-
公开(公告)号：US06423489B1
公开(公告)日：2002-07-23
申请号：US08452841
申请日：1995-05-30
申请人： Kevin P. Anderson , Ronnie C. Hanecak , Kazuya Hoshiko , Chikateru Nozaki , Tsukasa Nishihara , Hiroshi Nakatake , Fukusaburo Hamada , Tatsuo Eto , Shinichi Furukawa , Shoji Furusako , Thomas W. Bruice , Walter F. Lima
发明人： Kevin P. Anderson , Ronnie C. Hanecak , Kazuya Hoshiko , Chikateru Nozaki , Tsukasa Nishihara , Hiroshi Nakatake , Fukusaburo Hamada , Tatsuo Eto , Shinichi Furukawa , Shoji Furusako , Thomas W. Bruice , Walter F. Lima
IPC分类号： C12Q168
CPC分类号： C12N15/1131 , C07H21/00 , C07K14/005 , C12N2310/315 , C12N2310/33 , C12N2310/3521 , C12N2310/3527 , C12N2770/24222 , C12Q1/707
摘要： Antisense oligonucleotides are provided which are complementary to and hybridizable with at least a portion of HCV RNA and which are capable of inhibiting the function of the HCV RNA. These oligonucleotides can be administered to inhibit the activity of Hepatitis C virus in vivo or in vitro. These compounds can be used either prophylactically or therapeutically to reduce the severity of diseases associated with Hepatitis C virus, and for diagnosis and detection of HCV and HCV-associated diseases. Methods of using these compounds are also disclosed.
-
2.发明授权Compositions and methods for treatment of Hepatitis C virus-associated diseases 失效治疗丙型肝炎病毒相关疾病的组合物和方法公开(公告)号：US06391542B1
公开(公告)日：2002-05-21
申请号：US08650093
申请日：1996-05-17
申请人： Kevin P. Anderson , Ronnie C. Hanecak , Kazuya Hoshiko , Chikateru Nozaki , Tsukasa Nishihara , Hiroshi Nakatake , Fukusaburo Hamada , Tatsuo Eto , Shinichi Furukawa , Shoji Furasako , Thomas W. Bruice , Walter F. Lima
发明人： Kevin P. Anderson , Ronnie C. Hanecak , Kazuya Hoshiko , Chikateru Nozaki , Tsukasa Nishihara , Hiroshi Nakatake , Fukusaburo Hamada , Tatsuo Eto , Shinichi Furukawa , Shoji Furasako , Thomas W. Bruice , Walter F. Lima
IPC分类号： C12Q168
CPC分类号： C12N15/1131 , C07H21/00 , C07K14/005 , C12N2310/315 , C12N2310/33 , C12N2310/3521 , C12N2310/3527 , C12N2770/24222 , C12Q1/707
摘要： Antisense oligonucleotides are provided which are complementary to and hybridizable with at least a portion of HCV RNA and which are capable of inhibiting the function of the HCV RNA. These oligonucleotides can be administered to inhibit the activity of Hepatitis C virus in vivo or in vitro. These compounds can be used either prophylactically or therapeutically to reduce the severity of diseases associated with Hepatitis C virus, and for diagnosis and detection of HCV and HCV-associated diseases. Methods of using these compounds are also disclosed.
摘要翻译： 提供反义寡核苷酸，其与至少一部分HCV RNA互补并可与其相互杂交，并能够抑制HCV RNA的功能。 可以施用这些寡核苷酸来体内或体外抑制丙型肝炎病毒的活性。 这些化合物可以预防性地或治疗性地用于降低与丙型肝炎病毒相关的疾病的严重性，以及HCV和HCV相关疾病的诊断和检测。 还公开了使用这些化合物的方法。
-
3.发明授权
公开(公告)号：US5686242A
公开(公告)日：1997-11-11
申请号：US330000
申请日：1994-10-27
申请人： Thomas W. Bruice , Walter F. Lima
发明人： Thomas W. Bruice , Walter F. Lima
CPC分类号： A61K31/70 , C12Q1/6811
摘要： Oligonucleotides which selectively bind to target biomolecules are determined by in vitro assay of a pool of random oligonucleotides for activity against said biomolecules, followed by recovery and characterization of selected oligonucleotides. Oligonucleotides so determined may be utilized for therapeutic, diagnostic and research reagent purposes.
摘要翻译： 选择性地结合靶生物分子的寡核苷酸通过体外测定随机寡核苷酸库来测定针对所述生物分子的活性，随后恢复和表征所选择的寡核苷酸。 如此确定的寡核苷酸可用于治疗，诊断和研究试剂目的。
-
4.发明授权
公开(公告)号：US6022691A
公开(公告)日：2000-02-08
申请号：US965908
申请日：1997-11-07
申请人： Thomas W. Bruice , Walter F. Lima
发明人： Thomas W. Bruice , Walter F. Lima
CPC分类号： A61K31/70 , C12Q1/6811
摘要： Oligonucleotides which selectively bind to target biomolecules are determined by in vitro assay of a pool of random oligonucleotides for activity against the biomolecules, followed by recovery and characterization of selected oligonucleotides. Oligonucleotides so determined may be utilized for therapeutic, diagnostic and research reagent purposes.
摘要翻译： 选择性结合靶生物分子的寡核苷酸通过体外测定随机寡核苷酸库来测定生物分子的活性，随后选择寡核苷酸的恢复和表征。 如此确定的寡核苷酸可用于治疗，诊断和研究试剂目的。
-
公开(公告)号：US10023861B2
公开(公告)日：2018-07-17
申请号：US14342196
申请日：2012-08-29
IPC分类号： C07H21/04 , C12N15/113 , C12N15/11 , C07H21/00
摘要： Oligonucleotides, chemically-modified oligonucleotides, and oligonucleotide-conjugate complexes for use in research, diagnostics, and/or therapeutics are described herein. In some embodiments, oligonucleotides comprising a stabilized phosphate moiety covalently attached to the 5′-terminal nucleoside are provided.
-
公开(公告)号：US06376661B1
公开(公告)日：2002-04-23
申请号：US09684254
申请日：2000-10-06
申请人： Stanley T. Crooke , Walter F. Lima , Hongjiang Wu
发明人： Stanley T. Crooke , Walter F. Lima , Hongjiang Wu
IPC分类号： C07H2104
CPC分类号： C12N9/22 , A61K38/00 , C12N15/113 , C12N2310/11
摘要： The present invention provides polynucleotides and polypeptides encoded thereby of human Type 2 RNase H. Methods of using these polynucleotides and polypeptides in enhancing antisense oligonucleotide therapies are also provided.
-
公开(公告)号：US08987435B2
公开(公告)日：2015-03-24
申请号：US13125751
申请日：2009-10-23
CPC分类号： C12N15/1137 , C07H21/00 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/351
摘要： The present invention provides oligomeric compounds and uses thereof. In certain embodiments, such oligomeric compounds are useful as antisense compounds. Certain such antisense compounds are useful as RNase H antisense compounds or as RNAi compounds.
摘要翻译： 本发明提供低聚化合物及其用途。 在某些实施方案中，这些低聚化合物可用作反义化合物。 某些这样的反义化合物可用作RNase H反义化合物或作为RNAi化合物。
-
公开(公告)号：US06855530B2
公开(公告)日：2005-02-15
申请号：US09992738
申请日：2001-11-14
申请人： Hongjiang Wu , Walter F. Lima , Stanley T. Crooke
发明人： Hongjiang Wu , Walter F. Lima , Stanley T. Crooke
摘要： A human RNase H polypeptide and methods of use are provided.
摘要翻译： 提供人类RNA酶H多肽和使用方法。
-
公开(公告)号：US20150018540A1
公开(公告)日：2015-01-15
申请号：US14342196
申请日：2012-08-29
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C07H21/00 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2310/322 , C12N2310/341 , C12N2310/351 , C12N2310/3515 , C12N2320/51 , C12N2310/3525
摘要： Oligonucleotides, chemically-modified oligonucleotides, and oligonucleotide-conjugate compl in research, diagnostics, and/or therapeutics are described herein.
摘要翻译： 本文描述了研究，诊断和/或治疗中的寡核苷酸，化学修饰的寡核苷酸和寡核苷酸 - 缀合物的补体。
-
公开(公告)号：US20100093836A1
公开(公告)日：2010-04-15
申请号：US12524778
申请日：2008-01-29
IPC分类号： A61K31/7088 , C07H19/04 , C12N5/02
CPC分类号： C07H21/00 , C12N15/113 , C12N2310/315 , C12N2310/322 , C12N2310/344 , C12N2310/346 , C12N2310/3533
摘要： The present invention includes compositions and methods useful for modulating protein expression. In certain embodiments, the present invention includes oligomeric compounds comprising modified nucleosides and modified internucleoside linkages.
摘要翻译： 本发明包括可用于调节蛋白质表达的组合物和方法。 在某些实施方案中，本发明包括包含修饰的核苷和经修饰的核苷间键的寡聚化合物。
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.064 秒)
