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    Truncated ADAMTS molecules
    7.
    发明申请
    Truncated ADAMTS molecules 审中-公开
    截断的ADAMTS分子

    公开(公告)号：US20050277175A1

    公开(公告)日：2005-12-15

    申请号：US11109157

    申请日：2005-04-18

    申请人： Edward LaVallie ,  Lisa Collins-Racie ,  Christopher Corcoran ,  Natalie Twine ,  Michael Agostino

    发明人： Edward LaVallie ,  Lisa Collins-Racie ,  Christopher Corcoran ,  Natalie Twine ,  Michael Agostino

    IPC分类号： C07H21/04 ,  C12N9/64 ,  C12P21/06

    CPC分类号： C12N9/6489

    摘要： The invention provides truncated biologically active ADAMTS polypeptides, particularly those with hyalectenase activity, and more particularly those with aggrecanase activity, that exhibit greater stability and homogeneity and higher expression yields than their full-length counterparts. The invention also provides nucleic acid molecules encoding such truncated biologically active ADAMTS polypeptides and methods for producing the truncated biologically active ADAMTS polypeptides. In addition, the invention provides methods for identifying compounds capable of modulating biologically active ADAMTS polypeptides, particularly those compounds that inhibit aggrecanase activity.

    摘要翻译： 本发明提供截短的生物活性ADAMTS多肽，特别是那些具有透明质酸酶活性的多肽，更具体地，具有聚集蛋白聚糖蛋白聚糖酶活性的多肽，其表现出比其全长对应物更大的稳定性和均一性和更高的表达产率。 本发明还提供编码这种截短的生物活性ADAMTS多肽的核酸分子和用于产生截短的生物活性ADAMTS多肽的方法。 此外，本发明提供了鉴定能够调节生物活性ADAMTS多肽，特别是那些抑制聚蛋白聚糖蛋白酶活性的化合物的化合物的方法。

    Truncated aggrecanase molecules
    9.
    发明申请
    Truncated aggrecanase molecules 审中-公开
    截短的聚蛋白聚糖酶分子

    公开(公告)号：US20070161046A1

    公开(公告)日：2007-07-12

    申请号：US11640482

    申请日：2006-12-15

    申请人： Katy Georgiadis ,  Tara Crawford ,  Kathleen Tomkinson ,  Lisa Collins-Racie ,  Christopher Corcoran ,  Bethany Freeman ,  Edward LaVallie

    发明人： Katy Georgiadis ,  Tara Crawford ,  Kathleen Tomkinson ,  Lisa Collins-Racie ,  Christopher Corcoran ,  Bethany Freeman ,  Edward LaVallie

    IPC分类号： G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C12N9/64 ,  C07K16/40

    CPC分类号： C12N9/6421

    摘要： Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.

    摘要翻译： 公开了截短的聚蛋白聚糖蛋白聚糖蛋白和编码它们的核苷酸序列及其生产方法。 此外，还公开了与野生型或天然聚集蛋白聚糖蛋白聚糖酶相比导致增加的稳定性和表达水平的氨基酸突变的聚集蛋白聚糖蛋白聚糖酶。 本发明的骨灰蛋白酶特别可用于开发用于治疗疾病如骨关节炎的组合物。 还公开了开发聚蛋白聚糖酶的抑制剂的方法和用于治疗以聚集蛋白聚糖降解为特征的病症的酶的抗体的方法。