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公开(公告)号：US20050239770A1
公开(公告)日：2005-10-27
申请号：US11143430
申请日：2005-06-02
申请人： Kevin Moriarty , Yvonne Shimshock , Gulzar Ahmed , Junjun Wu , James Wen , Wei Li , Shawn Erickson , Jeffrey Letourneau , Edward McDonald , Katerina Leftheris , Stephen Wrobleski , Zahid Hussain , Ian Henderson , Axel Metzger , John Baldwin , Alaric Dyckman
发明人： Kevin Moriarty , Yvonne Shimshock , Gulzar Ahmed , Junjun Wu , James Wen , Wei Li , Shawn Erickson , Jeffrey Letourneau , Edward McDonald , Katerina Leftheris , Stephen Wrobleski , Zahid Hussain , Ian Henderson , Axel Metzger , John Baldwin , Alaric Dyckman
IPC分类号： A61K31/40 , A61K31/551 , C07D251/52 , C07D251/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D521/00
CPC分类号： C07D251/52 , C07D231/12 , C07D233/56 , C07D249/08 , C07D251/48 , C07D251/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
摘要翻译： 公开了通过抑制p38激酶阻断细胞因子产生的N-杂环化合物。 在一个实施方案中，本发明的化合物由式I表示：还公开了使用本发明化合物的生产方法，药物组合物和治疗与不适当的p38激酶活性或TNF-α表达相关的病症的方法。
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公开(公告)号：US06906067B2
公开(公告)日：2005-06-14
申请号：US09891750
申请日：2001-06-26
申请人： Kevin Joseph Moriarty , Yvonne Shimshock , Gulzar Ahmed , Junjun Wu , James Wen , Wei Li , Shawn David Erickson , Jeffrey John Letourneau , Edward McDonald , Katerina Leftheris , Stephen T. Wrobleski , Zahid Hussain , Ian Henderson , Axel Metzger , John J. Baldwin , Alaric J. Dyckman
发明人： Kevin Joseph Moriarty , Yvonne Shimshock , Gulzar Ahmed , Junjun Wu , James Wen , Wei Li , Shawn David Erickson , Jeffrey John Letourneau , Edward McDonald , Katerina Leftheris , Stephen T. Wrobleski , Zahid Hussain , Ian Henderson , Axel Metzger , John J. Baldwin , Alaric J. Dyckman
IPC分类号： A61K31/40 , A61K31/551 , C07D251/52 , C07D251/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D521/00 , C07D251/40 , A61K31/53 , A61P35/00 , C07D251/48
CPC分类号： C07D251/52 , C07D231/12 , C07D233/56 , C07D249/08 , C07D251/48 , C07D251/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
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公开(公告)号：US07479495B2
公开(公告)日：2009-01-20
申请号：US11143430
申请日：2005-06-02
申请人： Kevin Joseph Moriarty , Yvonne Shimshock , Gulzar Ahmed , Junjun Wu , James Wen , Wei Li , Shawn David Erickson , Jeffrey John Letourneau , Edward McDonald , Katerina Leftheris , Stephen T. Wrobleski , Zahid Hussain , Ian Henderson , Axel Metzger , John J. Baldwin , Alaric J. Dyckman
发明人： Kevin Joseph Moriarty , Yvonne Shimshock , Gulzar Ahmed , Junjun Wu , James Wen , Wei Li , Shawn David Erickson , Jeffrey John Letourneau , Edward McDonald , Katerina Leftheris , Stephen T. Wrobleski , Zahid Hussain , Ian Henderson , Axel Metzger , John J. Baldwin , Alaric J. Dyckman
IPC分类号： C07D239/32 , C07D239/48 , C07D239/50 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , A61K31/505 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号： C07D251/52 , C07D231/12 , C07D233/56 , C07D249/08 , C07D251/48 , C07D251/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
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公开(公告)号：US10665124B2
公开(公告)日：2020-05-26
申请号：US15935099
申请日：2018-03-26
申请人： James Wen
发明人： James Wen
摘要： A standard musical score represented in digital format is analyzed for its constituent parts in order to identify notational directives for traversing through the musical score. A linearized version of the musical score is generated that is in substantially the same visual format but allows the reader to traverse through the musical score exclusively in a forward direction and without need for jumps in a reverse direction or forward jumps beyond the subsequent consecutive page. In certain embodiments, forward jumps may be minimally limited to a page within the musical score while in other embodiments a forward jump may be minimally limited to a line or a measure. In yet other embodiments, reverse jumps may be entirely eliminated while in still other embodiments, reverse jumps within pages may remain unchanged.
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公开(公告)号：US20180277012A1
公开(公告)日：2018-09-27
申请号：US15935099
申请日：2018-03-26
申请人： James Wen
发明人： James Wen
CPC分类号： G09B15/023 , G10G1/00 , G10H1/0008 , G10H1/0033 , G10H2220/015 , G10H2220/441
摘要： A standard musical score represented in digital format is analyzed for its constituent parts in order to identify notational directives for traversing through the musical score. A linearized version of the musical score is generated that is in substantially the same visual format but allows the reader to traverse through the musical score exclusively in a forward direction and without need for jumps in a reverse direction or forward jumps beyond the subsequent consecutive page. In certain embodiments, forward jumps may be minimally limited to a page within the musical score while in other embodiments a forward jump may be minimally limited to a line or a measure. In yet other embodiments, reverse jumps may be entirely eliminated while in still other embodiments, reverse jumps within pages may remain unchanged.
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公开(公告)号：US20190235710A1
公开(公告)日：2019-08-01
申请号：US15881854
申请日：2018-01-29
申请人： James Wen
发明人： James Wen
IPC分类号： G06F3/0483 , G06F3/01 , G06F3/0488 , G06F3/16
CPC分类号： G06F3/0483 , G06F3/013 , G06F3/04883 , G06F3/167
摘要： Embodiments of the present invention disclose a method and system for traversing through digital content displayed on a digital device in a piecewise manner. According to one embodiment, a trigger event is received from a user causing an update of a portion of the display area resulting in discontiguous content being rendered. The balance of the display area is updated with continuous content upon the receipt of a subsequent trigger event.
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