摘要:
The present invention relates to a carboxylic acid compound of formula (I): wherein R1 is H, alkyl; m is 2, 3; n is 0-2; R2 is phenyl, naphthyl, benzofuran, benzothiophene; Q is —CH2—O-Cyc1, —CH2-Cyc2, -L-Cyc3; R3a and R3b each independently is hydrogen, alkyl or taken together form tetrahydro-2H-pyran; a pharmaceutically acceptable salt thereof, a method for producing a process of the preparation thereof and a pharmaceutical agent comprising the same as an active ingredient. The compound of formula (I) have an antagonizing activity against PGE2 receptor, specifically EP3 receptor which is subtype thereof, and are useful for the prevention and/or treatment of itching, pain, urinary disturbance or stress disease.
摘要:
Disclosed is a releasably sealable bag for low temperature cooking comprising a film material, wherein the film material does not deform at temperatures of up to about 125° C., and wherein the bag is air and liquid impermeable when sealed. Also disclosed are such bags wherein at least a portion of the film material is comprised of a composite film material provided with a pressure sensitive adhesive protected from inadvertent adherence. Further disclosed are methods for food preparation and cooking using any of the embodiments of the bag of the present invention.
摘要:
The present invention relates to a carboxylic acid compound of formula (I): wherein R1 is H, alkyl; m is 2, 3; n is 0-2; R2 is phenyl, naphthyl, benzofuran, benzothiophene; Q is —CH2—O-Cyc1, —CH2-Cyc2, -L-Cyc3; R3a and R3b each independently is hydrogen, alkyl or taken together form tetrahydro-2H-pyran; a pharmaceutically acceptable salt thereof, a method for producing a process of the preparation thereof and a pharmaceutical agent comprising the same as an active ingredient. The compound of formula (I) have an antagonizing activity against PGE2 receptor, specifically EP3 receptor which is subtype thereof, and are useful for the prevention and/or treatment of itching, pain, urinary disturbance or stress disease.
摘要翻译:本发明涉及式(I)的羧酸化合物:其中R 1是H,烷基; m为2,3; n为0-2; R 2是苯基,萘基,苯并呋喃,苯并噻吩; Q是-CH 2 -O-Cyc 1,-CH 2 -Cyc2,-L-Cyc 3; R 3a和R 3b各自独立地是氢,烷基或一起形成四氢-2H-吡喃; 其药学上可接受的盐,其制备方法的制备方法和包含其的药剂作为活性成分。 式(I)化合物对PGE2受体具有拮抗作用,特别是作为其亚型的EP 3受体,可用于预防和/或治疗 瘙痒,疼痛,尿失禁或压力疾病。
摘要:
[Problem] To provide a diphenyl sulfide derivative which is useful as a pharmaceutical product that has excellent S1P3 antagonist activity.[Solution] The inventors have discovered that a diphenyl sulfide derivative represented by general formula (1) (wherein R1 represents an alkoxy group having 1-6 carbon atoms, R2 represents a propyl group or an allyl group, X represents methylene or an oxygen atom, and Z represents a halogen atom) has excellent S1P3 antagonist activity as a result of extensive researches for the production of a compound that has S1P3 antagonist activity.
摘要:
A mobile telephone switching network 3, a server 5, and a terminal equipment 7 are connected to a network 4. A portable telephone set 2 manufactured by a manufacturer 1 is connected to the mobile telephone switching network 3. Not only a service application fabricated by an application maker 6 but also a key application determining a key layout based on API published by the manufacturer 1 are uploaded to the server 5. The service and the key applications are downloaded to the portable telephone set 2 in response to a requirement from the portable telephone set 2. In the portable telephone set 2, the service application is analyzed by using the key application downloaded as mentioned above. The key layout is then determined by analyzing the service application. The key layout is displayed on the liquid crystal display of the portable telephone set 2.
摘要:
A sealing apparatus has a metal ring having a cylindrical portion and an inward flange portion bending from the open-air side end of the cylindrical portion radially inward; a first sealing member formed integral with the metal ring, and having a first rubber-like sealing lip, and a flange-shaped interposed portion held between the inward flange position of the metal ring and the radial portion of the first sealing member. A second sealing member made of a resin material, extends from the inside-diameter end of the interposed portion axially toward the sealing liquid side, and is located in a gap between the open-air side surface of the first sealing lip and a rotary member, having the inner periphery thereof in slidable close contact with the surface of the rotary member, and regulates radial deformation of the first sealing lip. A screw pumping portion is provided to transport the liquid between the sliding surfaces to the sealing liquid side on rotation of the rotary member.
摘要:
[Problem] To provide a diphenyl sulfide derivative which is useful as a pharmaceutical product that has excellent S1P3 antagonist activity.[Solution] The inventors have discovered that a diphenyl sulfide derivative represented by general formula (1) (wherein R1 represents an alkoxy group having 1-6 carbon atoms, R2 represents a propyl group or an allyl group, X represents methylene or an oxygen atom, and Z represents a halogen atom) has excellent S1P3 antagonist activity as a result of extensive researches for the production of a compound that has S1P3 antagonist activity.
摘要:
For an oil seal (1) having a seal lip (6) with a slope (7) at the side of sealed fluid and a slope (8) at the side opposite to the sealed fluid, and a screw section (9) provided on the slope (8) for pushing back sealed fluid by a pumping effect at a time of rotation, in order to achieve low torque characteristics based on fluid lubrication by increasing the thickness of an oil film on sliding surfaces, an intermediate surface (10) is provided between the slopes (7, 8), and an oppositely threaded screw section (11) for sucking the sealed fluid by a pumping effect is provided on the intermediate surface (10) without reaching the boundary (13) between the intermediate surface (10) and the slope (8), so that a threadless region is provided in the entire circumference between the screw section (11) and the boundary (13).
摘要:
For an oil seal (1) having a seal lip (6) with a slope (7) at the side of sealed fluid and a slope (8) at the side opposite to the sealed fluid, and a screw section (9) provided on the slope (8) for pushing back sealed fluid by a pumping effect at a time of rotation, in order to achieve low torque characteristics based on fluid lubrication by increasing the thickness of an oil film on sliding surfaces, an intermediate surface (10) is provided between the slopes (7, 8), and an oppositely threaded screw section (11) for sucking the sealed fluid by a pumping effect is provided on the intermediate surface (10) without reaching the boundary (13) between the intermediate surface (10) and the slope (8), so that a threadless region is provided in the entire circumference between the screw section (11) and the boundary (13).
摘要:
To make it unnecessary to insert a plate spring as a separate part between a metal ring (2) and a mating member (11) to be coupled therewith such as a clutch plate, and reduce the number of parts and the assembly manhours, the sealing device (1) includes the metal ring (2) and seal sections (3) such as packings supported by the metal ring (2), and the metal ring (2) is provided with a intimate-contact region (4) for intimately contacting to the mating member (11) to be coupled, wherein the sealing device (1) is characterized in that the intimate-contact region (4) of the metal ring (2) is integrally formed with pawl-like intimate-contact sections (6) which are in the form of a pawl and which exert spring force on the mating member (11) to be coupled, and is used, for example, as a bonded piston seal (BPS) in an automatic transmission.