公开(公告)号：US06217540B1

公开(公告)日：2001-04-17

申请号：US09349173

申请日：1999-07-09

申请人： Kenichiro Yazawa ,  Keiichi Ishizaki ,  Takeshi Igarashi ,  Masao Kitajima ,  Shigeru Tezuka ,  Takaki Arai ,  Toshihisa Ito ,  Osamu Seshimoto

发明人： Kenichiro Yazawa ,  Keiichi Ishizaki ,  Takeshi Igarashi ,  Masao Kitajima ,  Shigeru Tezuka ,  Takaki Arai ,  Toshihisa Ito ,  Osamu Seshimoto

IPC分类号： A61M3700

CPC分类号： G01N33/491

摘要： The invention provides a blood filter cartridge which is made so that the filtrate discharged from the filtrate outlet is not drawn back to the inside of the filtering chamber. The blood filter cartridge includes a blood filtering material, a holder containing the blood filtering material and having a blood inlet and a filtrate outlet, and a filtrate receiver which receives the filtrate discharged from the filtrate outlet. The blood filter catridge is provided with a means for preventing the filtrate in the filtrate receiver from returning to inside of the holder upon finishing filtration. Such means include the following: removing opposite faces around the filtrate outlet, making length of lower end of the filtrate outlet 0.8 mm or more, smoothing surface around the filtrate outlet, and forming surface around the filtrate outlet by a material having a small surface energy.

摘要翻译： 本发明提供了一种血液过滤器滤芯，其被制成使得从滤液出口排出的滤液不会被抽回到过滤室的内部。 血液过滤器滤芯包括血液过滤材料，含有血液过滤材料并具有血液入口和滤液出口的保持器和接收从滤​​液出口排出的滤液的滤液接收器。 血液过滤器夹具设置有用于防止滤液接收器中的滤液在完成过滤时返回到保持器内部的装置。 这样的方法包括以下步骤：除去滤液出口周围的相对面，使滤液出口的下端长度为0.8mm以上，使滤液出口周围的表面光滑，并且通过具有小表面能的材料在滤液出口周围形成表面 。

公开(公告)号：US06471868B1

公开(公告)日：2002-10-29

申请号：US09680179

申请日：2000-10-05

申请人： Toshihisa Ito ,  Takaki Arai ,  Kenichiro Yazawa ,  Osamu Seshimoto

发明人： Toshihisa Ito ,  Takaki Arai ,  Kenichiro Yazawa ,  Osamu Seshimoto

IPC分类号： B01D6114

CPC分类号： B01D39/2017 ,  G01N1/4077 ,  Y10T436/25375 ,  Y10T436/255

摘要： A method for preparing a plasma or serum sample from a whole blood sample, by contacting a glass fiber filter which contains calcium, sodium or potassium components with an aqueous solution of an organic acid or a mineral acid to elute the calcium, sodium and potassium components in the glass fiber filter into the aqueous solution, separating the aqueous solution from the filter and washing the glass fiber filter with water to remove any residual aqueous solution adhered thereto and then filtering a whole blood sample through the thus treated fiber filter.

摘要翻译： 通过将含有钙，钠或钾组分的玻璃纤维过滤器与有机酸或无机酸的水溶液接触以洗脱钙，钠和钾组分，从全血样品制备血浆或血清样品的方法 在将玻璃纤维过滤到水溶液中，将水溶液与过滤器分离并用水洗涤玻璃纤维过滤器以除去粘附在其上的残留水溶液，然后通过如此处理的纤维过滤器过滤全血样品。

公开(公告)号：US06280621B1

公开(公告)日：2001-08-28

申请号：US09487679

申请日：2000-01-19

申请人： Kenichiro Yazawa ,  Takaki Arai ,  Osamu Seshimoto

发明人： Kenichiro Yazawa ,  Takaki Arai ,  Osamu Seshimoto

IPC分类号： B01D2905

CPC分类号： B01L3/502 ,  B01D61/18 ,  B01D61/20 ,  B01L3/0275 ,  B01L2300/0681 ,  G01N33/491

摘要： The blood filter cartridge of the invention can be used as a sample cup of an analyzer without sucking bubbles, which comprises a blood filtering material, a holder containing the blood filtering material and having a blood inlet and a filtrate outlet, and a filtrate receiver for receiving filtrate discharged from the filtrate outlet, the filtrate receiver has an upper end having a difference in height or structure for returning the filtrate from the upper end of the filtrate receiver to the filtrate outlet.

摘要翻译： 本发明的血液过滤器滤芯可用作分析器的样品杯而不吸入气泡，其包括血液过滤材料，含有血液过滤材料并具有血液入口和滤液出口的保持器，以及用于 接收从滤液出口排出的滤液，滤液接收器具有高度或结构差的上端，用于将滤液从滤液接收器的上端返回到滤液出口。

公开(公告)号：US06405876B1

公开(公告)日：2002-06-18

申请号：US09464612

申请日：1999-12-15

申请人： Osamu Seshimoto ,  Kenichiro Yazawa ,  Takaki Arai

发明人： Osamu Seshimoto ,  Kenichiro Yazawa ,  Takaki Arai

IPC分类号： B01D2900

CPC分类号： G01N1/4077 ,  B01D61/18 ,  B01D61/20 ,  B01D69/12 ,  B01D69/141 ,  B01D71/68 ,  G01N33/491 ,  G01N2001/4016

摘要： The blood filter cartridge which can collect a minor component of blood efficiently in a high concentration comprises a blood filtering material and a holder containing the blood filtering material and having a blood inlet and a filtrate outlet, wherein an antibody or an antigen is immobilized on at least a part from the blood inlet to the filtrate outlet or a filtrate receiver.

摘要翻译： 能够以高浓度有效地收集血液的次要成分的血液过滤器滤芯包括血液过滤材料和含有血液过滤材料并具有血液入口和滤液出口的保持器，其中将抗体或抗原固定在 从血液入口到滤液出口或滤液接收器的至少一部分。

公开(公告)号：US06383818B1

公开(公告)日：2002-05-07

申请号：US09496082

申请日：2000-02-01

申请人： Takaki Arai ,  Kenichiro Yazawa ,  Osamu Seshimoto

发明人： Takaki Arai ,  Kenichiro Yazawa ,  Osamu Seshimoto

IPC分类号： G01N100

CPC分类号： G01N33/491 ,  G01N1/4077 ,  Y10T436/25375

摘要： The present invention provides a method of analyzing a blood component by filtering blood using a glass fiber filter to obtain a plasma or serum sample and measuring the sample, wherein some plasma or serum samples obtained by using the same type glass fiber filter and by a standard method have previously been measured to determine a and b of the formula Y=ax+b wherein Y is the analytical value obtained by the standard method and x is the analytical value obtained by using the glass fiber filter, and the analytical value of the blood is corrected by using the above formula.

摘要翻译： 本发明提供一种通过使用玻璃纤维过滤器过滤血液来分析血液成分的方法，以获得血浆或血清样品并测量样品，其中通过使用相同类型的玻璃纤维过滤器和标准物获得的一些血浆或血清样品 先前已经测量了方法以确定糠醛的α和b，Y是通过标准方法获得的分析值，x是通过使用玻璃纤维过滤器获得的分析值，并且通过使用上述方法校正血液的分析值 式。

公开(公告)号：US06328167B1

公开(公告)日：2001-12-11

申请号：US09473497

申请日：1999-12-28

申请人： Osamu Seshimoto ,  Takaki Arai ,  Kenichiro Yazawa

发明人： Osamu Seshimoto ,  Takaki Arai ,  Kenichiro Yazawa

IPC分类号： B01D2900

CPC分类号： B01D61/18 ,  G01N33/491

摘要： The blood filter cartridge can filter almost total volume of drawn blood efficiently which comprises a blood filtering material and a holder containing the blood filtering material, wherein the holder is provided with a blood reservoir which connects with an inflow side of the blood filtering material and a filtrate receiver which connects with an outflow side of the blood filtering material.

摘要翻译： 血液过滤器滤芯能够高效地过滤包括血液过滤材料和含有血液过滤材料的保持器的几乎总体积的抽吸血液，其中，保持器设置有与血液过滤材料的流入侧连接的血液储存器， 滤液接收器，其与血液过滤材料的流出侧连接。

公开(公告)号：US06375856B1

公开(公告)日：2002-04-23

申请号：US09464614

申请日：1999-12-15

申请人： Osamu Seshimoto ,  Kenichiro Yazawa ,  Takaki Arai

发明人： Osamu Seshimoto ,  Kenichiro Yazawa ,  Takaki Arai

IPC分类号： B01D2962

CPC分类号： G01N1/4077 ,  B01D39/2017 ,  B01D61/14 ,  B01D61/147 ,  B01D61/18 ,  G01N33/491 ,  Y10T436/25375

摘要： The invention provides a method of recovering filtration residues of blood which comprises filtering blood by a blood filtering device comprising a blood filtering material which is a depth filtering material and a holder which contains the blood filtering material and has a blood inlet and filtrate outlet, after finishing the filtering blood, feeding aqueous liquid to the filtrate outlet to recover the filtration residues accumulated in the blood filtering material.

摘要翻译： 本发明提供了一种回收血液过滤残余物的方法，该方法包括通过血液过滤装置过滤血液，所述血液过滤装置包括作为深度过滤材料的血液过滤材料和含有血液过滤材料并具有血液入口和滤液出口的保持器， 完成过滤血液，将水性液体供给到滤液出口，以回收积聚在血液过滤材料中的过滤残留物。

公开(公告)号：US5639665A

公开(公告)日：1997-06-17

申请号：US568475

申请日：1995-12-07

申请人： Takaki Arai ,  Osamu Seshimoto

发明人： Takaki Arai ,  Osamu Seshimoto

IPC分类号： G01N1/00 ,  G01N1/28 ,  G01N21/78 ,  G01N33/52 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10

CPC分类号： G01N35/00029 ,  G01N35/10 ,  G01N2035/00277 ,  G01N2035/1034 ,  Y10T436/112499 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/119163 ,  Y10T436/12 ,  Y10T436/25 ,  Y10T436/2575

摘要： When spotting a sample liquid onto a plurality of frameless chemical analysis films, a predetermined amount of the sample liquid is sucked into a spotting tip, the lower end of the spotting tip is brought into contact with the surface of each chemical analysis film and the pressure in the spotting tip is increased to discharge the sample liquid therein onto the surface of the chemical analysis film while lifting the spotting tip away from the surface of the film. When a first chemical analysis film includes a component which can deteriorate the accuracy of measurement of the analyte for the second frameless chemical analysis film, the sample liquid is spotted, before the second chemical analysis film after the first chemical analysis film, on a third frameless chemical analysis film which does not include a component which can deteriorate the accuracy of measurement of the analyte of the second chemical analysis film and the analyte of which is not such that the accuracy of its measurement is substantially affected by a component of the first chemical analysis film which can be transferred to the third chemical analysis film.

摘要翻译： 当将样品液体检测到多个无框架化学分析膜上时，将预定量的样品液体吸入点样尖端，使点样尖端的下端与每个化学分析膜的表面接触，并且压力 在点样尖端被增加以将其中的样品液体排出到化学分析膜的表面上，同时将点样尖端远离膜的表面提升。 当第一化学分析膜包含可劣化第二无框化学分析膜的分析物的测量精度的成分时，在第一化学分析膜之后的第二化学分析膜之前，将样品液体点样， 化学分析膜不包含可能劣化第二化学分析膜的分析物的测定精度的成分，其分析物不能使其测定精度受到第一化学分析的成分的显着影响 可以转移到第三个化学分析膜的薄膜。

公开(公告)号：US5629206A

公开(公告)日：1997-05-13

申请号：US582046

申请日：1996-01-02

申请人： Takaki Arai ,  Osamu Seshimoto

发明人： Takaki Arai ,  Osamu Seshimoto

IPC分类号： G01N21/78 ,  G01N33/52 ,  G01N33/62 ,  G01N35/00 ,  G01N35/04

CPC分类号： G01N35/00029 ,  G01N2035/00277 ,  Y10T436/112499 ,  Y10T436/114165 ,  Y10T436/115831 ,  Y10T436/12

摘要： A dry chemical analysis film deposited with a sample liquid is inserted into an incubator to be incubated at a predetermined temperature, a coloring reaction of the chemical analysis film is measured after the incubation and then the chemical analysis film is discharged from the incubator. A plurality of chemical analysis films are subjected to these steps one by one after the preceding chemical analysis film is discharged from the incubator. When a first chemical analysis film is for an analyte which generates an interfering gas or the like which can adversely affects the accuracy of measurement of other chemical analysis films and a second chemical analysis film the accuracy of measurement on which can be adversely affected by the interfering gas or the like is to be inserted into the incubator after the first chemical analysis film is discharged, an adsorptive film which adsorbs the interfering gas or the like generated from the first chemical analysis film is inserted into the incubator after discharge of the first chemical analysis film prior to insertion of the second chemical analysis film.

摘要翻译： 将沉积有样品液体的干化学分析膜插入培养箱中以在预定温度下孵育，孵育后测量化学分析膜的着色反应，然后化学分析膜从培养箱中排出。 在先前的化学分析膜从培养箱中排出之后，多个化学分析膜经过这些步骤。 当第一化学分析膜用于产生可能不利地影响其他化学分析膜和第二化学分析膜的测量精度的干扰气体等的分析物时，测量的精度可能受到干扰的不利影响 在排出第一化学分析膜后，将气体等插入培养箱中，将第一化学分析膜产生的吸附了干扰气体等的吸附膜插入培养箱中，第一化学分析 在插入第二化学分析膜之前的膜。

公开(公告)号：US07022285B2

公开(公告)日：2006-04-04

申请号：US09978109

申请日：2001-10-15

申请人： Takaki Arai ,  Fuminori Arai ,  Keiichi Ishizaki

发明人： Takaki Arai ,  Fuminori Arai ,  Keiichi Ishizaki

IPC分类号： G01N31/00

CPC分类号： G01N31/223 ,  Y10T436/175383

摘要： An integral multilayer analytical element for analysis of ammonia or ammonia-producing substance is provided, which comprises a thin liquid blocking layer having a comparative facility with a thicker liquid blocking layer and is stably fabricated on a common production line employed for different type of slides.In the integral multilayer analytical element for analysis of ammonia or ammonia-producing substance comprising a transparent support, an indicator layer containing an indicator which produces a detectable change by gaseous ammonia, a liquid blocking layer permitting a gaseous ammonia to pass through, a reagent layer containing an alkaline buffering agent and optionally a reagent capable of reacting with said ammonia-producing substance to produce ammonia, and a spreading layer, adhesively laminated in this order, the improvement which comprises that said liquid blocking layer is composed of at least two porous membranes.