公开(公告)号：US06197552B1

公开(公告)日：2001-03-06

申请号：US09192286

申请日：1998-11-15

申请人： Kenzo Yokozeki ,  Takashi Tsuji ,  Kunisuke Izawa

发明人： Kenzo Yokozeki ,  Takashi Tsuji ,  Kunisuke Izawa

IPC分类号： C12P1940

CPC分类号： C12P19/40

摘要： A process for preparing 2,6-diaminopurine-2′-deoxyriboside and 2′-deoxyguanosine. These compounds may be used as materials for pharmaceuticals, such as antiviral agents and the like, and particularly as starting materials for antisense oligonucleotides.

摘要翻译： 制备2,6-二氨基嘌呤-2'-脱氧核糖苷和2'-脱氧鸟苷的方法。 这些化合物可以用作药物的材料，例如抗病毒剂等，特别是作为反义寡核苷酸的起始材料。

公开(公告)号：US07012152B2

公开(公告)日：2006-03-14

申请号：US10639513

申请日：2003-08-13

申请人： Masakazu Nakazawa ,  Daisuke Takahashi ,  Norimasa Onishi ,  Masaki Naito ,  Kunisuke Izawa ,  Kenzo Yokozeki

发明人： Masakazu Nakazawa ,  Daisuke Takahashi ,  Norimasa Onishi ,  Masaki Naito ,  Kunisuke Izawa ,  Kenzo Yokozeki

IPC分类号： C07C205/00 ,  C07C229/00

CPC分类号： C07C229/26 ,  C07B2200/07 ,  C07C205/08 ,  C07C205/15 ,  C07C205/44 ,  C07C205/51 ,  C07C227/04 ,  C07C227/08 ,  C07C227/18 ,  C07C227/32 ,  C07C229/20 ,  C07C233/47 ,  C07C271/22 ,  C07C309/66 ,  C07D233/76 ,  C07D233/96 ,  C12P13/08 ,  C12P41/007 ,  C12P41/009 ,  Y02P20/55

摘要： The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or an amino group and carboxyl group of optically active 2-amino-6-methyl-6-nitroheptanoic acid with a protecting group, reducing a nitro group to synthesize a 6,6-dimethyl lysine derivative and reacting the 6,6-dimethyl lysine derivative with an acetic acid derivative.

公开(公告)号：US06664412B2

公开(公告)日：2003-12-16

申请号：US10281977

申请日：2002-10-29

申请人： Masakazu Nakazawa ,  Daisuke Takahashi ,  Norimasa Onishi ,  Masaki Naito ,  Kunisuke Izawa ,  Kenzo Yokozeki

发明人： Masakazu Nakazawa ,  Daisuke Takahashi ,  Norimasa Onishi ,  Masaki Naito ,  Kunisuke Izawa ,  Kenzo Yokozeki

IPC分类号： C07C22900

CPC分类号： C07C229/26 ,  C07B2200/07 ,  C07C205/08 ,  C07C205/15 ,  C07C205/44 ,  C07C205/51 ,  C07C227/04 ,  C07C227/08 ,  C07C227/18 ,  C07C227/32 ,  C07C229/20 ,  C07C233/47 ,  C07C271/22 ,  C07C309/66 ,  C07D233/76 ,  C07D233/96 ,  C12P13/08 ,  C12P41/007 ,  C12P41/009 ,  Y02P20/55

摘要： The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or an amino group and carboxyl group of optically active 2-amino-6-methyl-6-nitroheptanoic acid with a protecting group, reducing a nitro group to synthesize a 6,6-dimethyl lysine derivative and reacting the 6,6-dimethyl lysine derivative with an acetic acid derivative.

公开(公告)号：US20060004103A1

公开(公告)日：2006-01-05

申请号：US11211442

申请日：2005-08-26

申请人： Masakazu Nakazawa ,  Daisuke Takahashi ,  Norimasa Onishi ,  Masaki Naito ,  Kunisuke Izawa ,  Kenzo Yokozeki

发明人： Masakazu Nakazawa ,  Daisuke Takahashi ,  Norimasa Onishi ,  Masaki Naito ,  Kunisuke Izawa ,  Kenzo Yokozeki

IPC分类号： A61K31/198 ,  C07C227/18

CPC分类号： C07C229/26 ,  C07B2200/07 ,  C07C205/08 ,  C07C205/15 ,  C07C205/44 ,  C07C205/51 ,  C07C227/04 ,  C07C227/08 ,  C07C227/18 ,  C07C227/32 ,  C07C229/20 ,  C07C233/47 ,  C07C271/22 ,  C07C309/66 ,  C07D233/76 ,  C07D233/96 ,  C12P13/08 ,  C12P41/007 ,  C12P41/009 ,  Y02P20/55

摘要： The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or an amino group and carboxyl group of optically active 2-amino-6-methyl-6-nitroheptanoic acid with a protecting group, reducing a nitro group to synthesize a 6,6-dimethyl lysine derivative and reacting the 6,6-dimethyl lysine derivative with an acetic acid derivative.

公开(公告)号：US5036004A

公开(公告)日：1991-07-30

申请号：US348112

申请日：1989-05-05

申请人： Eiji Majima ,  Hiroaki Takino ,  Kunisuke Izawa ,  Kenzo Yokozeki ,  Koji Kubota

发明人： Eiji Majima ,  Hiroaki Takino ,  Kunisuke Izawa ,  Kenzo Yokozeki ,  Koji Kubota

IPC分类号： C12P13/06 ,  C12P17/14

CPC分类号： C12P13/06 ,  C12P17/14

摘要： A process for producing L-serine by the combination of chemical synthesis and enzyme chemical synthesis is disclosed. In this process L-serine is biochemically produced from 2-oxo-axazolidine-4-carboxylic acid or a salt thereof.

摘要翻译： 公开了通过化学合成和酶化学合成的组合生产L-丝氨酸的方法。 在该方法中，L-丝氨酸由2-氧代 - 唑烷-4-羧酸或其盐生物化学产生。

公开(公告)号：US20080287687A1

公开(公告)日：2008-11-20

申请号：US11979110

申请日：2007-10-31

申请人： Takayuki Hamada ,  Kunisuke Izawa ,  Vadim A. Soloshonok

发明人： Takayuki Hamada ,  Kunisuke Izawa ,  Vadim A. Soloshonok

IPC分类号： C07F15/04 ,  C07C229/02 ,  C07D409/02 ,  C07F9/06 ,  C07D207/04

CPC分类号： C07D207/16 ,  C07C227/32 ,  C07D409/12 ,  C07F9/091 ,  C07F15/045 ,  C07C229/36

摘要： The present invention relates to a production method of a compound represented by the formula (3), which includes reacting a compound represented by the formula (2) with a diphenylmethyl halide compound represented by the formula (1) in the presence of alkali metal alkoxide. According to the method of the present invention, compound (3) can be produced at a high purity and in a high yield. wherein each symbol is as defined in the specification, *1 and *2 each show an asymmetric carbon atom, and the configuration of the asymmetric carbon atom of *1 and *2 is (S,S) or (R,R).

摘要翻译： 本发明涉及式（3）表示的化合物的制备方法，其包括使式（2）表示的化合物与式（1）所示的二苯甲基卤化物在碱金属醇盐存在下反应 。 根据本发明的方法，可以以高纯度和高产率制备化合物（3）。 其中每个符号如说明书中所定义，* 1和* 2各自表示不对称碳原子，* 1和* 2的不对称碳原子的构型为（S，S）或（R，R）。

公开(公告)号：US20080188667A1

公开(公告)日：2008-08-07

申请号：US12023508

申请日：2008-01-31

申请人： Daisuke TAKAHASHI ,  Kunisuke Izawa

发明人： Daisuke TAKAHASHI ,  Kunisuke Izawa

IPC分类号： C07D263/18

CPC分类号： C07D263/42

摘要： Compounds represented by formula (II): wherein M is a hydrogen atom, sodium, potassium, or lithium; P is a hydrogen atom, an alkyl group, and the like; and the wavy line indicates a cis form, a trans form, or a mixture thereof for the double bond to which it is attached, may be prepared by hydrolyzing a compound represented by formula (I), or a salt thereof: wherein R1 and R2 are the same or different and each is an alkyl group, or R1 and R2 together with the adjacent nitrogen atom may form an aliphatic heterocycle, and P and the wavy line are as defined above, in the presence of alkali metal hydroxide.

摘要翻译： 由式（II）表示的化合物：其中M是氢原子，钠，钾或锂; P是氢原子，烷基等; 并且波浪线表示其连接的双键的顺式，反式或其混合物，可以通过水解式（I）表示的化合物或其盐来制备：其中R ^{1和R 2相同或不同，并且各自为烷基，或R 1和R 2连同 在碱金属氢氧化物的存在下，相邻的氮原子可以形成脂族杂环，P和波浪线如上所定义。}

公开(公告)号：US07148371B2

公开(公告)日：2006-12-12

申请号：US11211442

申请日：2005-08-26

申请人： Masakazu Nakazawa ,  Daisuke Takahashi ,  Masaki Naito ,  Kunisuke Izawa

发明人： Masakazu Nakazawa ,  Daisuke Takahashi ,  Masaki Naito ,  Kunisuke Izawa

IPC分类号： C07C229/00

CPC分类号： C07C229/26 ,  C07B2200/07 ,  C07C205/08 ,  C07C205/15 ,  C07C205/44 ,  C07C205/51 ,  C07C227/04 ,  C07C227/08 ,  C07C227/18 ,  C07C227/32 ,  C07C229/20 ,  C07C233/47 ,  C07C271/22 ,  C07C309/66 ,  C07D233/76 ,  C07D233/96 ,  C12P13/08 ,  C12P41/007 ,  C12P41/009 ,  Y02P20/55

摘要： The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or an amino group and carboxyl group of optically active 2-amino-6-methyl-6-nitroheptanoic acid with a protecting group, reducing a nitro group to synthesize a 6,6-dimethyl lysine derivative and reacting the 6,6-dimethyl lysine derivative with an acetic acid derivative.

公开(公告)号：US07145030B2

公开(公告)日：2006-12-05

申请号：US10826374

申请日：2004-04-19

申请人： Takayuki Hamada ,  Kunisuke Izawa

发明人： Takayuki Hamada ,  Kunisuke Izawa

IPC分类号： C07C229/00

CPC分类号： C07C227/32 ,  C07B2200/07 ,  C07C229/18

摘要： The present invention provides an effective method for the production of optically active N-aryl-β-amino acid compounds, which at the same time is suitable for industrial production. In the method of the present invention optically active sulfonylated β-hydroxycarboxylic acid compounds, which are readily derived from β-keto carboxylic acid compounds, are reacted with aromatic amines to produce optically active N-aryl-β-amino acid compounds.

摘要翻译： 本发明提供了生产光学活性N-芳基-β-氨基酸化合物的有效方法，其同时适用于工业生产。 在本发明的方法中，易于得自β-酮羧酸化合物的光学活性磺酰化的β-羟基羧酸化合物与芳族胺反应以产生光学活性的N-芳基-β-氨基酸化合物。

公开(公告)号：US20050137408A1

公开(公告)日：2005-06-23

申请号：US10972520

申请日：2004-10-26

申请人： Yasuyuki Otake ,  Kunisuke Izawa

发明人： Yasuyuki Otake ,  Kunisuke Izawa

IPC分类号： C07D301/26 ,  C07D303/36 ,  C07D301/24

CPC分类号： C07D301/26 ,  C07D303/36

摘要： N-carbamate protected-3-amino-1,2-epoxy-4-(hydroxy substituted phenyl)butane may be produced in high optical purity and in high yield, by hydrogenating N-carbamate protected-3-amino-1-chloro-2-hydroxy-4-(benzyloxy substituted phenyl)butane in the presence of a metal catalyst to give N-carbamate protected-3-amino-1-chloro-2-hydroxy-4-(hydroxy substituted phenyl)butane and treating this compound with a base.

摘要翻译： N-氨基甲酸酯保护的3-氨基-1,2-环氧-4-（羟基取代的苯基）丁烷可以通过氢化N-氨基甲酸酯保护的3-氨基-1-氯 - 2-羟基-4-（苄氧基取代的苯基）丁烷，在金属催化剂存在下，得到N-氨基甲酸酯保护的3-氨基-1-氯-2-羟基-4-（羟基取代的苯基）丁烷并处理该化合物 与一个基地。