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公开(公告)号：US20060004103A1
公开(公告)日：2006-01-05
申请号：US11211442
申请日：2005-08-26
Applicant: Masakazu Nakazawa , Daisuke Takahashi , Norimasa Onishi , Masaki Naito , Kunisuke Izawa , Kenzo Yokozeki
Inventor： Masakazu Nakazawa , Daisuke Takahashi , Norimasa Onishi , Masaki Naito , Kunisuke Izawa , Kenzo Yokozeki
IPC: A61K31/198 , C07C227/18
CPC classification number: C07C229/26 , C07B2200/07 , C07C205/08 , C07C205/15 , C07C205/44 , C07C205/51 , C07C227/04 , C07C227/08 , C07C227/18 , C07C227/32 , C07C229/20 , C07C233/47 , C07C271/22 , C07C309/66 , C07D233/76 , C07D233/96 , C12P13/08 , C12P41/007 , C12P41/009 , Y02P20/55
Abstract: The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or an amino group and carboxyl group of optically active 2-amino-6-methyl-6-nitroheptanoic acid with a protecting group, reducing a nitro group to synthesize a 6,6-dimethyl lysine derivative and reacting the 6,6-dimethyl lysine derivative with an acetic acid derivative.
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公开(公告)号：US5728398A
公开(公告)日：1998-03-17
申请号：US745190
申请日：1996-11-07
Applicant: Norimasa Onishi , Yasuhiko Toride , Akinori Uehara , Ei-ichi Kokue
Inventor： Norimasa Onishi , Yasuhiko Toride , Akinori Uehara , Ei-ichi Kokue
CPC classification number: A23K50/00 , A23K10/10 , A23K10/20 , A23K20/116 , A23K20/168 , A23K20/195
Abstract: A feed additive for sows containing, as an active ingredient, a reduced form of folic acid. Included are 7,8-dihydrofolic acid, leucovorin, liver powder, disrupted cells or cell extract of a microorganism, etc.
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3.发明授权Method of the production of (s)-gamma-halogenated-.gamma.-hydroxybutyric acid esters 失效制备 - 卤代-β-羟基丁酸酯的方法
公开(公告)号：US5413921A
公开(公告)日：1995-05-09
申请号：US66239
申请日：1993-05-25
Applicant: Norimasa Onishi , Megumi Shimaoka , Ikuo Kira , Masakazu Nakazawa
Inventor： Norimasa Onishi , Megumi Shimaoka , Ikuo Kira , Masakazu Nakazawa
CPC classification number: C12P7/62 , Y10S435/911 , Y10S435/94
Abstract: The present invention provides a method of the production of (S)-.gamma.-halogenated-.beta.-hydroxybutyric acid esters at a high accumulation and a high yield. A microorganism belonging to the genus Stemphylium, Alternaria, Corynespora or Torulaspora is used to asymmetrically reduce a .gamma.-halogenated-acetoacetic acid ester into an (S)-.gamma.-halogenated-.beta.-hydroxybutyric acid ester, and the (S)-.gamma.-halogenated-.beta.-hydroxybutyric acid ester produced is recovered from the reaction mixture.
Abstract translation: 本发明提供以高积累和高产率生产（S）-γ-卤代-β-羟基丁酸酯的方法。 使用属于Stemphylium属，链格孢属，棒杆菌属或孢子虫属的微生物不对称地将γ-卤代乙酰乙酸酯还原成（S）-γ-卤代-β-羟基丁酸酯，（S）-γ- 从反应混合物中回收生成的卤代-β-羟基丁酸酯。
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公开(公告)号：US08105802B2
公开(公告)日：2012-01-31
申请号：US12714853
申请日：2010-03-01
Applicant: Yukiko Umezawa , Keiichi Yokoyama , Yoshimi Kikuchi , Masayo Date , Norimasa Onishi
Inventor： Yukiko Umezawa , Keiichi Yokoyama , Yoshimi Kikuchi , Masayo Date , Norimasa Onishi
CPC classification number: C12N9/1044 , C12N9/6489
Abstract: The present invention provides a neutral metalloprotease from actinomycetes which selectively cleaves a pro-structure part of a microbial protransglutaminase and a gene encoding said neutral metalloprotease. An active microbial transglutaminase having the pro-structure part cleaved can be obtained by culturing a microorganism into which a gene encoding the neutral metalloprotease from actinomycetes according to the present invention has been introduced, where by producing the neutral metalloprotease from actinomycetes, and reacting it on a microbial protransglutaminase.
Abstract translation: 本发明提供来自放线菌的中性金属蛋白酶，其选择性地切割微生物转谷氨酰胺酶的前体结构部分和编码所述中性金属蛋白酶的基因。 具有前体结构部分切割的活性微生物转谷氨酰胺酶可以通过培养从引入放线菌中产生中性金属蛋白酶的本发明的编码中性金属蛋白酶的基因的微生物获得，其中通过从放线菌产生中性金属蛋白酶， 微生物抗转谷氨酰胺酶。
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公开(公告)号：US07582454B2
公开(公告)日：2009-09-01
申请号：US11484680
申请日：2006-07-12
Applicant: Shunichi Suzuki , Norimasa Onishi , Kenzo Yokozeki
Inventor： Shunichi Suzuki , Norimasa Onishi , Kenzo Yokozeki
CPC classification number: C12P13/22 , C12N9/90 , C12P41/009
Abstract: The present invention relates to a 5-substituted hydantoin racemase, which efficiently catalyzes racemization reactions at a high optimum temperature for racemization reactions, DNA coding for the racemase, and processes for producing optically active amino acids.
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Patent Agency Ranking
公开(公告)号：US06664412B2
公开(公告)日：2003-12-16
申请号：US10281977
申请日：2002-10-29
Applicant: Masakazu Nakazawa , Daisuke Takahashi , Norimasa Onishi , Masaki Naito , Kunisuke Izawa , Kenzo Yokozeki
Inventor： Masakazu Nakazawa , Daisuke Takahashi , Norimasa Onishi , Masaki Naito , Kunisuke Izawa , Kenzo Yokozeki
IPC: C07C22900
CPC classification number: C07C229/26 , C07B2200/07 , C07C205/08 , C07C205/15 , C07C205/44 , C07C205/51 , C07C227/04 , C07C227/08 , C07C227/18 , C07C227/32 , C07C229/20 , C07C233/47 , C07C271/22 , C07C309/66 , C07D233/76 , C07D233/96 , C12P13/08 , C12P41/007 , C12P41/009 , Y02P20/55
Abstract: The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or an amino group and carboxyl group of optically active 2-amino-6-methyl-6-nitroheptanoic acid with a protecting group, reducing a nitro group to synthesize a 6,6-dimethyl lysine derivative and reacting the 6,6-dimethyl lysine derivative with an acetic acid derivative.
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7.发明授权
公开(公告)号：US5552145A
公开(公告)日：1996-09-03
申请号：US979885
申请日：1992-11-23
Applicant: Yasuhiko Toride , Norimasa Onishi , Yoichiro Togashi
Inventor： Yasuhiko Toride , Norimasa Onishi , Yoichiro Togashi
CPC classification number: A23K50/00 , A23K10/10 , Y10S424/825
Abstract: Administering a feed composition, containing at least one member selected from the group consisting of sterilized bacterial cells; disrupted cell fragments obtained by mechanical disruption or enzymatic decomposition of the cells and cell wall component-containing fractions obtained by fractionation of the disrupted cell fragments, to pregnant sows and mother sows results in a reduction in stillborn piglets, a decrease in mortality during the breast-feeding period, a reduction in the occurrence of diarrhea during the breast-feeding period, and an increase in body weight of piglets.
Abstract translation: 施用含有至少一种选自灭菌细菌细胞的成分的饲料组合物; 通过机械破碎或酶分解获得的破碎的细胞碎片和通过将破碎的细胞碎片分馏得到的含有细胞壁成分的级分，孕育母猪和母猪母猪，导致死胎率降低，死亡率降低 哺乳期，母乳喂养期腹泻发生率下降，仔猪体重增加。
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公开(公告)号：US07012152B2
公开(公告)日：2006-03-14
申请号：US10639513
申请日：2003-08-13
Applicant: Masakazu Nakazawa , Daisuke Takahashi , Norimasa Onishi , Masaki Naito , Kunisuke Izawa , Kenzo Yokozeki
Inventor： Masakazu Nakazawa , Daisuke Takahashi , Norimasa Onishi , Masaki Naito , Kunisuke Izawa , Kenzo Yokozeki
IPC: C07C205/00 , C07C229/00
CPC classification number: C07C229/26 , C07B2200/07 , C07C205/08 , C07C205/15 , C07C205/44 , C07C205/51 , C07C227/04 , C07C227/08 , C07C227/18 , C07C227/32 , C07C229/20 , C07C233/47 , C07C271/22 , C07C309/66 , C07D233/76 , C07D233/96 , C12P13/08 , C12P41/007 , C12P41/009 , Y02P20/55
Abstract: The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or an amino group and carboxyl group of optically active 2-amino-6-methyl-6-nitroheptanoic acid with a protecting group, reducing a nitro group to synthesize a 6,6-dimethyl lysine derivative and reacting the 6,6-dimethyl lysine derivative with an acetic acid derivative.
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公开(公告)号：US20060019367A1
公开(公告)日：2006-01-26
申请号：US11218780
申请日：2005-09-06
Applicant: Yukiko Umezawa , Keiichi Yokoyama , Yoshimi Kikuchi , Masayo Date , Norimasa Onishi
Inventor： Yukiko Umezawa , Keiichi Yokoyama , Yoshimi Kikuchi , Masayo Date , Norimasa Onishi
CPC classification number: C12N9/1044 , C12N9/6489
Abstract: The present invention provides a neutral metalloprotease from actinomycetes which selectively cleaves a pro-structure part of a microbial protransglutaminase and a gene encoding said neutral metalloprotease. An active microbial transglutaminase having the pro-structure part cleaved can be obtained by culturing a microorganism into which a gene encoding the neutral metalloprotease from actinomycetes according to the present invention has been introduced, where by producing the neutral metalloprotease from actinomycetes, and reacting it on a microbial protransglutaminase.
Abstract translation: 本发明提供来自放线菌的中性金属蛋白酶，其选择性地切割微生物转谷氨酰胺酶的前体结构部分和编码所述中性金属蛋白酶的基因。 具有前体结构部分切割的活性微生物转谷氨酰胺酶可以通过培养从引入放线菌中产生中性金属蛋白酶的本发明的编码中性金属蛋白酶的基因的微生物获得，其中通过从放线菌产生中性金属蛋白酶， 微生物抗转谷氨酰胺酶。
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公开(公告)号：US5372810A
公开(公告)日：1994-12-13
申请号：US973572
申请日：1992-11-09
Applicant: Norimasa Onishi , Akihiro Yamashiro
Inventor： Norimasa Onishi , Akihiro Yamashiro
IPC: A23K1/00 , A23K1/18 , A61K35/74 , A61K35/742 , A61K35/744 , A61K35/747 , A61K37/00 , C12N1/00 , C12N1/20
CPC classification number: A61K35/747 , A23K10/16 , A23K50/30 , A61K35/74 , A61K35/742 , A61K35/744 , Y10S435/832 , Y10S435/84 , Y10S435/843 , Y10S435/853
Abstract: A composition and method for the prevention and treatment of diarrhea in domesticated animals, comprising sterilized cells of aerobic bacteria belonging to the genus Bacillus, Brevibacterium, Corynebacterium, Escherichia, Lactobacillus, Streptococcus, or Streptomyces, a cell homogenate of said sterilized cells, a cell wall component-containing fraction of said homogenate or mixtures thereof. In particular species of Corynebacterium glutamicum and Brevibacterium lactofermentum as well as strains thereof, such as A.T.C.C. 13060 and A.T.C.C. 13869, respectively, are useful in the treatment of diarrhea in domesticated animals.
Abstract translation: 用于预防和治疗驯养动物腹泻的组合物和方法，包括属于芽孢杆菌属，短杆菌属，棒状杆菌属，埃希氏杆菌属，乳杆菌属，链球菌属或链霉菌属的需氧细菌的灭菌细胞，所述灭菌细胞的细胞匀浆，细胞 所述匀浆物的含壁组分的级分或其混合物。 特别是谷氨酸棒杆菌和乳发酵短杆菌的物种及其菌株，如A.T.C.C. 13060和A.T.C.C. 13869分别用于治疗驯养动物腹泻。
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