘要翻译： D型CpG寡脱氧核苷酸，其包含由下式表示的序列：5'X1X2X3Pu1 Py2 CpG Pu3 Py4 X4X5X6（W）M（G）N-3'其中中心CpG基序未甲基化，Pu是嘌呤核苷酸， Py是嘧啶核苷酸，X和W是任何核苷酸，M是0至10的任何整数，N是4至10的任何整数。提供使用这些寡脱氧核苷酸诱导免疫应答的方法。

公开(公告)号：US07919477B2

公开(公告)日：2011-04-05

申请号：US11801984

申请日：2007-05-10

申请人： Dennis Klinman ,  Ken Ishii ,  Daniela Verthelyi

发明人： Dennis Klinman ,  Ken Ishii ,  Daniela Verthelyi

IPC分类号： A61K47/00 ,  A61K45/00 ,  A61K31/70 ,  A01N43/04

CPC分类号： C12N15/117 ,  A61K2039/55561 ,  C12N2310/18 ,  C12N2310/315 ,  Y02A50/41 ,  Y02A50/412

摘要： Compositions including multiple oligodeoxynucleotides with a CpG motif are disclosed herein. The compositions can include either D or K type oligodeoxynucleotides. These compositions are of use in inducing an immune response in a large percentage of the individuals in a population.

摘要翻译： 包括具有CpG基序的多个寡脱氧核苷酸的组合物在本文中公开。 组合物可以包括D或K型寡脱氧核苷酸。 这些组合物可用于在群体中的大部分个体中诱导免疫应答。

公开(公告)号：US20070202575A1

公开(公告)日：2007-08-30

申请号：US11595211

申请日：2006-11-09

申请人： Dennis Klinman ,  Ken Ishii ,  Daniela Verthelyi ,  James Mond

发明人： Dennis Klinman ,  Ken Ishii ,  Daniela Verthelyi ,  James Mond

IPC分类号： A61K31/70 ,  C12P19/34 ,  C07K14/00 ,  A01N43/04 ,  C07K16/00 ,  A61K38/00 ,  C07K17/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00

CPC分类号： C07H21/04 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/008 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/55561 ,  C07H21/00 ,  C12N15/117 ,  C12N2310/17 ,  Y02A50/41 ,  Y02A50/423 ,  Y10T428/2989 ,  A61K2300/00

摘要： The present invention provides a substantially pure or isolated oligodeoxynucleotide of at least about 10 nucleotides comprising a sequence represented by either the formula: 5′ N1N2N3T-CpG-WN4N5N6 3′ wherein the central CpG motif is urnethylated, W is A or T, and N1, N2, N3, N4, N5, and N6 are any nucleotides, or the formula: 5′ RY—CpG-RY 3′wherein the central CpG motif is unmethylated, R is A or G, and Y is C or T, as well as an oligodeoxynucleotide delivery complex and a pharmacological composition comprising the present inventive oligodeoxynucleotide, and a method of inducing an immune response by administering the present inventive oligodeoxynucleotide to a host.

摘要翻译： 本发明提供了至少约10个核苷酸的基本上纯的或分离的寡脱氧核苷酸，其包含由下式表示的序列：<？in-line-formula description =“In-line Formulas”end =“lead”→5'N 4 N 2 N 3 N 2 N 3 N 3 N 2 N 3 N 3 N 3 N 3 N 3 N 3 N 其中中央CpG基序是亚甲基化的，W是A或T，N' N 1，N 2，N 3，N 4，N 5和N N > 6 是任何核苷酸，或下式：<？in-line-formula description =“In-line Formulas”end =“lead”？> 5'RY-CpG-RY 3' -formulae description =“In-line Formulas”end =“tail”？>其中中央CpG基序是未甲基化的，R是A或G，Y是C或T，以及寡脱氧核苷酸递送复合物和包含 本发明的寡脱氧核苷酸，以及通过给药诱导免疫应答的方法 将本发明的寡脱氧核苷酸引入宿主。

公开(公告)号：US06977245B2

公开(公告)日：2005-12-20

申请号：US10068160

申请日：2002-02-06

申请人： Dennis Klinman ,  Daniela Verthelyi ,  Ken Ishii ,  James J. Mond ,  Mayda Gursel

发明人： Dennis Klinman ,  Daniela Verthelyi ,  Ken Ishii ,  James J. Mond ,  Mayda Gursel

IPC分类号： A61K31/7088 ,  A61K39/008 ,  A61K39/39 ,  A61K48/00 ,  C07H21/04

CPC分类号： A61K39/008 ,  A61K31/7088 ,  A61K39/39 ,  A61K2039/55561 ,  C07H21/04 ,  Y02A50/41 ,  A61K2300/00

摘要： D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5′X1X2X3Pu1 Py2 CpG Pu3 Py4 X4X5X6(W)M(G)N-3′ wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.

摘要翻译： 本文提供D型CpG寡脱氧核苷酸，其包括由下式表示的序列：<？in-line-formula description =“In-line Formulas”end =“lead”？> 5'X 1 < X 2 X 3 P 1 P 2 C 2 CpG Pu 3 Py 3 （X）X（X）X（X）X（X）X 其中中心CpG基序是未甲基化的，Pu是嘌呤核苷酸，Py是嘧啶核苷酸，X 并且W是任何核苷酸，M是0至10的任何整数，N是4至10的任何整数。提供了使用这些寡脱氧核苷酸诱导免疫应答的方法。

公开(公告)号：US09056094B2

公开(公告)日：2015-06-16

申请号：US12740899

申请日：2008-10-31

申请人： Toshihiro Tsukui ,  Ken Ishii ,  Shizuo Akira ,  Cevayir Coban

发明人： Toshihiro Tsukui ,  Ken Ishii ,  Shizuo Akira ,  Cevayir Coban

IPC分类号： A61K9/00 ,  A61K39/00 ,  A61K39/39 ,  A61K47/46 ,  A61K39/35

CPC分类号： A61K39/39 ,  A61K9/0019 ,  A61K39/35 ,  A61K47/46 ,  A61K2039/55516

摘要： The present invention provides a vaccine adjuvant composition which is used in combination with an allergen vaccine, infection vaccine or tumor vaccine. The present invention specifically provides a vaccine adjuvant composition comprising hemozoin or β-hematin and being used in combination with an allergen vaccine, infection vaccine or tumor vaccine, and a vaccine composition comprising the vaccine adjuvant composition and an allergen vaccine, infection vaccine or tumor vaccine.

摘要翻译： 本发明提供了与变应原疫苗，感染疫苗或肿瘤疫苗组合使用的疫苗佐剂组合物。 本发明具体提供一种疫苗佐剂组合物，其包含血红素或重金属，并与变应原疫苗，感染疫苗或肿瘤疫苗组合使用，以及包含疫苗佐剂组合物和变应原疫苗，感染疫苗或肿瘤的疫苗组合物 疫苗。