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1.发明申请公开(公告)号：US20080064980A1
公开(公告)日：2008-03-13
申请号：US11833548
申请日：2007-08-03
CPC分类号： A61B5/053 , A61B5/02405 , A61B5/036 , A61B5/0816 , A61B5/145 , A61B5/14539 , A61B5/412 , A61N1/36521
摘要： The invention relates to systems, devices, and methods for detecting infections associated with implantable medical devices. In an embodiment, the invention includes a method of detecting infection in a patient including measuring a physiological parameter using a chronically implanted sensor at a plurality of time points and evaluating the physiological parameter measurements to determine if infection is indicated. In an embodiment, the invention includes an implantable medical device including a first chronically implantable sensor configured to generate a first signal corresponding to a physiological parameter and a controller disposed within a housing, the controller configured to evaluate the first physiological parameter signal to determine if an infection is indicated. Other embodiments are also included herein.
摘要翻译： 本发明涉及用于检测与可植入医疗装置相关的感染的系统，装置和方法。 在一个实施例中，本发明包括检测患者感染的方法，包括在多个时间点使用长期植入的传感器测量生理参数，并评估生理参数测量以确定是否指示感染。 在一个实施例中，本发明包括可植入医疗装置，其包括被配置为产生对应于生理参数的第一信号的第一长期可植入传感器和设置在壳体内的控制器，所述控制器被配置为评估第一生理参数信号以确定是否 表示感染。 本文还包括其它实施例。
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2.发明授权公开(公告)号：US08583224B2
公开(公告)日：2013-11-12
申请号：US11833548
申请日：2007-08-03
申请人： Kent Lee , Jonathan T. Kwok , Hugo Andres Belalcazar , Jennifer Lynn Pavlovic , Ronald W. Heil, Jr.
发明人： Kent Lee , Jonathan T. Kwok , Hugo Andres Belalcazar , Jennifer Lynn Pavlovic , Ronald W. Heil, Jr.
IPC分类号： A61B5/05
CPC分类号： A61B5/053 , A61B5/02405 , A61B5/036 , A61B5/0816 , A61B5/145 , A61B5/14539 , A61B5/412 , A61N1/36521
摘要： The invention relates to systems, devices, and methods for detecting infections associated with implantable medical devices. In an embodiment, the invention includes a method of detecting infection in a patient including measuring a physiological parameter using a chronically implanted sensor at a plurality of time points and evaluating the physiological parameter measurements to determine if infection is indicated. In an embodiment, the invention includes an implantable medical device including a first chronically implantable sensor configured to generate a first signal corresponding to a physiological parameter and a controller disposed within a housing, the controller configured to evaluate the first physiological parameter signal to determine if an infection is indicated. Other embodiments are also included herein.
摘要翻译： 本发明涉及用于检测与可植入医疗装置相关的感染的系统，装置和方法。 在一个实施例中，本发明包括检测患者感染的方法，包括在多个时间点使用长期植入的传感器测量生理参数，并评估生理参数测量以确定是否指示感染。 在一个实施例中，本发明包括可植入医疗装置，其包括被配置为产生对应于生理参数的第一信号的第一长期可植入传感器和设置在壳体内的控制器，所述控制器被配置为评估第一生理参数信号以确定是否 表示感染。 本文还包括其它实施例。
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公开(公告)号：US20100100000A1
公开(公告)日：2010-04-22
申请号：US12564741
申请日：2009-09-22
申请人： Kent Lee , Yi Zhang , Paul F. Emerson , Jesse W. Hartley , John D. Hatlestad , Jonathan T. Kwok , Weiguang Shao
发明人： Kent Lee , Yi Zhang , Paul F. Emerson , Jesse W. Hartley , John D. Hatlestad , Jonathan T. Kwok , Weiguang Shao
CPC分类号： A61B5/0809 , A61B5/029 , A61B5/04001 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/091 , A61B5/11 , A61B5/4818
摘要： A respiration pattern of a number of respiration cycles is detected and breath intervals (BI) and tidal volume (TVOL) measurements of each of the respiration cycles are respectively determined. An unevenly sampled instantaneous minute ventilation (iMV) signal is produced using the BI and TVOL measurements, and an evenly sampled iMV signal (resampled iMV signal) is produced using the unevenly sampled iMV signal. Disordered breathing is detected based on a comparison between a baseline threshold and the resampled iMV signal.
摘要翻译： 检测多个呼吸周期的呼吸模式，分别确定每个呼吸周期的呼吸间隔（BI）和潮气量（TVOL）测量值。 使用BI和TVOL测量产生不均匀采样的瞬时分钟通气（iMV）信号，并且使用不均匀采样的iMV信号产生均匀采样的iMV信号（重新采样的iMV信号）。 基于基线阈值和重新采样的iMV信号之间的比较来检测无效呼吸。
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公开(公告)号：US08936556B2
公开(公告)日：2015-01-20
申请号：US12564741
申请日：2009-09-22
申请人： Kent Lee , Yi Zhang , Paul F. Emerson , Jesse W. Hartley , John D. Hatlestad , Jonathan T. Kwok , Weiguang Shao
发明人： Kent Lee , Yi Zhang , Paul F. Emerson , Jesse W. Hartley , John D. Hatlestad , Jonathan T. Kwok , Weiguang Shao
IPC分类号： A61B5/02 , G06N5/02 , A61B5/08 , A61B5/00 , A61B5/091 , A61B5/04 , A61B5/0488 , A61B5/0476 , A61B5/0402 , A61B5/029 , A61B5/11
CPC分类号： A61B5/0809 , A61B5/029 , A61B5/04001 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/091 , A61B5/11 , A61B5/4818
摘要： A respiration pattern of a number of respiration cycles is detected and breath intervals (BI) and tidal volume (TVOL) measurements of each of the respiration cycles are respectively determined. An unevenly sampled instantaneous minute ventilation (iMV) signal is produced using the BI and TVOL measurements, and an evenly sampled iMV signal (resampled iMV signal) is produced using the unevenly sampled iMV signal. Disordered breathing is detected based on a comparison between a baseline threshold and the resampled iMV signal.
摘要翻译： 检测多个呼吸周期的呼吸模式，分别确定每个呼吸周期的呼吸间隔（BI）和潮气量（TVOL）测量值。 使用BI和TVOL测量产生不均匀采样的瞬时分钟通气（iMV）信号，并且使用不均匀采样的iMV信号产生均匀采样的iMV信号（重新采样的iMV信号）。 基于基线阈值和重新采样的iMV信号之间的比较来检测呼吸紊乱。
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5.发明授权Method and system for heart failure status evaluation based on a disordered breathing index 有权基于无序呼吸指数的心衰状态评估方法和系统公开(公告)号：US08696589B2
公开(公告)日：2014-04-15
申请号：US12847698
申请日：2010-07-30
申请人： Jonathan T. Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey E. Stahmann , Yi Zhang , Jesse W. Hartley
发明人： Jonathan T. Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey E. Stahmann , Yi Zhang , Jesse W. Hartley
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译： 基于无序呼吸指数提供心力衰竭状态评估。 感测患者呼吸并产生呼吸信号。 基于呼吸信号检测到无序呼吸事件。 基于无序呼吸发作确定无序呼吸指数。 无序呼吸指数趋向并用于评估心力衰竭状态。 无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。
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公开(公告)号：US08990153B2
公开(公告)日：2015-03-24
申请号：US11561680
申请日：2006-11-20
CPC分类号： H04L67/1095 , G06F3/0607 , G06F3/065 , G06F3/0659 , G06F3/067 , G06F11/1662 , H04L69/24
摘要： A data storage system, device, and method are provided for replicating data between different data storage systems or appliances. More specifically, the present invention affords communications between heterogeneous data storage systems that potential employ different communication protocols. A bridging communication protocol is utilized by one or both storage systems in order to accommodate different communication protocols. Alternatively, a storage appliance connecting the data storage systems may employ the bridging communication protocol.
摘要翻译： 提供了一种用于在不同数据存储系统或设备之间复制数据的数据存储系统，设备和方法。 更具体地，本发明提供了使用不同通信协议的异构数据存储系统之间的通信。 一个或两个存储系统利用桥接通信协议来适应不同的通信协议。 或者，连接数据存储系统的存储设备可以采用桥接通信协议。
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7.发明授权System and method for determining pulmonary performance from transthoracic impedance measures 有权用于确定经胸阻抗措施的肺功能的系统和方法公开(公告)号：US08795189B2
公开(公告)日：2014-08-05
申请号：US12029422
申请日：2008-02-11
申请人： Quan Ni , Jesse W. Hartley , Kent Lee , Jeffrey E. Stahmann
发明人： Quan Ni , Jesse W. Hartley , Kent Lee , Jeffrey E. Stahmann
IPC分类号： A61B5/08
CPC分类号： A61B5/0809 , A61B5/0002 , A61B5/0535 , A61N1/36521 , G06F19/3418
摘要： A system and method for determining pulmonary performance from transthoracic impedance measures is provided. Transthoracic impedance measures collected by an implantable medical device are correlated to pulmonary functional measures. The pulmonary functional measures are grouped by respiratory pattern. Pulmonary performance is evaluated. Differences are determined by comparing the pulmonary functional measures for each respiratory pattern to the pulmonary functional measures for at least one previous respiratory pattern. A trend is identified from the differences. An alert is generated upon sufficient deviation of the trend from a threshold criteria.
摘要翻译： 提供了一种通过经胸阻抗测量来确定肺功能的系统和方法。 由可植入医疗器械收集的经胸阻抗测量与肺功能测量相关。 肺功能测量按呼吸模式分组。 评估肺功能。 通过将每个呼吸模式的肺功能测量与至少一个之前的呼吸模式的肺功能测量进行比较来确定差异。 从差异中确定出一个趋势。 在趋势与阈值标准的充分偏差之后产生警报。
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公开(公告)号：US08655446B2
公开(公告)日：2014-02-18
申请号：US11986886
申请日：2007-11-27
申请人： Jeffrey E. Stahmann , Jesse W. Hartley , Kent Lee , Quan Ni
发明人： Jeffrey E. Stahmann , Jesse W. Hartley , Kent Lee , Quan Ni
IPC分类号： A61N1/365
CPC分类号： A61N1/3601 , A61N1/36514 , A61N1/36542 , A61N1/36578 , G06F19/00
摘要： Methods and systems involve adjusting cardiac pacing based on information acquired via a respiratory therapy device. A medical system includes a respiratory therapy device having one or more sensors and a therapy delivery unit. The one or more sensors are configured to sense respiration cycles. The therapy delivery unit is configured to deliver an external respiratory therapy to the patient. The medical system also includes a pulse generator configured to deliver cardiac pacing pulses to the patient. A controller is coupled to the one or more sensors and the pulse generator. The control unit configured to adjust a cardiac pacing rate based on the patient's respiration cycles.
摘要翻译： 方法和系统涉及根据通过呼吸治疗装置获取的信息来调节心脏起搏。 医疗系统包括具有一个或多个传感器和治疗递送单元的呼吸治疗装置。 一个或多个传感器被配置成感测呼吸循环。 治疗递送单元被配置为向患者输送外部呼吸治疗。 医疗系统还包括脉冲发生器，其被配置为向患者传送心脏起搏脉冲。 控制器耦合到一个或多个传感器和脉冲发生器。 所述控制单元被配置为基于所述患者的呼吸周期来调节心脏起搏速率。
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9.发明授权Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device 有权使用一个或多个可植入装置监测疾病和药物管理的计时生理节律公开(公告)号：US08401636B2
公开(公告)日：2013-03-19
申请号：US13209938
申请日：2011-08-15
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61N1/18
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译： 使用至少一个可植入装置自动评价或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。
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公开(公告)号：US08321022B2
公开(公告)日：2012-11-27
申请号：US12731103
申请日：2010-03-24
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
IPC分类号： A61N1/36
CPC分类号： A61N1/362 , A61N1/3601
摘要： An approach to providing disordered breathing therapy includes detecting disordered breathing and adapting a therapy to mitigate the disordered breathing. The therapy may be adapted to enhance therapy effectiveness, to provide therapy that reduces an impact of the therapy on the patient, or to achieve other therapeutic goals. Cardiac electrical therapy to mitigate the disordered breathing may include various cardiac pacing regimens and/or delivery of non-excitatory electrical stimulation to the heart.
摘要翻译： 提供无序呼吸治疗的方法包括检测无序呼吸并适应治疗以减轻无序呼吸。 治疗可以适应于增强治疗有效性，提供减少治疗对患者的影响或实现其它治疗目标的治疗。 减轻无序呼吸的心脏电疗可能包括各种心脏起搏方案和/或向心脏递送非兴奋性电刺激。
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